The chemokine receptor CCR5-Δ32 gene mutation is not protective against Alzheimer's disease

Neuroscience Letters

Volumn 366, Issue 3, 2004, Pages 312-314

  Combarros, Onofre ^a   Infante, Jon ^a   Llorca, Javier ^b   Peña, Nicolás ^c   Fernández Viadero, Carlos ^c   Berciano, José ^a  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^b UNIVERSITY OF CANTABRIA   (Spain)

^c Consejería de Sanidad ^*  (Spain)

Author keywords

Alzheimer's disease; CCR5; Chemokine; Polymorphism

Indexed keywords

CHEMOKINE RECEPTOR CCR5;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE MUTATION; HUMAN; MALE; NEUROPROTECTION; PERFORMANCE; PRIORITY JOURNAL; SAMPLE;

AGED; AGED, 80 AND OVER; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; FEMALE; GENE DELETION; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; RECEPTORS, CCR5; SEQUENCE ANALYSIS, DNA;

EID: 3543100441     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.05.058     Document Type: Article

References (16)

1. Abdi R., Huong T.T.B., Sahagun-Ruiz A., Murphy P.M., Brenner B.M., Milford E.L., McDermott D.H. Chemokine receptor polymorphism and risk of acute rejection in human renal transplantation. J. Am. Soc. Nephrol. 13:2002;754-758
2. Akiyama H., Barger S., Barnum S., Bradt B., Bauer J., Cole G.M., Cooper N.R., Eikelenboom P., Emmerling M., Fiebich B.L., Finch C.E., Frautschy S., Griffin W.S.T., Hampel H., Hull M., Landreth G., Lue L.F., Mrak R., Mackenzie I.R., McGeer P.L., O'Banion M.K., Pachter J., Pasinetti G., Plata-Salaman C., Rogers J., Rydel R., Shen Y., Streit W., Strohmeyer R., Tooyoma I., Van Muiswinkel F.L., Veerhuis R., Walker D., Webster S., Wegrzyniak B., Wenk G., Wyss-Coray T. Inflammation and Alzheimer's disease. Neurobiol. Aging. 21:2000;383-421
3. Bajetto A., Bonavia R., Barbero S., Schettini G. Characterization of chemokines and their receptors in the central nervous system: physiopathological implications. J. Neurochem. 82:2002;1311-1329
4. Combarros O., Leno C., Oterino A., Berciano J., Fernández-Luna J.L., Fernánez-Viadero C., Peña N., Miró J., Delgado M. Gender effect on apolipoprotein E ε4 allele-association risk for sporadic Alzheimer's disease. Acta Neurol. Scand. 97:1998;68-71
5. Gonzalez P., Alvarez R., Batalla A., Reguero J.R., Alvarez V., Astudillo A., Cubero G.I., Cortina A., Coto E. Genetic variation at the chemokine receptors CCR5/CCR2 in myocardial infarction. Genes Immunol. 2:2001;191-195
6. Hall I.P., Wheatley A., Christie G., McDougall C., Hubbard R., Helms P.J. Association of CCR5 Δ32 with reduced risk of asthma. Lancet. 354:1999;1264-1265
7. Kantor R., Bakhanashvili M., Achiron A. A mutated CCR5 gene may have favorable prognostic implications in MS. Neurology. 61:2003;238-240
8. Lucotte G. Distribution of the CCR5 gene 32-basepair deletion in West Europe. A hypothesis about the possible dispersion of the mutation by the Vikings in historical times. Hum. Immunol. 62:2001;933-936
9. McKhaan G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDA-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 34:1984;934-944
10. Menten P., Wuyts A., Van Damme J. Macrophage inflammatory protein-1. Cytokine Growth Factor Rev. 13:2002;455-481
11. Mueller A., Strange P.G. The chemokine receptor, CCR5. Int. J. Biochem. Cell Biol. 36:2004;35-38
12. Rogers J., Lue L.F. Microglial chemotaxis, activation, and phagocytosis of amyloid β-peptide as linked phenomena in Alzheimer's disease. Neurochem. Int. 39:2001;333-340
13. Samson M., Libert F., Doranz B.J., Rucker J., Liesnard C., Farber C.M., Saragosti S., Lapouméroulie C., Cognaux J., Forceille C., Muyldermans G., Verhofstede C., Burtonboy G., Georges M., Imai T., Rana S., Yi Y., Smyth R.J., Collman R.G., Doms R.W., Vassart G., Parmentier M. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature. 382:1996;722-725
14. Streit W.J., Conde J.R., Harrison J.K. Chemokines and Alzheimer's disease. Neurobiol. Aging. 22:2001;909-913
15. Walker D.G., Lue L.F., Beach T.G. Gene expression profiling of amyloid beta peptide-stimulated human post-mortem brain microglia. Neurobiol. Aging. 22:2001;957-966
16. Xia M.Q., Qin S.X., Wu L.J., Mackay C.R., Hyman B.T. Immunohistochemical study of the β-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. Am. J. Pathol. 153:1998;31-37