Numerical and functional defects of blood dendritic cells in early- and late-stage breast cancer

British Journal of Cancer

Volumn 97, Issue 9, 2007, Pages 1251-1259

  Pinzon Charry, A ^a,b   Ho, C S K ^c   Maxwell, T ^a   McGuckin, M A ^c   Schmidt, C ^a   Furnival, C ^d   Pyke, C M ^e   Lopez J A ^a,b,f  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c MATER MEDICAL RESEARCH INSTITUTE   (Australia)

^d WESLEY HOSPITAL   (Australia)

^e MATER HOSPITAL   (Australia)

^f Australian Centre for Vaccine Development   (Australia)

Author keywords

Breast cancer; Dendritic cells; Immune function; Immunotherapy CD40

Indexed keywords

CD40 LIGAND; CD86 ANTIGEN;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BLOOD CELL; BLOOD CELL COUNT; BREAST CANCER; CANCER INHIBITION; CANCER STAGING; CANCER SURGERY; CELL COUNT; CELL INTERACTION; CELL MATURATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DENDRITIC CELL; DISEASE ASSOCIATION; EX VIVO STUDY; FEMALE; HUMAN; IMMUNOSTIMULATION; IMMUNOTHERAPY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; OUTCOMES RESEARCH; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR IMMUNITY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; BLOOD CELLS; BREAST NEOPLASMS; CASE-CONTROL STUDIES; CD40 LIGAND; CELL COUNT; CROSS-SECTIONAL STUDIES; CULTURE MEDIA, CONDITIONED; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PHENOTYPE;

EID: 35648982344     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604018     Document Type: Article

References (44)

