Pulmonary adaptation to sustained changes in metabolic rate

Lung Development and Regeneration

Volumn , Issue , 2004, Pages 525-571

  Mortola, Jacopo P ^a  

^a MCGILL UNIVERSITY   (Canada)

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EID: 3543003789     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (214)

1. Mortola JP, Gautier H. Interaction between metabolism and ventilation: effects of respiratory gases and temperature. In: Dempsey JA, Pack AI, eds. Regulation of Breathing. 2d ed. Revised and Expanded, Lung Biology in Health and Disease Series. New York: Marcel Dekker, 1995:1011-1064.
2. Dempsey JA, Forster HV, Ainsworth DM. Regulation of hyperpnea, hyperventilation, and respiratory muscle recruitment during exercise. In: Dempsey JA, Pack AI, eds. Regulation of Breathing, 2d ed. Revised and Expanded, Lung Biology in Health and Disease Series. New York: Marcel Dekker, 1995:1065-1134.
3. Eden GJ, Hanson MA. Effects of chronic hypoxia from birth on the ventilatory response to acute hypoxia in the newborn rat. J Physiol (Lond) 1987; 392:11-19.
4. Hanson MA, Kumar P, Williams BA. The effect of chronic hypoxia upon the development of respiratory chemoreflexes in the newborn kitten. J Physiol (Lond) 1989; 411:563-574.
5. Okubo S, Mortola JP. Control of ventilation in adult rats hypoxic in the neonatal period. Am J Physiol 1990; 259:R836-R841.
6. Sladek M, Parker RA, Grogaard JB, Sundell HW. Long lasting effect of prolonged hypoxemia after birth on the immediate ventilatory response to changes in arterial partial pressure of oxygen in young lamb. Pediatr Res 1993; 34:821-828.
7. Ling L, Olson EB Jr, Vidruk EH, Mitchell GS. Attenuation of the hypoxic ventilatory response in adult rats following one month of perinatal hyperoxia. J Physiol (Lond) 1996; 495:561-571.
8. Matsuoka T, Yoda T, Ushikubo S, Matsuzawa S, Sasano T, Komiyama A. Repeated acute hypoxia temporarily attenuates the ventilatory respiratory response to hypoxia in conscious newborn rats. Pediatr Res 1999; 46:120-125.
9. Wohl MEB, Griscom NT, Strieder DJ, Schuster SR, Treves S, Zwerdling RG. The lung following repair of congenital diaphragmatic hernia. J Pediatr 1977; 90:405-414.
10. Cagle PT, Thurlbeck WM. Postpneumonectomy compensatory lung growth. Am Rev Respir Dis 1988; 138:1314-1326.
11. Rannels DE, Rannels SR. Compensatory growth of the lung following partial pneumonectomy. Exp Lung Res 1988; 14:157-182.
12. Hsia CCW, Herazo LF, Ramanathan M, Johnson RL Jr. Wagner PD. Cardiopulmonary adaptations to pneumonectomy in dogs. II. Va/Q relationships and microvascular recruitment. J Appl Physiol 74:1993;1299-1309.
13. Hsia CCW, Herazo LF, Ramanathan M, Johnson RL Jr. Cardiopulmonary adaptations to pneumonectomy in dogs. IV. Membrane diffusing capacity and capillary blood volume. J Appl Physiol 77:1994;998-1005.
14. Takeda SI, Hsia CCW, Wagner E, Ramanathan M, Estrera AS, Weibel ER. Compensatory alveolar growth normalizes gas-exchange function in immature dogs after pneumonectomy. J Appl Physiol 86:1999;1301-1310.
15. Kleiber M. Body size and metabolism. Hilgardia 1932; 6:315-353.
16. Brody S, Procter RC. Relation between basal metabolism and mature body weight in different species of mammals and birds. Univ Missouri Agric Exp Station Res Bull 1932; 166:89.
17. Dejours P. Principles of Comparative Respiratory Physiology. Amsterdam: North-Holland, 1975:1-253.
18. Mortola JP. Respiratory Physiology of Newborn Mammals. A Comparative Perspective. Baltimore: Johns Hopkins University Press, 2001:1-344.
19. Taylor CR, Weibel ER. Design of the mammalian respiratory system. 1. Problem and strategy. Respir Physiol 1981; 44:1-10.
20. Weibel ER, Taylor CR, O’Neil JJ, Leith DE, Gehr P, Hoppeler H, Langman V, Baudinette RV. Maximal oxygen consumption and pulmonary diffusing capacity: a direct comparison of physiologic and morphometric measurements in canids. Respir Physiol 1983; 54:173-188.
21. Gehr P, Mwangi DK, Ammann A, Maloiy GMO, Taylor CR, Weibel ER. Design of the mammalian respiratory system. V. Scaling morphometric pulmonary diffusing capacity to body mass: wild and domestic mammals. Respir Physiol 44:1981;61-86.
