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Volumn 37, Issue 3, 2007, Pages 277-290

Leukocyte involvement in the signs and symptoms of chronic venous disease. Perspectives for therapy

Author keywords

Chronic venous disease; Cramp; Edema; Heaviness; Leg; Leukocytes; Mast cell

Indexed keywords

ALLOPURINOL; BRADYKININ; DAFLON; ELASTASE; FREE RADICAL; GELATINASE B; ILOPROST; INTEGRIN; L SELECTIN; LACTOFERRIN;

EID: 35648957615     PISSN: 13860291     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (36)

References (63)
  • 1
    • 0001153981 scopus 로고    scopus 로고
    • What are the symptoms of varicose veins? Edinburgh vein study cross sectional population survey
    • A. Bradbury, C. Evans, P. Allan, A. Lee, V. Ruckley and F.G. Fowkes, What are the symptoms of varicose veins? Edinburgh vein study cross sectional population survey, BMJ 318 (1999), 353-356.
    • (1999) BMJ , vol.318 , pp. 353-356
    • Bradbury, A.1    Evans, C.2    Allan, P.3    Lee, A.4    Ruckley, V.5    Fowkes, F.G.6
  • 2
    • 33749579419 scopus 로고    scopus 로고
    • Peut-on proposer une stratégie d'indication des veinotoniques? Plaidoyer en vue d'un consensus. Position des médications veno-actives vis-à-vis de la douleur au cours de la maladie veineuse chronique
    • M.R. Boisseau, Peut-on proposer une stratégie d'indication des veinotoniques? Plaidoyer en vue d'un consensus. Position des médications veno-actives vis-à-vis de la douleur au cours de la maladie veineuse chronique, Phlebologie 58 (2005), 77-81.
    • (2005) Phlebologie , vol.58 , pp. 77-81
    • Boisseau, M.R.1
  • 3
    • 22544460261 scopus 로고    scopus 로고
    • Epidemiology of restless legs syndrome in French adults: A nationwide survey: The INSTANT Study
    • E. Tison, A. Crochard, D. Léger, S. Bouee, E. Lainey and A. El Hasnaoui, Epidemiology of restless legs syndrome in French adults: a nationwide survey: The INSTANT Study, Neurology 65 (2005), 239-246.
    • (2005) Neurology , vol.65 , pp. 239-246
    • Tison, E.1    Crochard, A.2    Léger, D.3    Bouee, S.4    Lainey, E.5    El Hasnaoui, A.6
  • 4
    • 19944392548 scopus 로고    scopus 로고
    • Revision of the CEAP classification for chronic venous disorders: Consensus statement, For the American Venous Forum International Ad Hoc Committee for Revision of the CEAP Classification
    • B. Eklof, R.B. Rutherford, J.J. Bergan et al., Revision of the CEAP classification for chronic venous disorders: consensus statement, For the American Venous Forum International Ad Hoc Committee for Revision of the CEAP Classification, J. Vasc. Surg. 40 (2004), 1248-1252.
    • (2004) J. Vasc. Surg , vol.40 , pp. 1248-1252
    • Eklof, B.1    Rutherford, R.B.2    Bergan, J.J.3
  • 5
    • 0033748805 scopus 로고    scopus 로고
    • The relationship between lower limb symptoms and superficial and deep venous reflux on duplex ultrasonography
    • A. Bradbury, C.J. Evans, P. Allan, A.J. Lee and V. Ruckley, The relationship between lower limb symptoms and superficial and deep venous reflux on duplex ultrasonography, J. Vasc. Surg. 32 (2000), 921-931.
    • (2000) J. Vasc. Surg , vol.32 , pp. 921-931
    • Bradbury, A.1    Evans, C.J.2    Allan, P.3    Lee, A.J.4    Ruckley, V.5
  • 6
    • 0028927351 scopus 로고
    • Symptomatology of vein diseases
    • M.N. Isaacs, Symptomatology of vein diseases, Dermatol. Surg. 21 (1995), 321-323.
    • (1995) Dermatol. Surg , vol.21 , pp. 321-323
    • Isaacs, M.N.1
  • 7
    • 22144468781 scopus 로고    scopus 로고
    • Relationship between symptoms and venous disease. The San Diego population study
    • R.D. Langer, E. Ho, J.O. Denenberg, A. Fronek, M. Allison and M.H. Criqui, Relationship between symptoms and venous disease. The San Diego population study, Arch. Int. Med. 165 (2005), 1420-1424.
