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Volumn 74, Issue 3, 2003, Pages 372-377

Clinical outcome observed in subjects with recurrent periodontal disease following local treatment with 25% metronidazole gel

Author keywords

Clinical trials; Metronidazole therapeutic use; Outcome assessment; Periodontal diseases drug therapy

Indexed keywords

METRONIDAZOLE; PLACEBO; ANTIINFECTIVE AGENT;

EID: 0038166555     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2003.74.3.372     Document Type: Article
Times cited : (15)

References (42)
  • 1
    • 0030280463 scopus 로고    scopus 로고
    • Periodontal diseases: Pathogenesis
    • Offenbacher S. Periodontal diseases: Pathogenesis. Ann Periodontol 1996;1:821-878.
    • (1996) Ann. Periodontol. , vol.1 , pp. 821-878
    • Offenbacher, S.1
  • 2
    • 0021403590 scopus 로고
    • Black-pigmented Bacteroides species, Capnocytophaga species, and Actinobacillus actinomycetemcomitans in human periodontal disease: Virulence factors in colonization, survival, and tissue destruction
    • Slots J, Genco RJ. Black-pigmented Bacteroides species, Capnocytophaga species, and Actinobacillus actinomycetemcomitans in human periodontal disease: Virulence factors in colonization, survival, and tissue destruction. J Dent Res 1984;63:412-421.
    • (1984) J. Dent. Res. , vol.63 , pp. 412-421
    • Slots, J.1    Genco, R.J.2
  • 3
    • 0028457299 scopus 로고
    • Evidence of bacterial etiology: A historical perspective
    • Socransky SS, Haffajee AD. Evidence of bacterial etiology: A historical perspective. Periodontol 2000 1994;5:7-25.
    • (1994) Periodontol. 2000 , vol.5 , pp. 7-25
    • Socransky, S.S.1    Haffajee, A.D.2
  • 4
    • 0030280519 scopus 로고    scopus 로고
    • Periodontal diseases: Microbial factors
    • Zambon JJ. Periodontal diseases: Microbial factors. Ann Periodontol 1996;1:879-925.
    • (1996) Ann. Periodontol. , vol.1 , pp. 879-925
    • Zambon, J.J.1
  • 5
    • 0019783952 scopus 로고
    • Four types of periodontal treatment compared over two years
    • Hill RW, Ramfjord SP, Morrison EC, et al. Four types of periodontal treatment compared over two years. J Periodontol 1981;52:655-662.
    • (1981) J. Periodontol. , vol.52 , pp. 655-662
    • Hill, R.W.1    Ramfjord, S.P.2    Morrison, E.C.3
  • 6
    • 0019523209 scopus 로고
    • Effect of nonsurgical periodontal therapy. I. Moderately advanced periodontitis
    • Badersten A, Nilveus R, Egelberg J. Effect of nonsurgical periodontal therapy. I. Moderately advanced periodontitis. J Clin Periodontol 1981;8:57-72.
    • (1981) J. Clin. Periodontol. , vol.8 , pp. 57-72
    • Badersten, A.1    Nilveus, R.2    Egelberg, J.3
  • 7
    • 0021298885 scopus 로고
    • Effect of nonsurgical periodontal therapy. II. Severely advanced periodontitis
    • Badersten A, Nilveus R, Egelberg J. Effect of nonsurgical periodontal therapy. II. Severely advanced periodontitis. J Clin Periodontol 1984;11:63-76.
    • (1984) J. Clin. Periodontol. , vol.11 , pp. 63-76
    • Badersten, A.1    Nilveus, R.2    Egelberg, J.3
  • 8
    • 0022780709 scopus 로고
    • Long-term effect of surgical and nonsurgical periodontal treatment. A 5-year clinical study
    • Isidor F, Karring T. Long-term effect of surgical and nonsurgical periodontal treatment. A 5-year clinical study. J Periodont Res 1986;21:462-472.
