A dosimetric analysis of behavioral effects of acute toluene exposure in rats and humans

Toxicological Sciences

Volumn 43, Issue 2, 1998, Pages 186-195

  Benignus, Vernon A ^a,b   Boyes, William K ^a   Bushnell, Philip J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TOLUENE; VOLATILE ORGANIC COMPOUND;

ANIMAL MODEL; ARTICLE; BEHAVIOR; BODY BURDEN; CONTROLLED STUDY; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; HUMAN; NEUROTOXICITY; NONHUMAN; RAT; SPECIES DIFFERENCE; TOXICOKINETICS;

ANIMALIA;

EID: 0031903987     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1006/toxs.1998.2458     Document Type: Article

References (62)

1. American Conference of Governmental Industrial Hygienists (1991). Guide to Occupational Exposure Values-1991, p 111. ACGIH, Cincinnati, OH.
2. Andersen, I., Lundqvist, G. R., Molhave, L., Pedersen, O. F., Proctor, D. F., Vaeth, M., and Wyon, D. P. (1983). Human response to controlled levels of toluene in six-hour exposure. Scand. J. Work Environ. Health 9, 405-418.
3. Arms, A. D., and Travis, C. C. (1988). Reference Physiological Parameters in Pharmacokinetic Modeling. EPA 600/6-88/004. U.S. Environmental Protection Agency, Research Triangle Park, NC.
4. Ashford, J. R. (1958). Quantal responses to mixtures of poisons under conditions of simple action - the analysis of uncontrolled data. Biometrika 45, 74-88.
5. Baelum, J. (1991). Human solvent exposure: Factors influencing pharmacokinetics and acute toxicity. Pharmacol. Toxicol. 68(Suppl. 1), 1-36.
6. Baelum, J., Andersen, I., Lundqvist, G. R., Molhave, L., Pedersen, O. F., Vaeth, M., and Wyon, D. P. (1985). Response of solvent-exposed printers and unexposed controls to six-hour toluene exposure. Scand. J. Work Environ. Health 11, 271-280.
7. Baelum, J., Lundqvist, G. R., Molhave, L., and Andersen, N. T. (1990). Human response to varying concentrations of toluene. Int. Arch. Occup. Environ. Health 62, 65-71.
8. Benignus, V. A. (1994). Behavioral effects of carbon monoxide: Meta analyses and extrapolations. J. Appl. Physiol. 76, 1310-1316.
9. Biological Simulators, Inc. Thomas Coleman, Ph.D., P.O. Box 14014, Jackson, MS. 39236-4014. Internet address: BIOSIM@NETBOX.COM.
10. Boyes, W. K., Bushnell, P. J., Crofton, K., Evans, M., and Simmons, J. E. (1997). Neurotoxic and pharmacokinetic responses to trichloroethylene as a function of exposure scenario. Trichloroethylene Risk Assessment Document. United States Environmental Protection Agency, Washington, DC. [Submitted for publication]
11. Bushnell, P. J., and Crofton, K. M. (1996). Neurobehavioral toxicology of organic solvents. In Behavioral Toxicology and Addiction (R. J. M. Niesink and R. Jaspers, Eds.), Chapter 14. The Open University of the Netherlands, Heerlein, The Netherlands.
12. Bushnell, P. J., Evans, H. L., and Palmes, E. D. (1985). Effects of toluene inhalation of carbon dioxide production and locomotor activity. Fundam. Appl. Toxicol. 5, 971-977.
13. Bushnell, P. J., Kelly, K. L., and Crofton, K. M. (1994). Effects of toluene inhalation on detection of auditory signals in rats. Neurotoxicol. Teratol. 16, 149-160.
14. Bushnell, P. J., Maloff, P., and Bowman, R. E. (1975). Loss of inhibitory motor control following a subanesthetic dose of thiobarbiturate in rhesus monkeys. Physiol. Psychol. 3, 205-209.
15. Carlsson, A. (1982). Exposure to toluene: Uptake, distribution and elimination in man. Scand. J. Work Environ. Health 8, 43-55.
16. Cherry, N., Johnston, J. D., Venables, H., Waldron, H. A., Buck, L., and MacKay, C. J. (1983). The effect of toluene and alcohol on psychomotor performance. Ergonomics 26, 1081-1087.
17. Corso, J. F. (1967). The Experimental Psychology of Sensory Behavior. Holt, Rinehart and Winston, New York.
