Transdifferentiation of cultured bovine lens epithelial cells into myofibroblast-like cells by serum modulation

Yonsei Medical Journal

Volumn 45, Issue 3, 2004, Pages 380-391

  Kim, Jong Tak ^a   Lee, Eunjoo H ^b   Chung, Kwang Hoe ^c   Kang, In Cheol ^d   Lee, Do Hyung ^d   Joo, Choun Ki ^a  

^a The Catholic University of Korea   (South Korea)

^b Kyung Hee University   (South Korea)

^c Yonsei University College of Medicine   (South Korea)

^d Inje University   (South Korea)

Author keywords

After cataract; Cataractogenesis; Epithelium; Lens; Mesenchyme; Serum; Transdifferentiation

Indexed keywords

ALPHA ACTIN; COLLAGEN; CYTOSKELETON PROTEIN; DISINTEGRIN; INTEGRIN; SCLEROPROTEIN;

ANIMAL CELL; ARTICLE; CATARACT; CATTLE; CELL ADHESION; CELL CULTURE; CELL DIFFERENTIATION; CELL ELONGATION; CELL GROWTH; CELL MIGRATION; CELL STRUCTURE; CELL SURFACE; CELL TRANSFORMATION; CONTROLLED STUDY; CULTURE MEDIUM; EPITHELIUM CELL; EXPLANT; GENE CONTROL; GENE EXPRESSION; IN VITRO STUDY; INTERMETHOD COMPARISON; LENS EPITHELIUM; MESENCHYME; MOLECULAR MODEL; MYOFIBROBLAST; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROCESSING; REGULATORY MECHANISM; SERUM; SMOOTH MUSCLE; TISSUE CULTURE; TRANSCRIPTION REGULATION;

EID: 3543023885     PISSN: 05135796     EISSN: None     Source Type: Journal    
DOI: 10.3349/ymj.2004.45.3.380     Document Type: Article

References (42)

