Inhibition of primordial germ cell proliferation by the medaka male determining gene Dmrt1bY

BMC Developmental Biology

Volumn 7, Issue , 2007, Pages

  Herpin, Amaury ^a   Schindler, Detlev ^a   Kraiss, Anita ^a   Hornung, Ute ^a   Winkler, Christoph ^a   Schartl, Manfred ^a,b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; DMRT1 GENE; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION; GERM CELL; GONAD DEVELOPMENT; MITOSIS INHIBITION; NONHUMAN; ORYZIAS; PRECAMBRIAN; REGULATOR GENE; SERTOLI CELL; SEX DETERMINATION; SEX DIFFERENTIATION; ANIMAL; ANIMAL EMBRYO; CELL CULTURE; CELL NUCLEUS; CYTOLOGY; DNA REPLICATION; FEMALE; GENDER AND SEX; GENE EXPRESSION REGULATION; GENETICS; GONAD; IN VITRO STUDY; MALE; METABOLISM; PHENOTYPE; PRENATAL DEVELOPMENT; TIME; TRANSGENIC ANIMAL;

MAMMALIA; ORYZIINAE; VERTEBRATA;

DMRT1 PROTEIN; DNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL NUCLEUS; CELL PROLIFERATION; CELLS, CULTURED; DNA; DNA REPLICATION; DOWN-REGULATION; EMBRYO, NONMAMMALIAN; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GERM CELLS; GONADS; MALE; ORYZIAS; PHENOTYPE; SEX DETERMINATION (GENETICS); TIME FACTORS; TRANSCRIPTION FACTORS;

EID: 35348986015     PISSN: None     EISSN: 1471213X     Source Type: Journal    
DOI: 10.1186/1471-213X-7-99     Document Type: Article

References (45)

