Do nonribosomal peptide synthetases occur in higher Eukaryotes?

IUBMB Life

Volumn 59, Issue 11, 2007, Pages 730-733

  Tiburzi, Federica ^b   Visca, Paolo ^b   Imperi, Francesco ^a  

^a ROMA TRE UNIVERSITY   (Italy)

^b NONE

Author keywords

Horizontal gene transfer; Nonribosomal peptide synthetases; Secondary metabolism

Indexed keywords

PEPTIDE SYNTHASE;

ADENYLATION; AMINO ACID SEQUENCE; ARCHEAN; BACTERIUM; BIOCHEMISTRY; CHEMICAL BOND; EUKARYOTE; FUNGUS; NONHUMAN; NONRIBOSOMAL PEPTIDE SYNTHESIS; PEPTIDE SYNTHESIS; POLYMERIZATION; PROTEIN DOMAIN; REVIEW; RIBOSOME; TAXONOMY;

ANIMALS; EVOLUTION, MOLECULAR; PEPTIDE BIOSYNTHESIS; PEPTIDE SYNTHASES; PHYLOGENY;

EUKARYOTA;

EID: 35648964701     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1080/15216540601055349     Document Type: Review

References (24)

1. Lipmann, F. (1971) Attempts to map a process evolution of peptide biosynthesis. Science 173, 875-884.
2. Lipmann, F., Gevers, W., Kleinkauf, H., and Roskoski, R. Jr. (1971) Polypeptide synthesis on protein templates: the enzymatic synthesis of gramicidin S and tyrocidine. Adv. Enzymol. Relat. Areas Mol. Biol. 35, 1-34.
3. Grunewald, J., and Marahiel, M. A. (2006) Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides. Microbiol. Mol. Biol. Rev. 70, 121-146.
4. Schwarzer, D., Finking, R., and Marahiel, M. A. (2003) Nonribosomal peptides: from genes to products. Nat. Prod. Rep. 20, 275-287.
5. Kohli, R. M., and Walsh, C. T. (2003) Enzymology of acyl chain macrocyclization in natural product biosynthesis. Chem. Commun. (Cambridge) 7, 297-307.
6. Linne, U., and Marahiel, M. A. (2000) Control of directionality in nonribosomal peptie synthesis: role of the condensation domain in preventing misinitiation and timing of epimerization. Biochemistry 39, 10439-10447.
7. von Döhren, H., Keller, U., Vater, J., and Zocher, R. (1997) Multifunctional peptide synthetases. Chem. Rev. 97, 2675-2706.
8. Stachelhaus, T., Mootz, H. D., Bergendahl, V., and Marahiel, M. A. (1998) Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain. J. Biol. Chem. 273, 22773-22781.
9. Jakubowski, H. (1998) Aminoacylation of coenzyme A and pantetheine by aminoacyl-tRNA synthetases: possible link between noncoded and coded peptide synthesis. Biochemistry 15, 5147-5153.
10. Di Giulio, M. (1996) The origin of protein synthesis: on some molecular fossils identified through comparison of protein sequences. Bio-Systems 39, 159-169.
11. Kasahara, T., and Kato, T. (2003) Nutritional biochemistry: a new redox-cofactor vitamin for mammals. Nature 422, 832.
12. Richardt, A., Kemme, T., Wagner, S., Schwarzer, D., Marahiel, M. A., and Hovemann, B. T. (2003) Ebony, a novel nonribosomal peptide synthetase for beta-alanine conjugation with biogenic amines in Drosophila. J. Biol. Chem. 278, 41160-41166.
13. Di Vincenzo, L., Grgurina, I., and Pascarella, S. (2005) In silico analysis of the adenylation domains of the freestanding enzymes belonging to the eucaryotic nonribosomal peptide synthetase-like family. FEBS J. 272, 929-941.
14. Williams, D. H., Stone, M. J., Hauck, P. R., and Rahman, S. K. (1989) Why are secondary metabolites (natural products) biosynthesized? J. Nat. Prod. 52, 1189-1208.
15. Vining, L. C. (1990) Functions of secondary metabolites. Annu. Rev. Microbiol. 44, 395-427.
16. Firn, R. D., and Jones, C. G. (2000) The evolution of secondary metabolism - a unifying model. Mol. Microbiol. 37, 989-994.
17. Buades, C., and Moya, A. (1996) Phylogenetic analysis of the isopenicillin-N-synthetase horizontal gene transfer. J. Mol. Evol. 42, 537-542.
18. Lopez, J. V. (2003) Naturally mosaic operons for secondary metablite biosynthesis: variability and putative horizontal transfer of discrete catalytic domains of the epothilone polyketide synthase locus. Mol. Genet. Genomics 270, 420-431.
19. Tanabe, Y., Kaya, K., and Watanabe, M. M. (2004) Evidence for recombination in the microcystin synthetase (mcy) genes of toxic cyanobacteria Microcystis spp. J. Mol. Evol. 58, 633-641.
20. von Döhren. H. (2004) Biochemistry and general genetics of nonribosomal peptide synthetases in fungi. Adv. Biochem. Eng. Biotechnol. 88, 217-264.
21. Meister, A. (1974) Glutathione synthesis. In The Enzymes 3rd edn (Boyer, P. D., ed.). pp. 671-697, Academic Press, New York.
22. Ziegler, K., Diener, A., Herpin, C., Richter, R., Deutzmann, R., and Lockau, W. (1998) Molecular characterization of cyanophycin synthetase, the enzyme catalyzing the biosynthesis of the cyanobacterial reserve material multi-L-arginyl-poly-L-aspartate (cyanophycin). Eur. J. Biochem. 254, 154-159.
23. Bergmann, M., and Fraenkel-Conrat, H. (1938) The enzymatic synthesis of peptide bonds. J. Biol. Chem. 124, 1-6.
24. Lombard, C., Saulnier, J., and Wallach, J. M. (2005) Recent trends in protease-catalyzed peptide synthesis. Protein Pept. Lett. 12, 621-629.