Ultrastructural analysis of bone marrow hematopoiesis in mice transgenic for the thymidine kinase gene driven by the α(IIb) promoter

Blood

Volumn 92, Issue 6, 1998, Pages 2012-2023

  Poujol, Christel ^b   Roux, Diana Tronik Le ^b   Tropel, Philippe ^b   Roullot, Valérie ^b   Nurden, Alan ^b   Marguerie, Gérard ^b   Nurden, Paquita ^a  

^a HAUT LÉVÊQUE HOSPITAL   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

THYMIDINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; ENZYME ACTIVITY; GENE EXPRESSION; HEMATOPOIESIS; MEGAKARYOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; STROMA CELL; TRANSGENIC MOUSE;

EID: 3543139967     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.6.2012     Document Type: Article

References (43)

1. Mazur EM, Huffman R, Chasis J, Marchesi S, Bruno E: Immunofluorescent Identification of human megakaryocyte colonies using an antiplatelet glycoprotein antiserum. Blood 57:277, 1981
2. Vinci G, Tabilio A, Deschamps JF, Van Haeke D, Henri A, Guichard J, Tetteroo P, Lansdorp PM, Hercend T, Vainchenker W, Breton-Gorius J: Immunological study of in vitro maturation of human megakaryocytes. Br J Haematol 56:589, 1984
3. Jenkins RB, Nichols WL, Mann KG, Solberg LA Jr: CFU-M-derived human megakaryocytes synthesize glycoproteins IIb and IIIa. Blood 67:682, 1986
4. Debili N, Issaad C, Massé J-M, Guichard J, Katz A, Breton-Gorius J, Vainchenker W: Expression of CD34 and platelet glycoproteins during human megakaryocytic differentiation. Blood 80:3022, 1992
5. + bone marrow cells) are enriched with megakaryocytes expressing CD4. Blood 87:1353, 1996
6. Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Mathews SL, Bailey MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565, 1994
7. Debili N, Wendung F, Katz A, Guichard J, Breton-Gorius J, Hunt P, Vainchenker W: The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Blood 86:2516, 1995
8. Cramer EM, Norol F, Guichard J, Breton-Gorius J, Vainchenker W, Massé J-M, Debili N: Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligand. Blood 89:2336, 1997
9. IIb promoter. J Exp Med 181:2141, 1995
10. IIb is transcriptionally active in primitive hematopoietic progenitor cells. Blood 90:2995, 1997
11. Hourdillé P, Pico M, Jandrot-Perrus M, Lacaze D, Lozano M, Nurden AT: Studies on the megakaryocytes of a patient with the Bernard-Soulier syndrome. Br J Haematol 76:521, 1986
12. Youssefian T, Massé J-M, Rendu F, Guichard J, Cramer EM: Platelet and megakaryocyte dense granules contain glycoproteins Ib and IIb-IIIa. Blood 89:4047, 1997
13. Yamamoto Y, Yasumizu R, Amou Y, Watanabe N, Nishio N, Toki J, Fukuhara S, Ikehara S: Characterization of peripheral blood stem cells in mice. Blood 88:445, 1996
14. Spangrude GJ, Brooks DM: Mouse strain variability in the expression of the hematopoietic stem cell antigen Ly-6A/E by bone marrow cells. Blood 82:3327, 1993
15. Spangrude GJ, Heimfeld S, Weissman IL: Purification and characterization of mouse hematopoietic stem cells. Science 241:58, 1988
16. Okada S, Nakauchi H, Nagayoshi K, Nishikawa S-I, Miura Y, Suda T: In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells. Blood 80:3044, 1992
17. Nishio N, Hisha H, Ogata H, Inaba M, Yamamoto Y, Amoh Y, Yasumizu R, Hanada K, Hamada H, Ikehara S: Changes in markers, receptors and adhesion molecules expressed on murine hematopoietic stem cells after a single injection of 5-fluorouracil. Stem Cells 14:584, 1996
18. Krause DS, Fackler MJ, Civin CI, May WS: CD34: Structure, biology, and clinical utility. Blood 87:1, 1996
19. Fraser JK, Leahy MF, Berridge MV: Expression of antigens of the platelet glycoprotein IIb/IIIa complex on human hematopoietic stem cells. Blood 68:762, 1986
20. Morel F, Szilvassy SJ, Travis M, Chen B, Galy A: Primitive hematopoietic cells in murine bone marrow express the CD34 antigen. Blood 88:3774, 1996