    • (2005) Arch. Int. Med , vol.165 , pp. 1420-1424
    • Langer, R.D.1    Ho, E.2    Denenberg, J.O.3    Fronek, A.4    Allison, M.5    Criqui, M.H.6
  • 9
    • 0242408312 scopus 로고    scopus 로고
    • Symptoms of chronic venous disease and association with systemic inflammatory markers
    • M.H. Howlader and P.D. Coleridge-Smith, Symptoms of chronic venous disease and association with systemic inflammatory markers, J. Vasc. Surg. 38 (2003), 950-954.
    • (2003) J. Vasc. Surg , vol.38 , pp. 950-954
    • Howlader, M.H.1    Coleridge-Smith, P.D.2
  • 10
    • 0036092803 scopus 로고    scopus 로고
    • Chronic venous insufficiency: Worldwide results of the RELIEF study. Reflux assEssment and quaLity of lIfe improvEment with micronized Flavonoids
    • G. Jantet, Chronic venous insufficiency: worldwide results of the RELIEF study. Reflux assEssment and quaLity of lIfe improvEment with micronized Flavonoids, Angiology 53 (2002), 245-256.
    • (2002) Angiology , vol.53 , pp. 245-256
    • Jantet, G.1
  • 11
    • 35648994125 scopus 로고    scopus 로고
    • White blood cell distribution in chronic venous insufficiency
    • P.D. Coleridge-Smith, ed, Landers Bioscience, Austin, TX
    • J. Edwards, G.M. McMullin, H. Ardoe, M. Saharay, H.J. Scott and L. Wilkinson, White blood cell distribution in chronic venous insufficiency, in: Microcirculation in Venous Disease, P.D. Coleridge-Smith, ed., Landers Bioscience, Austin, TX (1998), pp. 117-140.
    • (1998) Microcirculation in Venous Disease , pp. 117-140
    • Edwards, J.1    McMullin, G.M.2    Ardoe, H.3    Saharay, M.4    Scott, H.J.5    Wilkinson, L.6
  • 12
    • 0015835943 scopus 로고
    • Relationship between the velocity of rolling granulocytes and that of the blood flow in venules
    • A. Atherton and G.V.R. Born, Relationship between the velocity of rolling granulocytes and that of the blood flow in venules, J. Physiol. 233 (1973), 157-165.
    • (1973) J. Physiol , vol.233 , pp. 157-165
    • Atherton, A.1    Born, G.V.R.2
  • 13
    • 0032798496 scopus 로고    scopus 로고
    • Leukocyte activation in patients with venous insufficiency
    • S. Takase, G. Schmid-Shönbein and J.J. Bergan, Leukocyte activation in patients with venous insufficiency, J. Vasc. Surg. 30 (1999), 148-156.
    • (1999) J. Vasc. Surg , vol.30 , pp. 148-156
    • Takase, S.1    Schmid-Shönbein, G.2    Bergan, J.J.3
  • 14
    • 0033813165 scopus 로고    scopus 로고
    • Expression of adhesive molecules and cytokines on saphenous veins in chronic venous insufficiency
    • S. Takase, J.J. Bergan and G.W. Schmid-Shönbein, Expression of adhesive molecules and cytokines on saphenous veins in chronic venous insufficiency, Ann. Vasc. Surg. 14 (2000), 427-435.
    • (2000) Ann. Vasc. Surg , vol.14 , pp. 427-435
    • Takase, S.1    Bergan, J.J.2    Schmid-Shönbein, G.W.3
  • 15
    • 0030222164 scopus 로고    scopus 로고
    • Monocyte-endothelial cell interaction induces expression of adhesion molecules on human umbilical cord endothelial cells
    • M. Takahashi, U. Ikeda and J.I. Masuyama et al., Monocyte-endothelial cell interaction induces expression of adhesion molecules on human umbilical cord endothelial cells, Cardiovasc. Res. 32 (1996), 422-429.
    • (1996) Cardiovasc. Res , vol.32 , pp. 422-429
    • Takahashi, M.1    Ikeda, U.2    Masuyama, J.I.3
  • 16
    • 0032504766 scopus 로고    scopus 로고
    • Importance of E-selectin for firm adhesion in vivo
    • K. Ley, M. Allieta, D.C. Bullard and S. Morgan, Importance of E-selectin for firm adhesion in vivo, Circ. Res. 83 (1998), 287-294.
