Deterioration of growth hormone (GH) response and anterior pituitary function in young adults with childhood-onset GH deficiency and ectopic posterior pituitary: A two-year prospective follow-up study

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 10, 2007, Pages 3875-3884

  Di Iorgi, Natascia ^a   Secco, Andrea ^a   Napoli, Flavia ^a   Tinelli, Carmine ^b   Calcagno, Annalisa ^a   Fratangeli, Nadia ^a   Ambrosini, Linda ^a   Rossi, Andrea ^a   Lorini, Renata ^a   Maghnie, Mohamad ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CHOLESTEROL; FIBRINOGEN;

ADOLESCENT; ADULT; ARTICLE; BLOOD PRESSURE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; FIBRINOGEN BLOOD LEVEL; FOLLOW UP; GROWTH HORMONE DEFICIENCY; HORMONE RELEASE; HUMAN; HYPOPHYSIS FUNCTION; INSULIN TOLERANCE TEST; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIODIAGNOSIS; STATISTICAL SIGNIFICANCE; UNIVERSITY HOSPITAL; WAIST CIRCUMFERENCE;

EID: 35348991074     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2007-1081     Document Type: Article

References (40)

1. De Boer H, Blok GJ, Van Der Veen EA 1995 Clinical aspects of growth hormone deficiency in adults. Endocr Rev 16:63-86
2. Shalet SM, Rahim A, Toogood A 1999 Growth hormone therapy for adult growth hormone deficiency. Trends Endocrinol Metab 7:287-290
3. Rosen T, Bengtsson BA 1990 Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 336:285-288
4. Drake WM, Howell SJ, Monson JP, Shalet SM 2001 Optimizing GH therapy in adults and children. Endocr Rev 22:425-450
5. Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G 2001 Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients with GH deficiency. J Clin Endocrinol Metab 86:1874-1881
6. Longobardi S, Merola B, Pivonello R, Di Rella F, Di Somma C, Colao A, Ghigo E, Camanni F, Lombardi G 1996 Reevaluation of growth hormone (GH) secretion in 69 adults diagnosed as GH-deficient patients during childhood. J Clin Endocrinol Metab 81:1244-1247
7. Tauber M, Moulin P, Pienkowski C, Jouret B, Rochiccioli P 1997 Growth hormone (GH) retesting and auxological data in 131 GH-deficient patients after completion of treatment. J Clin Endocrinol Metab 82:352-356
8. Juul A, Kastrup KW, Pedersen SA, Skakkebaek NE 1997 Growth hormone (GH) provocative retesting of 108 young adults with childhood-onset GH deficiency and the diagnostic value of insulin-like growth factor I (IGF-I) and IGF-binding protein-3. J Clin Endocrinol Metab 82:1195-1201
9. Maghnie M, Strigazzi C, Tinelli C, Autelli M, Cisternino M, Loche S, Severi F 1999 Growth hormone (GH) deficiency (GHD) of childhood onset: reassessment of GH status and evaluation of the predictive criteria for permanent GHD in young adults. J Clin Endocrinol Metab 84:1324-1328
10. Maghnie M, Aimaretti G, Bellone S, Bona G, Bellone J, Baldelli R, de Sanctis C, Gargantini L, Gastaldi R, Ghizzoni L, Secco A, Tinelli C, Ghigo E 2005 Diagnosis of GH deficiency in the transition period: accuracy of insulin tolerance test and insulin-like growth factor-I measurement. Eur J Endocrinol 152:589-596
11. 1998 Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency. J Clin Endocrinol Metab 83:379-381
12. Clayton PE, Cuneo RC, Juul A, Monson JP, Shalet SM, Tauber M 2005 Consensus statement on the management of the GH-treated adolescent in the transition to adult care. Eur J Endocrinol152:165-170
13. Leger J, Danner S, Simon D, Garel C, Czernichow P 2005 Do all patients with childhood-onset growth hormone deficiency (GHD) and ectopic neurohypophysis have persistent GHD in adulthood? J Clin Endocrinol Metab 90:650-656
14. Maghnie M, Triulzi F, Larizza D, Preti P, Priora C, Scotti G, Severi F 1991 Hypothalamic-pituitary dysfunction in growth hormone-deficient patients with pituitary abnormalities. J Clin Endocrinol Metab 72:79-83
15. Maghnie M, Genovese E, Villa A, Spagnolo L, Campani R, Severi F 1996 Dynamic MRI in the congenital agenesis of the neural pituitary stalk syndrome: the role of the vascular pituitary stalk in predicting residual anterior pituitary function. Clin Endocrinol (Oxf) 45:281-290
16. Ghigo E, Aimaretti G, Arvat E and Camanni F 2001 Growth hormone-releasing hormone combined with arginine or growth hormone secretagogues for the diagnosis of growth hormone deficiency in adults. Endocrine 15:29-38
17. Elmlinger MW, Kuhnel W, Weber MM, Ranke MB 2004 Reference ranges for two automated chemiluminescent assays for serum insulin-like growth factor I (IGF-I) and IGF binding protein 3 (IGFBP-3). Clin Chem Lab Med 42:654-664
18. Metz CE 1978 Basic principles of ROC analysis. Semin Nucl Med 8:283-298
19. Schoonjans F, Zalata A, Depuydt CE, Comhaire FH 1995 MedCalc: a new computer program for medical statistics. Comput Methods Programs Biomed 48:257-262
20. Maghnie M, Uga E, Temporini F, Di Iorgi N, Secco A, Tinelli C, Papalia A, Casini MR, Loche S 2005 Evaluation of adrenal function in patients with growth hormone-deficiency and hypothalamic-pituitary disorders: comparison between insulin-induced hypoglycemia, low-dose ACTH, standard ACTH and CRH stimulation tests. Eur J Endocrinol 152:735-741
