Effect of the heme oxygenase inducer hemin on blood haemostasis measured by high-frequency ultrasound

Clinical and Experimental Pharmacology and Physiology

Volumn 34, Issue 12, 2007, Pages 1272-1275

  Rochefort, Gaël Y ^a   Libgot, Rachel ^a   Desbuards, Nicolas ^a   Schlecht, Deborah ^a   Halimi, Jean Michel ^a   Ossant, Frederic ^a   Eder, Veronique ^a   Antier, Daniel ^a,b  

^a UNIVERSITÉ DE TOURS   (France)

^b LABPART EA 3852   (France)

Author keywords

Haemostasis; Hemin; High frequency ultrasound; Rat

Indexed keywords

HEME OXYGENASE; HEMIN; HEPARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BLOOD CLOT; BLOOD DISEASE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; ECHOGRAPHY; HEMOSTASIS; IN VITRO STUDY; MALE; NONHUMAN; RAT; VELOCITY;

ANIMALS; ANTICOAGULANTS; HEME; HEME OXYGENASE (DECYCLIZING); HEMIN; HEMOSTASIS; MALE; RATS; RATS, WISTAR; ULTRASONICS; VENOUS THROMBOSIS;

EID: 35548935033     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2007.04720.x     Document Type: Article

References (42)

