In vitro cell culture model for anti-cataract drug penetration studies

Pharmazie

Volumn 62, Issue 10, 2007, Pages 767-772

  Jiang, T Y ^a   Wang, Siling L ^a   Liu, Y ^a   Nie, S F ^c   Ito, Y ^b   Nagai, N ^b   Wu, C F ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b KINKI UNIVERSITY   (Japan)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 3A1; DIETHYLDITHIOCARBAMIC ACID; DISULFIRAM; TRYPAN BLUE; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATARACT; CELL ASSAY; CELL CULTURE; CONTROLLED STUDY; CORNEA; DRUG PENETRATION; ELECTRIC RESISTANCE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALDEHYDE DEHYDROGENASE; ANIMALS; CATARACT; CELL LINE; CELL MEMBRANE PERMEABILITY; COLLAGEN TYPE IV; COLORING AGENTS; CORNEA; DISULFIRAM; DITIOCARB; ELECTRIC CONDUCTIVITY; EPITHELIAL CELLS; EPITHELIUM, CORNEAL; HUMANS; LENS, CRYSTALLINE; RABBITS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRYPAN BLUE;

EID: 35348997338     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2007.10.7035     Document Type: Article

References (13)

1. Adson A, Raub T, Burton P, Barsuhn C, Hilgers A, Audus K, Ho N (1994) Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayers. J Pharm Sci 83: 1529-1536.
2. Ahmed I, Francoeur M, Thombre A, Patton T (1989) The kinetics of timolol in the rabbit lens: implications for ocular drug delivery. Pharm Res 6: 772-778.
3. Harocopos GJ, Alvares KM, Kolker AE, Beebe DC (1998) Human age-related cataract and lens epithelial cell death. Invest Ophthalmol Vis Sci 39: 2696-2706.
4. Hightower K (1995) The role of the lens epithelium in development of UV cataract. Curr Eye Res 14: 71-78.
5. Ibaraki N, Chen SC, Lin LR, Okamoto H, Pipas JM, Reddy VN (1998) Human lens epithelial cell line. Exp Eye Res 67: 577-585.
6. Kalariya N, Rawal UM, Vasavada AR (1998) Human lens epithelial layer in cortical cataract. Indian J Ophthalmol 46: 159-162.
7. King G, Holmes R (1998) Human ocular aldehyde dehydrogenase isozymes: distribution and properties as major soluble proteins in cornea and lens. J Exp Zool 282: 12-17.
8. Li D, Ito Y, Wang S, Zhang J, Wu C (2005) Diethyldithiocarbamate inhibits iNOS expression in human lens epithelial cells stimulated by IFN-γ and LPS. Acta Pharmacol Sin 26: 359-363.
9. Toropainen E, Ranta VP, Talvitie A, Suhonen P, Urtti A (2001) Culture model of human corneal epithelium for prediction of ocular drug absorption. Invest Ophthalmol Vis Sci 42: 2942-2948.
10. Vallari RC, Pietruszko R (1982) Human aldehyde dehydrogenase: mechanism of inhibition of disulfiram. Science 216: 637-639.
11. Wang S, Li D, Ito Y, Nabekura T, Wang S, Zhang J, Wu C (2004) Bioavailability and anticataract effects of a topical ocular drug delivery system containing disulfiram and hydroxypropyl-beta-cyclodextrin on selenite-treated rats. Curr Eye Res 29: 51-58.
12. Yan Q, John IC, Thomas NW, Helene ES (2002) Alterations in the lens capsule contribute to cataractogenesis in SPARC-null mice. J Cell Sci 115: 2747-2756.
13. Zhang K, Li S (1995) Effect of homoharringtonine on lens epithelial cells in rabbits. Yan Ke Xue Bao 11: 192-196.