The chicken or the egg? Voltage and calcium dynamics in the heart

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 293, Issue 4, 2007, Pages

  Qu, Zhilin ^a,b   Weiss, James N ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CHS ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION;

ARRHYTHMOGENESIS; CALCIUM TRANSPORT; EDITORIAL; HEART ARRHYTHMIA; HEART AUTOMATICITY; HEART ELECTROPHYSIOLOGY; HEART REPOLARIZATION; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; SUDDEN DEATH; T WAVE; VOLTAGE CLAMP;

ACTION POTENTIALS; ALGORITHMS; ANIMALS; ARRHYTHMIAS, CARDIAC; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CARDIAC PACING, ARTIFICIAL; COMPUTER SIMULATION; HEART CONDUCTION SYSTEM; HUMANS; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; SARCOLEMMA; SARCOPLASMIC RETICULUM; SODIUM-CALCIUM EXCHANGER; TIME FACTORS;

EID: 35348958364     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00830.2007     Document Type: Editorial

References (34)

1. Bers DM. Cardiac excitation-contraction coupling. Nature 415: 198-205, 2002.
2. Cao JM, Qu Z, Kim YH, Wu TJ, Garfinkel A, Weiss JN, Karagueuzian HS, Chen PS. Spatiotemporal heterogeneity in the induction of ventricular fibrillation by rapid pacing: importance of cardiac restitution properties. Circ Res 84: 1318-1331, 1999.
3. 2+ triggers early afterdepolarizations and torsade de pointes in rabbit hearts with type 2 long QT syndrome. J Physiol 543: 615-631, 2002.
4. 2+ dynamics and the stability of ventricular tachycardia. Biophys J 77: 2930-2941, 1999.
5. Comtois P, Vinet A. Stability and bifurcation in an integral-delay model of cardiac reentry including spatial coupling in repolarization. Phys Rev E Stat Nonlin Soft Matter Phys 68: 051903, 2003.
6. Courtemanche M. Complex spiral wave dynamics in a spatially distributed ionic model of cardiac electrical activity. Chaos 6: 579-600, 1996.
7. Cytrynbaum E, Keener JP. Stability conditions for the traveling pulse: modifying the restitution hypothesis. Chaos 12: 788-799, 2002.
8. 2+ transient in rat ventricular myocytes. Circ Res 91: 585-593, 2002.
9. Hayashi H, Shiferaw Y, Sato D, Nihei M, Lin SF, Chen PS, Garfinkel A, Weiss JN, Qu Z. Dynamic origin of spatially discordant alternans in cardiac tissue. Biophys J 92: 448-460, 2007.
10. Huser J, Wang YG, Sheehan KA, Cifuentes F, Lipsius SL, Blatter LA. Functional coupling between glycolysis and excitation-contraction coupling underlies alternans in cat heart cells. J Physiol 524: 795-806, 2000.
11. Jordan PN, Christini DJ. Characterizing the contribution of voltage- and calcium-dependent coupling to action potential stability: implications for repolarization alternans. Am J Physiol Heart Circ Physiol June 22, 2007; doi:10.1152/ajpheart.00609.2007.
12. Lewis TJ, Guevara MR. Chaotic dynamics in an ionic model of the propagated cardiac action potential. J Theor Biol 146: 407-432, 1990.
13. Narayan SM. Is T-wave alternans as good or better than programmed ventricular stimulation? Heart Rhythm 4: 913-915, 2007.
14. Nolasco JB, Dahlen RW. A graphic method for the study of alternation in cardiac action potentials. J Appl Physiol 25: 191-196, 1968.