    • (1998) Circ. Res , vol.83 , pp. 287-294
    • Ley, K.1    Allieta, M.2    Bullard, D.C.3    Morgan, S.4
  • 17
    • 0023077842 scopus 로고
    • Haemoconcentration and accumulation of white cells in the feet during venous stasis
    • C. Moyses, S.A. Cederholm-Williams and C.C. Michel, Haemoconcentration and accumulation of white cells in the feet during venous stasis, Int. J. Microcirc. Clin. Exp. 5 (1987), 311-320.
    • (1987) Int. J. Microcirc. Clin. Exp , vol.5 , pp. 311-320
    • Moyses, C.1    Cederholm-Williams, S.A.2    Michel, C.C.3
  • 18
    • 0023916917 scopus 로고
    • White cell accumulation in dependent legs of patients with venous hypertension: A possible mechanism for trophic changes in the skin
    • P.R. Thomas, G.B. Nash and J.A. Dormandy, White cell accumulation in dependent legs of patients with venous hypertension: a possible mechanism for trophic changes in the skin, Br. Med. J. 296 (1988), 1693-1695.
    • (1988) Br. Med. J , vol.296 , pp. 1693-1695
    • Thomas, P.R.1    Nash, G.B.2    Dormandy, J.A.3
  • 22
    • 0033033806 scopus 로고    scopus 로고
    • Expression of the adhesion molecules ICAM-1, VCAM-1, LFA-1 and VLA-4 in the skin is modulated in progressing stages of chronic venous insufficiency
    • M. Peschen, T. Lahaye, B. Hennig, A. Weyl, J.C. Simon and W. Vanscheidt, Expression of the adhesion molecules ICAM-1, VCAM-1, LFA-1 and VLA-4 in the skin is modulated in progressing stages of chronic venous insufficiency, Acta Derm. Venereol. 79 (1999), 27-32.
    • (1999) Acta Derm. Venereol , vol.79 , pp. 27-32
    • Peschen, M.1    Lahaye, T.2    Hennig, B.3    Weyl, A.4    Simon, J.C.5    Vanscheidt, W.6
  • 23
    • 0028874370 scopus 로고
    • Role of leukocyte activation in patients with venous stasis ulcers
    • P.J. Pappas, F.R. Fallek and A. Garcia et al., Role of leukocyte activation in patients with venous stasis ulcers, J. Surg. Res. 59 (1995), 553-559.
    • (1995) J. Surg. Res , vol.59 , pp. 553-559
    • Pappas, P.J.1    Fallek, F.R.2    Garcia, A.3
  • 24
    • 0037199422 scopus 로고    scopus 로고
    • Plasma matrix metalloproteinase-9 as a marker of blood stasis in varicose veins
    • M.P. Jacob, M. Cazaubon and A. Scemama et al., Plasma matrix metalloproteinase-9 as a marker of blood stasis in varicose veins, Circulation. 106 (2002), 535-538.
    • (2002) Circulation , vol.106 , pp. 535-538
    • Jacob, M.P.1    Cazaubon, M.2    Scemama, A.3
  • 25
    • 0003087893 scopus 로고    scopus 로고
    • White cell activation
    • 2nd edition, P.D. Coleridge-Smith, ed, Landers Bioscience, Austin, TX
    • D. Shields and M. Saharay, White cell activation, in: Microcirculation in Venous Disease, 2nd edition, P.D. Coleridge-Smith, ed., Landers Bioscience, Austin, TX (1998), pp. 140-174.
    • (1998) Microcirculation in Venous Disease , pp. 140-174
    • Shields, D.1    Saharay, M.2
  • 26
    • 0034595586 scopus 로고    scopus 로고
    • Endothelial cell responses to hypoxia: Initiation of a cascade of cellular interactions
    • C. Michiels, T. Arnould and J. Remacle, Endothelial cell responses to hypoxia: initiation of a cascade of cellular interactions, Biochem. Biophys. Acta 1497 (2000), 1-10.
