Activation of a subset of genes by IFN-γ requires IKKβ but not interferon-dependent activation of NF-κB

Journal of Interferon and Cytokine Research

Volumn 27, Issue 10, 2007, Pages 875-883

  Shultz, David B ^a,b   Fuller, John D ^a   Yang, Yonghui ^c   Sizemore, Nywana ^a   Rani, M R Sandhya ^a   Stark, George R ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SCAFFOLD PROTEIN; SYNAPTOTAGMIN I;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; ENZYME INHIBITION; FIBROBLAST; GENE ACTIVATION; GENE EXPRESSION; GENE IDENTIFICATION; GENE INDUCTION; GENE REPRESSION; GENETIC TRANSCRIPTION; MACROPHAGE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; NULL ALLELE; PRIORITY JOURNAL; PROMOTER REGION;

ANIMALS; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; INTERFERON TYPE II; MACROPHAGES; MICE; MICROARRAY ANALYSIS; MODELS, BIOLOGICAL; PHOSPHORYLATION; RECEPTORS, CYTOKINE; RESPONSE ELEMENTS; TRANSCRIPTION FACTOR RELA;

EID: 35648948989     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.2007.0031     Document Type: Article

References (24)

1. Stark GR, Kerr IM, Williams BRG, Silverman RH, Shreiber RD. How cells respond to interferons. Annu. Rev. Biochem. 1998;67:227-264.
2. Qing Y, Stark GR. Alternative activation of Stat1 and Stat3 in response to interferon-gamma. J. Biol. Chem. 2004;279:41679-41685.
3. Scheidereit C. IκB kinase complexes: gatways to NFκB activation and transcription. Oncogene 2006;25:6685-6705.
4. Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S. Limb abnormatities in mice lacking IKKalpha. Science 1999;284:313-316.
5. Sizemore N, Lerner N, Dombrowski N, Sakurai H, Stark GR. Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B. J. Biol. Chem. 2002;277:3863-3869.
6. Coope HJ, Atkinson PGP, Huhse B, Belich M, Janzen J, Holman MJ, Klaus GGB, Johnston LH, Ley SC. CD40 regulates the processing of NFκB2 p100 to p52. EMBO J. 2002;21:5375-5385.
7. Claudio E, Brown K, Park S, Wang H, Siebenlist U. BAFF-induced NEMO-independent processing of NFκB2 in maturing B cells. Nat. Immunol. 2002;3:958-965.
8. Sizemore N, Agarwal A, Das K, Lerner N, Sulak M, Rani S, Ransohoff R, Shultz D, Stark G. Inhibitor of κB kinase is required to activate a subset of interferon-gamma-stimulated genes. Proc. Natl. Acad. Sci. USA 2004;101:7094-7098.
9. Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D. Embryonic lethality and liver generation in mice lacking the RelA component of NFκB. Nature 1995;376:167-170.
10. Hampson L, Hampson IN, Babichuk CK, Cotter L, Bleackley RC, Dexter TM, Cross MA. A minimal promoter with high activity in hematopoietic progenitors and activated T cells. Hematol. J. 2001;2:150-160.
11. Ohmori Y, Hamilton TA. The interferon-stimulated response elelment and kappa B site mediate synergisitic induction of murine IP-10 gene transcription by IFN-gamma and TNF-alpha. J. Immunol. 1995;154:5235-5244.
12. Himatsu T, Suzuki M, Polodsky D. Interferon-gamma augments CARD4/NOD1 gene and protein expression through interferon regulatory factor-1 in intestinal epithelial cells. J. Biol. Chem. 2003;278:32962-32968.
13. Hiroi M, Ohmori Y. Constitutive nuclear factor kappaB activity is required to elicit interferon-gamma-induced expression of chemokine CXC ligand 9 (CXCL9) and CXCL10 in human tumour cell lines. Biochem. J. 2003;376:393-402.
14. Gapuzan M-ER, Schmah O, Pollock AD, Hoffmann A, Gilmore T. Immortalized fibroblasts from NFκB Rel A knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor alpha after transformation by v-Ras. Oncogene 2005;24:6574-6583.
15. Yang CH, Murti A, Pfeffer SR, Basu L, Kim JG, Pfeffer LM. IFNalpha/ beta promotes cell survival by activating NF-κB. Proc. Natl. Acad. Sci. USA 2000;97:13631-13636.
16. Deb A, Haque SJ, Mogensen T, Silverman RH, Williams BRG. RNA-dependent protein kinase PKR is required for activation of NFκB by IFN-gamma in a Stat1-indpendent pathway. J. Immunol. 2001;166:6170-6180.
17. Nazar ASMI, Cheng G, Shin H, Brothers PN, Dhib-Jalbut S, Shin ML, Vanguri P. Induction of ip-10 chemokine promoter by measles virus: comparison with interferon-gamma shows the use of the same response element but with differential DNA-protein binding profiles. J. Neuroimmunol. 1997;77:116-127.
18. Wu C, Ohmori Y, Bandyopadhyay S, Sen G, Hamilton T. Interferon-stimulated response element and NF-κB sites cooperate to regulate double-stranded RNA-induced transcription of the ip-10 gene. J. Interferon Cytokine Res. 1994;14:357-363.
19. Rani S, Guazzi C, Pelegrini S, Fish E, Wei T, Ransohoff R. Induction of beta-R1/I-TAC by interferon-beta requires catalytically active tyk2. J. Biol. Chem. 1999;274:1891-1897.
20. Wong P, Severns CW, Guyer NB, Wright T. A unique palindromic element mediates gamma interferon induction of mig expression. Mol. Cell. Biol. 1994;14:914-922.
21. Deb A, Haque SJ, Morgensen T, Silverman RH, Williams BR. RNA-dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a Stat1-independent pathway. J. Immunol. 2001;166:6170-6180.
22. Hurgin V, Werman A, Dinarello CA, Rubinstein M. Antiviral and immunogegulatory activities of IFN-gamma depend on constitutively expressed IL-1alpha. Proc. Natl. Acad. Sci. USA 2007;104:5044-5049.
23. Rani MRS, Hibbert L, Sizemore N, Stark GR, Ransohoff R. Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-r1 (scyb11) gene. J. Biol. Chem. 2002;277:38456-38461.
24. Bluyssen HA, Muzaffar R, Vlieststra RJ, Made ACvd, Leung S, Stark GR, Kerr I, Trapman J, Levy DE. Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses. Proc. Natl. Acad. Sci. USA 1995;92:5645-5649.