Reduced stroke volume during exercise in postural tachycardia syndrome

Journal of Applied Physiology

Volumn 103, Issue 4, 2007, Pages 1128-1135

  Masuki, Shizue ^a,c   Eisenach, John H ^a   Schrage, William G ^a   Johnson, Christopher P ^a   Dietz, Niki M ^a   Wilkins, Brad W ^a   Sandroni, Paola ^b   Low, Phillip A ^b   Joyner, Michael J ^a,d  

^a DEPARTMENT OF UROLOGY   (United States)

^b MAYO CLINIC   (United States)

^c SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d Mayo Clinic   (United States)

Author keywords

Blood pressure; Cardiac output; Deconditioning; Orthostatic intolerance

Indexed keywords

ACETYLENE;

ADULT; ARTERIAL PRESSURE; ARTERY CATHETER; ARTICLE; CARDIOVASCULAR FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROCARDIOGRAM; EXERCISE; EXERCISE TOLERANCE; FEMALE; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HUMAN; MALE; MEAN ARTERIAL PRESSURE; POSTURAL TACHYCARDIA SYNDROME; PRIORITY JOURNAL; REST; STANDING; SUPINE POSITION; TACHYCARDIA; VASCULAR RESISTANCE;

ADULT; CARDIAC OUTPUT, LOW; EXERCISE; EXERCISE TEST; FEMALE; HEMODYNAMICS; HUMANS; HYPOTENSION, ORTHOSTATIC; MALE; POSTURE; STROKE VOLUME; TACHYCARDIA;

EID: 35348965658     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00175.2007     Document Type: Article

References (38)