18. De Ceaurriz, J., Desiles, J. P., Bonnet, P., Marignac, B., Muller, J., and Guenier, J. P. (1983). Concentration-dependent behavioral changes in mice following short-term inhalation exposure to various industrial solvents. Toxicol. Appl. Pharmacol. 67, 383-389.
19. Dick, R. B., Setzer, J. V., Wait, R., Hayden, M. B., Taylor, B. J., Tolos, B., and Putz-Anderson, V. (1984). Effects of acute exposure of toluene and methyl ethyl ketone on psychomotor performance. Int. Arch. Occup. Environ. Health 54, 91-109.
20. Echeverria, D., Fine, L., Langolf, G., Schork, A., and Sampaio, C. (1989). Acute neurobehavioural effects of toluene. Br. J. Ind. Med. 46, 483-495.
21. Evans, E. B., and Balster, R. L. (1991). CNS depressant effects of volatile organic solvents. Neurosci. Biobehav. Rev. 15, 233-241.
22. Gallant, A. R. (1975). Nonlinear Regression. Am. Stat. 29, 73-81.
23. Gamberale, F., and Hultengren, M. (1972). Toluene exposure II. Psychophysiological functions. Work-Environ. Health 9, 131-139.
24. Gause, E. M., Mendez, V., and Geller, I. (1985). Exploratory studies of a rodent model for inhalant abuse. Neurobehav. Toxicol. Teratol. 7, 143-148.
25. Geller, I., Hartman, R. J., Mendez, V., and Gause, E. M. (1985). Toluene and ethanol effects on baboon match-to-sample performance: Possible synergistic action. Pharmacol. Biochem. Behav. 22, 583-588.
26. Glowa, J. R. (1987). Comparisons of some behavioral effects of d-amphetamine and toluene. Neurotoxicology 8, 237-247.
27. Glowa, J. R., DeWeese, J., Natale, M. E., Holland, J. J., and Dews, P. B. (1986). Behavioral toxicology of volatile organic solvents. I. Methods: Acute effects of toluene. J. Environ. Pathol. Toxicol. Oncol. 6, 153-158.
28. Harabuchi, I., Kishi, R., Ikeda, T., Kiyosawa, H., and Miyake, H. (1993). Circadian variations of acute toxicity and blood and brain concentrations of inhaled toluene in rats. Br. J. Ind. Med. 50, 280-286.
29. Hinman, D. J. (1987). Biphasic dose-response relationship for the effects of toluene inhalation on locomotor activity. Pharmacol. Biochem. Behav. 26, 65-69.
30. Horvath, M., Frantik, E., and Krekule, P. (1981). Diazepam impairs alertness and potentiates the similar effect of toluene. Activitas Nerv. Super. 23, 177-179.
31. Iregren, A., Akerstedt, T., Anshelm Olsen, B., and Gamberale, F. (1986). Experimental exposure to toluene in combination with ethanol intake. Scand. J. Work Environ. Health 12, 128-136.
32. Kelman, G. R. (1982). Theoretic basis of alveolar sampling. Br. J. Ind. Med. 39, 259-264.
33. Kishi, R., Harabuchi, I., Ikeda, T., Yokata, H., and Miyake, H. (1988). Neurobehavioral effects and pharmacokinetics of toluene in rats and their relevance to man. Br. J. Ind. Med. 45, 396-408.
34. Kjellstrand, P., Holmquist, B., Jonsson, I., Romare, S., and Mansson, L. (1985). Effects of organic solvents on motor activity in mice. Toxicology 35, 35-46.
35. Moser, V. C., and Balster, R. L. (1981). The effects of acute and repeated toluene exposure on operant behavior in mice. Neurobehav. Toxicol. Teratol. 3, 471-475.
36. Moser, V. C., and Balster, R. L. (1985). Effects of toluene, halothane and ethanol vapor on fixed-ratio performance in mice. Pharmacol. Biochem. Behav. 22, 797-802.
37. Moser, V. C., and Balster, R. L. (1986). The effects of inhaled toluene, halothane, 1,1,1-trichloroethane and ethanol on fixed-interval responding in mice. Neurobehav. Toxicol. Teratol. 8, 525-531.
38. Mullin, L. S., and Krivanek, N. D. (1982). Comparison of unconditioned reflex and conditioned avoidance tests in rats exposed by inhalation to carbon monoxide, 1,1,1-trichloroethane, toluene or ethanol. Neurotoxicology 3, 126-137.
39. Nakagagi, K., Arito, H., and Tsuruta, H. (1983). Changes in sleep-waking rhythms of rats following a single injection of toluene. Ind. Health 21, 165-174.