22. Weibel ER. Morphometric estimation of pulmonary diffusion capacity. V. Comparative morphometry of alveolar lungs. Respir Physiol 1972; 14:26-43.
23. Tenney SM, Remmers JE. Comparative quantitative morphology of the mammalian lung: diffusing area. Nature 197:54-56.
24. Stahl WR. Scaling of respiratory variables in mammals. J Appl Physiol 1967; 22:453-460.
25. Lechner AJ. The scaling of maximal oxygen consumption and pulmonary dimensions in small mammals. Respir Physiol 1978; 34:29-44.
26. Taylor CR, Maloiy GMO, Weibel ER, Langman VA, Kamau JMZ, Seeherman HJ, Heglund NC. Design of the mammalian respiratory system. III. Scaling maximum aerobic capacity to body mass: wild and domestic mammals. Respir Physiol 1980; 44:25-37.
27. Pasquis P, Lacaisse A, Dejours P. Maximal oxygen uptake in four species of small mammals. Respir Physiol 1970; 9:298-309.
28. O’Neil JJ, Leith DE. Lung diffusing capacity scaled in mammals from 25 g to 500 kg [abstr]. Fed Proc 1980; 39:972.
29. Bartlett D Jr, Areson JG. Quantitative lung morphology in newborn mammals. Respir Physiol 1977; 29:193-200.
30. Burri PH. Development and growth of the human lung. In: Fishman AP, Fisher AB, eds. Handbook of Physiology. Section 3: The Respiratory System. Vol. 1. Circulation and Nonrespiratory Functions. Bethesda, MD: American Physiological Society, 1985:1-46.
31. Spells KE. Some physical considerations relevant to the dimensions of lung alveoli. Nature 1968; 219:64-66.
32. Piiper J. Series ventilation, diffusion in airways, and stratified inhomogeneity. Federation Proc 1979; 38:17-21.
33. Schmidt-Nielsen K, Larimer JL. Oxygen dissociation curves of mammalian blood in relation to body size. Am J Physiol 1958; 195:424-428.
34. Bartels H. Comparative physiology of oxygen transport in mammals. Lancet 1964; 2:599-604.
35. Lahiri S. Blood oxygen affinity and alveolar ventilation in relation to body weight in mammals. Am J Physiol 1975; 229:529-536.
36. Lindstedt SL. Pulmonary transit time and diffusing capacity in mammals. Am J Physiol 1984; 246:384-388.
37. Mortola JP, Frappell PB. Ventilatory responses to changes in temperature in mammals and other vertebrates. Annu Rev Physiol 2000; 62:847-874.
38. Gehr P, Erni H. Morphometric estimation of pulmonary diffusion capacity in two horse lungs. Respir Physiol 1980; 41:199-210.
39. Weibel ER, Marques LB, Constantinopol M, Doffey F, Gehr P, Taylor CR. Adaptive variation in the mammalian respiratory system in relation to energetic demand: VI. The pulmonary gas exchanger. Respir Physiol 1987; 69:81-100.
40. Karas RH, Taylor CR, Jones JH, Linstedt SL, Reeves RB, Weibel ER. Adaptive variation in the mammalian respiratory system in relation to energetic demand: VII. Flow of oxygen across the pulmonary gas exchanger. Respir Physiol 1987; 69:101-115.
41. Taylor CR, Karas RH, Weibel ER, Hoppeler H. Matching structures and functions in the respiratory system: allometric and adaptive variations in energy demand. In: Wood SC, ed. Comparative Pulmonary Physiology. Current Concepts, Lung Biology in Health and Disease Series. New York: Marcel Dekker, 1989:27-65.
42. Tenney SM, Tenney JB. Quantitative morphology of cold-blooded lungs: amphibia and reptilia. Respir Physiol 1970; 9:197-215.
43. Hughes GM, Morgan M. The structure of fish gills in relation to their respiratory function. Biol Rev 1973; 48:419-475.
44. Perry SF. Mainstreams in the evolution of vertebrate respiratory structures. In: King AS, McLelland J, eds. Form and Function in Birds. Vol. 4. London: Academic Press, 1989:1-67.
45. Perry SF. Recent advances and trends in the comparative morphometry of vertebrate gas exchange organs. In: Boutilier RG, ed. Advances in Comparative and Environmental Physiology. Vol. 6. Berlin: Springer-Verlag, 1990:45-71.
46. Schmidt-Nielsen K. Scaling. Why is Animal Size so Important? Cambridge, UK: Cambridge University Press, 1984:1-241.
47. Rahn H, Paganelli CV, Ar A. The avian egg: air-cell gas tension, metabolism and incubation time. Respir Physiol 1974; 22:297-309.
48. Ar A, Rahn H. Pores in avian eggshells: gas conductance, gas exchange and embryonic growth rate. Respir Physiol 1985; 61:1-20.
49. Monge C, Leon-Velarde F. Physiological adaptation to high altitude: oxygen transport in mammals and birds. Physiol Rev 1991; 71:1135-1172.
