Effects of large dose of dexamethasone on inflammatory mediators and pancreatic cell apoptosis of rats with severe acute pancreatitis

World Journal of Gastroenterology

Volumn 13, Issue 41, 2007, Pages 5506-5511

  Zhang, Xi Ping ^a   Chen, Li ^b   Hu, Qi Fang ^c   Tian, Hua ^b   Xu, Ru Jun ^a   Wang, Zhi Wei ^a   Wang, Ke Yi ^a   Cheng, Qi Hui ^a   Yan, Wei ^a   Li, Yun ^a   Li, Qing Yu ^a   He, Qing ^a   Wang, Fei ^a  

^a HANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c Zhejiang Traditional Chinese Medicine University   (China)

Author keywords

Apoptosis; Dexamethasone; Inflammatory mediators; Severe acute pancreatitis; Tissue microarrays

Indexed keywords

AMYLASE; DEXAMETHASONE; ENDOTOXIN; INTERLEUKIN 6; PHOSPHOLIPASE A2; TUMOR NECROSIS FACTOR ALPHA;

ACINAR CELL; ACUTE PANCREATITIS; AMYLASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; ASCITES; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG MEGADOSE; HISTOPATHOLOGY; MALE; MORTALITY; NICK END LABELING; NONHUMAN; PANCREAS CELL; PROTEIN BLOOD LEVEL; RAT; STATISTICAL SIGNIFICANCE; SURVIVAL RATE; TISSUE MICROARRAY;

EID: 35348990252     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v13.i41.5506     Document Type: Article

References (30)

