Pharmacokinetic-pharmacodynamic modelling of the electroencephalogram effect of imipenem in rats with experimental hypovolaemia or endotoxaemia

Journal of Antimicrobial Chemotherapy

Volumn 54, Issue 1, 2004, Pages 187-192

  Limosin, A ^a,b   Dupuis, A ^a,b   Lamarche, I ^a   Mimoz, O ^a,b   Paquereau, J ^c   Couet, William ^a  

^a Laboratoire de Biochimie   (France)

^b POITIERS UNIVERSITY HOSPITAL   (France)

^c PBS   (France)

Author keywords

Carbapenems; EEG; Epileptogenic

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BICARBONATE; CILASTATIN PLUS IMIPENEM; CREATININE; IMIPENEM; LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; BLOOD VOLUME; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; ELECTROENCEPHALOGRAPHY; ENDOTOXEMIA; EPILEPTOGENESIS; EXPERIMENTAL MODEL; FOCAL EPILEPSY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOVOLEMIA; MALE; NONHUMAN; RAT; TREMOR;

ALGORITHMS; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROENCEPHALOGRAPHY; ENDOTOXEMIA; HYPOVOLEMIA; IMIPENEM; INDICATORS AND REAGENTS; LIPOPOLYSACCHARIDES; LIVER FUNCTION TESTS; MALE; MODELS, BIOLOGICAL; RATS; RATS, SPRAGUE-DAWLEY; SPECTROPHOTOMETRY, ULTRAVIOLET; THIENAMYCINS;

EID: 3543068782     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkh255     Document Type: Article

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