Endocrine Complications of Hematopoietic Stem Cell Transplantation

Endocrinology and Metabolism Clinics of North America

Volumn 36, Issue 4, 2007, Pages 983-998

  Chemaitilly, Wassim ^a   Sklar, Charles A ^b  

^a SCHNEIDER CHILDREN'S HOSPITAL   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; BISPHOSPHONIC ACID DERIVATIVE; BUSULFAN; CYCLOPHOSPHAMIDE; FLUDARABINE; GLUCOCORTICOID; GROWTH HORMONE; MELPHALAN;

ABORTION; APLASTIC ANEMIA; BONE DENSITY; CANCER CHEMOTHERAPY; CELL DAMAGE; CELL FUNCTION; CHRONIC GRAFT VERSUS HOST DISEASE; CORTICOTROPIN DEFICIENCY; DIABETES MELLITUS; DRUG MEGADOSE; ENDOCRINE DISEASE; GERM CELL; GROWTH DISORDER; GROWTH HORMONE DEFICIENCY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HORMONE DEFICIENCY; HUMAN; HYPERGONADOTROPIC HYPOGONADISM; HYPERTHYROIDISM; HYPOPHYSIS DISEASE; HYPOTHALAMUS DISEASE; HYPOTHYROIDISM; LEYDIG CELL; METABOLIC SYNDROME X; MONOTHERAPY; OSTEOPENIA; OSTEOPOROSIS; OVARY INSUFFICIENCY; PREMATURITY; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SIDE EFFECT; THYROID DISEASE; THYROID TUMOR; THYROTOXICOSIS; TREATMENT OUTCOME; VITAMIN SUPPLEMENTATION; WHOLE BODY RADIATION;

BONE DENSITY; ENDOCRINE SYSTEM DISEASES; FEMALE; GLUCOSE; GONADOTROPINS; GROWTH DISORDERS; GROWTH HORMONE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; REPRODUCTION; THYROID DISEASES; THYROTROPIN; TRANSPLANTATION CONDITIONING; WHOLE-BODY IRRADIATION;

EID: 35648964192     PISSN: 08898529     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ecl.2007.07.002     Document Type: Review

References (103)

1. Thomas E.D. History of haemopoietic cell transplantation. Br J Haematol 105 (1999) 330-339
2. Fisher V.L., and Abramovitz L.Z. A brief overview of hemaotopoietic stem-cell transplantation. In: Kline R.M. (Ed). Pediatric hematopoietic stem cell transplantation (2006), Informa Healthcare, New York 601-602
3. Hows J.M., Passweg J.R., Tichelli A., et al. Comparison of long-term outcomes after allogeneic hematopoietic stem cell transplantation from matched sibling and unrelated donors. Bone Marrow Transplant 38 (2006) 799-805
4. Boulad F., Sands S., and Sklar C. Late complications after BMT in children and adolescents. Curr Probl Pediatr 28 (1998) 277-297
5. Cohen A., Rovelli A., Bakker B., et al. Final height of patients who underwent bone marrow transplantation for hematological disorders during childhood: a study by the Working Party for Late Effects-EBMT. Blood 93 (1999) 4109-4115
6. Clement-De Boers A., Oostdijk W., Van Weel-Sipman M.H., et al. Final height and hormonal function after bone marrow transplantation in children. J Pediatr 129 (1996) 544-550
7. Frisk P., Arvidson J., Gustafsson J., et al. Pubertal development and final height after autologous bone marrow transplantation for acute lymphoblastic leukemia. Bone Marrow Transplant 33 (2004) 205-210
8. Sklar C. Growth and endocrine disturbances after bone marrow transplantation in childhood. Acta Paediatr 411 (1995) 57-61
9. Kauppila M., Koskinen P., Irjala K., et al. Long-term effects of allogeneic bone marrow transplantation (BMT) on pituitary, gonad, thyroid, and adrenal function in adults. Bone Marrow Transplant 22 (1998) 331-337
10. Tauchmanova L., Selleri C., Rosa G.D., et al. High prevalence of endocrine dysfunction in long-term survivors after allogeneic bone marrow transplantation for hematologic diseases. Cancer 95 (2002) 1076-1084
