The microbial outcome observed with polymerase chain reaction in subjects with recurrent periodontal disease following local treatment with 25% Metronidazole Gel

Swedish Dental Journal

Volumn 28, Issue 2, 2004, Pages 67-76

  Jansson, Henrik ^a,c   Hamberg, Kristina ^a   Söderholm, Göran ^b   Bratthall, Gunilla ^a  

^a MALMÖ UNIVERSITY   (Sweden)

^b Public Dental Service   (Sweden)

^c MALMÖ UNIVERSITY   (Sweden)

Author keywords

Antibiotics; Clinical trial; Micro organism; Periodontal disease therapy; Polymerase chain reaction

Indexed keywords

METRONIDAZOLE; PLACEBO; ANTIINFECTIVE AGENT;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ADULT; ARTICLE; CONTROLLED STUDY; DENTAL CARE; FEMALE; GEL; HEALTH PROGRAM; HUMAN; MALE; MICROORGANISM; PATHOGENESIS; PERIODONTAL DISEASE; POLYMERASE CHAIN REACTION; PORPHYROMONAS GINGIVALIS; PREVENTIVE DENTISTRY; PREVOTELLA NIGRESCENS; STATISTICAL SIGNIFICANCE; TOOTH ROOT; TREATMENT OUTCOME; BACTERIAL COUNT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; EXPERIMENTAL THERAPY; ISOLATION AND PURIFICATION; MICROBIOLOGY; MIDDLE AGED; PREVOTELLA INTERMEDIA; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ADULT; ANTI-INFECTIVE AGENTS; COLONY COUNT, MICROBIAL; FEMALE; HUMANS; MALE; METRONIDAZOLE; MIDDLE AGED; PERIODONTAL DISEASES; POLYMERASE CHAIN REACTION; PORPHYROMONAS GINGIVALIS; PREVOTELLA INTERMEDIA; RECURRENCE; THERAPIES, INVESTIGATIONAL; TREATMENT OUTCOME;