40. Olson, B. A., Gamberale, F., and Iregren, A. (1985). Coexposure to toluene and p-xylene in man: Central nervous functions. Br. J. Ind. Med. 42, 117-122.
41. Paksy, K. A., Moinar, J., Naray, M., and Barcza, G. (1982). Comparative study on the acute effects of benzene, toluene and m-xylene in the rat. Acta Physiol. Hung. 59, 317-324.
42. Purcell, K. J., Cason, G. H., Gargas, M. L., and Travis, C. C. (1990). In vivo metabolic interactions of benzine and toluene. Toxicol. Lett. 52, 141-152.
43. Ramsey, J. C., and Anderson, M. E. (1984). A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Appl. Pharmacol. 73, 159-175.
44. Rahill, A. A., Weiss, B., Morrow, P. E., Frampton, M. W., Cox, C., Gibb, R., Gelein, R., Speers, D., and Utell, M. J. (1996). Human performance during exposure to toluene. Aviat. Space Environ. Med. 67, 640-647.
45. Reitz, R. H. (1991). PC-based PBPK model distributed as part of, SOT PBPK Continuing Education Class.
46. SAS (1996). The SAS System for Windows, Version 6.11, SAS Institute, Cary, NC.
47. Shigeta, S., Aikawa, H., Misawa, T., and Kondo, A. (1978). Effects of single exposure to toluene on Sidman avoidance response in rats. J. Toxicol. Sci. 3, 305-312.
48. Shigeta, S., Misawa, T., and Aikawa, H. (1980). Effects of concentration and duration of toluene exposure on Sidman avoidance in rats. Neurobehav. Toxicol. 2, 85-88.
49. Tardif, R., Lapare, S., Charest-Tardif, G., Brodeur, J., and Krishnan, K. (1995). Physiologically-based pharmacokinetic modeling of a mixture of toluene and xylene in humans. Risk Anal. 15, 335-342.
50. Taylor, J. D., and Evans, H. L. (1985). Effects of toluene on behavior and expired carbon dioxide in macaque monkeys. Toxicol. Appl. Pharmacol. 80, 487-495.
51. Tyuma, I., Ueda, Y., Imaizumi, K., and Kosaka, H. (1981). Prediction of carboxyhemoglobin levels during and after carbon monoxide exposures in various animal species. Jpn. J. Physiol. 31, 131-143.
52. United States Environmental Protection Agency (1991). Air Quality Criteria for Carbon Monoxide, EPA/600/8-90/045F, EPA Office of Research and Development, Washington, DC.
53. United States Environmental Protection Agency (1989). The Toxics Release Inventory: A National Perspective, EPA560/4-89-006, Office of Pesticides and Toxic Substances, Washington, DC.
54. Wada, H., Hosokawa, T., and Saito, K. (1986). Effects of single exposure to toluene on shock avoidance and time estimation in rats. Neurobehav. Toxicol. Teratol. 8, 727-730.
55. Wada, H., Hosokawa, T., and Saito, K. (1989). Single toluene exposure and changes of response latency in shock avoidance performance. Neurotoxicol. Teratol. 11, 265-272.
56. Wada, H., Marushichi, H., Abe, M., Kitadate, T., Kunoh, H., and Iwamoto, T. (1993). Effects of toluene administration on delayed matching-to-sample performance in the pigeon. Environ. Res. 61, 68-77.
57. Wallen, M., Naslund, P. H., and Bayfalt, N. M. (1984). The effects of ethanol on the kinetics of toluene in man. Toxicol. Applied Pharmacol. 76, 414-419.
58. cells factor in the normal and splenectomized Sherman rat. Am. J. Physiol. 196, 188-192.
59. Weiss, B., Wood, R. W., and Macys, D. A. (1979). Behavioral toxicology of carbon disulfide and toluene. Environ. Health Perspect. 30, 39-45.
60. Wood, R. W., and Colotla, V. A. (1990). Biphasic changes in mouse motor activity during exposure to toluene. Fundam. Appl. Toxicol. 14, 6-14.
61. Wood, R. W., and Cox, C. (1995). A repeated measures approach to the detection of the acute effects of toluene at low concentrations. Fundam. Appl. Toxicol. 25, 293-301.
62. Wood, R. W., Rees, D. C., and Laties, V. G. (1983). Behavioral effects of toluene are modulated by stimulus control. Toxicol. Appl. Pharmacol. 68, 462-472.