50. Spells KE. Comparative studies in lung mechanics based on a survey of literature data. Respir Physiol 1969-1970; 8:37-57.
51. Mortola JP, Matsuoka T, Saiki C, Naso L. Metabolism and ventilation in hypoxic rats: effect of body mass. Respir Physiol 1994; 97:225-234.
52. Tenney SM, Morrison DH. Tissue gas tensions in small wild mammals. Respir Physiol 1967; 3:160-165.
53. 2 in the rat during growth and aging. Pfliigers Arch 1991; 419:38-42.
54. Nunn JF. Nunn’s Applied Respiratory Physiology (4th ed.). Oxford: Butterworth, 1993:1-658.
55. Phillipson EA, Kozar LF. Effect of aging on metabolic respiratory control in sleeping dogs. Am Rev Respir Dis 1993; 147:1521-1525.
56. Boggs DF, Tenney SM. Scaling respiratory pattern and respiratory’drive’. Respir Physiol. 1984; 58:245-251.
57. Frappell P, Lanthier C, Baudinette RV, Mortola JP. Metabolism and ventilation in acute hypoxia: a comparative analysis in small mammalian species. Am J Physiol 1992; 262:R1040-R1046.
58. Mortola JP. Ventilatory responses to hypoxia in mammals. In: Haddad GG, Lister G, eds. Tissue Oxygen Deprivation: Developmental, Molecular and Integrated Function, Lung Biology in Health and Disease Series, Vol. 95. New York: Marcel Dekker, 1996:433-477.
59. Mortola JP, Rezzonico R, Lanthier C. Ventilation and oxygen consumption during acute hypoxia in newborn mammals: a comparative analysis. Respir Physiol 1989; 78:31-43.
60. Rohlicek CV, Saiki C, Matsuoka T, Mortola JP. Oxygen transport in conscious newborn dogs during hypoxic hypometabolism. J Appl Physiol 1998; 84:763-768.
61. Stiebellehner L, Quittan M, End A, Wieselthaler G, Klepetko W, Haber P, Burghuber OC. Aerobic endurance training program, improves exercise performance in lung transplant recipients. Chest 1998; 113:906-912.
62. Hallstrand TS, Bates PW, Schoene RB. Aerobic conditioning in mild asthma decreases the hyperpnea of exercise and improves exercise and ventilatory capacity. Chest 2000; 118:1460-1469.
63. McClaran SR, Babcock MA, Pegelow DF, Reddan WG, Dempsey JA. Longitudinal effects of aging on lung function at rest and exercise in healthy active fit elderly adults. J Appl Physiol 1995; 78:1957-1968.
64. Bannister RG, Cotes JE, Jones RS, Meade F. Pulmonary diffusing capacity on exercise in athletes and non-athletic subjects. J Physiol (Lond) 1960; 152:66P-67P.
65. Mostyn EM, Helle S, Gee JBL, Bentivoglio LG, Bates DV. Pulmonary diffusing capacity of athletes. J Appl Physiol 1963; 18:687-695.
66. 2 transport system in humans. J Appl Physiol 1966; 21: 1463-1470.
67. Mehrotra PK, Varma N, Tiwari S, Kumar P. Pulmonary functions in Indian sportsmen playing different sports. Indian J Physiol Pharmacol 1998; 42:412-416.
68. Reuschlein PS, Reddan WG, Burpee J, Gee JBL, Rankin J. Effect of physical training on the pulmonary diffusing capacity during submaximal work. J Appl Physiol 1968; 24:152-158.
69. Koch G, Eriksson BO. Effect of physical training on anatomical R-L shunt at rest and pulmonary diffusing capacity during near-maximal exercise in boys 11-13 years old. Scand J Clin Lab Invest 1973; 31:95-103.
70. Engstrom I, Eriksson BO, Karlberg P, Saltin B, Thoren C. Preliminary report on the development of lung volumes in young girl swimmers. Acta Paediatr Scand Suppl 1971; 217:73-76.
71. Bartlett D Postnatal growth of the mammalian lung: influence of exercise and thyroid activity. Respir Physiol 1970; 9:50-57.
72. Fu FH. The effects of physical training on the lung growth of infant rats. Med Sci Sports 1976; 8:226-229.
73. Weibel ER. Scaling of structural and functional variables in the respiratory system. Annu Rev Physiol 1987; 49:147-159.
74. Geelhaar A, Weibel ER. Morphometric estimation of pulmonary diffusing capacity. III. The effect of increased oxygen consumption in Japanese waltzing mice. Respir Physiol 1971; 11:354-366.
75. Bartlett D Jr, Areson JG. Quantitative lung morphology in Japanese waltzing mice. J Appl Physiol 1978; 44:446-449.
76. 2. IIDPN as inducer of hyperactivity. Respir Physiol 1976; 28:129-140.
77. Hugonnaud C, Gehr P, Weibel ER, Burri PH. Adaptation of the growing lung to increased oxygen consumption. II. Morphometric analysis. Respir Physiol 1977; 29:1-10.
