Secondary velocity fields in the conducting airways of the human lung

Journal of Biomechanical Engineering

Volumn 129, Issue 5, 2007, Pages 722-732

  Fresconi, Frank E ^a   Prasad, Ajay K ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

Aerosol transport; Bifurcation; Dispersion; Drug delivery; Lung flow; Respiratory airway; Secondary velocity

Indexed keywords

LUNG FLOW; RESPIRATORY AIRWAY; SECONDARY VELOCITY;

BIOLOGICAL ORGANS; MIXING; OPTIMIZATION; TOXIC MATERIALS; VELOCITY MEASUREMENT;

AERODYNAMICS;

AIRWAY CONDUCTANCE; ARTICLE; EXPIRATORY FLOW; FLOW RATE; IN VITRO STUDY; INSPIRATORY CAPACITY; LUNG FUNCTION; LUNG MODEL; MATHEMATICAL MODEL; OSCILLATION; PARTICLE IMAGE VELOCIMETRY; RESPIRATORY AIRFLOW; VELOCITY;

ADMINISTRATION, INHALATION; AEROSOLS; BIOLOGICAL TRANSPORT; CONVECTION; DIFFUSION; DRUG DELIVERY SYSTEMS; HUMANS; LUNG; MODELS, BIOLOGICAL; OSCILLOMETRY; PULMONARY GAS EXCHANGE; PULMONARY VENTILATION; RHEOLOGY; VISCOSITY;

EID: 35549005398     PISSN: 01480731     EISSN: None     Source Type: Journal    
DOI: 10.1115/1.2768374     Document Type: Article

References (39)

