Diagnosis of emphysema in patients with chronic bronchitis: A new approach

European Respiratory Journal

Volumn 12, Issue 4, 1998, Pages 793-798

  Kohlhaufl M ^a,c   Brand, P ^b   Selzer, T ^b   Scheuch, G ^b   Meyer, Th ^b   Weber, N ^b   Schulz, H ^b   Haussinger K ^a   Heyder, J ^b  

^a Clinic for Respiratory Medicine   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c ASKLEPIOS FACHKLINIKEN MÜNCHEN GAUTING   (Germany)

Author keywords

Aerosol; Aerosol bolus dispersion; Airway morphometry; Chronic obstructive pulmonary disease; Convective gas mixing

Indexed keywords

ADULT; AEROSOL; AGED; ARTICLE; CHRONIC BRONCHITIS; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DISPERSION; EMPHYSEMA; FEMALE; GAS MIXING; HUMAN; INTERMETHOD COMPARISON; LUNG FUNCTION TEST; MALE; MORPHOMETRICS; PRIORITY JOURNAL;

ADMINISTRATION, INHALATION; AEROSOLS; AGED; AIRWAY RESISTANCE; BRONCHI; BRONCHITIS; CHRONIC DISEASE; DIAGNOSIS, DIFFERENTIAL; EMPHYSEMA; FEMALE; FUNCTIONAL RESIDUAL CAPACITY; HUMANS; MALE; MIDDLE AGED; PARTICLE SIZE; ROC CURVE; SENSITIVITY AND SPECIFICITY; TOTAL LUNG CAPACITY;

EID: 0031722932     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.98.12040793     Document Type: Article

References (35)