78. Massaro GD, Massaro D. Formation of pulmonary alveoli and gas-exchange surface area: quantitation and regulation. Annu Rev Physiol 1996; 58:73-92.
79. Hoch FL. Metabolic effects of thyroid hormones. In: Greer MA, Solomon DH, eds. Handbook of Physiology. Endocrinology: Thyroid. Vol. III. Section 7. Washington DC: American Physiological Society, 1974:391-411.
80. Callas G, Adkisson VT. The effects of desiccated thyroid on the rat lung. Anat Rec 1980; 197:331-337.
81. Adkisson VT, Callas G. Morphometric changes in the lungs of rats following adrenalectomy supplemented by desiccated thyroid. Anat Rec 1982; 203:147-156.
82. Thompson ME. Lung growth in response to altered metabolic demands in hamsters: influence of thyroid function and cold exposure. Respir Physiol 1980; 40:335-347.
83. Massaro D, Teich N, Massaro GD. Postnatal development of pulmonary alveoli: modulation in rats by thyroid hormones. Am J Physiol 1986; 250:R51-R55.
84. Wilson WR, Bedell GN. The pulmonary abnormalities in myxedema. J Clin Invest 1960; 39:42-55.
85. Dagianti A, Verde AM, Giordano G, Mastroberardino G, Caselli G, Vizza C. Risultati di un decennio di esperienze sul comportamento della diffusione polmonare in fisiologia ed in patologia. Min Med 1968; 59:5879-5913.
86. Zwillich CW, Matthay M, Potts DE, Adler R, Hofeldt F, Weil JV. Thyrotoxicosis: comparison of effects of thyroid ablation and beta-adrenergic blockade on metabolic rate and ventilatory control. J Clin Endocrinol Metab 1978; 46:491-500.
87. Zwillich CW, Pierson DJ, Hofeldt FD, Lufkin EG, Weil JV. Ventilatory control in myxedema and hypothyroidism. N Engl J Med 1975; 292:662-665.
88. McKeever KH, Malinowski K, Christensen RA, Hafs HD. Chronic recombinant equine somatotropin (eST) administration does not affect aerobic capacity or exercise performance in geriatric mares. Vet J 1998; 155:19-25.
89. Hansen JA, Yen JT, Nelssen JL, Nienaber JA, Goodband RD, Wheeler TL. Effects of somatotropin and solbutamol in three genotypes of finishing barrows: growth, carcass, and calorimetric criteria. J Anim Sci 1997; 75:1798-1809.
90. Brody JS, Fisher AB, Gocmen A, DuBois AB. Acromegalic pneumo-nomegaly: lung growth in the adult. J Clin Invest 1970; 49:1051-1060.
91. Toppell KL, Atkinson R, Whitcomb ME. Lung growth in acromegaly. Am Rev Respir Dis 1973; 108:1254-1258.
92. Evans CC, Hipkin LJ, Murray GM. Pulmonary function in acromegaly. Thorax 1977; 32:322-327.
93. De Troyer A, Desir D, Copinschi G. Regression of lung size in adults with growth hormone deficiency. Q J Med 1980; 49:329-340.
94. Donnelly PM, Grunstein RR, Peat JK, Woolcock AJ, Bye PTP. Large lungs and growth hormone: an increased alveolar number?. Eur Respir J 1995; 8:938-947.
95. Iandelli I, Gorini M, Duranti R, Bassi F, Misuri G, Pacini F, Rosi E, Scano G. Respiratory muscle function and control of breathing in patients with acromegaly. Eur Respir J 1997; 10:977-982.
96. García-Río F, Pino JM, Diez JJ, Ruiz A, Villasante C, Villamor J. Reduction in lung distensibility in acromegaly after suppression of growth hormone hypersecretion. Am J Respir Crit Care Med 2001; 164:852-857.
97. Jain BP, Brody JS, Fisher AB. The small lung of hypopituitarism. Am Rev Respir Dis 1973; 108:49-55.
98. Mansell AL, Levison H, Bailey JD. Maturation of lung function in children with hypopituitarism. Am Rev Respir Dis 1983; 127:166-170.
99. Meineri I, Andreani O, Sanna R, Aglialoro A, Bottino G, Giusti M. Effect of low-dosage recombinant human growth hormone therapy on pulmonary function in hypopituitary patients with adult-onset growth hormone deficiency. J Endocrinol Invest 1998; 21:423-427.
100. Merola B, Sofia M, Longobardi S, Fazio S, Micco A, Esposito V, Colao A, Biondi B, Lombardi G. Impairment of lung volumes and respiratory muscle strength in adult patients with growth hormone deficiency. Eur J Endocrinol 1995; 133:680-685.
101. Merola B, Longobardi S, Sofia M, Pivonello R, Micco A, Di Rella F, Esposito V, Colao A, Lombardi G. Lung volumes and respiratory muscle strength in adult patients with childhood- or adult-onset growth hormone deficiency: effect of 12 months’ growth hormone replacement therapy. Eur J Endocrinol 1996; 135:553-558.
