Gr-1+ cells play an essential role in an experimental model of disseminated histoplasmosis

Microbes and Infection

Volumn 9, Issue 12-13, 2007, Pages 1393-1401

  Sá Nunes, Anderson ^a   Medeiros, Alexandra I ^a   Sorgi, Carlos A ^a   Soares, Edson G ^a   Maffei, Cláudia M L ^a   Silva, Célio L ^a   Faccioli, Lúcia H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cytokines; Gr 1+ cells; Histoplasma capsulatum; Immune response; MAb RB6 8C5; Nitric oxide

Indexed keywords

ANTIGEN; GRANULOCYTE DIFFERENTIATION ANTIGEN 1; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY RB6 8C5; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE MODEL; FUNGUS GROWTH; HISTOPLASMA CAPSULATUM; HISTOPLASMOSIS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LUNG; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; TH1 CELL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, DIFFERENTIATION; BLOOD CELL COUNT; CYTOKINES; GRANULOCYTES; HISTOPLASMA; HISTOPLASMOSIS; HUMANS; LUNG; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE; SPLEEN;

AJELLOMYCES CAPSULATUS; MUS;

EID: 35548994562     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2006.10.007     Document Type: Article

References (30)

1. Cano M.V., and Hajjeh R.A. The epidemiology of histoplasmosis: a review. Semin. Respir. Infect. 16 (2001) 109-118
2. Woods J.P. Histoplasma capsulatum molecular genetics, pathogenesis, and responsiveness to its environment. Fungal Genet. Biol. 35 (2002) 81-97
3. + T cells in host resistance to systemic infection with Histoplasma capsulatum in mice. J. Immunol. 152 (1994) 3491-3500
4. Zhou P., Miller G., and Seder R.A. Factors involved in regulating primary and secondary immunity to infection with Histoplasma capsulatum: TNF-α plays a critical role in maintaining secondary immunity in the absence of IFN-γ. J. Immunol. 160 (1998) 1359-1368
5. Clemons K.V., Darbonne W.C., Curnutte J.T., Sobel R.A., and Stevens D.A. Experimental histoplasmosis in mice treated with anti-murine interferon-γ antibody and in interferon-γ gene knockout mice. Microbes Infect. 2 (2000) 997-1001
6. Conlan J.W., and North R.J. Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody. J. Exp. Med. 179 (1994) 259-268
7. Tumpey T.M., Chen S.H., Oakes J.E., and Lausch R.N. Neutrophil-mediated suppression of virus replication after herpes simplex virus type 1 infection of the murine cornea. J. Virol. 70 (1996) 898-904
8. Gonzalez P.H., Ponzinibbio C., and Laguens R.P. Effect of polymorphonuclear depletion on experimental Argentine hemorrhagic fever in guinea pigs. J. Med. Virol. 22 (1987) 289-297
9. Seiler P., Aichele P., Raupach B., Odermatt B., Steinhoff U., and Kaufmann S.H. Rapid neutrophil response controls fast-replicating intracellular bacteria but not slow-replicating Mycobacterium tuberculosis. J. Infect. Dis. 181 (2000) 671-680
10. Tateda K., Moore T.A., Deng J.C., Newstead M.W., Zeng X., Matsukawa A., Swanson M.S., Yamaguchi K., and Standiford T.J. Early recruitment of neutrophils determines subsequent T1/T2 host responses in a murine model of Legionella pneumophila pneumonia. J. Immunol. 166 (2001) 3355-3361
11. Czuprynski C.J., Brown J.F., Maroushek N., Wagner S.D., and Steinberg H. Administration of anti-granulocyte mAb RB6-8C5 impairs the resistance of mice to Listeria monocytogenes infection. J. Immunol. 152 (1994) 1836-1846
12. + Th2 response in BALB/c mice infected with Leishmania major. J. Immunol. 165 (2000) 2628-2636
