Genotoxicity of three mouthwash products, Cepacol®, Periogard®, and Plax®, in the drosophila wing-spot test

Environmental and Molecular Mutagenesis

Volumn 48, Issue 8, 2007, Pages 644-649

  Rodrigues, Fábio ^a   Lehmann, Maurício ^a   Do Amaral, Viviane Souza ^a   Reguly, Maria Luíza ^a   De Andrade, Heloísa Helena Rodrigues ^a  

^a UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

Author keywords

Cetylpyridinium chloride (CPC); Chlorhexidine digluconate (CXD); SMART; Triclosan (TCS)

Indexed keywords

CETYLPYRIDINIUM SALT; CHLORHEXIDINE GLUCONATE; PERIOGARD; PLAX; TRICLOSAN; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; BIOTRANSFORMATION; CHEMICAL STRUCTURE; CHROMOSOME 3; DNA DAMAGE; DROSOPHILA MELANOGASTER; DRUG FORMULATION; FORELIMB; GENETIC MARKER; GENOTOXICITY; MOUTH HYGIENE; MOUTHWASH; MUTAGENICITY; NONHUMAN; SOMATIC CROSSING OVER; SOMATIC MUTATION;

ANIMALS; DROSOPHILA; MOUTHWASHES; MUTAGENICITY TESTS; WING;

DROSOPHILA MELANOGASTER;

EID: 35548933805     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20332     Document Type: Article

References (20)

1. Andrade HHR, Reguly ML, Lehmann M. 2004. Wing Somatic Mutation and Recombination Test (SMART). In: Henderson DS, editor. Drosophila Cytogenetics Protocols. Totowa: Human Press. pp 389-413.
2. Bhargava HN, Leonard PA. 1996. Triclosan: Applications and safety. Am J Infect Control 24:209-218.
3. Bishop AJR, Schiestl RH. 2003. Role of homologous recombination in carcinogenesis. Exp Mol Pathol 74:94-105.
4. Burgalassi S, Chetoni P, Monti D, Saetonne MF. 2001. Cytotoxicity of potential ocular permeation enhancers evaluated on rabbit and human corneal epithelial cell lines. Toxicol Lett 122:1-8.
5. Chetoni P, Burgalassi S, Monti D, Saetonne MF. 2003. Ocular toxicity of some corneal penetration enhancers evaluated by electrophysiology measurements on isolated rabbit corneas. Toxicol In Vitro 17:497-504.
6. Eren K, Özmric N, Sardas S. 2002. Monitoring of buccal epithelial cells by alkaline comet assay (single cell gel electrophoresis technique) in cytogenetic evaluation of Chlorhexidine. Clin Oral Investig 6:150-154.
7. Frei H, Würgler FE. 1988. Statistical methods to decide whether mutagenicity test data from Drosophila assays indicate positive, negative or inconclusive result. Mutat Res 203:297-308.
8. Frei H, Würgler FE. 1996. Induction of somatic mutation and recombination by four inhibitors of eukaryotic topoisomerases assayed in the wing spottest of Drosophila melanogaster. Mutagenesis 11:315-332.
9. Frei H, Clements J, Howe D, Würgler FE. 1992. The genotoxicity of anticancer drug mitoxantrone in somatic and germ cells of Drosophila melanogaster. Mutat Res 279:21-33.
10. Lewis K. 2001. Riddle of biofilm resistance - Minireview. Antimicrob Agents Chemother 45:999-1007.
11. Montooth KL, Siebenthal KT, Clark AG. 2006. Membrane lipid physiology and toxin catabolism underlie ethanol and acetic acid tolerance in Drosophila melanogaster. Exp Biol 209:3837-3850.
12. Obe, G, Jonas R, Schmidt S. 1986. Metabolism of ethanol in vitro produces a compound which induces sister-chromatid exchanges in human peripheral lymphocytes in vitro: Acetaldehyde not ethanol is mutagenic. Mutat Res 174:47-51.
13. Phillips BJ, Jenkinson P. 2001. Is ethanol genotoxic? A review of the published data. Mutagenesis 16:91-101.
14. Rey M, Palermo AM, Munoz ER. 1992. Nondisjunction induced by ethanol in Drosophila melanogaster females. Mutat Res 268:95-104.
15. Ribeiro DA, Bazo AP, Silva FCA, Marques MEA, Salvadori DMF. 2004. Chlorhexidine induces DNA damage in rat peripheral leukocytes and oral mucosal cells. J Periodontal Res 39:358-361.
16. Russel LB, Montgomery CS. 1980. Use of the mouse spot test to investigate the mutagenic potential of triclosan (Irgasan® DP300). Mutat Res 79:7-12.
17. Sakagami Y, Yamasaky H, Yokoyama H, Ose Y, Sato T. 1988a. DNA repair test of disinfectants by liquid rec-assay. Mutat Res 193:21-30.
18. Sakagami Y, Yamazaki H, Ogasavara N, Yokoyama H, Ose Y, Sato T. 1988b. The evaluation of genotoxic activities of disinfectants and their metabolites by umu test. Mutat Res 209:155-160.
19. St. John MAR, Xu T. 1997. Insights from model systems. Understanding human cancer in a fly? Am J Hum Genet 61:1006-1010.
20. Xie H, Cook GS, Costerton JW, Bruce G, Rose T, Lamont R. 2000. Intergeneric communication in dental plaque biofilms. J Bacteriol 182:7067-7069.