102. Brody JS, Buhain WJ. Hormone-induced growth of the adult lung. Am J Physiol 1972; 223:1444-1450.
103. Brody JS, Buhain WJ. Hormonal influence on post-pneumonectomy lung growth in the rat. Respir Physiol 1973; 19:344-355.
104. Bartlett D. Postnatal growth of the mammalian lung: influence of excess growth hormone. Respir Physiol 1971; 12:297-304.
105. Gaultier C, Harf A, Girard F. Lung mechanics in growing guinea pigs treated with growth hormone. J Dev Physiol 1986; 8:315-321.
106. Sahebjami H. Nutrition and the pulmonary parenchyma. Clin Chest Med 1986; 7:111-126.
107. Sahebjami H. Nutrition and lung structure and function. Exp Lung Res 1993; 19:105-124.
108. Gaultier C, Crapo R. Effects of nutrition, growth hormone disturbances, training, altitude and sleep on lung volumes. Eur Respir J 1997; 10:1919-2913.
109. Munch IC, Markussen NH, Øritsland NA. Resting oxygen consumption in rats during food restriction, starvation and refeeding. Acta Physiol Scand 1993; 148:335-340.
110. Gregorio CA, Gail DB, Massaro D. Influence of fasting on lung oxygen consumption and respiratory quotient. Am J Physiol 1976; 230:291-294.
111. Sant’Anna G, Mortola JP. Thermal and respiratory control in young rats with altered caloric intake during postnatal development. Respir Physiol Neurobiol 2002; 133:215-227.
112. Doekel RC Jr, Zwillich CH, Scoggin CH, Kryger M, Weil JV. Clinical semistarvation. Depression of hypoxic ventilatory response. N Engl J Med 1976; 295:358-361.
113. Lechner AJ. Perinatal age determines the severity of retarded lung development induced by starvation. Am Rev Respir Dis 1985; 131:638-643.
114. Lechner AJ, Winston DC, Bauman JE. Lung mechanics, cellularity, and surfactant after prenatal starvation in guinea pigs. J Appl Physiol 1986; 60:1610-1614.
115. Karlinsky JB, Goldstein RH, Ojserkis B, Sneider GL. Lung mechanic and connective tissue levels in starvation-induced emphysema in hamsters. Am J Physiol 1986; 251:R282-R288.
116. Sahebjami H, Wirman JA. Emphysema-like changes in the lungs of starved rats. Am Rev Respir Dis 1981; 124:619-624.
117. Das RM. The effects of intermittent starvation on lung development in suckling rats. Am J Pathol 1984; 117:326-332.
118. Harkema JR, Mauderly JL, Gregory RE, Pickrell JA. A comparison of starvation and elastase models of emphysema in the rat. Am Rev Respir Dis 1984; 129:584-591.
119. Sahebjami H, MacGee J. Effects of starvation on lung mechanics and biochemistry in young and old rats. J Appl Physiol 1985; 58:778-784.
120. Kerr JS, Riley DJ, Lanza-Jacoby S, Berg RA, Spilker HC, Yu SY, Edelman NH. Nutritional emphysema in the rat. Influence of protein depletion and impaired lung growth. Am Rev Respir Dis 1985; 131:644-650.
121. Massaro D, Teich N, Maxwell S, Massaro GD, Whitney P. Postnatal development of alveoli. Regulation and evidence for a critical period in rats. J Clin Invest 1985; 76:1297-1305.
122. Massaro GD, Radaeva S, Clerch LB, Massaro D. Lung alveoli: endogenous programmed destruction and regeneration. Am J Physiol 2002; 283:L305-L309.
123. Lechner AJ. Starvation-induced organ hypoplasia in prenatal and postnatal guinea pigs. Biol Neonate 1985; 48:36-42.
124. Sahebjami H, MacGee J. Effects of starvation and refeeding on lung biochemistry in rats. Am Rev Respir Dis 1982; 126:483-487.
125. Sahebjami H, MacGee J. Changes in connective tissue composition of the lung in starvation and refeeding. Am Rev Respir Dis 1983; 128:644-647.
126. Sahebjami H, Vassallo CL. Effects of starvation and refeeding on lung mechanics and morphometry. Am Rev Respir Dis 1979; 119:443-451.
127. Sahebjami H, Domino M. Effects of starvation and refeeding on elastase-induced emphysema. J Appl Physiol 1989; 66:2611-2616.
128. Weis HS, Jurrus E. Starvation on compliance and surfactant of the rat lung. Respir Physiol 1971; 12:123-129.
129. Thet LA, Alvarez H. Effect of hyperventilation and starvation on rat lung mechanics and surfactant. Am Rev Respir Dis 1982; 126:286-290.
130. Kalenga M, Henquin JC. Protein deprivation from the neonatal period impairs lung development in the rat. Pediatr Res 1987; 21:45-49.
