Quantitative comparisons of the acute neurotoxicity of toluene in rats and humans

Toxicological Sciences

Volumn 100, Issue 1, 2007, Pages 146-155

  Benignus, Vernon A ^a   Boyes, William K ^a   Kenyon, Elaina M ^a   Bushnell, Philip J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Agents; Behavior; Dose response; Neurotoxicology; Risk assessment; Volatile organic compounds

Indexed keywords

TOLUENE;

ACCURACY; ARTICLE; BEHAVIOR CONTROL; COGNITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; COPING BEHAVIOR; ESCAPE BEHAVIOR; EVOKED VISUAL RESPONSE; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; NEUROPHYSIOLOGY; NEUROTOXICITY; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; RATING SCALE; RESPONSE TIME; RISK ASSESSMENT; SIGNAL DETECTION; TOXICOKINETICS;

ACUTE DISEASE; ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; CHOICE BEHAVIOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCAPE REACTION; EVOKED POTENTIALS, VISUAL; HUMANS; MODELS, BIOLOGICAL; NEUROTOXICITY SYNDROMES; RATS; REACTION TIME; RISK ASSESSMENT; SIGNAL DETECTION (PSYCHOLOGY); SOLVENTS; SPECIES SPECIFICITY; TOLUENE;

RATTUS;

EID: 35448989847     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm203     Document Type: Article

References (43)