    • (2000) Biochem. Biophys. Acta , vol.1497 , pp. 1-10
    • Michiels, C.1    Arnould, T.2    Remacle, J.3
  • 27
    • 0038157220 scopus 로고    scopus 로고
    • Effect of shear stress in vascular endothelial changes
    • M. Boisseau, Effect of shear stress in vascular endothelial changes, Phlebolymphology 40 (2003), 143-155.
    • (2003) Phlebolymphology , vol.40 , pp. 143-155
    • Boisseau, M.1
  • 28
    • 0030007046 scopus 로고    scopus 로고
    • Increased mast cell infiltration in varicose vein of the lower limbs: A possible role in the development of varices
    • T. Yamada, S. Tomita, M. Mori, E. Sasatomi, E. Suenaga and T. Itoh, Increased mast cell infiltration in varicose vein of the lower limbs: a possible role in the development of varices, Surgery 119 (1996), 494-497.
    • (1996) Surgery , vol.119 , pp. 494-497
    • Yamada, T.1    Tomita, S.2    Mori, M.3    Sasatomi, E.4    Suenaga, E.5    Itoh, T.6
  • 29
    • 4744355701 scopus 로고    scopus 로고
    • Immunocytochemical characterisation of the inflammatory cell infiltrate of varicose veins
    • G.L. Sayer and P.D. Smith, Immunocytochemical characterisation of the inflammatory cell infiltrate of varicose veins, Eur. J. Vasc. Endovasc. Surg. 28 (2004), 479-483.
    • (2004) Eur. J. Vasc. Endovasc. Surg , vol.28 , pp. 479-483
    • Sayer, G.L.1    Smith, P.D.2
  • 31
    • 0033230125 scopus 로고    scopus 로고
    • Effects of the phlebotonic drug Daflon 500 mg on postischemic microvascular disturbances in striated skin muscle: An intravital microscopic study in the hamster
    • D. Nolte, S. Pickelmann and M. Mollmann et al., Effects of the phlebotonic drug Daflon 500 mg on postischemic microvascular disturbances in striated skin muscle: an intravital microscopic study in the hamster, J. Lab. Clin. Med. 134 (199), 526-535.
    • J. Lab. Clin. Med , vol.134 , Issue.199 , pp. 526-535
    • Nolte, D.1    Pickelmann, S.2    Mollmann, M.3
  • 33
    • 0034767463 scopus 로고    scopus 로고
    • Synergism between leukocyte adherence and shear determines venular permeability in the presence of nitric oxide
    • J. Zilberberg and N.R. Harris, Synergism between leukocyte adherence and shear determines venular permeability in the presence of nitric oxide, Microvasc. Res. 62 (2001), 410-420.
    • (2001) Microvasc. Res , vol.62 , pp. 410-420
    • Zilberberg, J.1    Harris, N.R.2
  • 34
    • 0003023689 scopus 로고    scopus 로고
    • Influence of polymorphonuclear leucocytes and platelets on the barrier function of cultured venular endothelial cells
    • K. Messmer and W.M. Kübler, eds, Monduzzi Editore, Bologna, Italy
    • S. Nees, G. Juchem, R. Fink and H. Abbogast, Influence of polymorphonuclear leucocytes and platelets on the barrier function of cultured venular endothelial cells, in: Sixth World Congress for Microcirculation, K. Messmer and W.M. Kübler, eds, Monduzzi Editore, Bologna, Italy (1996), 401-404.
    • (1996) Sixth World Congress for Microcirculation , pp. 401-404
    • Nees, S.1    Juchem, G.2    Fink, R.3    Abbogast, H.4
  • 36
    • 35648944017 scopus 로고    scopus 로고
    • Physiology of pain in venous disease]
    • N. Danziger, [Physiology of pain in venous disease], Concours Med. 126 (2004), 1521-1525.
    • (2004) Concours Med , vol.126 , pp. 1521-1525
    • Danziger, N.1
  • 37
    • 0029415192 scopus 로고
    • Effects of prostaglandin E1 on the intensity of bradykinin-evoked pain from skin and veins in humans
    • D. Kindgen-Milles, Effects of prostaglandin E1 on the intensity of bradykinin-evoked pain from skin and veins in humans. Eur. J. Pharmacol. 294 (1995), 491-496.
    • (1995) Eur. J. Pharmacol , vol.294 , pp. 491-496
    • Kindgen-Milles, D.1
  • 38
    • 3242746671 scopus 로고    scopus 로고
    • The effect of cutaneous mast-cell degranulation on sensitivity to heat
    • P.D. Drummond, The effect of cutaneous mast-cell degranulation on sensitivity to heat, Inflamm. Res. 53 (2004), 309-315.
