Issues in the design and interpretation of chronic toxicity and carcinogenicity studies in rodents: Approaches to dose selection

Critical Reviews in Toxicology

Volumn 37, Issue 9, 2007, Pages 729-837

  Rhomberg, Lorenz R ^a   Baetcke, Karl ^b   Blancato, Jerry ^b   Bus, James ^c   Cohen, Samuel ^d   Conolly, Rory ^b   Dixit, Rakesh ^e   Doe, John ^f   Ekelman, Karen ^g   Fenner Crisp, Penny ^h   Harvey, Paul ⁱ   Hattis, Dale ^j   Jacobs, Abigail ^g   Jacobson Kram, David ^g   Lewandowski, Tom ^a   Liteplo, Robert ^k   Pelkonen, Olavi ^l   Rice, Jerry ^m   Somers, Diana ⁿ   Turturro, Angelo ^o   West, Webster ^p   Olin, Stephen ^h   more..

^a GRADIENT   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c DOW CHEMICAL COMPANY   (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^e MEDIMMUNE   (United States)

^f JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^g CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^h International Life Sciences Institute   (United States)

ⁱ NICNAS   (Australia)

^j CLARK UNIVERSITY   (United States)

^k HEALTH CANADA   (Canada)

^l UNIVERSITY OF OULU   (Finland)

^m GEORGETOWN UNIVERSITY   (United States)

ⁿ Pest Management Regulatory Agency   (Canada)

^o NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^p UNIVERSITY OF SOUTH CAROLINA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACETOCHLOR; DICHLOROMETHANE; ENDOCRINE DISRUPTOR; FOOD ADDITIVE; FORMALDEHYDE; INDUSTRIAL CHEMICAL; PESTICIDE; TRICHLOROETHYLENE;

AREA UNDER THE CURVE; BIOASSAY; BIOTRANSFORMATION; BODY WEIGHT; CARCINOGENICITY; CELL PROLIFERATION; CHRONIC TOXICITY; DETOXIFICATION; DNA DAMAGE; DNA SEQUENCE; DNA STRAND; DNA SYNTHESIS; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; FISCHER 344 RAT; FOOD INTAKE; GENE EXPRESSION; HOMEOSTASIS; HUMAN; KNOCKOUT MOUSE; LIVER; MATHEMATICAL COMPUTING; METHYLATION; MUTAGENICITY; NASOPHARYNX CANCER; NONHUMAN; NUTRITIONAL DEFICIENCY; OCCUPATIONAL EXPOSURE; ORGAN WEIGHT; POLLUTANT; PROTEOMICS; REVIEW; RISK ASSESSMENT; RISK MANAGEMENT; RODENT; STATISTICAL SIGNIFICANCE; TESTIS; TRANSCRIPTOMICS;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; RESEARCH DESIGN; RODENTIA;

ANIMALIA; RODENTIA;

EID: 35648967655     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.1080/10408440701524949     Document Type: Review

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