1. Ali YS, Daamen N, Jacob G, Jordan J, Shannon JR, Biaggioni I, Robertson D. Orthostatic intolerance: a disorder of young women. Obstet Gynecol Surv 55: 251-259, 2000.
2. Benrud-Larson LM, Sandroni P, Haythornthwaite JA, Rummans TA, Low PA. Correlates of functional disability in patients with postural tachycardia syndrome: preliminary cross-sectional findings. Health Psychol 22: 643-648, 2003.
3. Bevegard BS, Shepherd JT. Regulation of the circulation during exercise in man. Physiol Rev 47: 178-213, 1967.
4. Bevegard S. Studies on the regulation of the circulation in man. With special reference to the stroke volume and the effect of muscular work, body position and artificially induced variations of the heart rate. Acta Physiol Scand Suppl 57: 1-36, 1962.
5. Coyle EF, Martin WH 3rd, Sinacore DR, Joyner MJ, Hagberg JM, Holloszy JO. Time course of loss of adaptations after stopping prolonged intense endurance training. J Appl Physiol 57: 1857-1864, 1984.
6. Dietz NM, Rivera JM, Eggener SE, Fix RT, Warner DO, Joyner MJ. Nitric oxide contributes to the rise in forearm blood flow during mental stress in humans. J Physiol 480: 361-368, 1994.
7. Dinenno FA, Joyner MJ. Blunted sympathetic vasoconstriction in contracting skeletal muscle of healthy humans: is nitric oxide obligatory? J Physiol 553: 281-292, 2003.
8. Fouad FM, Tadena-Thome L, Bravo EL, Tarazi RC. Idiopathic hypovolemia. Ann Intern Med 104: 298-303, 1986.
9. Freedman RR, Girgis R. Effects of menstrual cycle and race on peripheral vascular alpha-adrenergic responsiveness. Hypertension 35: 795-799, 2000.
10. Fu Q, Shook R, Shibata S, Okazaki K, Hastings J, Dorfman T, Conner C, Palmer MD, Jacob G, Levine BD. Cardiac size: a potential mechanism for gender differences in orthostatic intolerance and POTS? (Abstract). Clin Auton Res 16: 321, 2006.
11. Greenleaf JE, Convertino VA, Mangseth GR. Plasma volume during stress in man: osmolality and red cell volume. J Appl Physiol 47: 1031-1038, 1979.
12. Jacob G, Costa F, Shannon JR, Robertson RM, Wathen M, Stein M, Biaggioni I, Ertl A, Black B, Robertson D. The neuropathic postural tachycardia syndrome. N Engl J Med 343: 1008-1014, 2000.
13. Jacob G, Shannon JR, Black B, Biaggioni I, Mosqueda-Garcia R, Robertson RM, Robertson D. Effects of volume loading and pressor agents in idiopathic orthostatic tachycardia. Circulation 96: 575-580, 1997.
14. Jacob G, Shannon JR, Costa F, Furlan R, Biaggioni I, Mosqueda-Garcia R, Robertson RM, Robertson D. Abnormal norepinephrine clearance and adrenergic receptor sensitivity in idiopathic orthostatic intolerance. Circulation 99: 1706-1712, 1999.
15. Johnson BD, Beck KC, Proctor DN, Miller J, Dietz NM, Joyner MJ. Cardiac output during exercise by the open circuit acetylene washin method: comparison with direct Fick. J Appl Physiol 88: 1650-1658, 2000.
16. Kamijo Y, Okumoto T, Takeno Y, Okazaki K, Inaki M, Masuki S, Nose H. Transient cutaneous vasodilatation and hypotension after drinking in dehydrated and exercising men. J Physiol 568: 689-698, 2005.
17. Levine BD, Zuckerman JH, Pawelczyk JA. Cardiac atrophy after bed-rest deconditioning: a nonneural mechanism for orthostatic intolerance. Circulation 96: 517-525, 1997.
18. Low PA, Opfer-Gehrking TL, Textor SC, Benarroch EE, Shen WK, Schondorf R, Suarez GA, Rummans TA. Postural tachycardia syndrome (POTS). Neurology 45: S19-S25, 1995.
19. Low PA, Schondorf R, Novak V, Sandroni P, Opfer-Gehrking TL, Novak P. Postural tachycardia syndrome. In: Clinical Autonomic Disorders (2nd ed.), edited by Low PA. Philadelphia, PA: Lippincott-Raven, 1997, p. 681-697.
20. Marshall RJ, Schirger A, Shepherd JT. Blood pressure during supine exercise in idiopathic orthostatic hypotension. Circulation 24: 76-81, 1961.
21. Masuki S, Eisenach JH, Johnson CP, Dietz NM, Benrud-Larson LM, Schrage WG, Curry TB, Sandroni P, Low PA, Joyner MJ. Excessive heart rate response to orthostatic stress in postural tachycardia syndrome is not caused by anxiety. J Appl Physiol 102: 896-903, 2007.
22. Masuki S, Eisenach JH, Schrage WG, Dietz NM, Johnson CP, Wilkins BW, Dierkhising RA, Sandroni P, Low PA, Joyner MJ. Arterial baroreflex control of heart rate during exercise in postural tachycardia syndrome. J Appl Physiol. doi: 10.1152/japplphysiol.00176.2007.
23. Minson CT, Halliwill JR, Young TM, Joyner MJ. Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. Circulation 101: 862-868, 2000.
24. Perhonen MA, Franco F, Lane LD, Buckey JC, Blomqvist CG, Zerwekh JE, Peshock RM, Weatherall PT, Levine BD. Cardiac atrophy after bed rest and spaceflight. J Appl Physiol 91: 645-653, 2001.
25. Raj SR, Biaggioni I, Yamhure PC, Black BK, Paranjape SY, Byrne DW, Robertson D. Renin-aldosterone paradox and perturbed blood volume regulation underlying postural tachycardia syndrome. Circulation 111: 1574-1582, 2005.
26. Rosenmeier JB, Dinenno FA, Fritzlar SJ, Joyner MJ. Alpha1- and alpha2-adrenergic vasoconstriction is blunted in contracting human muscle. J Physiol 547: 971-976, 2003.
27. Saltin B, Blomqvist G, Mitchell JH, Johnson RL Jr, Wildenthal K, Chapman CB. Response to exercise after bed rest and after training. Circulation 38: VII1-78, 1968.
28. Sandroni P, Opfer-Gehrking TL, McPhee BR, Low PA. Postural tachycardia syndrome: clinical features and follow-up study. Mayo Clin Proc 74: 1106-1110, 1999.
29. Schondorf R, Low PA. Idiopathic postural orthostatic tachycardia syndrome: an attenuated form of acute pandysautonomia? Neurology 43: 132-137, 1993.
30. Schrage WG, Eisenach JH, Dinenno FA, Roberts SK, Johnson CP, Sandroni P, Low PA, Joyner MJ. Effects of midodrine on exercise-induced hypotension and blood pressure recovery in autonomic failure. J Appl Physiol 97: 1978-1984, 2004.
31. Schrage WG, Joyner MJ, Dinenno FA. Local inhibition of nitric oxide and prostaglandins independently reduces forearm exercise hyperaemia in humans. J Physiol 557: 599-611, 2004.
32. Stewart JM, Medow MS, Glover JL, Montgomery LD. Persistent splanchnic hyperemia during upright tilt in postural tachycardia syndrome. Am J Physiol Heart Circ Physiol 290: H665-H673, 2006.
33. Stewart JM, Montgomery LD. Regional blood volume and peripheral blood flow in postural tachycardia syndrome. Am J Physiol Heart Circ Physiol 287: H1319-H1327, 2004.
34. Stewart JM, Weldon A. Vascular perturbations in the chronic orthostatic intolerance of the postural orthostatic tachycardia syndrome. J Appl Physiol 89: 1505-1512, 2000.
35. Streeten DH, Anderson GH Jr, Richardson R, Thomas FD. Abnormal orthostatic changes in blood pressure and heart rate in subjects with intact sympathetic nervous function: evidence for excessive venous pooling. J Lab Clin Med 111: 326-335, 1988.
36. Taneja I, Raj SR, Harris P, Byrne D, Jordan J, Robertson D. Autonomic effect of water ingestion in Postural Tachycardia Syndrome (Abstract). FASEB J 21: A512, 2007.
37. Tani H, Singer W, McPhee BR, Opfer-Gehrking TL, Haruma K, Kajiyama G, Low PA. Splanchnic-mesenteric capacitance bed in the postural tachycardia syndrome (POTS). Auton Neurosci 86: 107-113, 2000.
38. Tschakovsky ME, Sujirattanawimol K, Ruble SB, Valic Z, Joyner MJ. Is sympathetic neural vasoconstriction blunted in the vascular bed of exercising human muscle? J Physiol 541: 623-635, 2002.