Haseman Elston regression in ascertained samples: Importance of dependent variable and mean correction factor selection

Human Heredity

Volumn 65, Issue 2, 2007, Pages 66-76

  Sinha, Ritwik ^a   Gray McGuire, Courtney ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Ascertainment; Haseman Elston regression; Linkage

Indexed keywords

ARTICLE; DEPENDENT VARIABLE; LINKAGE ANALYSIS; QUANTITATIVE TRAIT; REGRESSION ANALYSIS;

FAMILY; FEMALE; HUMANS; MALE; MODELS, GENETIC; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS; SELECTION (GENETICS); SIBLINGS;

EID: 35648972308     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000108938     Document Type: Article

References (17)

1. Haseman JK, Elston RC: The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 1972;2:3-19.
2. Elston RC, Buxbaum S, Jacobs KB, Olson JM: Haseman and Elston revisited. Genet Epidemiol 2000;19:1-17.
3. Etzel CJ, Shete S, Beasley TM, Fernandez JR, Allison DB, Amos CI: Effect of Box-Cox transformation on power of Haseman-Elston and maximum-likelihood variance components tests to detect quantitative trait loci. Hum Hered 2003;55:108-116.
4. Forrest WF: Weighting improves the 'new Haseman-Elston' method. Hum Hered 2001;52:47-54.
5. Palmer LJ, Jacobs KB, Elston RC: Haseman and Elston revisited: the effects of ascertainment and residual familial correlations on power to detect linkage. Genet Epidemiol 2000;19:456-460.
6. Shete S, Jacobs KB, Elston RC: Adding further power to the Haseman and Elston method for detecting linkage in larger sibships: weighting sums and differences. Hum Hered 2003;55:79-85.
7. Single RM, Finch SJ: Gain in efficiency from using generalized least squares in the Haseman-Elston test. Genet Epidemiol 1995;12:889-894.
8. Wiener H, Elston RC, Tiwari HK: X-linked extension of the revised Haseman-Elston algorithm for linkage analysis in sib pairs. Hum Hered 2003;55:97-107.
9. Wright FA: Information perspectives of the Haseman-Elston method. Hum Hered 2003;55:132-142.
10. Xu X, Weiss S, Xu X, Wei LJ: A unified Haseman-Elston method for testing linkage with quantitative traits. Am J Hum Genet 2000;67:1025-1028.
11. Wang T, Elston RC: A modified revisited Haseman-Elston method to further improve power. Hum Hered 2004;57:109-116.
12. Elston RC, Song D, Iyengar SK: Mathematical assumptions versus biological reality: myths in affected sib pair linkage analysis. Am J Hum Genet 2005;76:152-156.
13. Davis S, Weeks DE: Comparison of nonparametric statistics for detection of linkage in nuclear families: Single-marker evaluation. Am J Hum Genet 1997;61:1431-1444.
14. Lemire M, Roslin NM, Laprise C, Hudson TJ, Morgan K: Transmission-ratio distortion and allele sharing in affected sib pairs: A new linkage statistic with reduced bias, with application to chromosome 6q25.3. Am J Hum Genet 2004;75:571-586.
15. Xing C, Sinha R, Xing G, Lu Q, Elston RC: The affected-/discordant-sib- pair design can guarantee validity of multipoint model-free linkage analysis of incomplete pedigrees when there is marker-marker disequilibrium. Am J Hum Genet 2006;79:396-401.
16. Statistical Analysis for Genetic Epidemiology (S.A.G.E.). Version 5.3, 2006.
17. R Development Team Core: R: A language and environment for statistical computing. 2005.