1. A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators. CS Raymond ED Parker JR Kettlewell LG Brown DC Page K Kusz J Jaruzelska Y Reinberg WL Flejter VJ Bardwell B Hirsch D Zarkower, Hum Mol Genet 1999 8 989 96 10.1093/hmg/8.6.989 10332030
2. 300 million years of conserved synteny between chicken Z and human chromosome 9. I Nanda Z Shan M Schartl DW Burt M Koehler H Nothwang F Grutzner IR Paton D Windsor I Dunn W Engel P Staeheli S Mizuno T Haaf M Schmid, Nat Genet 1999 21 258 9 10.1038/6769 10080173
3. DMRT1 in a ratite bird: evidence for a role in sex determination and discovery of a putative regulatory element. S Shetty P Kirby D Zarkower JA Graves, Cytogenet Genome Res 2002 99 245 51 10.1159/000071600 12900571
4. A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes. I Nanda M Kondo U Hornung S Asakawa C Winkler A Shimizu Z Shan T Haaf N Shimizu A Shima M Schmid M Schartl, Proc Natl Acad Sci USA 2002 99 11778 83 12193652 10.1073/pnas.182314699
5. DMY is a Y-specific DM-domain gene required for male development in the medaka fish. M Matsuda Y Nagahama A Shinomiya T Sato C Matsuda T Kobayashi CE Morrey N Shibata S Asakawa N Shimizu H Hori S Hamaguchi M Sakaizumi, Nature 2002 417 559 563 10.1038/nature751 12037570
6. Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers. L Zhu J Wilken NB Phillips U Narendra G Chan SM Stratton SB Kent MA Weiss, Genes Dev 2000 14 1750 64 10898790 10.1101/gad.189500
7. Three protein binding sites form an enhancer that regulates sex- and fat body-specific transcription of Drosophila yolk protein genes. W An PC Wensink, Embo J 1995 14 1221 30 7720712
8. Similarity of DNA binding and transcriptional regulation by Caenorhabditis elegans MAB-3 and Drosophila melanogaster DSX suggests conservation of sex determining mechanisms. W Yi D Zarkower, Development 1999 126 873 81 9927589
9. Mab-3 is a direct tra-1 target gene regulating diverse aspects of C. elegans male sexual development and behavior. W Yi JM Ross D Zarkower, Development 2000 127 4469 80 11003845
10. Sex and the single cell. I. On the action of major loci affecting sex determination in Drosophila melanogaster. BS Baker KA Ridge, Genetics 1980 94 383 423 6771185
11. Sex comes in from the cold: the integration of sex and pattern. AE Christiansen EL Keisman SM Ahmad BS Baker, Trends Genet 2002 18 510 6 10.1016/S0168-9525(02)02769-5 12350340
12. Developmentally regulated and non-sex-specific expression of autosomal dmrt genes in embryos of the Medaka fish (Oryzias latipes). C Winkler U Hornung M Kondo C Neuner J Duschl A Shima M Schartl, Mech Dev 2004 121 997 1005 10.1016/j.mod.2004.03.018 15210205
13. Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development. CS Raymond JR Kettlewell B Hirsch VJ Bardwell D Zarkower, Dev Biol 1999 215 208 220 10.1006/dbio.1999.9461 10545231
14. Conservation of a sex-determining gene. CA Smith PJ McClive PS Western KJ Reed AH Sinclair, Nature 1999 402 601 602 10.1038/45130 10604464
15. Temperature-dependent expression of turtle Dmrt1 prior to sexual differentiation [letter]. JR Kettlewell CS Raymond D Zarkower, Genesis 2000 26 174 178 10.1002/(SICI)1526-968X(200003)26:3<174::AID-GENE2>3.0.CO;2-J 10705377
16. DMRT1 expression during gonadal differentiation and spermatogenesis in the rainbow trout, Oncorhynchus mykiss. O Marchand M Govoroun H D'Cotta O McMeel J Lareyre A Bernot V Laudet Y Guiguen, Biochim Biophys Acta 2000 1493 180 7 10978520
17. Expression of Dmrt1 protein in developing and in sex-reversed gonads of amphibians. S Aoyama K Shibata S Tokunaga M Takase K Matsui M Nakamura, Cytogenet Genome Res 2003 101 295 301 10.1159/000074352 14684998
18. Two DM domain genes, DMY and DMRT1, involved in testicular differentiation and development in the medaka, Oryzias latipes. T Kobayashi M Matsuda H Kajiura-Kobayashi A Suzuki N Saito M Nakamoto N Shibata Y Nagahama, Dev Dyn 2004 231 3 518 26 10.1002/dvdy.20158 15376325
19. Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation. CS Raymond MW Murphy MG O'Sullivan VJ Bardwell D Zarkower, Genes Dev 2000 14 20 2587 95 11040213 10.1101/gad.834100
20. Evolution of DMY, a newly emergent male sex-determination gene of medaka fish. J Zhang, Genetics 2004 166 1887 95 15126406 10.1534/genetics.166.4.1887
21. Sex differentiation of germ cells in the teleost, Oryzias latipes, during noraml embryonic development. N Satoh N Egami, J Embryol Exp Morphol 1972 28 385 95 4642993
