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Diarra D, Stolina M, Polzer K, et al.: Dickkopf-1 is a master regulator of joint remodeling. Nature Med 2007, 13:156-163. New data on DKK-1 as a regulator of the Wnt pathway, known to be important in osteoblastic bone formation, may play a role in understanding the current disconnect between improvement in disease activity achieved by TNF inhibitors and their inability to prevent radiographic progression.
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Diarra D, Stolina M, Polzer K, et al.: Dickkopf-1 is a master regulator of joint remodeling. Nature Med 2007, 13:156-163. New data on DKK-1 as a regulator of the Wnt pathway, known to be important in osteoblastic bone formation, may play a role in understanding the current disconnect between improvement in disease activity achieved by TNF inhibitors and their inability to prevent radiographic progression.
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