131. Kalenga M, Henquin JC. Alteration of lung mechanics by protein-calorie malnutrition in weaned rats. Respir Physiol 1987; 68:29-39.
132. Curle DC, Adamson IYR. Retarded development of neonatal rat lung by maternal malnutrition. J Histochem Cytochem 1978; 26:401-408.
133. Lechner AJ. Interaction of prenatal starvation and dexamethasone treatment on lung development in newborn guinea pigs. Am Rev Respir Dis 1987; 135:991-996.
134. Rochester DF. Obesity and abdominal distention. In: Roussos C ed. The Thorax. 2d ed. Revised and Expanded, Lung Biology in Health and Disease Series. Vol. 85. New York: Marcel Dekker, 1995:1951-1973.
135. Winick M, Noble A. Cellular response with increased feeding in neonatal rats. J Nutr 1967; 91:179-182.
136. Inselman LS, Wapnir RA, Spencer H. Obesity-induced hyperplastic lung growth. Am Rev Respir Dis 1987; 135:613-616.
137. Inselman LS, Padilla-Burgos LB, Teichberg S, Spencer H. Alveolar enlargement in obesity-induced hyperplastic lung growth. J Appl Physiol 1988; 65:2291-2296.
138. Zwillich CW, Sahn SA, Weil JV. Effects of hypermetabolism on ventilation and chemosensitivity. J Clin Invest 1977; 60:900-906.
139. Lechner AJ, Tull DS. Prenatal starvation retards development of the ventilatory response to hypoxia in newborn guinea pigs. Pediatr Res 1986; 20:920-924.
140. Secor SM, Diamond JM. Evolution of regulatory responses to feeding in snakes. Physiol Biochem Zool 2000; 73:123-141.
141. Wikelski M, Thom C. Marine iguanas shrink to survive El Nino. Nature 2000; 403:37-38.
142. Secor SM. Physiological responses to long-term fasting in amphibians and reptiles (abstract # 2493) IUPS meeting, Christchurch, NZ, 2001.
143. Sahebjami H, Domino M. Effects of repeated cycles of starvation and refeeding on lungs of growing rats. J Appl Physiol 1992; 73:2349-2354.
144. Weiss AK. Tissue responses in the cold-exposed rat. Am J Physiol 1957; 188:430-434.
145. 2: III. The effect of exposure to cold environment in rats. Respir Physiol 1978; 32:345-353.
146. Lechner AJ, Banchero N. Lung morphometry in guinea pigs acclimated to cold during growth. J Appl Physiol 1980; 48:886-891.
147. Lechner AJ, Grimes MJ, Aquin L, Banchero N. Adaptive lung growth during chronic cold plus hypoxia is age-dependent. J Exp Zool 1982; 219: 285-291.
148. Shishkin GS, Ustyuzhaninova NV. Morphological peculiarities of respiratory compartments of arctic animal lungs. Anat Rec 1997; 247:494-500.
149. Saetta M, Noworaj A, Mortola JP. Cold exposure of the pregnant rat and neonatal respiration. Exp Biol 1988; 47:177-181.
150. Sant’Anna G, Mortola JP. Thermal and respiratory control in young rats exposed to cold during postnatal development. Comp Biochem Physiol A 2003; 134:449-459.
151. Symonds ME, Andrews DC, Buss DS, Clarke L, Darby CJ, Johnson P, Lomax MA. Environmental effects on thermoregulation and breathing patterns during early postnatal development in hand-reared lambs. Exp Physiol 1995; 80:779-792.
152. Arciero PJ, Goran MI, Poehlman ET. Resting metabolic rate is lower in women than in men. J Appl Physiol 1993; 75:1520-2514.
153. Becklake MR, Kauffmann F. Gender differences in airway behaviour over the human life span. Thorax 1999; 54:1119-1138.
154. Nasr SZ, Amato P, Wilmott RW. Predicted values for lung diffusing capacity in healthy children. Pediatr Pulmonol 1991; 10:267-272.
155. Neas LM, Schwartz J. The determinants of pulmonary diffusing capacity in a national sample of U. S. adults. Am J Respir Crit Care Med 1996; 153:656-664.
156. Massaro GD, Mortola JP, Massaro D. Sexual dimorphism in the architecture of the lung’s gas-exchange region. Proc Natl Acad Sci USA 1995; 92:1105-1107.
157. Massaro GD, Mortola JP, Massaro D. Estrogen modulates the dimensions of the lung’s gas-exchange surface area and alveoli in female rats. Am J Physiol 1996; 270:L110-L114.
158. Faridy EE, Bucher S, Sanii MR. Relationship between maternal and fetal lung growth. Respir Physiol 1988; 72:171-186.
159. Faridy EE, Bucher S. Maternal lung growth in surgically reduced litter size pregnancy. Respir Physiol 1988; 72:187-194.
160. Faridy EE, Sanii MR, Thliveris JA. fetal lung growth: influence of maternal exposure to cold and exercise in rats. Respir Physiol 1989; 75:309-326.