1. Zhang XP, Zhang L, Chen LJ, Cheng QH, Wang JM, Cai W, Shen HP, Cai J. Influence of dexamethasone on inflammatory mediators and NF-kappaB expression in multiple organs of rats with severe acute pancreatitis. World J Gastroenterol 2007; 13:548-556
2. Zhang XP, Zhang L, Yang P, Zhang RP, Cheng QH. Protective Effects of Baicalin and Octreotide on Multiple Organ Injury in Severe Acute Pancreatitis. Dig Dis Sci 2007 Jun 5; [Epub ahead of print]
3. Wang ZF, Pan CE, Liu SG. The role of inflammatory mediators in acute pancreatitis. Shijie Huaren Xiaohua Zazhi 1998, 6:170-171
4. Gu J, Li N. Acute pancreatitis and SIRS. Gandan Waike Zazhi 2004, 12:149-152
5. Dugernier TL, Laterre PF, Wittebole X, Roeseler J, Latinne D, Reynaert MS, Pugin J. Compartmentalization of the inflammatory response during acute pancreatitis: correlation with local and systemic complications. Am J Respir Crit Care Med 2003; 168:148-157
6. Bentrem DJ, Joehl RJ. Pancreas: healing response in critical illness. Crit Care Med 2003; 31:S582-S589
7. Yang J, Murphy C, Denham W, Botchkina G, Tracey KJ, Norman J. Evidence of a central role for p38 map kinase induction of tumor necrosis factor alpha in pancreatitis-associated pulmonary injury. Surgery 1999; 126:216-222
8. Kerekes L, Antal-Szalmas P, Dezso B, Sipka S, Furka A, Miko I, Sapy P. In vitro examination of the influence of lipase and amylase on dog's pancreas tissue incubated with endotoxins, phospholipase A2 or cytokines. Magy Seb 2005; 58:120-124
9. Norman JG, Fink GW, Franz MG. Acute pancreatitis induces intrapancreatic tumor necrosis factor gene expression. Arch Surg 1995; 130:966-970
10. Friess H, Shrikhande S, Riesle E, Kashiwagi M, Baczako K, Zimmermann A, Uhl W, Buchler MW. Phospholipase A2 isoforms in acute pancreatitis. Ann Surg 2001; 233:204-212
11. Caronna R, Diana L, Nofroni I, Sibio S, Catinelli S, Sammartino P, Chirletti P. Effects of gabexate mesilate (FOY) on amylase and phospholipase A2 in human serum and pancreatic juice. Dig Dis Sci 2005; 50:868-873
12. Caronna R, Loretta D, Campedelli P, Catinelli S, Nofroni I, Sibio S, Sinibaldi G, Chirletti P. Gabexate mesilate (FOY) inhibition of amylase and phospholipase A(2) activity in sow pancreatic juice. J. Invest Surg 2003; 16:345-351
13. Bhatia M. Novel therapeutic targets for acute pancreatitis and associated multiple organ dysfunction syndrome. Curr Drug Targets Inflamm Allergy 2002; 1:343-351
14. Kaiser AM, Saluja AK, Lu L, Yamanaka K, Yamaguchi Y, Steer ML. Effects of cycloheximide on pancreatic endonuclease activity, apoptosis, and severity of acute pancreatitis. Am J Physiol 1996; 271:C982-C993
15. Bhatia M. Apoptosis of pancreatic acinar cells in acute pancreatitis: is it good or bad? J Cell Mol Med 2004; 8:402-409
16. Wu ZJ, Zhang YD, Lei ZM, Yu SH. Discuss apoptosis in pathogenesis of rat acute pancreatitis. Zhongguo Xiandai Yixue Zazhi 2003, 13:13-15
17. Yasuda T, Takeyama Y, Ueda T, Shinzeki M, Sawa H, Nakajima T, Kuroda Y. Breakdown of intestinal mucosa via accelerated apoptosis increases intestinal permeability in experimental severe acute pancreatitis. J Surg Res 2006; 135:18-26
18. Chen HM, Hsu JT, Chen JC, Ng CJ, Chiu DF, Chen MF. Delayed neutrophil apoptosis attenuated by melatonin in human acute pancreatitis. Pancreas 2005; 31:360-364
19. McHugh P, Turina M. Apoptosis and necrosis: a review for surgeons. Surg Infect (Larchmt) 2006; 7:53-68
20. Samuilov VD, Oleskin AV, Lagunova EM. Programmed cell death. Biochemistry (Mosc) 2000; 65:873-887
21. Stephenson HE Jr, Pfeffer RB, Saypol GM. Acute hemorrhagic pancreatitis; report of a case with cortisone treatment. AMA Arch Surg 1952; 65:307-308
22. Sugiyama Y, Kato S, Abe M, Mitsufuji S, Takeuchi K. Different effects of dexamethasone and the nitric oxide synthase inhibitor L-NAME on caerulein-induced rat acute pancreatitis, depending on the severity. Inflammopharmacology 2005; 13: 291-301
23. Paszt A, Takacs T, Rakonczay Z, Kaszaki J, Wolfard A, Tiszlavicz L, Lazar G, Duda E, Szentpali K, Czako L, Boros M, Balogh A, Lazar G Jr. The role of the glucocorticoid-dependent mechanism in the progression of sodium taurocholate-induced acute pancreatitis in the rat. Pancreas 2004; 29:75-82
24. Sugiyama Y, Kato S, Abe M, Mitsufuji S, Takeuchi K. Different effects of dexamethasone and the nitric oxide synthase inhibitor L-NAME on caerulein-induced rat acute pancreatitis, depending on the severity. Inflammopharmacology 2005; 13: 291-301
25. Wang ZF, Pan CE, Lu Y, Liu SG, Zhang GJ, Zhang XB. The role of inflammatory mediators in severe acute pancreatitis and regulation of glucocorticoids. Hepatobiliary Panereat Dis Int 2003; 2:458-462
26. Liu JS, Wei XG, Fu J, Liu J, Yuan YZ, Wu YL. Stady of the relationship among endothelin, nitric oxide,oxgen free radical and acute pancreatitis. Zhongguo Yishi Zazhi 2003; 5:28-29
27. Dong R, Wang ZF, LV Y, Ma QJ. Treatment of severe acute pancreatitis with large dosage of dexamethsone in the earlier time. Gandan Waike Zazhi 2005; 13:58-60
28. Dong R, Wang ZF, Lu Y, Pan CE. Empirical study on severe acute pancreatitis treated by large dose of dexamethasone. Zhonghua Putong Waike Zahi 2001; 10:314-317
29. Aho HJ. Experimental pancreatitis in the rats: sodium taurocholate-induced acute hemorrhagic pancreatitis. Scand J Gastroenterol 1980; 15:411-416
30. Zhang XP, Lin Q. Advancement of study on the relationship between mediators of inflammation and apoptosis in acute pancreatitis. Shijie Huaren Xiaohua Zazhi 2005; 13:2773-2777