Connecting small molecules to nuclear receptor pathways

Current Topics in Medicinal Chemistry

Volumn 7, Issue 15, 2007, Pages 1530-1536

  Hettne, Kristina ^a   Cases, Montserrat ^b   Boyer, Scott ^a   Mestres, Jordi ^b  

^a ASTRAZENECA R AND D   (Sweden)

^b UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

CYP7A1 inhibition; Farnesoid X receptor; Lipid metabolism; Retinoic X receptor; Wnt signaling pathway

Indexed keywords

CELL NUCLEUS RECEPTOR; CORTICOSTEROID; ESTROGEN RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PARACETAMOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEASOME; PROTEIN; RETINOID X RECEPTOR; TOLL LIKE RECEPTOR; VITAMIN D RECEPTOR; WNT PROTEIN;

BREAST TUMOR; CHOLESTEROL METABOLISM; DATA EXTRACTION; DIFFERENTIATION; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFICACY; DRUG SELECTIVITY; DRUG TARGETING; ENZYME INACTIVATION; GENE EXPRESSION REGULATION; GROWTH; HAEMOPHILUS INFLUENZAE; HEART PROTECTION; INFORMATION PROCESSING; INTRAABDOMINAL FAT; LIPID METABOLISM; METABOLIC SYNDROME X; MOLECULAR LIBRARY; MOLECULE; OBESITY; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN TARGETING; PUBLICATION; REVIEW; SIGNAL TRANSDUCTION; THERMOGENESIS; TRANSCRIPTION REGULATION;

DRUG DESIGN; HUMANS; PROTEASOME ENDOPEPTIDASE COMPLEX; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION;

EID: 35448981499     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802607782194671     Document Type: Review

References (25)

1. Lamb, J.; Crawford, E. D.; Peck, D.; Modell, I. W.; Blat, I. C.; Wrobel, M. J.; Lerner, J.; Brunet, J.-P.; Subramanian, A.; Ross, K. N.; Reich, M.; Hieronymus, H.; Wei, G.; Armstrong, S. A.; Haggarty, S. J.; Clemons, P. A.; Carr, S. A.; Lander, E. S.; Golub, T. R. The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease. Science 2006, 313, 1929-1935.
2. Bleicher, K. H.; Böhm, H.-J.; Müller, K.; Alanine, A. I. Hit and lead generation: Beyond high-throughput screening. Nature Rev. Drug Discov. 2003, 2, 369-378.
3. Mestres J. Computational chemogenomics approaches to systematic knowledge-based drug discovery. Curr. Opin. Drug Discov. Dev. 2004, 7, 304-313.
4. Savchuk, N. P.; Balakin, K. V.; Tkachenko, S. E. Exploring the chemogenomic knowledge space with annotated chemical libraries. Curr. Opin. Chem. Biol. 2004, 8, 412-417.
5. Olah, M.; Mracec, M.; Ostopovici, L.; Rad, R.; Bora, A.; Hadaruga, N.; Olah, I.; Banda, M.; Simon, Z.; Oprea, T. I. WOMBAT: World of Molecular Bioactivity. In Chemoinformatics in Drug Discovery. T.I. Oprea (Ed), Wiley-VCH, New York, 2004, pp. 223-239. http://www.sunsetmolecular.com/
6. MDL Drug Data Report. MDL Information Systems Inc., USA. http://www.mdl.com/
7. AurSCOPE databases. Aureus Pharma, France. http://www.aureuspharma.com/
8. MedChem Target Inhibitor databases. GVK Biosciences, India. http://www.gvkbio.com/
9. Paolini, G. V.; Shapland, R. H. B.; van Hoorn, W. P.; Mason, J. S.; Hopkins, A. L. Global mapping of pharmacological space. Nature. Biotech. 2006, 24, 805-815.
10. Schuffenhauer, A.; Jacoby, E. Annotating and mining the ligand-target chemogenomics knowledge space. Drug Discov. Today Biosilico 2004, 2, 190-200.
11. Mestres J.; Martin-Couce, L.; Gregori-Puigjané, E.; Cases, M.; Boyer, S. Ligand-based approach to in silico pharmacology: Nuclear receptor profiling. J. Chem. Inf. Model. 2006, 46, 2725-2736
12. Ekins, S.; Nikolsky, Y.; Bugrim, A.; Kirillov, E.; Nikolskaya, T. Pathway mapping tools for analysis of high content data. Methods Mol. Biol. 2007, 356, 319-350.
13. Kanehisa, M.; Goto, S.; Hattori, M.; Aoki-Kinoshita, K. F.; Itoh, M.; Kawashima, S.; Katayama, T.; Araki, M.; Hirakawa, M. From genomics to chemical genomics: New developments in KEGG. Nucleic Acids Res. 2006, 34, D354-D357.
14. Butcher, E. C.; Berg, E. L.; Kunkel, E. J. Systems biology in drug discovery. Nat. Biotechnol. 2004, 22, 1253-1259.
15. Cases, M.; Garcia-Serna, R.; Hettne, K.; Weeber, M.; van der Lei, J.; Boyer, S.; Mestres, J. Chemical and Biological Profiling of an Annotated Compound Library Directed to the Nuclear Receptor Family. Curr. Top. Med. Chem. 2005, 5, 763-772.
16. http://www.biocarta.com/
17. http://www.cellsignal.com/
18. http://expasy.org/
19. http://www.genome.jp/kegg/
20. http://stke.sciencemag.org/
21. Nikitin, A.; Egorov, S.; Daraselia, N.; Mazo, I. Pathway studio: The analysis and navigation of molecular networks. Bioinformatics 2003, 19, 2155-2157. http://www.ariadnegenomics.com/
22. Ananiadou, S.; Kell, D. B.; Tsujii, J.-I. Text mining and its potential applications in systems biology. Trends Biotechnol. 2006, 24, 571-579.
23. Wain, H. M.; Bruford, E. A.; Lovering, R. C.; Lush, M. J.; Wright, M. W.; Povey, S. Guidelines for human gene nomenclature. Genomics 2002, 79, 464-470.
24. Paek, E.; Park, J.; Lee, K. J. Multi-layered representation for cell signaling pathways. Mol. Cell. Proteomics 2004, 3, 1009-1022.
25. Apic, G.; Ignjatovic, T.; Boyer, S.; Russell, R. B. Illuminating drug discovery with biological pathways. FEBS Lett. 2005, 579, 1872-1877.