    • (1986) J. Periodont. Res. , vol.21 , pp. 462-472
    • Isidor, F.1    Karring, T.2
  • 9
    • 0024257063 scopus 로고
    • Evaluation of four modalities of periodontal therapy. Mean probing depth, probing attachment level and recession changes
    • Kaldahl WB, Kalkwarf KL, Patil KD, Dyer JK, Bates RE Jr. Evaluation of four modalities of periodontal therapy. Mean probing depth, probing attachment level and recession changes. J Periodontol 1988;59:783-793.
    • (1988) J. Periodontol. , vol.59 , pp. 783-793
    • Kaldahl, W.B.1    Kalkwarf, K.L.2    Patil, K.D.3    Dyer, J.K.4    Bates R.E., Jr.5
  • 12
    • 0025289227 scopus 로고
    • The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults
    • Soder PO, Frithiof L, Wikner S, et al. The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults. J Periodontol 1990;61:281-288.
    • (1990) J. Periodontol. , vol.61 , pp. 281-288
    • Soder, P.O.1    Frithiof, L.2    Wikner, S.3
  • 13
    • 0018746073 scopus 로고
    • Local tetracycline delivery using hollow fiber devices in periodontal therapy
    • Lindhe J, Heijl L, Goodson JM, Socransky SS. Local tetracycline delivery using hollow fiber devices in periodontal therapy. J Clin Periodontol 1979;6:141-149.
    • (1979) J. Clin. Periodontol. , vol.6 , pp. 141-149
    • Lindhe, J.1    Heijl, L.2    Goodson, J.M.3    Socransky, S.S.4
  • 14
    • 0025740975 scopus 로고
    • Multicenter evaluation of tetracycline fiber therapy: II. Clinical response
    • Goodson JM, Cugini MA, Kent RL, et al. Multicenter evaluation of tetracycline fiber therapy: II. Clinical response. J Periodont Res 1991;26:371-379.
    • (1991) J. Periodont. Res. , vol.26 , pp. 371-379
    • Goodson, J.M.1    Cugini, M.A.2    Kent, R.L.3
  • 15
    • 0026673649 scopus 로고
    • Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis
    • Ainamo J, Lie T, Ellingsen BH, et al. Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis. J Clin Periodontol 1992;19:723-729.
    • (1992) J. Clin. Periodontol. , vol.19 , pp. 723-729
    • Ainamo, J.1    Lie, T.2    Ellingsen, B.H.3
  • 16
    • 0027179321 scopus 로고
    • Subgingival minocycline hydrochloride ointment in moderate to severe chronic adult periodontitis: A randomized, double-blind, vehicle-controlled, multicenter study
    • van Steenberghe D, Bercy P, Kohl J, et al. Subgingival minocycline hydrochloride ointment in moderate to severe chronic adult periodontitis: A randomized, double-blind, vehicle-controlled, multicenter study. J Periodontol 1993;64:637-644.
    • (1993) J. Periodontol. , vol.64 , pp. 637-644
    • van Steenberghe, D.1    Bercy, P.2    Kohl, J.3
  • 17
    • 0026738519 scopus 로고
    • Three regimens of topical metronidazole compared with subgingival scaling on periodontal pathology in adults
    • Klinge B, Attstrom R, Karring T, Kisch J, Lewin B, Stoltze K. Three regimens of topical metronidazole compared with subgingival scaling on periodontal pathology in adults. J Clin Periodontol 1992;19:708-714.
    • (1992) J. Clin. Periodontol. , vol.19 , pp. 708-714
    • Klinge, B.1    Attstrom, R.2    Karring, T.3    Kisch, J.4    Lewin, B.5    Stoltze, K.6
  • 18
    • 0026940790 scopus 로고
    • Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis
    • Pedrazzoli V, Kilian M, Karring T. Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis. J Clin Periodontol 1992;19:715-722.