11. de Lima M., Couriel D., Thall P.F., et al. Once-daily intravenous busulfan and fludarabine: clinical and pharmacokinetic results of a myeloablative, reduced-toxicity conditioning regimen for allogeneic stem cell transplantation in AML and MDS. Blood 104 (2004) 857-864
12. Sanders J.E., Pritchard S., Mahoney P., et al. Growth and development following marrow transplantation for leukemia. Blood 68 (1986) 1129-1135
13. Giorgiani G., Bozzola M., Locatelli F., et al. Role of busulfan and total body irradiation on growth of prepubertal children receiving bone marrow transplantation and results of treatment with recombinant human growth hormone. Blood 86 (1995) 825-831
14. Adan L., de Lanversin M.-L., Thalassinos C., et al. Growth after bone marrow transplantation in young children conditioned with chemotherapy alone. Bone Marrow Transplant 19 (1997) 253-256
15. Afify A., Shaw P.J., Clavano-Harding A., et al. Growth and endocrine function in children with acute myeloid leukaemia after bone marrow transplantation using busulfan/cyclophosphamide. Bone Marrow Transplant 25 (2000) 1087-1092
16. Lähteenmäki P.M., Chakrabarti S., Cornish J.M., et al. Outcome of single-fraction total body irradiation-conditioned stem cell transplantation in younger children with malignant disease, comparison with a busulfan-cyclophosphamide regimen. Acta Oncol 43 (2004) 196-203
17. Sanders J.E. Growth and development after bone marrow transplantation. In: Forman S.J., Blume K.G., and Thomas E.D. (Eds). Bone marrow transplantation (1994), Blackwell Scientific Publications, Boston 527-537
18. Bakker B., Oostdijk W., Bresters D., et al. Disturbances of growth and endocrine function after busulfan-based conditioning for haematopoietic stem cell transplantation during infancy and childhood. Bone Marrow Transplant 33 (2004) 1049-1056
19. De Sanctis V. Growth and puberty and its management in thalassemia. Horm Res 58 (2002) 72-79
20. Molitch M.E., Clemmons D.R., Malozowski S., et al., Endocrine Society's Clinical Guidelines Subcommittee. Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 91 (2006) 1621-1634
21. Bushhouse S., Ramsay N.K.C., Pescovitz O.H., et al. Growth in children following irradiation for bone marrow transplantation. Am J Pediatr Hematol Oncol 11 (1989) 134-140
22. Couto-Silva A.C., Trivin C., Esperou H., et al. Changes in height, weight, and plasma leptin after bone marrow transplantation. Bone Marrow Transplant 26 (2000) 1205-1210
23. Brauner R., Fontoura M., Zucker J.M., et al. Growth and growth hormone secretion after bone marrow transplantation. Arch Dis Child 68 (1993) 458-463
24. Thomas B.C., Stanhope R., Plowman P.N., et al. Growth following single-fraction and fractionated total body irradiation for bone marrow transplantation. Eur J Pediatr 152 (1993) 888-892
25. Wither H.R. Biologic basis for altered fractionation schemes. Cancer 55 (1985) 2086-2095
26. Yahalom J., and Fuks Z.Y. Strategies for the use of total body irradiation as a systemic therapy in leukemia and lymphoma. In: Armitage J.O., and Antman K.H. (Eds). High-dose chemotherapy (1992), Williams and Wilkins, Baltimore (MD) 61-83
27. Bakker B., Oostdijk W., Geskus R.B., et al. Patterns of growth and body proportions after total body irradiation and hematopoietic stem cell transplantation during childhood. Pediatr Res 59 (2006) 259-264
28. Bakker B., Massa G.G., Oostdijk W., et al. Pubertal development and growth after total-body irradiation and bone marrow transplantation for haematological malignancies. Eur J Pediatr 159 (2000) 31-37
