Production of macrophage IL-1β was inhibited both at the levels of transcription and maturation by caspase-1 following inhalation exposure to isobutyl nitrite

Toxicology Letters

Volumn 152, Issue 1, 2004, Pages 47-56

  Soderberg, L S F ^a   Ponnappan, U ^a   Roy, A ^b   Schafer, R ^b   Barnett, J B ^b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b Immunicon Corporation   (United States)

Author keywords

AIDS; Inhalant; Innate immunity; p38 MAPK

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; ISOBUTYL NITRITE; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN PRECURSOR;

ANIMAL CELL; ARTICLE; BLOCKING FACTOR; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXPOSURE; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; STIMULATION; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANIMALS; BLOTTING, WESTERN; CASPASE 1; FEMALE; HUMANS; INFLAMMATION; INHALATION EXPOSURE; INTERFERON TYPE II; INTERLEUKIN-1; MACROPHAGES; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; NITRITES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RISK FACTORS; TRANSCRIPTION, GENETIC; VASODILATOR AGENTS;

EID: 3543141204     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2004.03.020     Document Type: Article

References (21)

1. Archibald C.P., Schechter M.T., Le T.N., Craib K.J.P., Montaner J.S.G., O'Shaughnessy M.V. Evidence for a sexually transmitted cofactor for AIDS-related Kaposi's sarcoma in a cohort of homosexual men. Epidemiology. 3:1993;203-209
2. Baldassare J.J., Bi Y., Bellone C.J. The role of p38 mitogen-activated protein kinase in IL-1 beta transcription. J. Immunol. 162:1999;5367-5373
3. Dimmeler S., Haendeler J., Nehls M., Zeiher A.M. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1 beta converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. J. Exp. Med. 185:1997;601-607
4. Feinberg A., Vogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 137:1984;266-267
5. Gao W., Kumar S., Lotze M.T., Hanning C., Robbins P.D., Gambotto A. Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity. J. Immunol. 170:2003;107-113
6. Haverkos H.W., Pinsky P.F., Drotman D.P., Bregman D.J. Disease manifestation among homosexual men with acquired immunodeficiency syndrome: a possible role of nitrites in Kaposi's sarcoma. Sex. Transm. Dis. 12:1985;203-208
7. Kim Y.M., Talanian R.V., Li J., Billiar T.R. Nitric oxide prevents IL-1 beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1-beta-converting enzyme). J. Immunol. 161:1998;4122-4128
8. SF162 expression in acutely infected human brain cell cultures. J. Immunol. 158:1997;2449-2455
9. Marmor M., Friedman-Kien A.E., Laubenstein L., Byrum R.D., William D.C., D'onofrio S., Dubin N. Risk factors for Kaposi's sarcoma in homosexual men. Lancet. 8281:1982;1083-1086
10. Moss A.R., Osmond D., Bacchetti P., Chermann J.-C., Barre-Sinoussi F., Carlson J. Risk factors for AIDS and HIV seropositivity in homosexual men. Am. J. Epidemiol. 125:1987;1035-1047
11. Pauk J., Huang M.L., Brodie S.J., Wald A., Koelle D.M., Schacker T., Celum C., Selke S., Corey L. Mucosal shedding of human herpesvirus 8 in men. N. Engl. J. Med. 343:2000;1369-1377
12. Ponnappan U., Soderberg L.S. Inflammatory macrophage nuclear factor-kappa B and proteasome activity are inhibited following exposure to inhaled isobutyl nitrite. J. Leuk. Biol. 69:2001;639-644
13. Ramage P., Cheneval D., Chvei M., Graff P., Hemmig R., Heng R., Kocher H.P., Mackenzie A., Memmert K., Revesz L. Expression, refolding, and autocatalytic proteolytic processing of the interleukin-1-beta-converting enzyme precursor. J. Biol. Chem. 270:1995;9378-9383
14. Sambrook, J., Fritsh E.F., Maniatis, T., 1989. Molecular cloning, Second, 1, 7.43-7.45.
15. Seage G.R., Mayer K.H., Horsburgh C.R. Jr., Holmberg S.D., Moon M.W., Lamb G.A. The relation between nitrite inhalants, unprotected receptive anal intercourse, and the risk of human immunodeficiency virus infection. Am. J. Epidemiol. 135:1992;1-11
16. Soderberg L.S.F. T-cell functions are impaired by inhaled isobutyl nitrite through a T-independent mechanism. Toxicol. Lett. 70:1994;319-329
17. Soderberg L.S.F. Increased tumor growth in mice exposed to inhaled isobutyl nitrite. Toxicol. Lett. 104:1999;35-41
18. Soderberg L.S.F., Barnett J.B. Inhaled isobutyl nitrite compromises T-dependent, but not T-independent antibody induction. Int. J. Immunopharmacol. 15:1993;821-827
19. Soderberg L.S.F., Barnett J.B. Inhalation exposure to isobutyl nitrite inhibits macrophage tumoricidal activity and modulates inducible nitric oxide. J. Leuk. Biol. 57:1995;135-140
20. Soderberg L.S.F., Ponnappan U. Cytotoxicity by nitrite inhalants is not related to peroxynitrite formation. Toxicol. Lett. 132:2002;37-45
21. Trebilcock G.U., Ponnappan U. Evidence for lowered induction of nuclear factor kappa B in activated human T-lymphocytes during aging. Gerontology. 42:1996;137-146