    • (1992) J. Clin. Periodontol. , vol.19 , pp. 715-722
    • Pedrazzoli, V.1    Kilian, M.2    Karring, T.3
  • 19
    • 0029684789 scopus 로고    scopus 로고
    • Topical metronidazole application compared with subgingival scaling. A clinical and microbiological study on recall patients
    • Stelzel M, Flores-de-Jacoby L. Topical metronidazole application compared with subgingival scaling. A clinical and microbiological study on recall patients. J Clin Periodontol 1996;23:24-29.
    • (1996) J. Clin. Periodontol. , vol.23 , pp. 24-29
    • Stelzel, M.1    Flores-de-Jacoby, L.2
  • 20
    • 0031309647 scopus 로고    scopus 로고
    • Topical metronidazole application in recall patients. Long-term results
    • Stelzel M, Flores-de-Jacoby L. Topical metronidazole application in recall patients. Long-term results. J Clin Periodontol 1997;24:914-919.
    • (1997) J. Clin. Periodontol. , vol.24 , pp. 914-919
    • Stelzel, M.1    Flores-de-Jacoby, L.2
  • 21
    • 0022710747 scopus 로고
    • Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age
    • Löe H, Anerud A, Boysen H, Morrison E. Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age. J Clin Periodontol 1986;13:431-445.
    • (1986) J. Clin. Periodontol. , vol.13 , pp. 431-445
    • Löe, H.1    Anerud, A.2    Boysen, H.3    Morrison, E.4
  • 22
    • 0032113314 scopus 로고    scopus 로고
    • Distribution of periodontal disease in a Swedish adult population 1973, 1983 and 1993
    • Hugoson A, Norderyd O, Slotte C, Thorstensson H. Distribution of periodontal disease in a Swedish adult population 1973, 1983 and 1993. J Clin Periodontol 1998; 25:542-548.
    • (1998) J. Clin. Periodontol. , vol.25 , pp. 542-548
    • Hugoson, A.1    Norderyd, O.2    Slotte, C.3    Thorstensson, H.4
  • 23
    • 0032610940 scopus 로고    scopus 로고
    • Destructive periodontal disease in adults 30 years of age and older in the United States, 1988-1994
    • Albandar JM, Brunelle JA, Kingman A. Destructive periodontal disease in adults 30 years of age and older in the United States, 1988-1994. J Periodontol 1999;70:13-29.
    • (1999) J. Periodontol. , vol.70 , pp. 13-29
    • Albandar, J.M.1    Brunelle, J.A.2    Kingman, A.3
  • 24
    • 0031252438 scopus 로고    scopus 로고
    • Clinical and microbiological features of subjects with adult periodontitis who responded poorly to scaling and root planing
    • Haffajee AD, Cugini MA, Dibart S, Smith C, Kent RL Jr., Socransky SS. Clinical and microbiological features of subjects with adult periodontitis who responded poorly to scaling and root planing. J Clin Periodontol 1997;24:767-776.
    • (1997) J. Clin. Periodontol. , vol.24 , pp. 767-776
    • Haffajee, A.D.1    Cugini, M.A.2    Dibart, S.3    Smith, C.4    Kent R.L., Jr.5    Socransky, S.S.6
  • 25
    • 75949163484 scopus 로고
    • Periodontal disease in pregnancy II. Correlation between oral hygine and periodontal condition
    • Silness J, Löe H. Periodontal disease in pregnancy II. Correlation between oral hygine and periodontal condition. Acta Odontol Scand 1964;22:121-135.
    • (1964) Acta Odontol. Scand. , vol.22 , pp. 121-135
    • Silness, J.1    Löe, H.2
  • 26
    • 75549115165 scopus 로고
    • Periodontal disease in pregnancy I. Prevalence and severity
    • Löe H, Silness J. Periodontal disease in pregnancy I. Prevalence and severity. Acta Odontol Scand 1963;21:533-551.