161. Romanova LK, Zhikhareva IA. On the humoral regulation of restorative growth in the lungs, kidneys and liver. Biull Eksp Biol Med 1972; 73:84-87.
162. Faridy EE, Sanii MR, Thliveris JA. Influence of maternal pneumonectomy on fetal lung growth. Respir Physiol 1988; 72:195-210.
163. Aitken ML, Franklin JL, Pierson DJ, Schoene RB. Influence of body size and gender on control of ventilation. J Appl Physiol 1986; 60:1894-1899.
164. White DP, Douglas NJ, Pickett CK, Weil JV, Zwillich CW. Sexual influences on the control of breathing. J Appl Physiol 1983; 54:874-879.
165. Machida H. Influence of progesterone on arterial blood and CSF acid-base balance in women. J Appl Physiol 1981; 51:1433-1436.
166. Mortola JP, Saiki C. Ventilatory response to hypoxia in rats: gender differences. Respir Physiol 1996; 106:21-34.
167. Gonzales R, Wood S. The effect of gender and body temperature on the ventilatory response to hypoxia in hooded rats [abstr]. FASEB J 1994; 8: A840.
168. Tenney SM, Remmers JE. Alveolar dimensions in the lungs of animals raised at high altitude. J Appl Physiol 1966; 21:1328-1330.
169. Lechner AJ. Metabolic performance during hypoxia in native and acclimated pocket gophers. J Appl Physiol 1977; 43:965-970.
170. Pearson OP, Pearson AK. A stereological analysis of the ultrastructure of the lungs of wild mice living at low and high altitude. J Morphol 1976; 150:359-368.
171. Olson EB Jr, Dempsey JA. Rat as a model for humanlike ventilatory adaptation to chronic hypoxia. J Appl Physiol 1978; 44:763-769.
172. Seifert EL, Mortola JP. Circadian pattern of ventilation during prolonged hypoxia in conscious rats. Respir Physiol Neurobiol 2002; 133:23-34.
173. Bartlett D Jr. Postnatal growth of the mammalian lung: influence of low and high oxygen tension. Respir Physiol 1970; 9:58-64.
174. Bartlett D Jr, Remmers JE. Effects of high altitude exposure on the lungs of young rats. Respir Physiol 1971; 13:116-125.
175. Mortola JP, Morgan CA, Virgona V. Respiratory adaptation to chronic hypoxia in newborn rats. J Appl Physiol 1986; 61:1329-1336.
176. Lechner AJ, Banchero N. Lung morphometry in guinea pigs acclimated to hypoxia during growth. Respir Physiol 1980; 42:155-169.
177. Johnson RL Jr, Cassidy SS, Grover RF, Schutte JE, Epstein RH. Functional capacities of lungs and thorax in beagles after prolonged residence at 3,100 m. J Appl Physiol 1985; 59:1773-1782.
178. Okubo S, Mortola JP. Respiratory mechanics in adult rats hypoxic in the neonatal period. J Appl Physiol 1989; 66:1772-1778.
179. Bucher JR, Roberts RJ. The development of the newborn rat lung in hyperoxia: a dose-response study of lung growth, maturation, and changes in antioxidant enzyme activities. Pediatr Res 1981; 15:999-1008.
180. Randell SH, Mercer RR, Young SL. Postnatal growth of pulmonary acini and alveoli in normal and oxygen-exposed rats studied by serial section reconstructions. Am J Anat 1989; 186:55-68.
181. Randell SH, Mercer RR, Young SL. Neonatal hyperoxia alters the pulmonary alveolar and capillary structure of 40-day-old rats. Am J Pathol 1990; 136:1259-1266.
182. 2 on the growing lung. Adaptation of the growing rat lung to hypoxia and hyperoxia. Respir Physiol 1971; 11:247-264.
183. Dotta A, Mortola JP. Postnatal development of the denervated lung in normoxia, hypoxia, or hyperoxia. J Appl Physiol 1992; 73:1461-1466.
184. Cunningham EL, Brody JS, Jain BP. Lung growth induced by hypoxia. J Appl Physiol 1974; 37:362-366.
185. Sekhon HS, Thurlbeck WM. Lung morphometric changes after exposure to hypobaria and/or hypoxia and undernutrition. Respir Physiol 1996; 106:99-107.
186. Sekhon HS, Wright JL, Thurlbeck WM. Pulmonary function alterations after 3 wk of exposure to hypobaria and/or hypoxia in growing rats. J Appl Physiol 1995; 78:1787-1792.
187. 2. Am J Physiol 1991; 261:L370-L377.
188. Xu J, Liu M, Tanswell AK, Post M. Mesenchymal determination of mechanical strain-induced fetal lung cell proliferation. Am J Physiol 1998; 275:L545-L550.
189. Mourgeon E, Xu J, Tanswell AK, Liu M, Post M. Mechanical strain-induced posttranscriptional regulation of fibronectin production in fetal lung cells. Am J Physiol 1999; 277:L142-L149.
