Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes

EMBO Journal

Volumn 23, Issue 14, 2004, Pages 2723-2733

  Li, Yuanhe ^a   Karnak, David ^b   Demeler, Borries ^c   Margolis, Ben ^b   Lavie, Arnon ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Heterodimer; L27; PALS1; PATJ; Structure

Indexed keywords

PROTEIN; PROTEIN CRUMBS; PROTEIN LIN2; PROTEIN LIN7; PROTEIN PALS1; PROTEIN PATJ; UNCLASSIFIED DRUG;

ARTICLE; CELL POLARITY; COMPLEX FORMATION; CRYSTAL STRUCTURE; DIMERIZATION; L27 DOMAIN; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CELL POLARITY; CENTRIFUGATION, DENSITY GRADIENT; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; EYE PROTEINS; HUMANS; HYDROPHOBICITY; MEMBRANE PROTEINS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3543040058     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600294     Document Type: Article

References (35)

1. Bachmann A, Schneider M, Theilenberg E, Grawe F, Knust E (2001) Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity. Nature 414: 638-643
2. Bhat MA, Izaddoost S, Lu Y, Cho KO, Choi KW, Bellen HJ (1999) Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity. Cell 96: 833-845
3. Borg JP, Straight SW, Kaech SM, de Taddeo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B (1998) Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. J Biol Chem 273: 31633-31636
4. Brünger AT, Adams PD, Clore GM, Delano WL, Gros P, Grosse-Kunstleve RW, Jiang J-S, Kuszewskli J, Nilges N, Read RJ, Rice LM, Simonson T, Warren GL (1998) Crystallography and NMR system (CNS): a new software system for macromolecular structure determination. Acta Crystallogr D 54: 905-921
5. Butz S, Okamoto M, Sudhof TC (1998) A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Cell 94: 773-782
6. Chetkovich DM, Bunn RC, Kuo SH, Kawasaki Y, Kohwi M, Bredt DS (2002) Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms. J Neurosci 22: 6415-6425
7. Doerks T, Bork P, Kamberov E, Makarova O, Muecke S, Margolis B (2000) L27, a novel heterodimerization domain in receptor targeting proteins Lin-2 and Lin-7. Trends Biochem Sci 25: 317-318
8. Doublie S (1997) Preparation of selenomethionyl proteins for phase determination. In Methods in Enzymology, Carter CW, Sweet RM (eds) Vol. 276, pp 461-472. San Diego: Academic Press
9. Feng W, Long JF, Fan JS, Suetake T, Zhang M (2004) The tetrameric L27 domain complex as an organization platform for supramolecular assemblies. Nat Struct Mol Biol 11: 475-480
10. Gruber M, Lupas AN (2003) Historical review: another 50th anniversary-new periodicities in coiled coils. Trends Biochem Sci 28: 679-685
11. Harris BZ, Venkatasubrahmanyam S, Lim WA (2002) Coordinated folding and association of the LIN-2, -7 (L27) domain. An obligate heterodimerization involved in assembly of signaling and cell polarity complexes. J Biol Chem 277: 34902-34908
12. Hong Y, Stronach B, Perrimon N, Jan LY, Jan YN (2001) Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts. Nature 414: 634-638
13. Joberty G, Petersen C, Gao L, Macara IG (2000) The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol 2: 531-539
14. Jones TA, Zhou J-Y, Cowan SW, Kjeldgaard M (1991) Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A 47: 110-119
15. Kabsch W (1993) Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants. J Appl Crystallogr 24: 795-800
16. Kaech SM, Whitfield CW, Kim SK (1998) The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Cell 94: 761-771
17. Kamberov E, Makarova O, Roh M, Liu A, Karnak D, Straight S, Margolis B (2000) Molecular cloning and characterization of Pals, proteins associated with mLin-7. J Biol Chem 275: 11425-11431
18. Karnak D, Lee S, Margolis B (2002) Identification of multiple binding partners for the amino-terminal domain of synapse-associated protein 97. J Biol Chem 277: 46730-46735
19. Knust E, Tepass U, Wodarz A (1993) Crumbs and stardust, two genes of Drosophila required for the development of epithelial cell polarity. Dev Suppl 261-268
20. Kraulis PJ (1991) MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J Appl Crystallogr 24: 946-950
21. Laskowski RA, MacArthur MW, Moss DS, Thornton JM (1993) PROCHECK: a program to check the stereochemical quality of protein structures. J Appl Crystallogr 26: 283-291
22. Lee S, Fan S, Makarova O, Straight S, Margolis B (2002) A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epithelia. Mol Cell Biol 22: 1778-1791
23. Lemmers C, Medina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A (2002) hINAD1/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells. J Biol Chem 277: 25408-25415
24. Lin D, Edwards AS, Fawcett JP, Mbamalu G, Scott JD, Pawson T (2000) A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol 2: 540-547
25. Makarova O, Roh MH, Liu CJ, Laurinec S, Margolis B (2003) Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1). Gene 302: 21-29
26. Merrit EA, Murphy MEP (1994) Raster3D Version 2.0-a program for photorealistic molecular graphics. Acta Crystallogr D 50: 869-873
27. Perrakis A, Morris R, Lamzin VS (1999) Automated protein model building combined with iterative structure refinement. Nat Struct Biol 6: 458-463
28. Petronczki M, Knoblich JA (2001) DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila. Nat Cell Biol 3: 43-49
29. Roh MH, Fan S, Liu CJ, Margolis B (2003) The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells. J Cell Sci 116: 2895-2906
30. Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (2002) The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. J Cell Biol 157: 161-172
31. Roh MH, Margolis B (2003) Composition and function of PDZ protein complexes during cell polarization. Am J Physiol Renal Physiol 285: F377-F387
32. Simske JS, Kaech SM, Harp SA, Kim SK (1996) LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction. Cell 85: 195-204
33. Straight SW, Shin K, Fogg VC, Fan S, Liu CJ, Roh M, Margolis B (2004) Loss of PALS1 expression leads to tight junction and polarity defects. Mol Biol Cell 15: 1981-1990
34. Terwilliger TC, Berendzen J (1999) Automated structure solution for MIR and MAD. Acta Crystallogr D 55: 849-861
35. Wodarz A, Ramrath A, Grimm A, Knust E (2000) Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. J Cell Biol 150: 1361-1374