Microinjection of the preferential dopamine receptor D3 agonist 7-hydroxy-N,N-di-n-propylaminotetralin hydrobromide into the hypothalamic medial preoptic area induced ejaculation in anesthetized rats

Neuroscience

Volumn 149, Issue 3, 2007, Pages 636-641

  Kitrey, N D ^a,b   Clement P ^b   Bernabe J ^b   Alexandre, L ^b   Giuliano, F ^b,c  

^a SHEBA MEDICAL CENTER   (Israel)

^b CNRS   (France)

^c RAYMOND POINCARÉ HOSPITAL   (France)

Author keywords

brain; bulbospongiosus muscles; pharmacology; seminal vesicle pressure; sexual physiology

Indexed keywords

2 DIPROPYLAMINO 7 HYDROXYTETRALIN; DOPAMINE; DOPAMINE 3 RECEPTOR; DOPAMINE 3 RECEPTOR BLOCKING AGENT; DOPAMINE 3 RECEPTOR STIMULATING AGENT; NAFADOTRIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG EFFECT; EJACULATION; ELECTROMYOGRAM; HYPOTHALAMUS; MALE; MEDIAL PREOPTIC AREA; MICROINJECTION; MUSCLE CONTRACTION; NEUROTRANSMISSION; NONHUMAN; PRESSURE MEASUREMENT; PRIORITY JOURNAL; RAT; SEMINAL VESICLE; SEXUAL FUNCTION;

ANIMALS; BLOOD PRESSURE; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EJACULATION; ELECTROMYOGRAPHY; MALE; MICROINJECTIONS; NAPHTHALENES; PREOPTIC AREA; PYRROLIDINES; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D3; TETRAHYDRONAPHTHALENES;

EID: 35548982684     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2007.06.051     Document Type: Article

References (27)

1. Adachi H., Sato Y., Kato R., Hisasue S., Suzuki K., Masumori N., Itoh N., and Tsukamoto T. Direct evidence of facilitative actions of dopamine in the medial preoptic area on reflexive and noncontact erections in male rats. J Urol 169 (2003) 386-389
2. 3 receptor ligand 7-OH-DPAT on male rat ejaculatory behavior. Pharmacol Biochem Behav 51 (1995) 545-547
3. Beyer C., Contreras J.L., Larsson K., Olmedo M., and Morali G. Patterns of motor and seminal vesicle activities during copulation in the male rat. Physiol Behav 29 (1982) 495-500
4. 2 dopamine receptor agonist, facilitates seminal emission, but inhibits penile erection in the rat. Pharmacol Biochem Behav 34 (1989) 453-458
5. Clement P., Kia H.K., Droupy S., Bernabe J., Alexandre L., Denys P., and Giuliano F. Role of peripheral innervation in p-chloroamphetamine-induced ejaculation in anesthetized rats. J Androl 27 (2006) 381-389
6. 2-like receptors mediate the expulsion phase of ejaculation elicited by 8-hydroxy-2-(di-N-propylamino)tetralin in rats. J Pharmacol Exp Ther 316 (2006) 830-834
7. 3 receptor agonist 7-hydroxy-2-(di-N-propylamino)tetralin in anesthetized rats. Neuroscience 145 (2007) 605-610
8. Coolen L.M., Peters H.J., and Veening J.G. Fos immunoreactivity in the rat brain following consummatory elements of sexual behavior: a sex comparison. Brain Res 738 (1996) 67-82
9. 2 receptors in the paraventricular nucleus regulate genital responses and copulation in male rats. Pharmacol Biochem Behav 39 (1991) 177-181
10. 3 agonist 7-OH-DPAT in sexually-active and -inactive male rats. Neuropharmacology 35 (1996) 279-284
11. Giuliano F., and Allard J. Dopamine and male sexual function. Eur Urol 40 (2001) 601-608
12. Giuliano F., and Clement P. Physiology of ejaculation: emphasis on serotonergic control. Eur Urol 48 (2005) 408-417
13. Giuliano F. 5-Hydroxytryptamine in premature ejaculation: opportunities for therapeutic intervention. Trends Neurosci 30 (2007) 79-84
14. Holmes G.M., Chapple W.D., Leipheimer R.E., and Sachs B.D. Electromyographic analysis of male rat perineal muscles during copulation and reflexive erections. Physiol Behav 49 (1991) 1235-1246
15. 1 ratio in the medial preoptic area affects copulation of male rats. J Pharmacol Exp Ther 251 (1989) 422-427
16. 2 receptors on genital reflexes: implications for copulation. Life Sci 51 (1992) 1705-1713
17. Hull E.M., Du J., Lorrain D.S., and Matuszewich L. Extracellular dopamine in the medial preoptic area: implications for sexual motivation and hormonal control of copulation. J Neurosci 15 (1995) 7465-7471
18. Hull E.M., Muschamp J.W., and Sato S. Dopamine and serotonin: influences on male sexual behavior. Physiol Behav 83 (2004) 291-307
19. 3 dopamine receptor: neurobiology and potential clinical relevance. Pharmacol Rev 49 (1997) 231-252
20. Melis M.R., Succu S., Mascia M.S., Cortis L., and Argiolas A. Extra-cellular dopamine increases in the paraventricular nucleus of male rats during sexual activity. Eur J Neurosci 17 (2003) 1266-1272
21. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates. 3rd ed. (1998), Academic Press, New York
22. 3 receptor antagonist, activates locomotion in rodents. J Pharmacol Exp Ther 275 (1995) 1239-1246
23. Simerly R.B., and Swanson L.W. The organization of neural inputs to the medial preoptic nucleus of the rat. J Comp Neurol 246 (1986) 312-342
24. Simerly R.B., and Swanson L.W. Projections of the medial preoptic nucleus: a Phaseolus vulgaris leucoagglutinin anterograde tract-tracing study in the rat. J Comp Neurol 270 (1988) 209-242
25. 2-like receptors induces sympathetic climactic-like responses in male and female anaesthetised rats. Br J Pharmacol 148 (2006) 510-516
26. Succu S., Sanna F., Melis T., Boi A., Argiolas A., and Melis M.R. Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin. Neuropharmacology 52 (2007) 1034-1043
27. Terasaki T. Effects of autonomic drugs on intraluminal pressure and excretion of rat seminal vesicles in vivo. Tohoku J Exp Med 157 (1989) 373-379