    • (2004) Inflamm. Res , vol.53 , pp. 309-315
    • Drummond, P.D.1
  • 39
    • 0042168895 scopus 로고    scopus 로고
    • Substance P increases neutrophil adhesion to human umbilical vein endothelial cells
    • C. Dianzani, M. Collino, G. Lombardi, G. Garbarino and R. Fantozzi, Substance P increases neutrophil adhesion to human umbilical vein endothelial cells, Br. J. Pharmacol. 139 (2003), 1103-1110.
    • (2003) Br. J. Pharmacol , vol.139 , pp. 1103-1110
    • Dianzani, C.1    Collino, M.2    Lombardi, G.3    Garbarino, G.4    Fantozzi, R.5
  • 41
    • 0344413691 scopus 로고    scopus 로고
    • Activation of mast cells by systemic hypoxia, but not by local hypoxia, mediates increased leucocyte-endothelial adherence in cremaster venules
    • R. Dix, T. Orth, J. Allen, J.G. Wood and N.C. Gonzalez, Activation of mast cells by systemic hypoxia, but not by local hypoxia, mediates increased leucocyte-endothelial adherence in cremaster venules, J. Appl. Physiol. 95 (2003), 2495-2502.
    • (2003) J. Appl. Physiol , vol.95 , pp. 2495-2502
    • Dix, R.1    Orth, T.2    Allen, J.3    Wood, J.G.4    Gonzalez, N.C.5
  • 42
    • 0346264726 scopus 로고    scopus 로고
    • Relationship of plasma vascular endothelial growth factor to CEAP clinical stage and symptoms in patients with chronic venous disease
    • M.H. Howlader and P.D. Coleridge-Smith, Relationship of plasma vascular endothelial growth factor to CEAP clinical stage and symptoms in patients with chronic venous disease, Eur. J. Vasc. Endovasc. Surg. 27 (2004), 89-93.
    • (2004) Eur. J. Vasc. Endovasc. Surg , vol.27 , pp. 89-93
    • Howlader, M.H.1    Coleridge-Smith, P.D.2
  • 43
    • 0034218529 scopus 로고    scopus 로고
    • Spontaneous leukocyte rolling in rat and mouse microvessels is independent of mast cell activity
    • Y. Guo, L. Lindbom and P. Hedqvist, Spontaneous leukocyte rolling in rat and mouse microvessels is independent of mast cell activity, Inflamm. Res. 49 (2000), 325-329.
    • (2000) Inflamm. Res , vol.49 , pp. 325-329
    • Guo, Y.1    Lindbom, L.2    Hedqvist, P.3
  • 44
    • 0036284898 scopus 로고    scopus 로고
    • Psychological analysis of visceral and cutaneous pain in human subjects
    • I.A. Strigo, M.C. Bushnell, M. Boivin and G.H. Duncan, Psychological analysis of visceral and cutaneous pain in human subjects, Pain 97 (2002), 235-246.
    • (2002) Pain , vol.97 , pp. 235-246
    • Strigo, I.A.1    Bushnell, M.C.2    Boivin, M.3    Duncan, G.H.4
  • 45
    • 3543000517 scopus 로고    scopus 로고
    • Pain management, a new culture]
    • A. Serrie, [Pain management, a new culture], Presse Med. 33 (2004), Sp13-16.
    • (2004) Presse Med , vol.33
    • Serrie, A.1
  • 46
    • 0033963076 scopus 로고    scopus 로고
    • Blocking P-selectin protects from ischemia-reperfusion induced acute renal failure
    • K. Singbarti, S.A. Green and K. Ley, Blocking P-selectin protects from ischemia-reperfusion induced acute renal failure, FASEB J. 14 (2000), 48-54.
    • (2000) FASEB J , vol.14 , pp. 48-54
    • Singbarti, K.1    Green, S.A.2    Ley, K.3
  • 47
    • 0036976082 scopus 로고    scopus 로고
    • Induced changes of leukocyte slow rolling in an in flow pharmacological model of adhesion to endothelial cells
    • M. Renard, F. Heutte, O. Boutherin-Falson, M. Finet and M.R. Boisseau, Induced changes of leukocyte slow rolling in an in flow pharmacological model of adhesion to endothelial cells, Biorheology 40 (2003), 173-178.