1. Drazen, J. M., Kamm, R. D., and Slutsky, A. S., 1984, "High-Frequency Ventilation," Physiol. Rev., 64(2), pp. 505-543.
2. Kohlhaufl, M., Brand, P., Selzer, T., Scheuch, G., Meyer, T., Weber, N., Schulz, H., Haussinger, K., and Heyder, J., 1998, "Diagnosis of Emphysema in Patients With Chronic Bronchitis: A New Approach," Eur. Respir. J., 12, pp. 793-798.
3. Edwards, D. A., and Dunbar, C., 2002, "Bioengineering of Therapeutic Aerosols," Annu. Rev. Biomed. Eng., 4, pp. 93-107.
4. Robinson, R. J., and Yu, C. P., 2001, "Deposition of Cigarette Smoke Particles in the Human Respiratory Tract," Aerosol Sci. Technol., 34, pp. 202-215.
5. Schwartz, J., and Dockery, D. W., 1992, "Increased Mortality in Philadelphia Associated With Daily air Pollution Concentrations," Am. Rev. Respir. Dis., 145, pp. 600-604.
6. Edwards, D. A., Man, J. C., Brand, P., Katstra, J. P., Sommerer, K., Stone, H. A., Nardell, E., and Scheuch, G., 2004, "Inhaling to Mitigate Exhaled Bioaerosols," Proc. Natl. Acad. Sci. U.S.A., 101(50), pp. 17383-17388.
7. Heyder, J., Blanchard, J. D., Feldman, H. A., and Brain, J. D., 1988, "Convective Mixing in Human Respiratory Tract: Estimates With Aerosol Boli," J. Appl. Physiol., 64(3), pp. 1273-1278.
8. Haselton, F. R., and Scherer, P. W., 1980, "Bronchial Bifurcations and Respiratory Mass Transport," Science, 208(4439), pp. 69-71.
9. Haselton, F. R., and Scherer, P. W., 1982, "Flow Visualization of Steady Streaming in Oscillatory Flow Through a Bifurcating Tube," J. Fluid Mech., 123, pp. 315-333.
10. Scherer, P. W., and Haselton, F. R., 1982, "Convective Exchange in Oscillatory Flow Through Bronchial-tree Models," J. Appl. Physiol.: Respir., Environ. Exercise Physiol., 53(4), pp. 1023-1033.
11. Taylor, G. I., 1953, "Dispersion of Soluble Matter in Solvent Flowing Slowly Through a Tube," Proc. R. Soc. London, Ser. A, 219, pp. 186-203.
12. Taylor, G. I., 1954, "The Dispersion of Matter in Turbulent Flow Through a Pipe," Proc. R. Soc. London, Ser. A, 223, pp. 446-468.
13. Aris, R., 1956, "On the Dispersion of Solute in a Fluid Flowing Through a Tube," Proc. R. Soc. London, Ser. A, 235, pp. 66-77.
14. Chang, H. K., 1976, "Effect of Taylor Dispersion on Stratified Inhomogeneity (Abstract)," Physiologist, 19, p. 151.
15. Horsfield, K., Davies, A., and Cumming, G., 1977, "Role of Conducting Airways in Partial Separation of Inhaled Gas Mixtures," J. Appl. Physiol.: Respir., Environ. Exercise Physiol., 43(3), pp. 391-396.
16. Fredberg, J. J., 1980, "Augmented Diffusion in the Airways Can Support Pulmonary Gas Exchange," J. Appl. Physiol.: Respir., Environ. Exercise Physiol., 49(2), pp. 232-238.
17. Scherer, P. W., Shendalman, L. H., Greene, N. M., and Bouhuys, A., 1975, "Measurement of Axial Diffusivities in a Model of the Bronchial Airways," J. Appl. Physiol., 38(4), pp. 719-723.
18. Kamm, R. D., Collins, J., Whang, J., Slutsky, A. S., and Greiner, M., 1984, "Gas Transport During Oscillatory Flow in a Network of Branching Tubes," J. Biomed. Eng., 106, pp. 315-320.
19. Tarbell, J. M., Ultman, J. S., and Durlofsky, L., 1982, "Oscillatory Convective Dispersion in a Branching Tube Network," J. Biomed. Eng., 104, pp. 338-342.
20. Permutt, S., Mitzner, W., and Weinmann, G., 1985, "Model of Gas Transport During High-Frequency Ventilation," J. Appl. Physiol., 58, pp. 1956-1970.
21. Paloski, W. H., Slosberg, R. B., and Kamm, R. D., 1987, "Effects of Gas Properties and Waveform Asymmetry on Gas Transport in a Branching Tube Network," J. Appl. Physiol., 62(3), pp. 892-901.
22. Pedley, T. J., and Kamm, R. D., 1988, "The Effect of Secondary Motion on Axial Transport in Oscillatory Tube Flow," J. Fluid Mech., 193, pp. 347-367.
23. Jan, D. L., Shapiro, A. H., and Kamm, R. D., 1989, "Some Features of Oscillatory Flow in a Model Bifurcation," J. Appl. Physiol., 67(1), pp. 147-159.
24. Tanaka, G., Ueda, Y., and Tanishita, K., 1998, "Augmentation of Axial Dispersion by Intermittent Oscillatory Flow," ASME J. Biomech. Eng., 120, pp. 405-415.
25. Isabey, D., and Chang, H. K., 1982, "Model Study of Flow Dynamics in Human Central Airways. Part II: Secondary Flow Velocities," Respir. Physiol., 55, pp. 255-275.
26. Zhao, Y., and Lieber, B. B., 1994, "Steady Inspiratory Flow in a Model Symmetric Bifurcation," ASME J. Biomech. Eng., 116, pp. 488-496.
27. Zhao, Y., and Lieber, B. B., 1994, "Steady Expiratory Flow in a Model Symmetric Bifurcation," ASME J. Biomech. Eng., 116, pp. 318-323.
28. Tanaka, G., Ogata, T., Oka, K., and Tanishita, K., 1999, "Spatial and Temporal Variation of Secondary Flow During Oscillatory Flow in Model Human Central Airways," ASME J. Biomech. Eng., 121, pp. 565-573.
29. Farag, A., Hammersley, J., Olson, D., and Ng, T., 2000, "Mechanics of the Flow in the Small and Middle Human Airways," ASME J. Biomech. Eng., 122, pp. 576-584.
30. Fresconi, F. E., Wexler, A. S., and Prasad, A. K., 2003, "Expiration Flow in a Symmetric Bifurcation," Exp. Fluids, 35, pp. 493-501.
31. Dean, W. R., 1927, "Note on the Motion of Fluid in a Curved Pipe," Philos. Mag., 4(7), pp. 208-223.
32. Comer, J. K., Kleinstreuer, C., and Zhang, Z., 2001, "Flow Structures and Particle Deposition Patterns in Double-Bifurcation Airway Models. Part 1. Air Flow Fields," J. Fluid Mech., 435, pp. 25-54.
33. Zhang, Z., and Kleinstreuer, C., 2002, "Transient Airflow Structures and Particle Transport in a Sequentially Branching Lung Airway Model," Phys. Fluids, 14(2), pp. 862-880.
34. Godleski, D. A., and Grotberg, J. B., 1988, "Convection-Diffusion Interaction for Oscillatory Flow in a Tapered Tube," ASME J. Biomech. Eng., 110, pp. 283-291.
35. Pedley, T. J., 1977, "Pulmonary Fluid Dynamics," Annu. Rev. Fluid Mech., 9, pp. 229-274.
36. Hopkins, L. M., Kelly, J. T., Wexler, A. S., and Prasad A. K., 2000, "PIV Measurements in Complex Geometries," Exp. Fluids, 29(1), pp. 91-95.
37. Weibel, E. R., 1963, Morphometry of the Lung, Springer-Verlag, Berlin.
38. Daskopoulos, P., and Lenhoff, A. M., 1989, "Flow in Curved Ducts: Bifurcation Structure for Stationary Ducts," J. Fluid Mech., 203, pp. 125-148.
39. Berger, S. A., Talbot, L., and Yao, L. S., 1983, "Flow in Curved Pipes," Annu. Rev. Fluid Mech., 15, pp. 461-512.