Is there an association between T102C polymorphism of the serotonin receptor 2A gene and urinary incontinence?

Brazilian Journal of Medical and Biological Research

Volumn 40, Issue 10, 2007, Pages 1315-1322

  Schwanke, C H A ^a   Bittencourt, L ^a   Noronha, J A P ^a   Augustin, S A J ^b   Jung, I E ^c   Cruz, I B M ^d  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

^c UNIVERSIDADE REGIONAL DO NOROESTE DO ESTADO DO RIO GRANDE DO SUL   (Brazil)

^d FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

5 HT2A gene polymorphism; Elderly patients; T102C polymorphism of the serotonin receptor 2A gene; Urinary incontinence

Indexed keywords

CYSTEINE; RESTRICTION ENDONUCLEASE; SEROTONIN 2A RECEPTOR; THREONINE;

ADL DISABILITY; ADULT; AGE; AGED; ARTICLE; BIOCHEMISTRY; BLADDER FUNCTION; BRAZIL; CASE CONTROL STUDY; CLINICAL EXAMINATION; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHYSICAL EXAMINATION; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEROTONINERGIC SYSTEM; SEX RATIO; SYSTOLIC HYPERTENSION; URINE INCONTINENCE; URODYNAMICS; VOLUNTEER;

EID: 35549011447     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2006005000151     Document Type: Article

References (24)

1. Martin C. Urinary incontinence in the elderly. http://www.ascp.com/ public/pubs/tcp/199/aug/elderly.html. Accessed June, 2004.
2. Michel MC, Peters SL. Role of serotonin and noradrenaline in stress urinary incontinence. BJU Int 2004; 94 (Suppl 1): 23-30.
3. de Groat WC. Influence of central serotonergic mechanisms on lower urinary tract function. Urology 2002; 59: 30-36.
4. Thor KB. Serotonin and norepinephrine involvement in efferent pathways to the urethral rhabdosphincter: implications for treating stress urinary incontinence. Urology 2003; 62: 3-9.
5. Burgard EC, Fraser MO, Thor KB. Serotonergic modulation of bladder afferent pathways. Urology 2003; 62 (Suppl 4A): 10.
6. Cohen ML. Canine, but not rat bladder contracts to serotonin via activation of 5HT2 receptors. J Urol 1990; 143: 1037-1040.
7. Burnet PW, Eastwood SL, Lacey K, Harrison PJ. The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain. Brain Res 1995; 676: 157-168.
8. Maggi CA, Borsini F, Lecci A, Giuliani S, Meli P, Gragnani L, et al. Effect of acute or chronic administration of imipramine on spinal and supraspinal micturition reflexes in rats. J Pharmacol Exp Ther 1989; 248: 278-285.
9. Yamada S, Akita H, Kanazawa K, Ishida T, Hirata K, Ito K, et al. T102C polymorphism of the serotonin (5-HT) 2A receptor gene in patients with non-fatal acute myocardial infarction. Atherosclerosis 2000; 150: 143-148.
10. Cusin C, Serretti A, Lattuada E, Lilli R, Lorenzi C, Smeraldi E. Association study of MAO-A, COMT, 5-HT2A, DRD2, and DRD4 polymorphisms with illness time course in mood disorders. Am J Med Genet 2002; 114: 380-390.
11. Warren JT Jr, Peacock ML, Rodriguez LC, Fink JK. An Mspl polymorphism in the human serotonin receptor gene (HTR2): detection by DGGE and RFLP analysis. Hum Mol Genet 1993; 2: 338.
12. Little J, Bradley L, Bray MS, Clyne M, Dorman J, Ellsworth DL, et al. Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations. Am J Epidemiol 2002; 156: 300-310.
13. Parra FC, Amado.RC, Lambertucci JR, Rocha J, Antunes CM, Pena SD. Color and genomic ancestry in Brazilians. Proc Natl Acad Sci USA 2003; 100: 177-182.
14. Schwanke CH, da Cruz I, Leal NF, Scheibe R, Moriguchi Y, Moriguchi EH. Analysis of the association between apolipoprotein E polymorphism and cardiovascular risk factors in an elderly population with longevity. Arq Bras Cardiol 2002; 78: 561-579.
15. do Prado-Lima PA, Chatkin JM, Taufer M, Oliveira G, Silveira E, Neto CA, et al. Polymorphism of 5HT2A serotonin receptor gene is implicated in smoking addiction. Am J Med Genet B Neuropsychiatr Genet 2004; 128: 90-93.
16. Lumb BM. Brainstem control of visceral afferent pathways in the spinal cord. Prog Brain Res 1986; 67: 279-293.
17. Oh UT, Hobbs SF, Garrison D, Foreman RD. Responses of raphe-spinal neurons (RSN) to urinary bladder distension (UBD) and sympathetic nerve stimulation. Soc Neurosci Abstr 1986; 12: 375.
18. Espey MJ, Downie JW, Fine A. Effect of 5-HT receptor and adrenoceptor antagonists on micturition in conscious cats. Eur J Pharmacol 1992; 221: 167-170.
19. Kim HJ, Lee G, Kim DH, Lee SJ, Yoon DK, Cho JH. Acute effects of serotonin on rat bladder contractility. Urol Int 2002; 68: 44-48.
20. Kodama M, Takimoto Y. Influence of 5-hydroxytryptamine and the effect of a new serotonin receptor antagonist (sarpogrelate) on detrusor smooth muscle of streptozotocin-induced diabetes mellitus in the rat. Int J Urol 2000; 7: 231-235.
21. Polesskaya OO, Sokolov BP. Differential expression of the "C" and "T" alleles ot the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics. J Neurosci Res 2002; 67: 812-822.
22. Wacholder S, Rothman N, Caporaso N. Population stratification in epidemiologic studies of common genetic variants and cancer: quantification of bias. J Natl Cancer Inst 2000; 92: 1151-1158.
23. Schuessler B, Baessler K. Pharmacologic treatment of stress urinary incontinence: expectations for outcome. Urology 2003; 62: 31-38.
24. Chapple CR. Duloxetine for male stress incontinence. Eur Urol 2006; 49: 958-960.