Heritability and genetic correlations of insulin sensitivity measured by the euglycaemic clamp

Diabetic Medicine

Volumn 24, Issue 11, 2007, Pages 1286-1289

  Rasmussen Torvik, L J ^a   Pankow, J S ^a,d   Jacobs Jr , D R ^a,b   Steffen, L M ^a   Moran, A M ^c   Steinberger, J ^c   Sinaiko, A R ^a,c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Euglycaemic clamp; Heritability; Insulin sensitivity

Indexed keywords

INSULIN;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; FEMALE; GENETIC CORRELATION; HERITABILITY; HOMEOSTASIS; HUMAN; HYPERINSULINEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; NUCLEAR FAMILY; PHENOTYPE; VARIANCE;

ADOLESCENT; BLOOD GLUCOSE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; NUCLEAR FAMILY; QUANTITATIVE TRAIT, HERITABLE;

EID: 35448932509     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2007.02271.x     Document Type: Article

References (21)

1. Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, Ravussin E et al. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med 1993 329 : 1988 1992.
2. Kahn R, Buse J, Ferrannini E, Stern M. The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2005 28 : 2289 2304.
3. Reaven GM. The metabolic syndrome: requiescat in pace. Clin Chem 2005 51 : 931 938.
4. Bergman RN, Zaccaro DJ, Watanabe RM, Haffner SM, Saad MF, Norris JM et al. Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin. Diabetes 2003 52 : 2168 2174.
5. Lehtovirta M, Kaprio J, Forsblom C, Eriksson J, Tuomilehto J, Groop L. Insulin sensitivity and insulin secretion in monozygotic and dizygotic twins. Diabetologia 2000 43 : 285 293.
6. Sakul H, Pratley R, Cardon L, Ravussin E, Mott D, Bogardus C. Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians. Am J Hum Genet 1997 60 : 651 656.
7. Watanabe RM, Valle T, Hauser ER, Ghosh S, Eriksson J, Kohtamaki K et al. Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus. Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators. Hum Hered 1999 49 : 159 168.
8. Sinaiko AR, Jacobs DR Jr., Steinberger J, Moran A, Luepker R, Rocchini AP et al. Insulin resistance syndrome in childhood: associations of the euglycemic insulin clamp and fasting insulin with fatness and other risk factors. J Pediatr 2001 139 : 700 707.
9. Sinaiko AR, Steinberger J, Moran A, Prineas RJ, Vessby B, Basu S et al. Relation of body mass index and insulin resistance to cardiovascular risk factors, inflammatory factors, and oxidative stress during adolescence. Circulation 2005 111 : 1985 1991.
10. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985 28 : 412 419.
11. Cheng LS, Davis RC, Raffel LJ, Xiang AH, Wang N, Quinones M et al. Coincident linkage of fasting plasma insulin and blood pressure to chromosome 7q in hypertensive hispanic families. Circulation 2001 104 : 1255 1260.
12. Li Q, Zhan S, Lu J, Qin Y, Guo X, He P et al. Heritability of insulin sensitivity in twins (in Chinese). Beijing Da Xue Xue Bao 2003 35 : 591 595.
13. Mills GW, Avery PJ, McCarthy MI, Hattersley AT, Levy JC, Hitman GA et al. Heritability estimates for beta-cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes. Diabetologia 2004 47 : 732 738.
14. Mitchell BD, Kammerer CM, Blangero J, Mahaney MC, Rainwater DL, Dyke B et al. Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans. The San Antonio Family Heart Study. Circulation 1996 94 : 2159 2170.
15. Sullivan CM, Futers TS, Barrett JH, Hudson BI, Freeman MS, Grant PJ. RAGE polymorphisms and the heritability of insulin resistance: the Leeds family study. Diab Vasc Dis Res 2005 2 : 42 44.
16. Poulsen P, Levin K, Petersen I, Christensen K, Beck-Nielsen H, Vaag A. Heritability of insulin secretion, peripheral and hepatic insulin action, and intracellular glucose partitioning in young and old Danish twins. Diabetes 2005 54 : 275 283.
17. Hong Y, Weisnagel SJ, Rice T, Sun G, Mandel SA, Gu C et al. Familial resemblance for glucose and insulin metabolism indices derived from an intravenous glucose tolerance test in Blacks and Whites of the HERITAGE Family Study. Clin Genet 2001 60 : 22 30.
18. Elbein SC, Hasstedt SJ, Wegner K, Kahn SE. Heritability of pancreatic beta-cell function among non-diabetic members of Caucasian familial type 2 diabetic kindreds. J Clin Endocrinol Metab 1999 84 : 1398 1403.
19. Phillips DI. Twin studies in medical research: can they tell us whether diseases are genetically determined? Lancet 1993 341 : 1008 1009.
20. Moran A, Jacobs DR Jr., Steinberger J, Hong CP, Prineas R, Luepker R et al. Insulin resistance during puberty: results from clamp studies in 357 children. Diabetes 1999 48 : 2039 2044.
21. Mather KJ, Hunt AE, Steinberg HO, Paradisi G, Hook G, Katz A et al. Repeatability characteristics of simple indices of insulin resistance: implications for research applications. J Clin Endocrinol Metab 2001 86 : 5457 5464.