29. Couto-Silva A.C., Trivin C., Esperou H., et al. Final height and gonad function after total body irradiation during childhood. Bone Marrow Transplant 38 (2006) 427-432
30. Sanders J.E., Guthrie K.A., Hoffmeister P.A., et al. Final adult height of patients who received hematopoietic cell transplantation in childhood. Blood 105 (2005) 1348-1354
31. Shalitin S., Philip M., Stein J., et al. Endocrine dysfunction and parameters of the metabolic syndrome after bone marrow transplantation during childhood and adolescence. Bone Marrow Transplant 37 (2006) 1109-1117
32. Holm K., Nysom K., Rasmussen M.H., et al. Growth, growth hormone, and final height after BMT. Possible recovery of irradiation-induced growth hormone insufficiency. Bone Marrow Transplant 18 (1996) 163-170
33. Chemaitilly W., Boulad F., Heller G., et al. Final height in pediatric patients after hyperfractionated total body irradiation and stem cell transplantation. Bone Marrow Transplant 40 (2007) 29-35
34. Brennan B.M.D., and Shalet M.S. Endocrine late effects after bone marrow transplantation. Br J Haematol 118 (2002) 56-66
35. Brauner R., Adan L., Souberbielle J.C., et al. Contribution of growth hormone deficiency to the growth failure that follows bone marrow transplantation. J Pediatr 130 (1997) 785-792
36. Papadimitrou A., Uruena M., Stanhope R., et al. Growth hormone treatment of growth failure secondary to total body irradiation and bone marrow transplantation. Arch Dis Child 66 (1991) 689-692
37. Ogilvy-Stuart A.L., Clark D.J., Wallace W.H.B., et al. Endocrine deficit after fractionated total body irradiation. Arch Dis Child 67 (1992) 1107-1110
38. Huma Z., Boulad F., Black P., et al. Growth in children after bone marrow transplantation for acute leukemia. Blood 86 (1995) 819-824
39. Sklar C.A., Mertens A.C., Mitsby P., et al. Risk of disease recurrence and second neoplasms in survivors of childhood cancer treated with growth hormone: a report from the childhood cancer survivor study. J Clin Endocrinol Metab 87 (2002) 3136-3141
40. Wingard J.R., Plotnick L.P., Freemer C.S., et al. Growth in children after bone marrow transplantation: busulfan plus cyclophosphamide versus cyclophosphamide plus total body irradiation. Blood 79 (1992) 1068-1073
41. Bozzola M., Giorgiani G., Locatelli F., et al. Growth in children after bone marrow transplantation. Horm Res 39 (1993) 122-126
42. Sarafoglou K., Boulad F., Gillio A., et al. Gonadal function after bone marrow transplantation for acute leukemia during childhood. J Pediatr 130 (1997) 210-216
43. Rose S.R., Lustig R.H., Pituksheewanont P., et al. Diagnosis of hidden central hypothyroidism in survivors of childhood cancer. J Clin Endocrinol Metab 84 (1999) 4472-4479
44. Darzy K.H., and Shalet S.M. Circadian and stimulated thyrotropin secretion in cranially irradiated adult cancer survivors. J Clin Endocrinol Metab 90 (2005) 6490-6497
45. Thomas O., Mahe M., Campion L., et al. Long-term complications of total body irradiation in adults. Int J Radiat Oncol Biol Phys 49 (2001) 125-131
46. Sanders J.E. The impact of marrow transplant preparative regimens on subsequent growth and development. The Seattle Marrow Transplant Team. Semin Hematol 28 (1991) 244-249
47. Thomas B.C., Stanhope R., Plowman P.N., et al. Endocrine function following single fraction and fractionated total body irradiation for bone marrow transplantation in childhood. Acta Endocrinol 128 (1993) 508-512