15. Omichi C, Lamp ST, Lin SF, Yang J, Baher A, Zhou S, Attin M, Lee MH, Karagueuzian HS, Kogan B, Qu Z, Garfinkel A, Chen PS, Weiss JN. Intracellular Ca dynamics in ventricular fibrillation. Am J Physiol Heart Circ Physiol 286: H1836-H1844, 2004.
16. Panfilov AV. Spiral breakup as a model of ventricular fibrillation. Chaos 8: 57-64, 1998.
17. Pastore JM, Girouard SD, Laurita KR, Akar FG, Rosenbaum DS. Mechanism linking T-wave alternans to the genesis of cardiac fibrillation. Circulation 99: 1385-1394, 1999.
18. Pogwizd SM, Bers DM. Cellular basis of triggered arrhythmias in heart failure. Trends Cardiovasc Med 14: 61-66, 2004.
19. Pruvot E, Katra RP, Rosenbaum DS, Laurita KR. Calcium cycling as mechanism of repolarization alternans onset in the intact heart. Circulation 106: 191-192, 2002.
20. Qian YW, Clusin WT, Lin SF, Han J, Sung RJ. Spatial heterogeneity of calcium transient alternans during the early phase of myocardial ischemia in the blood-perfused rabbit heart. Circulation 104: 2082-2087, 2001.
21. Qu Z, Shiferaw Y, Weiss JN. Nonlinear dynamics of cardiac excitation-contraction coupling: An iterated map study. Phys Rev E Stat Nonlin Soft Matter Phys 75: 011927, 2007.
22. Qu Z, Weiss JN. Dynamics and cardiac arrhythmias. J Cardiovasc Electrophysiol 17: 1042-1049, 2006.
23. Qu Z, Weiss JN, Garfinkel A. Cardiac electrical restitution properties and the stability of reentrant spiral waves: a simulation study. Am J Physiol Heart Circ Physiol 276: H269-H283, 1999.
24. Qu Z, Xie F, Garfinkel A. Diffusion-induced 3-dimensional vortex filament instability in excitable media. Phys Rev Lett 83: 2668-2671, 1999.
25. Rosenbaum DS, Jackson LE, Smith JM, Garan H, Ruskin JN, Cohen RJ. Electrical alternans and vulnerability to ventricular arrhythmias. N Engl J Med 330: 235-241, 1994.
26. Sato D, Shiferaw Y, Garfinkel A, Weiss JN, Qu Z, Karma A. Spatially discordant alternans in cardiac tissue. Role of calcium cycling. Circ Res 99: 520-527, 2006.
27. Sato D, Shiferaw Y, Qu Z, Garfinkel A, Weiss JN, Karma A. Inferring the cellular origin of voltage and calcium alternans from the spatial scales of phase reversal during discordant alternans. Biophys J 92: L33-L35, 2007.
28. Shiferaw Y, Sato D, Karma A. Coupled dynamics of voltage and calcium in paced cardiac cells. Phys Rev E Stat Nonlin Soft Matter Phys 71: 021903, 2005.
29. Vinogradova TM, Zhou YY, Maltsev V, Lyashkov A, Stern M, Lakatta EG. Rhythmic ryanodine receptor Ca2+ releases during diastolic depolarization of sinoatrial pacemaker cells do not require membrane depolarization. Circ Res 94: 802-809, 2004.
30. Walker ML, Rosenbaum DS. Repolarization alternans: implications for the mechanism and prevention of sudden cardiac death. Cardiovasc Res 57: 599-614, 2003.
31. Walker ML, Wan X, Kirsch GE, Rosenbaum DS. Hysteresis effect implicates calcium cycling as a mechanism of repolarization alternans. Circulation 108: 2704-2709, 2003.
32. Wan X, Laurita KR, Pruvot EJ, Rosenbaum DS. Molecular correlates of repolarization alternans in cardiac myocytes. J Mol Cell Cardiol 39: 419-428, 2005.
33. Watanabe M, Otani NF, Gilmour RF. Biphasic restitution of action potential duration and complex dynamics in ventricular myocardium. Circ Res 76: 915-921, 1995.
34. Weiss JN, Karma A, Shiferaw Y, Chen PS, Garfinkel A, Qu Z. From pulsus to pulseless: the saga of cardiac alternans. Circ Res 98: 1244-1253, 2006.