    • (2003) Biorheology , vol.40 , pp. 173-178
    • Renard, M.1    Heutte, F.2    Boutherin-Falson, O.3    Finet, M.4    Boisseau, M.R.5
  • 48
    • 0036966156 scopus 로고    scopus 로고
    • Endothelium venotropic drugs in chronic venous insufficiency: A review
    • C. Michiels, J. Remacle and N. Bouaziz, Endothelium venotropic drugs in chronic venous insufficiency: a review, Phlebology 17 (2002), 145-150.
    • (2002) Phlebology , vol.17 , pp. 145-150
    • Michiels, C.1    Remacle, J.2    Bouaziz, N.3
  • 49
    • 0033866990 scopus 로고    scopus 로고
    • Effect of venotropic drugs on the respiratory activity of isolated mitochondria and in endothelial cells
    • D. Janssens, E. Delaive, A. Houblon, F. Eliaers, J. Remacle and C. Michiels, Effect of venotropic drugs on the respiratory activity of isolated mitochondria and in endothelial cells, Br. J. Pharmacol. 130 (2000), 1513-1524.
    • (2000) Br. J. Pharmacol , vol.130 , pp. 1513-1524
    • Janssens, D.1    Delaive, E.2    Houblon, A.3    Eliaers, F.4    Remacle, J.5    Michiels, C.6
  • 50
    • 0028191818 scopus 로고
    • Oral administration of purified micronized flavonoid fraction suppresses leukocyte adhesion in ischemia-reperfusion injury: In vivo observation in the hamster skin fold
    • B. Friesenecker, A.G. Tsai, C. Allegra and M. Intaglietta, Oral administration of purified micronized flavonoid fraction suppresses leukocyte adhesion in ischemia-reperfusion injury: in vivo observation in the hamster skin fold, Int. J. Microcirc. 14 (1994), 50-55.
    • (1994) Int. J. Microcirc , vol.14 , pp. 50-55
    • Friesenecker, B.1    Tsai, A.G.2    Allegra, C.3    Intaglietta, M.4
  • 51
    • 85056020758 scopus 로고    scopus 로고
    • Increased plasma endothelial growth factor among patients with chronic venous disease
    • S.S. Shoab, J.H. Scurr and P.D. Coleridge-Smith, Increased plasma endothelial growth factor among patients with chronic venous disease, J. Vasc. Surg. 271 (1998), H2520-H2528.
    • (1998) J. Vasc. Surg , vol.271
    • Shoab, S.S.1    Scurr, J.H.2    Coleridge-Smith, P.D.3
  • 52
    • 0033213858 scopus 로고    scopus 로고
    • Plasma VEGF as a marker of therapy in patients with chronic venous disease treated with oral micronised flavonoid fraction, a pilot study
    • S.S. Shoab, J.H. Scurr and P.D. Coleridge-Smith, Plasma VEGF as a marker of therapy in patients with chronic venous disease treated with oral micronised flavonoid fraction, a pilot study, Eur. J. Vasc. Endovasc. Surg. 18 (1999), 334-338.
    • (1999) Eur. J. Vasc. Endovasc. Surg , vol.18 , pp. 334-338
    • Shoab, S.S.1    Scurr, J.H.2    Coleridge-Smith, P.D.3
  • 54
    • 0034133466 scopus 로고    scopus 로고
    • The inflammatory reaction during venous hypertension in the rat
    • S. Takase, L. Lerond and J.J. Bergan et al., The inflammatory reaction during venous hypertension in the rat, Microcirculation 7 (2000), 41-52.
    • (2000) Microcirculation , vol.7 , pp. 41-52
    • Takase, S.1    Lerond, L.2    Bergan, J.J.3
  • 55
    • 0031305686 scopus 로고    scopus 로고
    • Postischemic leucocyte/endothelial cell interactions and microvascular barrier dysfunction in skeletal muscle: Cellular mechanisms and effect of Daflon 500 mg
    • R.J. Korthuis and D.C. Gute, Postischemic leucocyte/endothelial cell interactions and microvascular barrier dysfunction in skeletal muscle: cellular mechanisms and effect of Daflon 500 mg, Int. J. Microcirc. Clin. Exp. 17 (suppl. 1) (1997), 11-17.
