Reduction of podocytes number in late diabetic alloxan nephropathy. Prevention by glycemic control

Acta Cirurgica Brasileira

Volumn 22, Issue 5, 2007, Pages 337-341

  Macedo, Célia Sperandéo ^a   Lerco, Mauro Masson ^a   Capelletti, Sônia Maria ^a   Silva, Reinaldo José ^a   Pinheiro, Daniela De Oliveira ^a   Spadella, César Tadeu ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Diabetes mellitus, experimental; Microscopy, electron; Podocytes; Rats

Indexed keywords

ACARBOSE; GLUCOSE; INSULIN; INSULIN ZINC SUSPENSION;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL COUNT; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DIURESIS; ELECTRON MICROSCOPY; FEMALE; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSURIA; GLYCEMIC CONTROL; KIDNEY PARENCHYMA; MALE; NONHUMAN; PODOCYTE; PROPHYLAXIS; RAT;

EID: 35348983990     PISSN: 01028650     EISSN: 16782674     Source Type: Journal    
DOI: 10.1590/s0102-86502007000500003     Document Type: Article

References (30)

1. Lemley KV, Blouch K, Abdullah I, Boothroyd DB, Bennett PH, Myers BD, Nelson RG. Glomerular perm selectivity at the onset of nephropathy in type 2 diabetes mellitus J Am Soc Nephrol 2000;11:2095-105.
2. Meyer TW, Bennett PH, Nelson RG. Podocyte number predicts long-term urinary albumin excretion in Pima Indians with type II diabetes and microalbuminuria. Diabetologia. 1999;42:1341-4.
3. Steffes MW, Schmidt D, McCrery R. Glomerular cell number in normal subjects and in type I diabetic patients. Kidney Int. 2001;59:2104-13.
4. Mifsud SA, Allen TJ, Bertam JF, Hulthen UL, Kelly DJ, Cooper ME, Wilkinson-Berka JL, Gilbert RE. Podocyte foot process boadening in experimental diabetic nephropathy: amelioration with renin-angiotensin blockade. Diabetologia. 2001;44:878-82.
5. Gross ML, Shakmak A, El, Szabo A, Koch A, Kuhlmann A, Munter K, Ritz E, Amann K. ACE - inhibitors but not endothelin receptor blockers prevent podocyte loss in early diabetic nephropathy. Diabetologia. 2003;46:856-68.
6. Lerco MM, Macedo CS, Silva RJ, Pinheiro DO, Spadella CT. The number of podocyte and slit diaphragm is decreased in experimental diabetic nephropathy. Acta Cir Bras. 2006;21(2):87-91.
7. Rash R. Prevention of diabetic glomerulopathy in streptozotocin diabetic rats by insulin treatment: glomerular basement membrane thickness. Diabetologia. 1979;16:319-24.
8. Rash R. Prevention of diabetic glomerulopathy in streptozotocin diabetic rats by insulin treatment: the mesangial regions. Diabetologia. 1979;17:243-8.
9. Job D, Esehwege E, Guyot G, Aubry JP and Tchobroutsky G. Effect of multiple daily insulin injections on the course of diabetic retinopathy. Diabetes. 1976;25:463-9.
10. Schmidt DD, Frommer W, Jenge B, Muller L, Wingender W, Truscheit E, Shafer D. Alpha-glucosidase inhibitors: new complex oligosaccharides of microbial origin. Naturwissenschaften. 1977;64:635-6.
11. Puls W, Keup U, Krausse HP, Thomas G and Hoffmeister F. Glucosidase inhibition, a new approach to the treatment of diabetes, obesity and hyperlipoproteinemia. Naturwissenschaften. 1977;64:536-7.
12. Sachse G and Willms B. Effect of the alpha-glucosidase inhibitor Bay-g-5421 on blood glucose control of sulphonylurea treated diabetics and insulin treated diabetics. Diabetologia. 1979;17:287-90.
13. Macedo CS, Silva MD, Spadella CT, Breim LC, Capeletti S, Mercadante MCS, Hernandes D, Macedo AR. Effect of long-term treatment with insulin and/or acarbose on glomerular basement membrane thickening in alloxan-diabetic rats. Braz J Med Biol Res. 1996;29:1329-35.
14. Kriz W. Progressive renal failure: inability of podocytes to replicate and the consequences for development of glomeruloscleroses. Nephrol Dial Transplant. 1996;11:1738-42.
15. Kerjaschki D. Dysfunction of cell biological mechanisms of visceral epithelial cell (podocytes) in glomerular diseases. Kidney Int. 1994;45:300-13.
16. Kriz W, Elger M, Nagata M. The role of podocytes in the development of glomerular sclerosis. Kidney Int. 1994;45(42):S64-72.
17. Kriz W, Gretz N, Lemley KV. Progression of glomerular disease: is the podocyte the culprit ? Kidney Int. 1998;54:687-97.
18. Adler S. Diabetic nephropathy: linking histology, cell biology and genetics. Kidney Int. 2004;66:2095-106.
19. Petermann AT, Pippin J, Durvasula R, Pichler R, Hikomura K, Monkawa T, Couser WG and Shankland SJ. Mechanical stretch induces podocyte hypertrophy in vitro. Kidney Int. 2005;67:157-66.
20. Nakamura T, Ushiwama C, Suzuki S, Hara M, Shimada N, Ebihara I, Koide H. Urinary excretion of podocytes in patients with diabetic nephropathy. Nephrol Dial Transplant. 2000;15:1379-83.
21. Viera Jr JM, Fujihara CK, Zatz R. Mecanismos de progressão da doença renal. In: Toporovski J, Mello VR, Mrtini Filho D, Benini V, Andrade OVB. Nefrologia pediátrica. 2ed. Rio de Janeiro: Guanabara Koogan; 2006. p.67-76.
22. Mundel P, Shankland SJ. Podocyte biology and response to injury. J Am Soc Nephrol. 2002;13:3005-15.
23. Spadella CT, Lerco MM, Machado JLM, Macedo CS. Long-term effects of insulin therapy, islet transplantation and pâncreas transplantation in the prevention of glomerular changes in kidneys of alloxan-induced diabetic rats. Transplant Proc. 2005;37:3468-71.
24. Hoffmann S; Podlich D; Hahnel B; Kriz W; Gretz N. Angiotensin II Type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic rats. J Am Soc Nephrol. 2004;15:1475-87.
25. Attia DM; Feron O; Goldschmeding R; Radermakers LH; Vaziri ND; Boer P; Balligand JL;Koomans HA; Joles JA. Hypercholesterolemia in rats induces podocytes stresss and decreases renal cortical nitric oxide synthesis via an angiotensin II type I receptor-sensitive mechanism. J Am Soc Nephrol. 2004;15:949-57.
26. Hostetter TH; Troy JL; Brenner BM. Glomerular hemodynamics in experimental diabetes mellitus. Kidney Int. 1981;19:410-5.
27. Border WA; Yamamoto T; Noble NA. Transforming growth factor in diabetic nephropathy. Diabetes Metabol Rev. 1996;12:309-39.
28. Reckelhoff JF; Tygart VL; Mitias MM; Walcott JL. Stz-induced diabetes results in decreased activity of glomerular cathepsin and metalloprotease in rats. Diabetes. 1993;42:1425-32.
29. Sharma K; Ziyadeh FN. Biochemical events and cytokine interactions linking glucose metabolism to the development of diabetic nephropaty. Semin Nephrol. 1997;17:80-92.
30. Ziyadeh FN; Sharma K. Role of transforming growth factor-beta in diabetic glomerulosclerosis and renal hypertrophy. Kidney Int. 1995;51:534-6.