13. Sayles P.C., and Johnson L.L. Exacerbation of toxoplasmosis in neutrophil-depleted mice. Nat. Immun. 15 (1996) 249-258
14. Romani L., Mencacci A., Cenci E., Spaccapelo R., Del Sero G., Nicoletti I., Trinchieri G., Bistoni F., and Puccetti P. Neutrophil production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice. J. Immunol. 158 (1997) 5349-5356
15. Stephens-Romero S.D., Mednick A.J., and Feldmesser M. The pathogenesis of fatal outcome in murine pulmonary aspergillosis depends on the neutrophil depletion strategy. Infect. Immun. 73 (2005) 114-125
16. Pina A., Saldiva P.H., Restrepo L.E., and Calich V.L. Neutrophil role in pulmonary paracoccidioidomycosis depends on the resistance pattern of hosts. J. Leukoc. Biol. 79 (2006) 1202-1213
17. Mednick A.J., Feldmesser M., Rivera J., and Casadevall A. Neutropenia alters lung cytokine production in mice and reduces their susceptibility to pulmonary cryptococcosis. Eur. J. Immunol. 33 (2003) 1744-1753
18. Tepper R.I., Coffman R.L., and Leder P. An eosinophil-dependent mechanism for the antitumor effect of interleukin-4. Science 257 (1992) 548-551
19. Julia V., Hessel E.M., Malherbe L., Glaichenhaus N., O'Garra A., and Coffman R.L. A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure. Immunity 16 (2002) 272-283
20. + T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo. Cell. Immunol. 224 (2003) 98-105
21. Medeiros A.I., Sá-Nunes A., Soares E.G., Peres C.M., Silva C.L., and Faccioli L.H. Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis. Infect. Immun. 72 (2004) 1637-1644
22. Rogerio A.P., Sá-Nunes A., Albuquerque D.A., Anibal F.F., Medeiros A.I., Machado E.R., Souza A.O., Prado Jr. J.C., and Faccioli L.H. Lafoensia pacari extract inhibits IL-5 production in toxocariasis. Parasite Immunol. 25 (2003) 393-400
23. Sá-Nunes A., Medeiros A.I., Nicolete R., Frantz F.G., Panunto-Castelo A., Silva C.L., and Faccioli L.H. Efficacy of cell-free antigens in evaluating cell immunity and inducing protection in a murine model of histoplasmosis. Microbes Infect. 7 (2005) 584-592
24. Lane T.E., Wu-Hsieh B.A., and Howard D.H. Antihistoplasma effect of activated mouse splenic macrophages involves production of reactive nitrogen intermediates. Infect. Immun. 62 (1994) 1940-1945
25. Scapini P., Lapinet-Vera J.A., Gasperini S., Calzetti F., Bazzoni F., and Cassatella M.A. The neutrophil as a cellular source of chemokines. Immunol. Rev. 177 (2000) 195-203
26. Zhou P., Sieve M.C., Bennett J., Kwon-Chung K.J., Tewari R.P., Gazzinelli R.T., Sher A., and Seder R.A. IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-γ. J. Immunol. 155 (1995) 785-795
27. Schaffner A., Davis C.E., Schaffner T., Markert M., Douglas H., and Braude A.I. In vitro susceptibility of fungi to killing by neutrophil granulocytes discriminates between primary pathogenicity and opportunism. J. Clin. Invest. 78 (1986) 511-524
28. Newman S.L., Gootee L., and Gabay J.E. Human neutrophil-mediated fungistasis against Histoplasma capsulatum. Localization of fungistatic activity to the azurophil granules. J. Clin. Invest. 92 (1993) 624-631
29. Gildea L.A., Morris R.E., and Newman S.L. Histoplasma capsulatum yeasts are phagocytosed via very late antigen-5, killed, and processed for antigen presentation by human dendritic cells. J. Immunol. 166 (2001) 1049-1056
30. Lin J.S., Yang C.W., Wang D.W., and Wu-Hsieh B.A. Dendritic cells cross-present exogenous fungal antigens to stimulate a protective CD8 T cell response in infection by Histoplasma capsulatum. J. Immunol. 174 (2005) 6282-6291