1. Flenley DC. Diagnosis and follow-up of emphysema. Eur Respir J 1990; Suppl. 9: 5s-8s.
2. Thurlbeck WM. Chronic airflow obstruction. In: Thurlbeck WM, Churg AM, eds. Pathology of the Lung. New York, Thieme, 1995; pp. 739-825.
3. Snider GL. Defining chronic obstructive pulmonary disease. In: Calverly PMA, Pride NB, eds. Chronic Obstructive Pulmonary Disease. London, Chapman & Hall, 1995; pp. 1-8.
4. Siafakas NM, Vermiere P, Pride NB, et al. ERS - Consensus Statement. Optimal assessment and management of chronic obstructive pulmonary disease (COPD). Eur Respir J 1995; 8: 1398-1420.
5. Stern EJ, Frank MS. CT of the lung in patients with pulmonary emphysema: diagnosis, quantification, and correlation with pathologic and physiologic findings. Am J Roentgenol 1994; 162: 791-798.
6. Beinert Th, Brand P, Behr J, Vogelmeier C, Heyder J. Peripheral airspace dimensions in patients with COPD. Chest 1995; 108: 998-1003.
7. Kohlhäufl M, Brand P, Meyer T, et al. Aerosol bolus dispersion: a discriminator between healthy subjects and patients with emphysema. Eur J Med Res 1997; 2: 121-128.
8. Brand P, Tuch T, Manuwald O, et al. Detection of early lung impairment with aerosol bolus dispersion. Eur Respir J 1994; 7: 1830-1838.
9. Rosenthal FS, Wright S. Aerosol deposition and dispersion characterize lung injury in a canine model of emphysema. J Appl Physiol 1995; 78: 1585-1595.
10. McCawley M, Lippmann M. Development of an aerosol dispersion test to detect early changes in lung function. Am Ind Hyg Assoc 1988; 49: 357-366.
11. Brand P, Rieger C, Beinert T, Heyder J. Aerosol derived airway morphometry in healthy subjects. Eur Respir J 1995; 8: 1639-1646.
12. Brand P, Rieger C, Schuiz H, Beinert T, Heyder J. Aerosol bolus dispersion in healthy subjects. Eur Respir J 1997; 10: 460-467.
13. Heyder J. Assessment of airway geometry with inert aerosols. J Aerosol Med 1989; 2: 89-97.
14. Rosenthal FS. Aerosol recovery following breathholding derived from the distribution of chord length in pulmonary tissue. J Aerosol Sci 1989; 20: 267-277.
15. Brand P, Beinert T, Fruhmann G, Heyder J. Aerosol derived airway morphometry at different levels of lung inflation. J Aerosol Med 1993; 6: 165-176.
16. Heyder J, Blanchard JD, Feldman HA, Brain JD. Convective mixing in the human respiratory tract: estimates with aerosol boli. J Appl Physiol 1988; 64: 1273-1278.
17. Heyder J, Davies CK. The breathing of half micron aerosols. III. Dispersion of particles in the respiratory tract. J Aerosol Sci 1971; 2: 437-452.
18. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Report working party. Standardization of lung function tests. European Community for Steel and Coal. Eur Respir J 1993; 6: Suppl. 16, 5-52.
19. Cotes JE, Chinn DJ, Quanjer Ph H, Roca J, Yernault J-C. Standardization of the measurement of lung function tests. Report working party standardization of lung function tests. Official statement of the European Respiratory Society. Eur Respir J 1993; 6: Suppl. 16, 41-52.
20. Goddard PR, Nicholson EM, Laszlo G, Watt I. Computed tomography in pulmonary emphysema. Clin Radiol 1982; 33: 379-387.
21. Gevenois PA, De Vuyst P, de Maertelaer V, et al. Comparison of computed density and microscopic morphometry in pulmonary emphysema. Am J Respir Crit Care Med 1996; 154: 187-192.
22. Ferris BG. Recommended respiratory disease questionaires for use with adults and children in epidemiological research. Am Rev Respir Dis 1978; 118: 7-55.
23. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristics (ROC) curve. Radiology 1982; 143: 29-36.
24. Metz CE. Basic principles of ROC analysis. Semin Nucl Med 1978; 8: 283-298.
25. Nikiforov AI, Lippmann M, Palmes FD. Validation of an in vivo aerosol probe technique by measurements of deposition and morphometry in excised human lungs. Ann Occup Hyg 1988; 32: 33-39.
26. Blanchard JD. Aerosol bolus dispersion and aerosol-derived airway morphometry: assessment of lung pathology and response to therapy, part 2. J Aerosol Med 1996; 9: 453-475.
27. Anderson PJ, Blanchard JD, Brain JD, Feldman HA, McNamara JJ, Heyder J. Effect of cystic fibrosis on inhaled aerosol boluses. Am Rev Respir Dis 1989; 140: 1317-1324.
28. Muir DCF. Bulk flow and diffusion in the airways of the lung. Br J Dis Chest 1966; 60: 169-176.
29. Banjerjee M, Evans J, Jaeger MJ. Uneven ventilation in smokers. Respir Physiol 1976; 27: 277-291.
30. Barter SJ, Cunningham DA. Lavender JP, Gibellino F, Connellan SJ, Pride NB. Abnormal ventilation scan in middle-aged smokers. Am Rev Respir Dis 1985; 132: 148-151.
31. Rosenthal FS. The effect of nonuniform ventilation on the dispersion of inspired aerosol boluses: a modeling study. J Aerosol Med 1993; 6: 177-197.
32. Morell NW, Wignall BK, Biggs T, Seed WA. Collateral ventilation and gas exchange in emphysema. Am J Respir Crit Care Med 1994; 150: 635-641.
33. Saetta M, Finkelstein R, Cosio MG. Morphological and cellular basis for airflow limitation in smokers. Eur Respir J 1994; 7: 1505-1515.
34. Lamb D, McLean A, Gillooly M, Warren PM, Gould GA, MacNee W. Relation between distal airspace size, bronchiolar attachments and lung function. Thorax 1993; 48: 1012-1017.
35. McLean A, Warren PM, Gillooly M, MacNee W, Lamb D. Microscopic and macroscopic measurements of emphysema: relation to carbon monoxide gas transfer. Thorax 1992; 47: 144-149.