    • (1997) Int. J. Microcirc. Clin. Exp , vol.17 , Issue.SUPPL. 1 , pp. 11-17
    • Korthuis, R.J.1    Gute, D.C.2
  • 56
    • 0030918551 scopus 로고    scopus 로고
    • Effects of oral administration of purified micronized flavonoid fraction on increased microvascular permeability induced by various agents and on ischemia/ reperfusion in the hamster cheek pouch
    • E. Bouskela and K.A. Donyo, Effects of oral administration of purified micronized flavonoid fraction on increased microvascular permeability induced by various agents and on ischemia/ reperfusion in the hamster cheek pouch, Angiology 48 (1997), 391-399.
    • (1997) Angiology , vol.48 , pp. 391-399
    • Bouskela, E.1    Donyo, K.A.2
  • 57
    • 0043052674 scopus 로고    scopus 로고
    • Micronization enhances the protective effect of purified flavonoid fraction on postischemic microvascular injury in the hamster cheek pouch
    • E. Bouskela, F.Z. Cyrino and L. Lerond, Micronization enhances the protective effect of purified flavonoid fraction on postischemic microvascular injury in the hamster cheek pouch, Int. Angiol. 20 (Suppl. 1) (2001), 19.
    • (2001) Int. Angiol , vol.20 , Issue.SUPPL. 1 , pp. 19
    • Bouskela, E.1    Cyrino, F.Z.2    Lerond, L.3
  • 58
    • 0028247093 scopus 로고
    • Mediators involved in inflammation: Effects of Daflon 500 mg on their release
    • T. Jean and M.C. Bodinier, Mediators involved in inflammation: effects of Daflon 500 mg on their release, Angiology 45 (1994), 554-559.
    • (1994) Angiology , vol.45 , pp. 554-559
    • Jean, T.1    Bodinier, M.C.2
  • 59
    • 0023629450 scopus 로고
    • Effect of chronic treatment with a purified flavonoid fraction on inflammatory granuloma in the rat. Study of prostaglandin E2 and F2 alpha and thromboxane B2 release and histological changes
    • M. Damon, O. Flandre and F. Michel et al., Effect of chronic treatment with a purified flavonoid fraction on inflammatory granuloma in the rat. Study of prostaglandin E2 and F2 alpha and thromboxane B2 release and histological changes, Arzneimittelforschung 37 (1987), 1149-1153.
    • (1987) Arzneimittelforschung , vol.37 , pp. 1149-1153
    • Damon, M.1    Flandre, O.2    Michel, F.3
  • 60
    • 33947599569 scopus 로고    scopus 로고
    • Leukocytes and venous valve damage in chronic venous disease
    • J. Bergan, Leukocytes and venous valve damage in chronic venous disease, Medicographia 28 (2006), 101-108.
    • (2006) Medicographia , vol.28 , pp. 101-108
    • Bergan, J.1
  • 61
    • 21644463605 scopus 로고    scopus 로고
    • Venous leg ulcer: A meta-analysis of adjunctive therapy with micronized purified flavonoid fraction
    • P. Coleridge-Smith, C. Lok and A.A. Ramelet, Venous leg ulcer: a meta-analysis of adjunctive therapy with micronized purified flavonoid fraction, Eur. J. Vasc. Endovasc. Surg. 30 (2005), 198-208.
    • (2005) Eur. J. Vasc. Endovasc. Surg , vol.30 , pp. 198-208
    • Coleridge-Smith, P.1    Lok, C.2    Ramelet, A.A.3
  • 62
    • 18444412628 scopus 로고    scopus 로고
    • Chronic venous insufficiency
    • R.T. Eberhardt and J.D. Raffetto, Chronic venous insufficiency, Circulation 111 (2005), 2398-2409.
    • (2005) Circulation , vol.111 , pp. 2398-2409
    • Eberhardt, R.T.1    Raffetto, J.D.2
  • 63
    • 0037248572 scopus 로고    scopus 로고
    • Micronised purified flavonoid fraction. A review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids
    • A. Lyseng-Williamson and C.M. Perry, Micronised purified flavonoid fraction. A review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids, Drugs 63 (2003), 71-100.
    • (2003) Drugs , vol.63 , pp. 71-100
    • Lyseng-Williamson, A.1    Perry, C.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.