1. Almand B, Resser JR, Lindman B, Nadaf S, Clark JI, Kwon ED, Carbone DP, Gabrilovich DI (2000) Clinical significance of defective dendritic cell differentiation in cancer. Clin Cancer Res 6: 1755-1766
2. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K (2000) Immunobiology of dendritic cells. Annu Rev Immunol 18: 767-811
3. Bell D, Chomarat P, Broyles D, Netto G, Harb GM, Lebecque S, Valladeau J, Davoust J, Palucka KA, Banchereau J (1999) In breast carcinoma tissue, immature dendritic cells reside within the tumor, whereas mature dendritic cells are located in peritumoral areas. J Exp Med 190: 1417-1426
4. Bengtsson AK, Ryan EJ, Giordano D, Magaletti DM, Clark EA (2004) 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells. Blood 104: 1404-1410
5. Berghofer B, Frommer T, Haley G, Fink L, Bein G, Hackstein H (2006) TLR7 ligands induce higher IFN-alpha production in females. J Immunol 177: 2088-2096
6. Cella M, Salio M, Sakakibara Y, Langen H, Julkunen I, Lanzavecchia A (1999) Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. J Exp Med 189: 821-829
7. Coventry BJ, Lee PL, Gibbs D, Hart DN (2002) Dendritic cell density and activation status in human breast cancer - CD1a, CMRF-44, CMRF-56 and CD-83 expression. Br J Cancer 86: 546-551
8. Davis ID, Chen Q, Morris L, Quirk J, Stanley M, Tavarnesi ML, Parente P, Cavicchiolo T, Hopkins W, Jackson H, Dimopoulos N, Tai TY, MacGregor D, Browning J, Svobodova S, Caron D, Maraskovsky E, Old LJ, Chen W, Cebon J (2006) Blood dendritic cells generated with Flt3 ligand and CD40 ligand prime CD8+ T cells efficiently in cancer patients. J Immunother 29: 499-511
9. Della Bella S, Gennaro M, Vaccari M, Ferraris C, Nicola S, Riva A, Clerici M, Greco M, Villa ML (2003) Altered maturation of peripheral blood dendritic cells in patients with breast cancer. Br J Cancer 89: 1463-1472
10. Gabrilovich DI, Chen HL, Girgis KR, Cunningham HT, Meny GM, Nadaf S, Kavanaugh D, Carbone DP (1996) Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat Med 2: 1096-1103
11. Gabrilovich DI, Corak J, Ciernik IF, Kavanaugh D, Carbone DP (1997) Decreased antigen presentation by dendritic cells in patients with breast cancer. Clin Cancer Res 3: 483-490
12. Ho CS, Lopez JA, Vuckovic S, Pyke CM, Hockey RL, Hart DN (2001) Surgical and physical stress increases circulating blood dendritic cell counts independently of monocyte counts. Blood 98: 140-145
13. Ho CS, Munster D, Pyke CM, Hart DN, Lopez JA (2002) Spontaneous generation and survival of blood dendritic cells in mononuclear cell culture without exogenous cytokines. Blood 99: 2897-2904
14. Hoffmann TK, Muller-Berghaus J, Ferris RL, Johnson JT, Storkus WJ, Whiteside TL (2002) Alterations in the frequency of dendritic cell subsets in the peripheral circulation of patients with squamous cell carcinomas of the head and neck. Clin Cancer Res 8: 1787-1793
15. Janni W, Rjosk D, Braun S (2000) Clinical relevance of occult metastatic cells in the bone marrow of patients with different stages of breast cancer. Clin Breast Cancer 1: 217-225
16. Jonuleit H, Kuhn U, Muller G, Steinbrink K, Paragnik L, Schmitt E, Knop J, Enk AH (1997) Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol 27: 3135-3142
17. Komi J, Lassila O (2000) Nonsteroidal anti-estrogens inhibit the functional differentiation of human monocyte-derived dendritic cells. Blood 95: 2875-2882
18. Komi J, Mottonen M, Luukkainen R, Lassila O (2001) Non-steroidal anti-oestrogens inhibit the differentiation of synovial macrophages into dendritic cells. Rheumatology (Oxford) 40: 185-191
19. Lespagnard L, Gancberg D, Rouas G, Leclercq G, de Saint-Aubain Somerhausen N, Di Leo A, Piccart M, Verhest A, Larsimont D (1999) Tumor-infiltrating dendritic cells in adenocarcinomas of the breast: a study of 143 neoplasms with a correlation to usual prognostic factors and to clinical outcome. Int J Cancer 84: 309-314
20. Lissoni P, Vigore L, Ferranti R, Bukovec R, Meregalli S, Mandala M, Barni S, Tancini G, Fumagalli L, Giani L (1999) Circulating dendritic cells in early and advanced cancer patients: diminished percent in the metastatic disease. J Biol Regul Homeost Agents 13: 216-219
21. Markowicz S, Walewski J, Zajda K, Wiechno PJ, Skurzak HM, Giermek J, Gajkowska A, Krzakowski M, Pienkowski T (2002) Recovery of dendritic cell counts and function in peripheral blood of cancer patients after chemotherapy. Cytokines Cell Mol Ther 7: 15-24