1. Hay ED. An overview of epithelio-mesenchymal transformation. Acta Anat (Basel) 1995;154:8-20.
2. Hay ED, Zuk A. Transformations between epithelium and mesenchyme: normal, pathological, and experimentally induced. Am J Kidney Dis 1995;26:678-90.
3. Reichmann E. Oncogenes and epithelial cell transformation. Semin Cancer Biol 1994;5:157-65.
4. Behrens J, Vakaet L, Friis R, Winterhager E, Van Roy F, Mareel MM, et al. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J Cell Biol 1993;120:757-66.
5. Cobo LM, Ohsawa E, Chandler D, Arguello R, George G. Pathogenesis of capsular opacification after extracapsular cataract extraction. An animal model. Ophthalmology 1984;91:857-63.
6. Duncan G, Wormstone IM, Liu CS, Marcantonio JM, Davies PD. Thapsigargin-coated intraocular lenses inhibit human lens cell growth. Nat Med 1997;3:1026-8.
7. Liu CS, Wormstone IM, Duncan G, Marcantonio JM, Webb SF, Davies PD. A study of human lens cell growth in vitro. A model for posterior capsule opacification. Invest Ophthalmol Vis Sci 1996;37:906-14.
8. Hales AM, Schulz MW, Chamberlain CG, McAvoy JW. TGF-beta 1 induces lens cells to accumulate alpha-smooth muscle actin, a marker for subcapsular cataracts. Curr Eye Res 1994;13:885-90.
9. Hales AM, Chamberlain CG, McAvoy JW. Cataract induction in lenses cultured with transforming growth factor-beta. Invest Ophthalmol Vis Sci 1995;36:1709-13.
10. Zuk A, Matlin KS, Hay ED. Type I collagen gel induces Madin-Darby canine kidney cells to become fusiform in shape and lose apical-basal polarity. J Cell Biol 1989; 108:903-19.
11. Greenburg G, Hay ED. Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. J Cell Biol 1982;95:333-9.
12. Greenburg G, Hay ED. Cytodifferentiation and tissue phenotype change during transformation of embryonic lens epithelium to mesenchyme-like cells in vitro. Dev Biol 1986;115:363-79.
13. Zuk A, Hay ED. Expression of beta 1 integrins changes during transformation of avian lens epithelium to mesenchyme in collagen gels. Dev Dyn 1994;201:378-93.
14. Andley UP, Fritz C, Morrison AR, Becker B. The role of prostaglandins E2 and F2 alpha in ultraviolet radiation-induced cortical cataracts in vivo. Invest Ophthalmol Vis Sci 1996;37:1539-48.
15. Miyake K, Shirasawa E, Hikita M. Active transport system of prostaglandins: clinical implications and considerations. J Cataract Refract Surg 1992;18:100-5.
16. Grabner G, Zehetbauer G, Bettelheim H, Dorda W. Immediate changes in protein-concentration in aqueous humor induced by intracapsular lens extraction in human eyes. Albrecht Von Graefes Arch Klin Exp Ophthalmol 1979;210:275-89.
17. Latour E, Driot JY, Coquelet C, Bonne C. The role of platelets in blood-aqueous barrier breakdown induced by anterior chamber paracentesis in the rabbit. Curr Eye Res 1989;8:1105-10.
18. Wallentin N, Wickstrom K, Lundberg C. Effect of cataract surgery on aqueous TGF-beta and lens epithelial cell proliferation. Invest Ophthalmol Vis Sci 1998;39: 1410-8.
19. Boyer B, Tucker GC, Valles AM, Franke WW, Thiery JP. Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells. J Cell Biol 1989;109:1495-509.
20. Lee EH, Joo CK. Role of transforming growth factor-beta in transdifferentiation and fibrosis of lens epithelial cells. Invest Ophthalmol Vis Sci 1999;40:2025-32.
21. Leavesley DI, Ferguson GD, Wayner EA, Cheresh DA. Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen. J Cell Biol 1992;117:1101-7.
22. Kang IC, Chung KH, Lee SJ, Yun Y, Moon HM, Kim DS. Purification and molecular cloning of a platelet aggregation inhibitor from the snake (Agkistrodon halys brevicaudus) venom. Thromb Res 1998;91:65-73.
23. Andley UP, Song Z, Wawrousek EF, Bassnett S. The molecular chaperone alphaA-crystallin enhances lens epithelial cell growth and resistance to UVA stress. J Biol Chem 1998;273:31252-61.
24. Sun TX, Das BK, Liang JJ. Conformational and functional differences between recombinant human lens alphaA- and alphaB-crystallin. J Biol Chem 1997;272: 6220-5.
25. Wang K, Spector A. alpha-crystallin stabilizes actin filaments and prevents cytochalasin- induced depolymerization in a phosphorylation-dependent manner. Eur J Biochem 1996;242:56-66.
26. Saika S, Kawashima Y, Miyamoto T, Okada Y, Tanaka SI, Ohmi S, et al. Immunolocalization of prolyl 4-hydroxylase subunits, alpha-smooth muscle actin, and extracellular matrix components in human lens capsules with lens implants. Exp Eye Res 1998;66: 283-94.
27. Lazard D, Sastre X, Frid MG, Glukhova MA, Thiery JP, Koteliansky VE. Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue. Proc Natl Acad Sci U S A 1993;90:999-1003.
28. Schmitt-Graff A, Pau H, Spahr R, Piper HM, Skalli O, Gabbiani G. Appearance of alpha-smooth muscle actin in human eye lens cells of anterior capsular cataract and in cultured bovine lens-forming cells. Differentiation 1990;43:115-22.
29. Nagamoto T, Eguchi G, Beebe DC. Alpha-smooth muscle actin expression in cultured lens epithelial cells. Invest Ophthalmol Vis Sci 2000;41:1122-9.
30. Santoro SA, Zutter MM. The alpha 2 beta 1 integrin: a collagen receptor on platelets and other cells. Thromb Haemost 1995;74:813-21.
31. Vandenberg P, Kern A, Ries A, Luckenbill-Edds L, Mann K, Kuhn K. Characterization of a type IV collagen major cell binding site with affinity to the alpha 1 beta 1 and the alpha 2 beta 1 integrins. J Cell Biol 1991;113:1475-83.
32. Elner SG, Elner VM. The integrin superfamily and the eye. Invest Ophthalmol Vis Sci 1996;37:696-701.
33. Kang IC, Lee YD, Kim DS. A novel disintegrin salmosin inhibits tumor angiogenesis. Cancer Res 1999;59:3754-60.
34. Kang IC, Kim DS, Jang Y, Chung KH. Suppressive mechanism of salmosin, a novel disintegrin in B16 melanoma cell metastasis. Biochem Biophys Res Commun 2000;275:169-73.
35. Gimona M, Mital R. The single CH domain of calponin is neither sufficient nor necessary for F-actin binding. J Cell Sci 1998;111:1813-21.
36. Qu G, Yan H, Strauch AR. Actin isoform utilization during differentiation and remodeling of BC3H1 myogenic cells. J Cell Biochem 1997;67:514-27.
37. Lebart MC, Mejean C, Boyer M, Roustan C, Benyamin Y. Localization of a new alpha-actinin binding site in the COOH-terminal part of actin sequence. Biochem Biophys Res Commun 1990;173:120-6.
38. Mitton KP, Tumminia SJ, Arora J, Zelenka P, Epstein DL, Russell P. Transient loss of alphaB-crystallin: an early cellular response to mechanical stretch. Biochem Biophys Res Commun 1997;235:69-73.
39. Serini G, Bochaton-Piallat ML, Ropraz P, Geinoz A, Borsi L, Zardi L, et al. The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. J Cell Biol 1998:142: 873-81.
40. Guilherme A, Torres K, Czech MP. Cross-talk between insulin receptor and integrin alpha5 beta1 signaling pathways. J Biol Chem 1998;273:22899-903.
41. Hazan RB, Norton L. The epidermal growth factor receptor modulates the interaction of E- cadherin with the actin cytoskeleton. J Biol Chem 1998;273:9078-84.
42. Wu C, Keightley SY, Leung-Hagesteijn C, Radeva G, Coppolino M, Goicoechea S, et al. Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity. J Biol Chem 1998;273:528-36.