Heat map visualization of high-density clinical chemistry data

Physiological Genomics

Volumn 31, Issue 2, 2007, Pages 352-356

  Auman, J Todd ^a   Boorman, Gary A ^a   Wilson, Ralph E ^a   Travlos, Gregory S ^a   Paules, Richard S ^a,b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b Mail Drop D2 03 ^*  (United States)

Author keywords

Clinical pathology; Hepatotoxicity; Hierarchical clustering; Rat; Toxicogenomics

Indexed keywords

ARTICLE; CLINICAL CHEMISTRY; HEAT; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; TOXICOGENETICS;

ANIMALS; CLINICAL CHEMISTRY TESTS; CLUSTER ANALYSIS; COLOR; COMPUTER GRAPHICS; HEPATITIS, TOXIC; LIVER FUNCTION TESTS; MALE; RATS; RATS, INBRED F344;

ANIMALIA; RATTUS;

EID: 35548991130     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00276.2006     Document Type: Article

References (12)

1. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 95: 14863-14868, 1998.
2. Hamadeh HK, Knight BL, Haugen AC, Sieber S, Amin RP, Bushel PR, Stoll R, Blanchard K, Jayadev S, Tennant RW, Cunningham ML, Afshari CA, Paules RS. Methapyrilene toxicity: anchorage of pathologic observations to gene expression alterations. Toxicol Pathol 30: 470-482, 2002.
3. Lobenhofer EK, Boorman GA, Phillips KL, Heinloth AN, Malarkey DE, Blackshear PE, Houle C, Hurban P. Application of visualization tools to the analysis of histopathology data enhances biological insight and interpretation. Toxicol Pathol 34: 921-928, 2006.
4. Loeb WF. The Clinical Chemistry of Laboratory Animals. Philadelphia, PA: Taylor & Francis, 1999, p. 753.
5. National Heart, Lung, and Blood Institute. Framingham Heart Study. http://www.nhlbi.nih.gov/about/framingham/index.html.
6. National Research Council, (US) Institute of Laboratory Animal Resources. Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press, 1996, p. 125.
7. Paules R. Phenotypic anchoring: linking cause and effect. Environ Health Perspect 111: A338-A339, 2003.
8. Rao GN. New nonpurified diet (NTP-2000) for rodents in the National Toxicology Program's toxicology and carcinogenesis studies. J Nutr 127: 842S-846S, 1997.
9. Stine ER, Gunawardhana L, Sipes IG. The acute hepatotoxicity of the isomers of dichlorobenzene in Fischer-344 and Sprague-Dawley rats: isomer-specific and strain specific differential toxicity. Toxicol Appl Pharmacol 109: 472-481, 1991.
10. Sunderman FW Jr. Current concepts of "normal values," "reference values," and "discrimination values" in clinical chemistry. Clin Chem 21: 1873-1877, 1975.
11. Tennant RW. The National Center for Toxicogenomics: using new technologies to inform mechanistic toxicology. Environ Health Perspect 110: A8-A10, 2002.
12. Waters MD, Fostel JM. Toxicogenomics and systems toxicology: aims and prospects. Nat Rev Genet 5: 936-948, 2004.