Extramedullary BCR-ABL1-negative myeloid leukemia in a patient with chronic myeloid leukemia and synchronous cytogenetic abnormalities in Philadelphia-positive and -negative clones during imatinib therapy [17]

Leukemia

Volumn 21, Issue 11, 2007, Pages 2394-2396

  Quintas Cardama A ^a   Kantarjian, H ^a   Abruzzo, L V ^a   Cortes, J ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BCR ABL PROTEIN; CD135 ANTIGEN; CD68 ANTIGEN; HEMOGLOBIN; IMATINIB; JANUS KINASE 2; LEUKOSIALIN; NILOTINIB; RAS PROTEIN;

AGED; BONE MARROW BIOPSY; CASE REPORT; CELL CLONE; CHROMOSOME 11; CHROMOSOME 7; CHROMOSOME ANALYSIS; CHRONIC MYELOID LEUKEMIA; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; ERYTHEMA; FATIGUE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; IMMUNOHISTOCHEMISTRY; KARYOTYPE 46,XY; LETTER; LEUKOCYTE COUNT; MALE; MUTATIONAL ANALYSIS; MYALGIA; PATIENT REFERRAL; PHILADELPHIA CHROMOSOME NEGATIVE CELL; PHILADELPHIA CHROMOSOME POSITIVE CELL; PRIORITY JOURNAL; SKIN BIOPSY; SUBCUTANEOUS NODULE; THROMBOCYTE COUNT;

EID: 35549009764     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404865     Document Type: Letter

References (8)

1. Cortes J, O'Dwyer ME. Clonal evolution in chronic myelogenous leukemia. Hematol Oncol Clin N Am 2004; 18: 671-684.
2. Fayad L, Kantarjian H, O'Brien S, Seong D, Albitar M, Keating M et al. Emergence of new clonal abnormalities following interferon-alpha induced complete cytogenetic response in patients with chronic myeloid leukemia: Report of three cases. Leukemia 1997; 11: 767-771.
3. Medina J, Kantarjian H, Talpaz M, O'Brien S, Garcia-Manero G, Giles F et al. Chromosomal abnormalities in Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelo genous leukemia in chronic phase. Cancer 2003; 98: 1905-1911.
4. Kovitz C, Kantarjian H, Garcia-Manero G, Abruzzo LV, Cortes J. Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia. Blood 2006; 108 2811-2813.
5. Loriaux M, Deininger M. Clonal cytogenetic abnormalities in Philadelphia chromosome negative cells in chronic myeloid leukemia patients treated with imatinib. Leuk Lymphoma 2004; 45: 2197-2203.
6. Jabbour E, Kantarjian H, Abruzzo L, Giles F, Rios MB, Cortes J. Chromosomal abnormalities in Philadelphia chromosome (Ph)-negative metaphases appearing during novel tyrosine kinase inhibitors (NTKI) therapy in patients (pts) with chronic myeloid leukemia (CML) after imatinib-failure. Blood 2006; 108, Abstract 2115.
7. Casali M, Truglio F, Milone G, Di Raimondo F, Parrinello G, Maserati E et al. Trisomy 8 in Philadelphia chromosome (Ph1)- negative cells in the course of Ph1-positive chronic myelocytic leukemia. Genes Chromosomes Cancer 1992; 4: 269-270.
8. Royer-Pokora B, Hildebrandt B, Redmann A, Herold C, Kronenwett R, Haas R et al. Simultaneous occurrence of a t(9;22) (Ph) with a t(2;11) in a patient with CML and emergence of a new clone with the t(2;11) alone after imatinib mesylate treatment. Leukemia 2003; 17: 807-810.