48. Boulad F., Bromley M., Black P., et al. Thyroid dysfunction following bone marrow transplantation using hyperfractionated radiation. Bone Marrow Transplant 15 (1995) 71-76
49. Sklar C.A., Kim T.H., and Ramsay N.K.C. Thyroid dysfunction among long-term survivors of bone marrow transplantation. Am J Med 73 (1982) 688-694
50. Berger C., Le-Gallo B., Donadieu J., et al. Late thyroid toxicity in 153 long-term survivors of allogeneic bone marrow transplantation for acute lymphoblastic leukaemia. Bone Marrow Transplant 35 (2005) 991-995
51. Ishiguro H., Yasuda Y., Tomita Y., et al. Long-term follow-up of thyroid function in patients who received bone marrow transplantation during childhood and adolescence. J Clin Endocrinol Metab 89 (2004) 5981-5986
52. Al-Fiar F.Z., Colwill R., Lipton J.H., et al. Abnormal thyroid stimulating hormone (TSH) levels in adults following allogeneic bone marrow transplants. Bone Marrow Transplant 19 (1997) 1019-1022
53. Michel G., Socie G., Gebhard F., et al. Late effects of allogeneic bone marrow transplantation for children with acute myeloblastic leukemia in first complete remission: the impact of conditioning regimen without total-body irradiation-a report from the Société Française de Greffe de Moelle. J Clin Oncol 15 (1997) 2238-2246
54. Slatter M.A., Gennery A.R., Cheetham T.D., et al. Thyroid dysfunction after bone marrow transplantation for primary immune deficiency without the use of total body irradiation. Bone Marrow Transplant 33 (2004) 949-953
55. Karthaus M., Gabrysiak T., Brabant G., et al. Immune thyroiditis after transplantation of allogeneic CD34+ selected peripheral blood cells. Bone Marrow Transplant 20 (1997) 697-699
56. Au W.Y., Lie A.K.W., Kung A.W.C., et al. Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation. Bone Marrow Transplant 35 (2005) 383-388
57. Sklar C., Boulad F., Small T., et al. Endocrine complications of pediatric stem cell transplantation. Front Biosci 6 (2001) G17-G22
58. Holland F.J., McConnon J.K., Volpé R., et al. Concordant Graves' disease after bone marrow transplantation: implications for pathogenesis. J Clin Endocrinol Metab 72 (1991) 837-840
59. Ron E., Lubin J.H., Shore R.E., et al. Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies. Radiat Res 141 (1995) 259-277
60. Tucker M.A., Jones P.H., Boice Jr. J.D., et al. Therapeutic radiation at a young age is linked to secondary thyroid cancer. Cancer Res 51 (1991) 2885-2888
61. Acharya S., Sarafoglou K., LaQuaglia M., et al. Thyroid neoplasms after therapeutic radiation for malignancies during childhood and adolescence. Cancer 97 (2003) 2397-2403
62. Uderzo C., van Lint M.T., Rovelli A., et al. Papillary thyroid carcinoma after total body irradiation. Arch Dis Child 71 (1994) 256-258
63. Cohen A., Rovelli A., van Lint M.T., et al. Secondary thyroid carcinoma after allogeneic bone marrow transplantation during childhood. Bone Marrow Transplant 28 (2001) 1125-1128
64. Sanders J.E. Endocrine complications of high-dose therapy with stem cell transplantation. Pediatr Transplant 8 Suppl 5 (2004) 39-50
65. Sanders J.E., Hawley J., Levy W., et al. Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation. Blood 87 (1996) 3045-3052
66. Grigg A.P., McLachlan R., Zajac J., et al. Reproductive status in long-term bone marrow transplant survivors receiving busulfan-cyclophosphamide (120mg/kg). Bone Marrow Transplant 26 (2000) 1089-1095