22. Knock-down of DMY initiates female pathway in the genetic male medaka, Oryzias latipes. B Paul-Prasanth M Matsuda EL Lau A Suzuki F Sakai T Kobayashi Y Nagahama, Biochem Biophys Res Commun 2006 351 815 9 10.1016/j.bbrc.2006.10.095 17092483
23. Molecular characterization of three gonad cell lines. A Beverdam D Wilhelm P Koopman, Cytogenet Genome Res 2003 101 242 9 10.1159/000074344 14684990
24. The nuclear localization signal of zebrafish terra is located within the DM domain. L Zhang Z Hua J Ren A Meng, FEBS Lett 2001 503 25 9 10.1016/S0014-5793(01)02677-1 11513848
25. Loss of XChk1 function triggers apoptosis after the midblastula transition in Xenopus laevis embryos. AD Carter JC Sible, Mech Dev 2003 120 315 23 10.1016/S0925-4773(02)00443-4 12591601
26. Number of germ cells in known male and known female genotypes of vertebrate embryos (Oryzias latipes). JG Quirk JB Hamilton, Science 1973 180 963 4 10.1126/science.180.4089.963 4706685
27. Sex reversal of genetic females (XX) induced by the transplantation of XY somatic cells in the medaka, Oryzias latipes. A Shinomiya N Shibata M Sakaizumi S Hamaguchi, Int J Dev Biol 2002 46 711 7 12216983
28. Establishment of medaka (Oryzias latipes) transgenic lines with the expression of green fluorescent protein fluorescence exclusively in germ cells: a useful model to monitor germ cells in a live vertebrate. M Tanaka M Kinoshita D Kobayashi Y Nagahama, Proc Natl Acad Sci USA 2001 98 2544 9 11226275 10.1073/pnas.041315498
29. Quantitative bio-imaging analysis for evaluation of sexual differentiation in germ cells of olvas-GFP/ST-II YI medaka (Oryzias latipes) nanoinjected in ovo with ethinylestradiol. T Hano Y Oshima T Oe M Kinoshita M Tanaka Y Wakamatsu K Ozato T Honjo, Environ Toxicol Chem 2005 24 70 7 10.1897/03-610.1 15683169
30. Bilaterally asymetrical testes in fishes of the genus Oryzias. S Hamaguchi, Zoolog Sci 1996 13 757 763
31. Wild-derived XY sex-reversal mutants in the Medaka, Oryzias latipes. H Otake A Shinomiya M Matsuda S Hamaguchi M Sakaizumi, Genetics 2006 173 2083 90 16702419 10.1534/genetics.106.058941
32. A comparative view on sex determination in medaka. M Schartl, Mech Dev 2004 121 639 45 10.1016/j.mod.2004.03.001 15210173
33. mab-3, a gene required for sex-specific yolk protein expression and a male-specific lineage in C. elegans. MM Shen J Hodgkin, Cell 1988 54 1019 31 10.1016/0092-8674(88)90117-1 3046751
34. Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides. KC Burtis BS Baker, Cell 1989 56 997 1010 10.1016/0092-8674(89) 90633-8 2493994
35. Sex determination and sex differentiation in fish: an overview of genetic, physiological, and environmental influences. RH Devlin Y Nagahama, Aquaculture 2002 208 191 364 10.1016/S0044-8486(02)00057-1
36. Sex determination in the teleost medaka, Oryzias latipes. M Matsuda, Annu Rev Genet 2005 39 293 307 10.1146/annurev.genet.39.110304.095800 16285862
37. The DM domain protein MAB-3 promotes sex-specific neurogenesis in C. elegans by regulating bHLH proteins. JM Ross AK Kalis MW Murphy D Zarkower, Dev Cell 2005 8 881 92 10.1016/j.devcel.2005.03.017 15935777
38. The doublesex proteins of Drosophila melanogaster bind directly to a sex-specific yolk protein gene enhancer. KC Burtis KT Coschigano BS Baker PC Wensink, Embo J 1991 10 2577 82 1907913
39. Sexual differentiation of germ cell deficient gonads in the medaka, Oryzias latipes. A Shinomiya S Hamaguchi N Shibata, J Exp Zool 2001 290 402 10 10.1002/jez.1081 11550188
40. Stages of normal development in the medaka Oryzias latipes. T Iwamatsu, Mech Dev 2004 121 605 18 10.1016/j.mod.2004.03.012 15210170
41. I-SceI meganuclease mediates highly efficient transgenesis in fish. V Thermes C Grabher F Ristoratore F Bourrat A Choulika J Wittbrodt JS Joly, Mech Dev 2002 118 91 8 10.1016/S0925-4773(02)00218-6 12351173
42. Medaka spalt acts as a target gene of hedgehog signaling. R Koster R Stick F Loosli J Wittbrodt, Development 1997 124 3147 56 9272955
43. Expression of the male determining gene dmrt1bY and its autosomal coorthologue dmrt1a in Medaka. U Hornung A Herpin M Schartl, Sex Dev 2007 1 197 206 10.1159/000102108
44. Field survey of sex-reversals in the medaka, Oryzias latipes: genotypic sexing of wild populations. A Shinomiya H Otake K Togashi S Hamaguchi M Sakaizumi, Zoolog Sci 2004 21 613 9 10.2108/zsj.21.613 15226583
45. Cell cultures derived from embryos and melanoma of poeciliid fish. C Kuhn U Vielkind F Anders, In Vitro 1979 15 537 44 10.1007/BF02618156 528010