22. Menetrier-Caux C, Montmain G, Dieu MC, Bain C, Favrot MC, Caux C, Blay JY (1998) Inhibition of the differentiation of dendritic cells from CD34(+) progenitors by tumor cells: role of interleukin-6 and macrophage colony-stimulating factor. Blood 92: 4778-4791
23. Nalbandian G, Paharkova-Vatchkova V, Mao A, Nale S, Kovats S (2005) The selective estrogen receptor modulators, tamoxifen and raloxifene, impair dendritic cell differentiation and activation. J Immunol 175: 2666-2675
24. Onaitis MW, Kalady MF, Emani S, Abdel-Wahab Z, Tyler DS, Pruitt SK (2003) CD40 ligand is essential for generation of specific cytotoxic T cell responses in RNA-pulsed dendritic cell immunotherapy. Surgery 134: 300-305
25. Papatestas AE, Kark AE (1974) Peripheral lymphocyte counts in breast carcinoma. An index of immune competence. Cancer 34: 2014-2017
26. Peguet-Navarro J, Sportouch M, Popa I, Berthier O, Schmitt D, Portoukalian J (2003) Gangliosides from human melanoma tumors impair dendritic cell differentiation from monocytes and induce their apoptosis. J Immunol 170: 3488-3494
27. Pinzon-Charry A, Ho CS, Laherty R, Maxwell T, Walker D, Gardiner RA, O'Connor L, Pyke C, Schmidt C, Furnival C, Lopez JA (2005a) A population of HLA-DR+ immature cells accumulates in the blood dendritic cell compartment of patients with different types of cancer. Neoplasia 7: 1112-1122
28. Pinzon-Charry A, Maxwell T, Lopez JA (2005b) Dendritic cell dysfunction in cancer: a mechanism for immunosuppression. Immunol Cell Biol 83: 451-461
29. Pinzon-Charry A, Maxwell T, McGuckin MA, Schmidt C, Furnival C, Lopez JA (2005c) Spontaneous apoptosis of blood dendritic cells in patients with breast cancer. Breast Cancer Res 8: R5
30. Pinzon-Charry A, Maxwell T, Prato S, Furnival C, Schmidt C, Lopez JA (2005d) HLA-DR+ immature cells exhibit reduced antigen-presenting cell function but respond to CD40 stimulation. Neoplasia 7: 1123-1132
31. Pinzon-Charry A, Schmidt C, Lopez JA (2006a) Dendritic cell immunotherapy for breast cancer. Expert Opin Biol Ther 6: 591-604
32. Pinzon-Charry A, Schmidt CW, Lopez JA (2006b) The key role of CD40 ligand in overcoming tumor-induced dendritic cell dysfunction. Breast Cancer Res 8: 402
33. Randolph GJ, Inaba K, Robbiani DF, Steinman RM, Muller WA (1999) Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity 11: 753-761
34. Ratta M, Fagnoni F, Curti A, Vescovini R, Sansoni P, Oliviero B, Fogli M, Ferri E, Della Cuna GR, Tura S, Baccarani M, Lemoli RM (2002) Dendritic cells are functionally defective in multiple myeloma: the role of interleukin-6. Blood 100: 230-237
35. Robinson SP, Patterson S, English N, Davies D, Knight SC, Reid CD (1999) Human peripheral blood contains two distinct lineages of dendritic cells. Eur J Immunol 29: 2769-2778
36. Sallusto F, Lanzavecchia A (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and down-regulated by tumor necrosis factor alpha. J Exp Med 179: 1109-1118
37. Satthaporn S, Robins A, Vassanasiri W, El-Sheemy M, Jibril JA, Clark D, Valerio D, Eremin O (2004) Dendritic cells are dysfunctional in patients with operable breast cancer. Cancer Immunol Immunother 53: 510-518
38. Savary CA, Grazziutti ML, Melichar B, Przepiorka D, Freedman RS, Cowart RE, Cohen DM, Anaissie EJ, Woodside DG, McIntyre BW, Pierson DL, Pellis NR, Rex JH (1998) Multidimensional flow-cytometric analysis of dendritic cells in peripheral blood of normal donors and cancer patients. Cancer Immunol Immunother 45: 234-240
39. Sobin LH, Wittekind C (2002) International Union Against Cancer: TNM Classification of Malignant Tumors. Wiley-Liss: New York
40. Sombroek CC, Stam AG, Masterson AJ, Lougheed SM, Schakel MJ, Meijer CJ, Pinedo HM, van den Eertwegh AJ, Scheper RJ, de Gruijl TD (2002) Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation. J Immunol 168: 4333-4343
41. Terheyden P, Straten P, Brocker EB, Kampgen E, Becker JC (2000) CD40-ligated dendritic cells effectively expand melanoma-specific CD8+ CTLs and CD4+ IFN-gamma-producing T cells from tumor-infiltrating lymphocytes. J Immunol 164: 6633-6639
42. Thomas R, Davis LS, Lipsky PE (1993a) Isolation and characterization of human peripheral blood dendritic cells. J Immunol 150: 821-834
43. Thomas R, Davis LS, Lipsky PE (1993b) Isolation and characterization of human peripheral blood dendritic cells. J Immunol 150: 821-834
44. Zeid NA, Muller HK (1993) S100 positive dendritic cells in human lung tumors associated with cell differentiation and enhanced survival. Pathology 25: 338-343