21. Osawa M, Hanada K, Hamada H, Nakauchi H: Long-term lymphohematopoietic reconstitution by a single CD34- low/negative hematopoietic stem cell. Science 273:242, 1996
22. Zhou W, Toombs CF, Zou T, Guo J, Robinson MO: Transgenic mice overexpressing human c-mpl ligand exhibit chronic thrombocytosis and display enhanced recovery from 5-fluorouracil or antiplatelet serum treatment. Blood 89:1551, 1997
23. Davis RE, Stenberg PE, Levin J, Beckstead JH: Localization of megakaryocytes in normal mice and following administration of platelet anti-serum, 5-fluorouracil, or radiostrontium: Evidence for the site of platelet production. Exp Hematol 25:638, 1997
24. + bone marrow cells. Exp Hematol 23:161, 1995
25. low/- hemopoeitic stem cells. J Immunol 156:3207, 1996
26. Quesenberry P, Alberico T, Song Z, Donowitz G, Stewart M, Gualtieri R, Boswell S, McGrath E, Kleeman E, Baber G, Cranston S: Studies on the regulation of hemopoiesis. Exp Hematol 13:43, 1985
27. Yamazaki K, Allen TD: Ultrastructural and morphometric alterations in bone marrow stromal tissue after 7 Gy irradiation. Blood Cells 17:527, 1991
28. Gualtieri RJ: Consequences of extremely high doses of irradiation on bone marrow stromal cells and release of hematopoietic growth factors. Exp Hematol 15:952, 1987
29. Kaushansky K, Lin N, Grossmann A, Humes J, Sprugel KH, Broudy VC: Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice. Exp Hematol 24:265, 1996
30. Sitnicka E, Lin N, Priestley GV, Fox N, Broudy VC, Wolf NS, Kaushansky K: The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood 87:4998, 1996
31. Ku H, Yonemura Y, Kaushansky K, Ogawa M: Thombopoietin, the ligand for the Mp1 receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 87:4544, 1996
32. Andrews RG, Winkler A, Myerson D, Briddell RA, Knitter GH, McNiece IK, Hunt P: Recombinant human ligand for MPL, megakaryocyte growth and development factor (MGDF) stimulates thrombopoiesis in vivo in normal and myelosuppressed baboons. Stem Cells 14:661, 1996
33. Grossman A, Lenox J, Ping Ren H, Humes JM, Forstrom JW, Kaushansky K, Sprugel KH: Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice. Exp Hematol 24:1238, 1996
34. Kuter DJ, Rosenberg RD: The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 85:2720, 1995
35. Emmons RVB, Reid DM, Cohen RL, Meng G, Young NS, Dunbar CE, Shulman NR: Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 87:4068, 1996
36. Shivdasani RA, Fielder P, Keller G-A, Orkin SH, de Sauvage FJ: Regulation of the serum concentration of thrombopoietin in thrombocy-topenic NF-E2 knockout mice. Blood 90:1821, 1997
37. Arnold JT, Daw NC, Stenberg PE, Jayawardene D, Kumar Srivastava D, Jackson CW: A single injection of pegylated murine megakaryocyte growth and development factor (MGDF) into mice is sufficient to produce a profound stimulation of megakaryocyte frequency, size, and ploidization. Blood 89:823, 1997
38. Dolzhanskiy A, Bash RS, Karpatkin S: The development of human megakaryocytes: III Development of mature megakaryocytes from highly purified committed progenitors in synthetic culture media and inhibition of thrombopoietin-induced polyploidization by interleukin-3. Blood 89:426, 1997
39. Choi ES, Hokom M, Bartley T, Li YS, Ohashi H, Kato T, Nichol JL, Skrine J, Knudten A, Chen J: Recombinant human megakaryocyte growth and development factor (rHuMGDF), a ligand for c-Mpl, produces functional human platelets in vitro. Stem Cells 13:317, 1995
40. Tavassoli M, Aoki M: Migration of entire megakaryocytes through the marrow-blood barrier. Br J Haematol 48:25, 1981
41. Choi ES, Nichol JL, Hokom MM, Hornkohl AC, Hunt P: Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional. Blood 85:402, 1995
42. Trowbridge EA: Pulmonary platelet production: a physical analogue of mitosis? Blood Cells 13:451, 1988
43. 3) in human platelets and megakaryocytes reveals an intracellular pool and labelling of the α-granule membrane. Br J Haematol 97:823, 1997