190. Mansell AL, Rojas JV, Sillos EM, Stolar CJ, Collins MH, Rozovski SJ. Diaphragmatic activity is a determinant of postnatal lung growth. J Appl Physiol 1986; 61:1098-1103.
191. Mortola JP, Saetta M, Bartlett D Jr, Postnatal development of the lung following denervation. Respir Physiol 1987; 67:137-145.
192. Pepelko WE. Effects of hypoxia and hypercapnia, singly and combined, on growing rats. J Appl Physiol 1970; 28:646-651.
193. Lechner AJ, Blake CI, Banchero N. Pulmonary development in growing guinea pigs exposed to chronic hypercapnia. Respiration 1987; 52:108-114.
194. Rezzonico R, Mortola JP. Respiratory adaptation to chronic hypercapnia in newborn rats. J Appl Physiol 1989; 67:311-315.
195. Dusseau JW, Hutchins PM. Hypoxia-induced angiogenesis in chick chorioallantoic membranes: a role for adenosine. Respir Physiol 1988; 71:33-44.
196. Bond AN. An analysis of the response of salamander gills to changes in the oxygen concentration of the medium. Dev Biol 1960; 2:1-20.
197. Sollid J, De Angelis P, Gundersen K, Nilsson GE. Hypoxia induces adaptive and reversible gross morphological changes in crucian carp gills. J Exp Biol 2003; 206:3667-3673.
198. Schmitz A, Harrison JF. Hypoxic tolerance in air-breathing invertebrates. Respir Physiol Neurobiol 2004. In press.
199. Simnett JD, Fisher JM, Heppleston AG. Tissue-specific inhibition of lung alveolar mitosis in organ culture. Nature 1969; 223:944-946.
200. Fisher JM, Simnett JD. Morphogenetic and proliferative changes in the regenerating lung of the rat. Anat Rec 1973; 176:389-396.
201. Smith BT, Galaugher W, Thurlbeck WM. Serum from pneumonectomized rabbits stimulates alveolar type II cell proliferation in vitro. Am Rev Respir Dis 1980; 121:701-707.
202. Teitel D, Sidi D, Bernstein D, Heymann MA, Rudolph AM. Chronic hypoxemia in the newborn lamb: cardiovascular, hematopoietic, and growth adaptations. Pediatr Res 1985; 19:1004-1010.
203. Bernstein D, Teitel DF, Rudolph AM. Chronic anemia in the newborn lamb: cardiovascular adaptations and comparison to chronic hypoxemia. Pediatr Res 1988; 23:621-627.
204. Cote A, Porras H. Respiratory, cardiovascular, and metabolic adjustments to hypoxemia during sleep in piglets. Can J Physiol Pharmacol 1998; 76:747-755.
205. Rohlicek CV, Saiki C, Matsuoka T, Mortola JP. Cardiovascular and respiratory consequences of body warming during hypoxia in conscious newborn cats. Pediatr Res 1996; 40:1-5.
206. Lister G. Metabolic demands during hypoxia. In: Haddad GG, Lister G, eds. Tissue Oxygen Deprivation: Developmental, Molecular and Integrated Function, Lung Biology in Health and Disease Series. Vol. 95. New York: Marcel Dekker, 1996:885-914.
207. Sukumar M, Morin FCResponse of the fetal circulation to stress. In: Polin RA, Fox WW, eds. Fetal and Neonatal Physiology. Philadelphia: WB Saunders, 1998:1014-1031.
208. Brubakk AM, Oh W, Stonestreet BS. Prolonged hypercarbia in the awake newborn piglet: effect on brain blood flow and cardiac output. Pediatr Res 1987; 21:29-33.
209. Pitt BR, Davies P, Schwarz MA. Gene regulation during hypoxia. In: Haddad GG, Lister G, eds. Tissue Oxygen Deprivation: Developmental, Molecular and Integrated Function, Lung Biology in Health and Disease Series. Vol. 95. New York: Marcel Dekker, 1996:101-111.
210. Han RNN, Buch S, Tseu I, Young J, Christie NA, Frndova H, Lye SJ, Post M, Tanswell AK. Changes in structure, mechanics, and insulin-like growth factor-related gene expression in the lungs of newborn rats exposed to air or 60% oxygen. Pediatr Res 1996; 39:921-926.
211. 2. Pediatr Res 2000; 48:423-433.
212. Bartlett D Jr. Postnatal growth of the mammalian lung; lack of influence by carbon monoxide exposure. Respir Physiol 1975; 23:343-349.
213. Paulone ME, Edelstone DI, Shedd A. Effects of maternal anemia on uteroplacental and fetal oxidative metabolism. Am J Obstet Gynecol 1987; 156:230-236.
214. Wilkening RB, Meschia G. Fetal oxygen uptake, oxygenation and acid-base balance as a function of uterine blood flow. Am J Physiol 1983; 244:H749-H755.