Self-assembly of okadaic acid as a pathway to the cell

Organic Letters

Volumn 9, Issue 21, 2007, Pages 4191-4194

  Daranas, Antonio Hernández ^a   Cruz, Patricia G ^a   Creus, Alberto Hernández ^a   Norte, Manuel ^a   Fernández, José J ^a  

^a UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; MARINE TOXIN; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE;

ARTICLE; BIOLOGICAL MODEL; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; METHODOLOGY; SCANNING TUNNELING MICROSCOPY;

CELL MEMBRANE; ENZYME INHIBITORS; MARINE TOXINS; MICROSCOPY, SCANNING TUNNELING; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASES;

EID: 35548978493     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol701687m     Document Type: Article

References (22)

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14. + free inner solution, the system does not resemble by any means a physiological situation; therefore, OA dimers could not exist in that part of the system. In addition, in the proposed experiment, the inner solution would be a nonionic media (highly dielectrical), and in this way, the application of an electrical potential would promote a very important ohmic drop across the inner side of the system, preventing the acquisition of reliable results.
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21. This cartoon is only a proposal of the mechanism by which OA could enter into the cell. The existence of more extensive aggregation has been studied in our laboratory, but definitive results need further and detailed research.
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