1. Bale, A. S., Meacham, C. A., Benignus, V. A., Bushnell, P. J., and Shafer, T. J. (2005). Volatile organic compounds inhibit human and rat neuronal nicotinic acetylcholine receptors expressed in Xenopus ooeytes. Toxicol. Appl. Pharmacol. 205, 77-88.
2. Battig, K., and Grandjean, E. (1964). Industrial solvents and avoidance conditioning in rats. A comparison of the effects of acetone, ethyl alcohol, carbon disulfide, carbon tetrachloride, toluene, and xylene on acquisition and extinction. Arch. Environ. Health 9, 745-749.
3. Benignus, V. A. (2001). Quantitative cross-species extrapolation in noncancer risk assessment. Regul. Toxicol. Pharmacol. 34, 62-68.
4. Benignus, V. A., Boyes, W. K., and Bushnell, P. J. (1998). A dosimetric analysis of behavioral effects of acute toluene exposure in rats and humans. Toxicol. Sci. 43, 186-195.
5. Benignus, V. A., Bushnell, P. J., and Boyes, W. K. (2005). Toward cost-benefit analysis of acute behavioral effects of toluene in humans. Risk Anal. 25, 447-456.
6. Benignus, V. A., Coleman, T., Eklund, C., and Kenyon, E. (2006). A general physiological and toxicokinetic (GPAT) model for simulating complex toluene exposure scenarios in humans. Toxicol. Mech. Methods 16, 27-36.
7. Boyes, W. K., Bercegeay, M., Krantz, T., Evans, M., Benignus, V. A., and Simmons, J. E. (2005). Momentary brain concentration of trichloroethylene predicts the effects on rat visual function. Toxicol. Sci. 87, 187-196.
8. Boyes, W. K., Bercegeay, M., Krantz, T., Kenyon, E., Bale, A., Shafer, T., Bushnell, P. J., and Benignus, V. A. (2007). Acute toluene exposure alters rat visual function in proportion to momentary brain concentration. Toxicol. Sci. (in press).
9. Bruckner, J. V., and Peterson, R. G. (1981). Evaluation of toluene and acetone inhalant abuse: II Model development and toxicology. Toxicol. Appl. Pharmacol. 61, 302-312.
10. Bushnell, P. J. (1997). Concentration-time relationships for the effects of inhaled trichloroethylene on signal detection behavior in rats. Fundam Appl. Toxicol. 36, 30-38.
11. Bushnell, P. J., Kelly, K. L., and Crofton, K. M. (1994). Effects of toluene inhalation on detection of auditory signals in rats. Neurotoxicol. Teratol. 16, 149-160.
12. Bushnell, P. J., Oshiro, W. M., Samsam, T. E., Benignus, V. A., and Kenyon, E. M. (2007). A dosimetric analysis of the acute behavioral effects of inhaled toluene in rats. Toxicol. Sci. (in press).
13. Bushnell, P. J., Shafer, T. J., Bale, A. S., and Boyes, W. K. (2005). Development and application of an exposure-dose-response model for organic solvents. Environ. Toxicol. Pharmacol. 19, 607-614.
14. Cherry, N., Johnston, J. D., Venables, H., Waldron, H. A., Buck, L., and MacKay, C. J. (1983). The effect of toluene and alcohol on psychomotor performance. Ergonomics 26, 1081-1087.
15. Colotla, V. A., Bautista, S., Lorenzana-Jimenes, M., and Rodrigues, R. (1979). Effects of solvents on schedule-controlled behavior. Neurobehav. Toxicol. 1(Suppl. 1), 113-118.
16. Corso, J. F. (1967). The Experimental Psychology of Sensory Behavior Holt, Rinehart and Winston, New York.
17. Cruz, S. L., Mirshahi, T., Thomas, B., Balster, R. L., and Woodward, J. J. (1998). Effects of the abused solvent toluene on recombinant N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors expressed in Xenopus oocytes. J. Pharmacol. Exp. Ther. 286, 334-340.
18. Dews, P. B. (1955). Studies on behavior: I. Differential sensitivity to pentobarbital of pecking performance in pigeons depending on the schedule of reward. J. Pharmacol. Exp. Ther. 113, 393-401.
19. Dick, R. B., Setzer, J. V., Wait, R., Hayden, M. B., Taylor, B. J., Tolos, B., and Putz-Anderson, V. (1984). Effects of acute exposure of toluene and methyl ethyl ketone on psychomotor performance. Int. Arch. Occup. Environ. Health 54, 91-109.
20. Echeverria, D., Fine, L., Langolf, G., Schork, A., and Sampaio, C. (1989). Acute neurobehavioural effects of toluene. Br. J. Ind. Med. 46, 483-495.
21. Evans, E. B., and Balster, R. L. (1991). CNS depressant effects of volatile organic solvents. Neurosci. Biobehav. Rev. 15, 233-241.
22. Gamberale, F., and Hultengren, M. (1972). Toluene exposure II. Psychophysiological functions. Work-Environ.-Health. 9, 131-139.
23. Geller, I., Harman, R. J., Tangle, S. R., and Gauze, E. M. (1979). Effects of acetone and toluene vapors on multiple schedule performance of rats. Pharmacol. Biochem. Behav. 11, 395-399.
24. Harabuchi, I., Kishi, R., Ikeda, T., Kiyosawa, H., and Miyake, H. (1993). Circadian variations of acute toxicity and blood and brain concentrations of inhaled toluene in rats. Br. J. Ind. Med. 50 280-286.
25. Ikeda, T., and Miyake, H. (1978). Decreased learning in rats following repeated exposure to toluene: Preliminary report. Toxicol. Lett. 1, 235-239.
26. Iregren, A., Akerstedt, T., Anshelm Olsen, B., and Gamberale, F. (1986). Experimental exposure to toluene in combination with ethanol intake. Scand. J. Work Environ. Health 12, 128-136.
27. Kennedy, R. S., Turnage, J. J., and Dunlap, W. P. (1992). The use of dose-equivalency as a risk assessment index in behavioral neurotoxicology. Neurotoxicol. Teratol. 14, 167-175.
28. Kenyon, E. M., Benignus, V. A., Eklund, C., and Bushnell, P. A. (2008). Modeling the toxicokinetics of inhaled toluene in rats: Influence of physical activity and feeding schedule. J. Toxicol. Environ. Health (in press).
29. Kishi, R., Harabuchi, I., Ikeda, T., Yokota, H., and Miyake, H. (1988). Neurobehavioural effects and pharmacokinetics in rats and their relevance to man. Br. J. Ind. Med. 45, 396-408.
30. Kleinbaum, D. G., Kupper, L. L., and Muller, K. M. (1988). Applied Regression Analysis and Other Multivariable Methods, 2nd ed. PWS-Kent, Boston.
31. Laties, V. G., and Evans, H. L. (1980). Methylmercury-induced changes in operant discrimination by the pigeon. J. Pharmacol. Exp. Ther. 214, 620-628.
32. Lehman, A. J., and Fitzhugh, O. G. (1954). 100-fold margin of safety. Assoc. Food Drug Off. U.S. Quarterly Bull. 18, 33-35.
33. Mullin, L. S., and Krivanek, N. D. (1982). Comparison of unconditioned reflex and conditioned avoidance tests in rats exposed by inhalation to carbon monoxide, 1,1,1-trichloromethane, toluene or ethanol. Neurotoxicology 3, 126-137.
34. Nevin, J. A. (1974). Response strength in multiple schedules. J.-Exp. Anal. Behav. 21, 389-408.
35. Olson, B. A., Gamberale, F., and Iregren, A. (1985). Coexposure to toluene and p-xylene in man: Central nervous functions. Br. J. Ind. Med. 4, 117-122.
36. Oshiro, W. M., Krantz, Q. T., and Bushnell, P. J. (2007). Repeated inhalation of toluene by rats performing a signal detection task leads to behavioral tolerance on some performance measures. Neurotoxicol. Teratol. 29, 247-254.
37. Rahill, A. A., Weiss, B., Morrow, P. E., Frampton, M. W., Cox, C., Gibb, R., Gelein, R., Speers, D., and Utell, M. J. (1996). Human performance during exposure to toluene. Aviat. Space Environ. Med. 67, 640-647.
38. Shafer, T. J., Bushnell, P. J., Benignus, V. A., and Woodward, J. J. (2005). Perturbation of voltage-sensitive Ca2+ channel function by volatile organic solvents. J. Pharmacol. Exp. Ther. 315, 1109-1118.
39. Shigeta, S., Aikawa, H., Misawa, T., and Kondo, A. (1978). Effect of single exposure to toluene on Sidman avoidance response in rats. J. Toxicol. Sci. 3, 305-312.
40. Shigeta, S., Misawa, T., and Aikawa, H. (1980). Effects of concentration and duration of toluene exposure on Sidman avoidance in rats. Neurobehav. Toxicol. 2, 85-88.
41. Thompson, D. M. (1978). Stimulus control and drug effects. In Contemporary Research in Behavioral Pharmacology (D. E. Blackman and D. J. Sanger, Eds.), pp. 159-207. Plenum, New York.
42. Von Oettingen, W., Neal, P., and Donahue, D. (1942). The toxicity and potential dangers of toluene. JAMA 118, 579-584.
43. Wada, H., Hosokawa, T., and Saito, K. (1989). Single toluene exposure and changes of response latency in shock avoidance performance. Neurotoxicol. Teratol. 11, 265-272.