EID: 3543137090     PISSN: 03479994     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Ainamo J, Lie T, Ellingsen BH et al. Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis. J Clin Periodontol. 1992; 19: 723-9.
2. Albandar JM, Brunelle JA, Kingman A. Destructive periodontal disease in adults 30 years of age and older in the United States, 1988-1994. J Periodontol. 1999; 70: 13-29.
3. Ashimoto A, Chen C, Bakker I, Slots J. Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions. Oral Microbiol Immunol 1996; 11: 266-73
4. Badersten A, Nilveus R, Egelberg J. Effect of nonsurgical periodontal therapy. I. Moderately advanced periodontitis. J Clin Periodontol. 1981; 8: 57-72.
5. Badersten A, Nilveus R, Egelberg J. Effect of nonsurgical periodontal therapy. II. Severely advanced periodontitis. J Clin Periodontol. 1984; 11: 63-76.
6. Baker PJ, Evans RT, Slots J, Genco RJ. Antibiotic susceptibility of anaerobic bacteria from the human oral cavity. J Dent Res. 1985; 64: 1233-44.
7. Bergstrom J. Cigarette smoking as risk factor in chronic periodontal disease. Community Dent Oral Epidemiol 1989; 17: 245-7.
8. Ceri H, Olson ME, Stremick C, Read RR, Morck D, Buret A. The Calgary Biofilm Device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms. J Clin Microbiol 1999; 37: 1771-6.
9. Costerton JW, Lewandowski Z, Caldwell DE, Korber DR, Lappin-Scott HM. Microbial biofilms. Annu Rev Microbiol 1995; 49: 711-45.
10. Darby IB, Hodge PJ, Riggio MP, Kinane DF. Microbial comparison of smoker and non-smoker adult and early-onset periodontitis patients by polymerase chain reaction. J Clin Periodontol 2000; 27: 417-24.
11. Goodson JM, Cugini MA, Kent RL et al. Multicenter evaluation of tetracycline fiber therapy: II. Clinical response. J Periodontal Res. 1991; 26: 371-9.
12. Haffajee AD, Cugini MA, Dibart S, Smith C, Kent RL, Jr., Socransky SS. Clinical and microbiological features of subjects with adult periodontitis who responded poorly to scaling and root planing. J Clin Periodontol. 1997; 24: 767-76.
13. Hill RW, Ramfjord SP, Morrison EC et al. Four types of periodontal treatment compared over two years. J Periodontol. 1981; 52: 655-62.
14. Hugoson A, Norderyd O, Slotte C, Thorstensson H. Distribution of periodontal disease in a Swedish adult population 1973, 1983 and 1993. J Clin Periodontol. 1998; 25: 542-8.
15. Isidor F, Karring T. Long-term effect of surgical and non-surgical periodontal treatment. A 5-year clinical study. J Periodontal Res. 1986; 21: 462-72.
16. Jansson H, Bratthall G, Söderholm G. Clinical outcome observed in subjects with recurrent periodontal disease following local treatment with 25% metronidazole gel. J Periodontol 2003; 74: 372-77.
17. Johnson JL, Holdeman LV. Bacteroides intermedius comb. Nov. and descriptions of Bacteroides corporis sp. Nov. and Bacteroides levii sp. nov. Int J Syst Bacteriol 1983; 33: 15-25.
18. Kaldahl WB, Kalkwarf KL, Patil KD, Dyer JK, Bates RE, Jr. Evaluation of four modalities of periodontal therapy. Mean probing depth, probing attachment level and recession changes. J Periodontol. 1988; 59: 783-93.
19. Kwok S, Higuchi R. Avoiding false positives with PCR. Nature 1989; 339: 237-8.
20. Larsen T. Susceptibility of Porphyromonas gingivalis in biofilms to amoxicillin, doxycycline and metronidazole. Oral Microbiol Immunol 2002; 17: 267-71.
21. Lindhe J, Liljenberg B, Adielson B, Borjesson I. The effect of metronidazole therapy on human periodontal disease. J Periodontal Res. 1982; 17: 534-6.
22. Lindhe J, Heijl L, Goodson JM, Socransky SS. Local tetracycline delivery using hollow fiber devices in periodontal therapy. J Clin Periodontol. 1979; 6: 141-9.
23. Loe H, Anerud A, Boysen H, Morrison E. Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age. J Clin Periodontol. 1986; 13: 431-45.
24. Loe H, Silness J. Periodontal disease in pregnancy I. Prevalence and severity. Acta Odontologica Scandinavica. 1963; 21: 533-51.
25. Norling T, Lading P, Engstrom S, Larsson K, Krog N, Nissen SS. Formulation of a drug delivery system based on a mixture of monoglycerides and triglycerides for use in the treatment of periodontal disease. J Clin Periodontol. 1992;19:687-92.
26. Offenbacher S. Periodontal diseases: pathogenesis. Ann Periodontol. 1996; 1: 821-78.
27. Palmer RM, Matthews JP, Wilson RF. Adjunctive systemic and locally delivered metronidazole in the treatment of periodontitis: a controlled clinical study. Br Dent J. 1998; 184: 548-52.
28. Palmer RM, Matthews JP, Wilson RF. Non-surgical periodontal treatment with and without adjunctive metronidazole in smokers and non-smokers. J Clin Periodontol 1999; 26: 158-63.
29. Preber H, Bergstrom J, Linder LE. Occurrence of periopathogens in smoker and non-smoker patients. J Clin Periodontol 1992; 19(9 Pt 1): 667-71.
30. Preber H, Linder L, Bergstrom J. Periodontal healing and periopathogenic microflora in smokers and non-smokers. J Clin Periodontol 1995 Dec;22(12):946-52
31. Ramfjord SP, Caffesse RG, Morrison EC et al. 4 modalities of periodontal treatment compared over 5 years. J Clin Periodontol. 1987; 14: 445-52.
32. Riep B, Purucker P, Bernimoulin JP. Repeated local metronidazole-therapy as adjunct to scaling and root planing in maintenance patients. J Clin Periodontol. 1999; 26: 710-5.
33. Riggio MP, Macfarlane TW, Mackenzie D, Lennon A, Smith AJ, Kinane D. Comparison of polymerase chain reaction and culture methods for detection of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in subgingival plaque samples. J Periodontal Res 1996; 31: 496-501.
34. Renvert S, Dahlen G, Wikstrom M. The clinical and microbiological effects of non-surgical periodontal therapy in smokers and non-smokers. J Clin Periodontol 1998; 25: 153-7.
35. Rudhart A, Purucker P, Kage A, Hopfenmuller W, Bernimoulin JP. Local metronidazole application in maintenance patients. Clinical and microbiological evaluation. J Periodontol. 1998; 69: 1148-54.
36. Shah HN, Gharbia SE. Biochemical and chemical studies on strains designated Prevotella intermedia and proposal of a new pigmented species, Prevotella nigrescens sp. nov. Int J Syst Bacteriol 1992; 42: 542-6.
37. Silness J, Loe H. Periodontal disease in pregnancy II. Correlation between oral hygine and periodontal condition. Acta Odontologica Scandinavica. 1964; 22: 121-35.
38. Slots J, Genco RJ. Black-pigmented Bacteroides species. Capnocytophaga species, and Actinobacillus actinomycetemcomitans in human periodontal disease: virulence factors in colonization, survival, and tissue destruction. J Dent Res. 1984; 63: 412-21.
39. Socransky SS, Haffajee AD. Evidence of bacterial etiology: a historical perspective. Periodontol 2000. 1994; 5: 7-25.
40. Soder PO, Frithiof L, Wikner S et al. The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults. J Periodontol. 1990; 61: 281-8.
41. Stelzel M, Flores-de-Jacoby L. Topical metronidazole application compared with subgingival scaling. A clinical and microbiological study on recall patients. J Clin Periodontol. 1996; 23: 24-9.
42. Stelzel M, Flores-de-Jacoby L. Topical metronidazole application in recall patients. Long-term results. J Clin Periodontol. 1997; 24: 914-9.
43. Stelzel M, Flores-de-Jacoby L. Topical metronidazole application as an adjunct to scaling and root planing. J Clin Periodontol. 2000; 27: 447-52.
44. Stoltze K. Concentration of metronidazole in periodontal pockets after application of a metronidazole 25% dental gel. J Clin Periodontol. 1992; 19: 698-701.
45. van Steenberghe D, Bercy P, Kohl J et al. Subgingival minocycline hydrochloride ointment in moderate to severe chronic adult periodontitis: a randomized, double-blind, vehicle-controlled, multicenter study. J Periodontol. 1993; 64: 637-44.
46. Walker CB, Gordon JM, Cornwall HA, Murphy JC, Socransky SS. Gingival crevicular fluid levels of clindamycin compared with its minimal inhibitory concentrations for periodontal bacteria. Antimicrob Agents Chemother. 1981; 19: 867-71.
47. Wright TL, Ellen RP, Lacroix JM, Sinnadurai S, Mittelman MW. Effects of metronidazole on Porphyromonas gingivalis biofilms. J Periodontal Res. 1997; 32: 473-7.
48. Zambon JJ. Periodontal diseases: microbial factors. Ann Periodontol. 1996;1:879-925.