    • (1963) Acta Odontol. Scand. , vol.21 , pp. 533-551
    • Löe, H.1    Silness, J.2
  • 27
    • 0015410463 scopus 로고
    • Survival of human dental plaque flora in various transport media
    • Syed SA, Loesche WJ. Survival of human dental plaque flora in various transport media. Appl Microbiol 1972;24:638-644.
    • (1972) Appl. Microbiol. , vol.24 , pp. 638-644
    • Syed, S.A.1    Loesche, W.J.2
  • 28
    • 0026641726 scopus 로고
    • Formulation of a drug delivery system based on a mixture of monoglycerides and triglycerides for use in the treatment of periodontal disease
    • Norling T, Lading P, Engstrom S, Larsson K, Krog N, Nissen SS. Formulation of a drug delivery system based on a mixture of monoglycerides and triglycerides for use in the treatment of periodontal disease. J Clin Periodontol 1992;19:687-692.
    • (1992) J. Clin. Periodontol. , vol.19 , pp. 687-692
    • Norling, T.1    Lading, P.2    Engstrom, S.3    Larsson, K.4    Krog, N.5    Nissen, S.S.6
  • 29
    • 0026715217 scopus 로고
    • The effect of topical metronidazole therapy on experimentally-induced periodontitis in the beagle dog
    • Klinge B, Kuvatanasuhati J, Attstrom R, Kalfas S, Edwardsson S. The effect of topical metronidazole therapy on experimentally-induced periodontitis in the beagle dog. J Clin Periodontol 1992;19:702-707.
    • (1992) J. Clin. Periodontol. , vol.19 , pp. 702-707
    • Klinge, B.1    Kuvatanasuhati, J.2    Attstrom, R.3    Kalfas, S.4    Edwardsson, S.5
  • 30
    • 0031735840 scopus 로고    scopus 로고
    • Local metronidazole application in maintenance patients. Clinical and microbiological evaluation
    • Rudhart A, Purucker P, Kage A, Hopfenmuller W, Bernimoulin JP. Local metronidazole application in maintenance patients. Clinical and microbiological evaluation. J Periodontol 1998;69:1148-1154.
    • (1998) J. Periodontol. , vol.69 , pp. 1148-1154
    • Rudhart, A.1    Purucker, P.2    Kage, A.3    Hopfenmuller, W.4    Bernimoulin, J.P.5
  • 31
    • 0033228737 scopus 로고    scopus 로고
    • Repeated local metronidazole therapy as adjunct to scaling and root planing in maintenance patients
    • Riep B, Purucker P, Bernimoulin JP. Repeated local metronidazole therapy as adjunct to scaling and root planing in maintenance patients. J Clin Periodontol 1999; 26:710-715.
    • (1999) J. Clin. Periodontol. , vol.26 , pp. 710-715
    • Riep, B.1    Purucker, P.2    Bernimoulin, J.P.3
  • 32
    • 0032513779 scopus 로고    scopus 로고
    • Adjunctive systemic and locally delivered metronidazole in the treatment of periodontitis: A controlled clinical study
    • Palmer RM, Matthews JP, Wilson RF. Adjunctive systemic and locally delivered metronidazole in the treatment of periodontitis: A controlled clinical study. Br Dent J 1998;184:548- 552.
    • (1998) Br. Dent. J. , vol.184 , pp. 548-552
    • Palmer, R.M.1    Matthews, J.P.2    Wilson, R.F.3
  • 33
    • 0034197884 scopus 로고    scopus 로고
    • Topical metronidazole application as an adjunct to scaling and root planing
    • Stelzel M, Flores-de-Jacoby L. Topical metronidazole application as an adjunct to scaling and root planing. J Clin Periodontol 2000;27:447-452.