1. Peters HA, Levine R, Cripps D. Acute intermittent porphyria. Neurology 1998 50 : 1932 3.
2. Pierach CA. Haem and porphyria attacks. Lancet 1989 ii : 213 14.
3. Volin L, Rasi V, Vahtera E, Tenhunen R. Heme arginate: Effects on hemostasis. Blood 1988 71 : 625 8.
4. Anderson KE, Bloomer JR, Bonkovsky HL et al. Recommendations for the diagnosis and treatment of the acute porphyrias. Ann. Intern. Med. 2005 142 : 439 50.
5. Glueck R, Green D, Cohen I, Ts'ao CH. Hematin: Unique effects of hemostasis. Blood 1983 61 : 243 9.
6. Hift RJ, Meissner PN. An analysis of 112 acute porphyric attacks in Cape Town, South Africa: Evidence that acute intermittent porphyria and variegate porphyria differ in susceptibility and severity. Medicine 2005 84 : 48 60.
7. Anderson KE, Bonkovsky HL, Bloomer JR, Shedlofsky SI. Reconstitution of hematin for intravenous infusion. Ann. Intern. Med. 2006 144 : 537 8.
8. Suarez JI, Cohen ML, Larkin J, Kernich CA, Hricik DE, Daroff RB. Acute intermittent porphyria: Clinicopathologic correlation. Report of a case and review of the literature. Neurology 1997 48 : 1678 83.
9. Dellon ES, Szczepiorkowski ZM, Dzik WH et al. Treatment of recurrent allograft dysfunction with intravenous hematin after liver transplantation for erythropoietic protoporphyria. Transplantation 2002 73 : 911 15.
10. Daimon M, Susa S, Igarashi M, Kato T, Kameda W. Administration of heme arginate, but not hematin, caused anaphylactic shock. Am. J. Med. 2001 110 : 240.
11. Green D, Ts'ao CH. Hematin: Effects on hemostasis. J. Lab. Clin. Med. 1990 115 : 144 7.
12. Mustajoki P, Nordmann Y. Early administration of heme arginate for acute porphyric attacks. Arch. Intern. Med. 1993 153 : 2004 8.
13. Jones RL. Hematin-derived anticoagulant. Generation in vitro and in vivo. J. Exp. Med. 1986 163 : 724 39.
14. Maeshima K, Takahashi T, Uehara K et al. Prevention of hemorrhagic shock-induced lung injury by heme arginate treatment in rats. Biochem. Pharmacol. 2005 69 : 1667 80.
15. You KS, Wu B, Huang ZQ et al. Effect of hemin in treating hemorrhagic anemia and toxicity. Zhongguo Yao Li Xue Bao 1996 17 : 284 6 (in Chinese).
16. Odaka Y, Takahashi T, Yamasaki A et al. Prevention of halothane-induced hepatotoxicity by hemin pretreatment: Protective role of heme oxygenase-1 induction. Biochem. Pharmacol. 2000 59 : 871 80.
17. Chiu H, Brittingham JA, Laskin DL. Differential induction of heme oxygenase-1 in macrophages and hepatocytes during acetaminophen-induced hepatotoxicity in the rat: Effects of hemin and biliverdin. Toxicol. Appl. Pharmacol. 2002 181 : 106 15.
18. Morio LA, Leone A, Sawant SP et al. Hepatic expression of heme oxygenase-1 and antioxidant response element-mediated genes following administration of ethinyl estradiol to rats. Toxicol. Appl. Pharmacol. 2006 216 : 416 25.
19. Huang CC, Wang SH, Tsui PH. Detection of blood coagulation and clot formation using quantitative ultrasonic parameters. Ultrasound Med. Biol. 2005 31 : 1567 73.
20. Libgot R, Ossant F, Gruel Y, Lermusiaux P, Patat F. High frequency ultrasound characterization of the blood clotting process. Intra- and inter-individual variations. IEEE Ultrasonics Symp. 2005 4 : 2259 62.
21. Ossant F, Libgot R, Coupé P, Lermusiaux P, Patat F. High frequency ultrasound characterization of the coagulation process of whole blood. IEEE Ultrasonics Symp. 2004 2 : 846 9.
22. Shung KK, Fei DY, Ballard 3rd JO. Further studies on ultrasonic properties of blood clots. J. Clin. Ultrasound 1986 14 : 269 75.
23. Shung KK, Fei DY, Yuan YW, Reeves WC. Ultrasonic characterization of blood during coagulation. J. Clin. Ultrasound 1984 12 : 147 53.
24. Voleisis A, Kazys R, Mazeika L, Sliteris R, Voleisiene B, Grybauskas P. Ultrasonic method for the whole blood coagulation analysis. Ultrasonics 2002 40 : 101 7.
25. Machado JC, von Kruger MA, Fontes EM, de Almeida MM. Evaluation of an ultrasonic method applied to the measurement of blood coagulation time. Physiol. Meas. 1997 18 : 129 43.
26. Shamloul R, Wang R. Monitoring circulatory heme level in hemin therapy for lowering blood pressure in rats. Cell Mol. Biol. 2005 51 : 507 12.
27. Peng L, Mundada L, Stomel JM et al. Induction of heme oxygenase-1 expression inhibits platelet-dependent thrombosis. Antioxid. Redox Signal. 2004 6 : 729 35.
28. Maines MD. The heme oxygenase system: A regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol. 1997 37 : 517 54.
29. Morita T. Heme oxygenase and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2005 25 : 1786 95.
30. Otterbein LE, Bach FH, Alam J et al. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat. Med. 2000 6 : 422 8.
31. Wagener FA, Volk HD, Willis D et al. Different faces of the heme-heme oxygenase system in inflammation. Pharmacol. Rev. 2003 55 : 551 71.
32. Wunder C, Potter RF. The heme oxygenase system: Its role in liver inflammation. Curr. Drug Targets Cardiovasc. Haematol. Disord. 2003 3 : 199 208.
33. Morita T, Mitsialis SA, Koike H, Liu Y, Kourembanas S. Carbon monoxide controls the proliferation of hypoxic vascular smooth muscle cells. J. Biol. Chem. 1997 272 : 32 804 9.
34. Duckers HJ, Boehm M, True AL et al. Heme oxygenase-1 protects against vascular constriction and proliferation. Nat. Med. 2001 7 : 693 8.
35. Brouard S, Otterbein LE, Anrather J et al. Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis. J. Exp. Med. 2000 192 : 1015 26.
36. Silva G, Cunha A, Gregoire IP, Seldon MP, Soares MP. The antiapoptotic effect of heme oxygenase-1 in endothelial cells involves the degradation of p38 alpha MAPK isoform. J. Immunol. 2006 177 : 1894 903.
37. Brune B, Ullrich V. Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase. Mol. Pharmacol. 1987 32 : 497 504.
38. Casali B, Lampugnani MG, Riganti M et al. DMSO-induced changes in the procoagulant and fibrinolytic activity of B16 melanoma cells: Influence on lung colony formation. Clin. Exp. Metastasis 1988 6 : 377 85.
39. Gorog P, Kovacs IB. Antiarthritic and antithrombotic effects of topically applied dimethyl sulfoxide. Ann. N.Y. Acad. Sci. 1975 243 : 91 7.
40. Jacob SW, Herschler R. Pharmacology of DMSO. Cryobiology 1986 23 : 14 27.
41. Saeed SA, Karimi SJ, Suria A. Differential effects of dimethyl sulfoxide on human platelet aggregation and arachidonic acid metabolism. Biochem. Med. Metab. Biol. 1988 40 : 143 50.
42. Lindenblatt N, Bordel R, Schareck W, Menger MD, Vollmar B. Vascular heme oxygenase-1 induction suppresses microvascular thrombus formation in vivo. Arterioscler. Thromb. Vasc. Biol. 2004 24 : 601 6.