67. Anserini P., Chiodi S., Costa M., et al. Semen analysis following allogeneic bone marrow transplantation. Additional data for evidence-based counseling. Bone Marrow Transplant 30 (2002) 447-451
68. Kyriacou C., Kottaridis P.D., Eliahoo J., et al. Germ cell damage and Leydig cell insufficiency in recipients of nonmyeloablative transplantation for haematological malignancies. Bone Marrow Transplant 31 (2003) 45-50
69. Sklar C.A., Robison L.L., Nesbit M.E., et al. Effects of radiation on testicular function in long-term survivors of childhood acute lymphoblastic leukemia: a report from the Children's Cancer Study Group. J Clin Oncol 8 (1990) 1981-1987
70. Rovo A., Tichelli A., Passweg J.R., et al. Spermatogenesis in long-term survivors after allogeneic hematopoietic stem cell transplantation is associated with age, time interval since transplantation, and apparently absence of chronic GvHD. Blood 108 (2006) 1100-1105
71. Savani B.N., Kozanas E., Shenoy A., et al. Recovery of spermatogenesis after total body irradiation. Blood 108 (2006) 4292-4293
72. Ishiguro H., Yasuda Y., Tomita Y., et al. Gonadal shielding to irradiation is effective in protecting testicular growth and function in long-term survivors of bone marrow transplantation during childhood or adolescence. Bone Marrow Transplant 39 (2007) 483-490
73. Chatterjee R., and Kottaridis P.D. Treatment of gonadal damage in recipients of allogeneic or autologous transplantation for haematological malignancies. Bone Marrow Transplant 30 (2002) 629-635
74. Sanders J.E., Buckner C.D., Amos D., et al. Ovarian function following marrow transplantation for aplastic anemia or leukemia. J Clin Oncol 6 (1988) 813-818
75. Byrne J., Fears T.R., Gail M.H., et al. Early menopause in long-term survivors of cancer during adolescence. Am J Obstet Gynecol 166 (1992) 788-793
76. Sklar C.A., Mertens A.C., Mitby P., et al. Premature menopause in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Natl Cancer Inst 98 (2006) 890-896
77. Mertens A.C., Ramsay N.K.C., Kouris S., et al. Patterns of gonadal dysfunction following bone marrow transplantation. Bone Marrow Transplant 22 (1998) 345-350
78. Matsumoto M., Shinohara O., Ishiguro H., et al. Ovarian function after bone marrow transplantation performed before menarche. Arch Dis Child 80 (1999) 452-454
79. Salooja N., Szydio R.M., Socle G., et al. Pregnancy outcomes after peripheral blood or bone marrow transplantation: a retrospective study. Lancet 358 (2001) 271-276
80. Carter A., Robison L.L., Francisco L., et al. Prevalence of conception and pregnancy outcomes after hematopoietic stem cell transplantation: report from the bone marrow transplant survivor study. Bone Marrow Transplant 37 (2006) 1023-1029
81. Nakagawa K., Kanda Y., Yamashita H., et al. Preservation of ovarian function by ovarian shielding when undergoing total body irradiation for hematopoietic stem cell transplantation: a report of two successful cases. Bone Marrow Transplant 37 (2006) 583-587
82. Holm K., Nysom K., Brocks V., et al. Ultrasound B-mode changes in the uterus and ovaries and Doppler changes in the uterus after total body irradiation and allogeneic bone marrow transplantation in childhood. Bone Marrow Transplant 23 (1999) 259-263
83. Bath L.E., Critchley H.O.D., Chambers S.E., et al. Ovarian and uterine characteristics after total body irradiation in childhood and adolescence: response to sex steroid replacement. Br J Obstet Gynaecol 106 (1999) 1265-1272
84. Aisenberg J., Hsieh K., Kalaitzoglou G., et al. Bone mineral density (BMD) in long-term survivors of childhood cancer. J Pediatr Hematol Oncol 20 (1998) 241-245