21. Colao A, Di Somma C, Spiezia S, Rota F, Pivonello R, Savastano S, Lombardi G 2006 The natural history of partial growth hormone deficiency in adults: a prospective study on the cardiovascular risk and atherosclerosis. J Clin Endocrinol Metab 91:2191-2200
22. Colao A, Cerbone G, Pivonello R, Aimaretti G, Loche S, Di Somma C, Faggiano A, Corneli G, Ghigo E, Lombardi G 1999 The growth hormone (GH) response to the arginine plus GH-releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH deficiency. J Clin Endocrinol Metab 84:1277-1282
23. Colao A, Di Somma C, Pivonello R, Loche S, Aimaretti G, Cerbone G, Faggiano A, Corneli G, Ghigo E, Lombardi G 1999 Bone loss is correlated to the severity of growth hormone deficiency in adult patients with hypopituitarism. J Clin Endocrinol Metab 84:1919-1924
24. Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G 2004 The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: an observational, case-control study. J Clin Endocrinol Metab 89:5998-6004
25. Murray RD, Bidlingmaier M, Strasburger CJ, Shalet SM 2007 The diagnosis of partial GH deficiency in adults with a putative insult to the hypothalamopituitary axis. J Clin Endocrinol Metab 92:1705-1709
26. Zucchini S, Pirazzoli P, Baronio F, Gennari M, Bal MO, Balsamo A, Gualandi S, Cicognani A 2006 Effect on adult height of pubertal growth hormone retesting and withdrawal of therapy in patients with previously diagnosed growth hormone deficiency. J Clin Endocrinol Metab 91:4271-4276
27. Loche S, Bizzarri C, Maghnie M, Faedda A, Tzialla C, Autelli M, Casini MR, Cappa M 2002 Results of early reevaluation of growth hormone secretion in short children with apparent growth hormone deficiency. J Pediatr 140:445-449
28. Corneli G, Di Somma C, Baldelli R, Rovere S, Gasco V, Croce CG, Grottoli S, Maccario M, Colao A, Lombardi G, Ghigo E, Camanni F, Aimaretti G 2005 The cut-off limits of the GH response to GH-releasing hormone-arginine test related to body mass index. Eur J Endocrinol 153:257-264
29. Maghnie M, Salati B, Bianchi S, Rallo M, Tinelli C, Autelli M, Aimaretti GL, Ghigo E 2001 Relationship between the morphological evaluation of the pituitary and the growth hormone (GH) response to GH-releasing hormone plus arginine in children and adults with congenital hypopituitarism. J Clin Endocrinol Metab 86:1574-1579
30. Maghnie M, Cavigioli F, Tinelli C, Autelli M, Aricò M, Aimaretti G, Ghigo E 2002 GHRH plus arginine in the diagnosis of acquired GH deficiency of childhood-onset. J Clin Endocrinol Metab 87:2740-2744
31. Maghnie M, Pennati MC, Civardi E, Di Iorgi N, Aimaretti G, Foschini ML, Corneli G, Tinelli C, Ghigo E, Lorini R, Loche S 2007 GH response to ghrelin in subjects with congenital GH deficiency: evidence that ghrelin action requires hypothalamic-pituitary connections. Eur J Endocrinol 156:449-454
32. Radetti G, di Iorgi N, Paganini C, Gastaldi R, Napoli F, Lorini R, Maghnie M 2007 The advantage of measuring spontaneous growth hormone secretion compared with the insulin tolerance test in the diagnosis of growth hormone deficiency in young adults. Clin Endocrinol (Oxf) 67:78-84
33. Tauber M, Jouret B, Cartault A, Lounis N, Gayrard M, Marcouyeux C, Pienkowski C, Oliver I, Moulin P, Otal P, Joffre F, Arnaud C, Rochiccioli P 2003 Adolescents with partial growth hormone (GH) deficiency develop alterations of body composition after GH discontinuation and require follow-up. J Clin Endocrinol Metab 88:5101-5106
34. Murray RD, Adams JE, Shalet SM 2004 Adults with partial growth hormone deficiency have an adverse body composition. J Clin Endocrinol Metab 89:1586-1591
35. Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G 2005 Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency. J Clin Endocrinol Metab 90:5146-5155
36. Vahl N, Juul A, Jorgensen JO, Orskov H, Skakkebaek NE, Christiansen JS 2000 Continuation of growth hormone (GH) replacement in GH-deficient patients during transition from childhood to adulthood: a two-year placebo-controlled study. J Clin Endocrinol Metab 85:1874-1881
37. Darzy KH, Aimaretti G, Wieringa G, Gattamaneni HR, Ghigo E, Shalet SM 2003 The usefulness of the combined growth hormone (GH)-releasing hormone and arginine stimulation test in the diagnosis of radiation-induced GH deficiency is dependent on the post-irradiation time interval. J Clin Endocrinol Metab 88:95-102
38. Molitch ME, Clemmons DR, Malozowski S, Merriam GR, Shalet SM, Vance ML; Endocrine Society's Clinical Guidelines Subcommittee; Stephens PA 2006 Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 91:1621-1634
39. Biller BM, Samuels MH, Zagar A, Cook DM, Arafah BM, Bonert V, Stavrou S, Kleinberg DL, Chipman JJ, Hartman ML 2002 Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency. J Clin Endocrinol Metab 87:2067-2079
40. Radovick S, DiVall S 2007 Approach to the growth hormone-deficient child during transition to adulthood. J Clin Endocrinol Metab 92:1195-1200