    • (2000) J. Clin. Periodontol. , vol.27 , pp. 447-452
    • Stelzel, M.1    Flores-de-Jacoby, L.2
  • 34
    • 0023686861 scopus 로고
    • Use of antimicrobial containing acrylic strips in the treatment of chronic periodontal disease. A three-month follow-up study
    • Addy M, Hassan H, Moran J, Wade W, Newcombe R. Use of antimicrobial containing acrylic strips in the treatment of chronic periodontal disease. A three-month follow-up study. J Periodontol 1988;59:557-564.
    • (1988) J. Periodontol. , vol.59 , pp. 557-564
    • Addy, M.1    Hassan, H.2    Moran, J.3    Wade, W.4    Newcombe, R.5
  • 35
    • 0024743564 scopus 로고
    • Cigarette smoking as a risk factor in chronic periodontal disease
    • Bergstrom J. Cigarette smoking as a risk factor in chronic periodontal disease. Community Dent Oral Epidemiol 1989;17:245-247.
    • (1989) Community Dent. Oral Epidemiol. , vol.17 , pp. 245-247
    • Bergstrom, J.1
  • 36
    • 0029443949 scopus 로고
    • Periodontal healing and periopathogenic microflora in smokers and non-smokers
    • Preber H, Linder L, Bergstrom J. Periodontal healing and periopathogenic microflora in smokers and non-smokers. J Clin Periodontol 1995;22:946-952.
    • (1995) J. Clin. Periodontol. , vol.22 , pp. 946-952
    • Preber, H.1    Linder, L.2    Bergstrom, J.3
  • 37
    • 0033090180 scopus 로고    scopus 로고
    • Non-surgical periodontal treatment with and without adjunctive metronidazole in smokers and non-smokers
    • Palmer RM, Matthews JP, Wilson RF. Non-surgical periodontal treatment with and without adjunctive metronidazole in smokers and non-smokers. J Clin Periodontol 1999;26:158-163.
    • (1999) J. Clin. Periodontol. , vol.26 , pp. 158-163
    • Palmer, R.M.1    Matthews, J.P.2    Wilson, R.F.3
  • 38
    • 0026145908 scopus 로고
    • Bleeding on probing as it relates to probing pressure and gingival health
    • Lang NP, Nyman S, Senn C, Joss A. Bleeding on probing as it relates to probing pressure and gingival health. J Clin Periodontol 1991;18:257-261.
    • (1991) J. Clin. Periodontol. , vol.18 , pp. 257-261
    • Lang, N.P.1    Nyman, S.2    Senn, C.3    Joss, A.4
  • 39
    • 0021933775 scopus 로고
    • Antibiotic susceptibility of anaerobic bacteria from the human oral cavity
    • Baker PJ, Evans RT, Slots J, Genco RJ. Antibiotic susceptibility of anaerobic bacteria from the human oral cavity. J Dent Res 1985;64:1233-1244.
    • (1985) J. Dent. Res. , vol.64 , pp. 1233-1244
    • Baker, P.J.1    Evans, R.T.2    Slots, J.3    Genco, R.J.4
  • 40
    • 0019828176 scopus 로고
    • Gingival crevicular fluid levels of clindamycin compared with its minimal inhibitory concentrations for periodontal bacteria
    • Walker CB, Gordon JM, Cornwall HA, Murphy JC, Socransky SS. Gingival crevicular fluid levels of clindamycin compared with its minimal inhibitory concentrations for periodontal bacteria. Antimicrob Agents Chemother 1981;19:867-871.
    • (1981) Antimicrob. Agents Chemother. , vol.19 , pp. 867-871
    • Walker, C.B.1    Gordon, J.M.2    Cornwall, H.A.3    Murphy, J.C.4    Socransky, S.S.5
  • 41
    • 0026665504 scopus 로고
    • Concentration of metronidazole in periodontal pockets after application of a metronidazole 25% dental gel
    • Stoltze K. Concentration of metronidazole in periodontal pockets after application of a metronidazole 25% dental gel. J Clin Periodontol 1992;19:698-701.
    • (1992) J. Clin. Periodontol. , vol.19 , pp. 698-701
    • Stoltze, K.1


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