85. Bhatia S., Ramsay N.K.C., Weisdorf D., et al. Bone mineral density in patients undergoing bone marrow transplantation for myeloid malignancies. Bone Marrow Transplant 22 (1998) 87-90
86. Nysom K., Holm K., Michaelsen K.F., et al. Bone mass after allogeneic bone marrow transplantation for childhood leukaemia or lymphoma. Bone Marrow Transplant 25 (2000) 191-196
87. Schimmer A.D., Mah K., Bordeleau L., et al. Decreased bone mineral density is common after autologous blood or marrow transplantation. Bone Marrow Transplant 28 (2001) 387-391
88. Kerschan-Schindl K., Mitterbauer M., Füreder W., et al. Bone metabolism in patients more than five years after bone marrow transplantation. Bone Marrow Transplant 34 (2006) 491-496
89. Cohen A., and Shane E. Osteoporosis after solid organ and bone marrow transplantation. Osteoporos Int 14 (2003) 617-630
90. Stern J.M., Chesnut III C.H., Bruemmer B., et al. Bone density loss during treatment of chronic GVHD. Bone Marrow Transplant 17 (1996) 395-400
91. Gilsanz V., Carlson M.E., Roe T.F., et al. Osteoporosis after cranial irradiation for acute lymphoblastic leukemia. J Pediatr 117 (1990) 238-244
92. Lee W.Y., Cho S.W., Oh E.S., et al. The effect of bone marrow transplantation on the osteoblastic differentiation of human bone marrow stromal cells. J Clin Endocrinol Metab 87 (2002) 329-335
93. Lee W.Y., Kang M.I., Oh E.S., et al. The role of cytokines in the changes in bone turnover following bone marrow transplantation. Osteoporos Int 13 (2002) 62-68
94. Smedmyr B., Wilbell L., Simonsson B., et al. Impaired glucose tolerance after autologous bone marrow transplantation. Bone Marrow Transplant 6 (1990) 89-92
95. Lorini R., Cortona L., Scaramuzza A., et al. Hyperinsulinemia in children and adolescents after bone marrow transplantation. Bone Marrow Transplant 15 (1995) 873-877
96. Taskinen M., Saarinen-Pihkala U.M., Hovi L., et al. Impaired glucose tolerance and dyslipidaemia as late effects after bone marrow transplantation in childhood. Lancet 356 (2000) 993-997
97. Traggiai C., Stanhope R., Nussey S., et al. Diabetes mellitus after bone marrow transplantation during childhood. Med Pediatr Oncol 40 (2003) 128-129
98. Hoffmeister P.A., Storer B.E., and Sanders J.E. Diabetes mellitus in long-term survivors of pediatric hematopietic cell transplantation. J Pediatr Hematol Oncol 26 (2004) 81-90
99. d'Annunzio G., Bonetti F., Locatelli F., et al. Insulin resistance in children and adolescents after bone marrow transplant for malignancies. Haematologica 91 (2006) 20-21
100. Chatterjee R., Palla K., McGarrigle H.H., et al. Syndrome X in adult female recipients of bone marrow transplantation for haematological malignancies. Bone Marrow Transplant 35 (2005) 209-210
101. Higgins K., Noon C., Davies M., et al. Features of the metabolic syndrome present in survivors of bone marrow transplantation in adulthood. Bone Marrow Transplant 36 (2005) 279-280
102. Neville K.A., Cohn R.J., Steinbeck K.S., et al. Hyperinsulinemia, impaired glucose tolerance and diabetes mellitus in survivors of childhood cancer: prevalence and risk factors. J Clin Endocrinol Metab 91 (2006) 4401-4407
103. Baker K.S., Ness K.K., Steinberger J., et al. Diabetes, hypertension, and cardiovascular events in survivors of hematopoietic stem cell transplantation: a report from the bone marrow transplant survivor study. Blood 109 (2007) 1765-1772