The β-thymosin enigma

Annals of the New York Academy of Sciences

Volumn 1112, Issue , 2007, Pages 45-55

  Hui, Qiao Sun ^a   Yin, Helen L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Actin; Cell migration; Integrin signaling; Thymosin 10; Thymosin 4

Indexed keywords

ACTIN; ACTIN BINDING PROTEIN; INTEGRIN; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; THYMOSIN BETA4;

ACTIN POLYMERIZATION; CELL FUNCTION; CELL MOTILITY; CLONING; CONFERENCE PAPER; CYTOSKELETON; DYNAMICS; ENDOTHELIUM CELL; ENZYME ACTIVATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN FUNCTION; PROTEIN INTERACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; X RAY CRYSTALLOGRAPHY;

EID: 35348956868     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1415.021     Document Type: Conference Paper

References (55)

1. GOLDSTEIN, A.L., F.D. SLATER & A. WHITE. 1966. Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin). Proc. Natl. Acad. Sci. USA 56: 1010-1017.
2. LOW, T.L., S.K. HU & A.L. GOLDSTEIN. 1981. Complete amino acid sequence of bovine thymosin beta 4: a thymic hormone that induces terminal deoxynucleotidyl transferase activity in thymocyte populations. Proc. Natl. Acad. Sci. USA 78: 1162-1166.
3. YU, F.X. et al. 1994. Effects of thymosin beta 4 and thymosin beta 10 on actin structures in living cells. Cell Motil. Cytoskel. 27: 13-25.
4. CARLIER, M.F. et al. 1993. Modulation of the interaction between G-actin and thymosin beta 4 by the ATP/ADP ratio: possible implication in the regulation of actin dynamics. Proc. Natl. Acad. Sci. USA 90: 5034-5038.
5. EADIE, J.S., et al. 2000. C-terminal variations in beta-thymosin family members specify functional differences in actin-binding properties. J. Cell Biochem. 77: 277-287.
6. SUN, H.Q., K. KWIATKOWSKA & H.L. YIN. 1995. Actin monomer binding proteins. Curr. Opin. Cell Biol. 7: 102-110.
7. SUN, H.-Q., K. KWIATKOWSKA & H.L. YIN. 1996. Beta-thymosins are not simple actin monomer buffering proteins. J. Biol. Chem. 271: 9223-9230.
8. CARLIER, M.-F. et al. 1996. T beta 4 is not a simple G-actin sequestering protein and interacts with F-actin at high concentration. J. Biol. Chem. 271: 9231-9239.
9. GOLDSTEIN, A.L., E. HANNAPPEL & H.K. KLEINMAN. 2005. Thymosin beta 4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol. Med. 11: 421-429.
10. IWASA, J.H. & R.D. MULLINS. 2007. Spatial and temporal relationships between actin-filament nucleation, capping, and disassembly. Curr. Biol. 17: 395-406.
11. STOSSEL, T.P., G. FENTEANY & J.H. HARTWIG. 2006. Cell surface actin remodeling. J. Cell Sci. 119: 3261-3264.
12. YU, F.X. et al. 1993. Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins. J. Biol. Chem. 268: 502-509.
13. JEAN, C. et al. 1994. Interaction of G-actin with thymosin beta 4 and its variants thymosin beta 9 and thymosin beta met9. J. Musc. Res. Cell Motil. 15: 278-286.
14. CASSIMERIS, L. et al. 1992. Thymosin beta 4 sequesters the majority of G-actin in resting human polymorphonuclear leukocytes. J. Cell Biol. 119: 1261-1270.
15. SAFER, D., M. ELZINGA & V.T. NACHMIAS. 1991. Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. J. Biol. Chem. 266: 4029-4032.
16. YIN, H.L. & P.A. JANMEY. 2003. Phosphoinositide regulation of the actin cytoskeleton. Annu. Rev. Physiol. 65: 761-789.
17. PANTALONI, D. & M.-F. CARLIER. 1993. How profilin promotes actin filament assembly in the presence of thymosin beta 4. Cell 75: 1007-1014.
18. ZARBOCK, J., et al. 1990. Solution conformation of thymosin beta 4: a nuclear magnetic resonance and simulated annealing study. Biochemistry 29: 7814-7821.
19. DOMANSKI, M. et al. 2004. Coupling of folding and binding of thymosin beta 4 upon interaction with monomeric actin monitored by nuclear magnetic resonance. J. Biol. Chem. 279: 23637-23645.
20. IROBI, E. et al. 2004. Structural basis of actin sequestration by thymosin-beta 4: implications for WH2 proteins. EMBO J. 23: 3599-3608.
21. CHEREAU, D. et al. 2005. Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly. PNAS 102: 16644-16649.
22. HERTZOG, M. et al. 2002. Control of actin dynamics by proteins made of beta -thymosin repeats. Actobindin Fam. 277: 14786-14792.
23. HERTZOG, M. et al. 2004. The beta-thymosin/WH2 domain: structural basis for the switch from inhibition to promotion of actin assembly. Cell 117: 611-623.
24. DEDOVA, I.V. et al. 2006. Thymosin beta 4 induces a conformational change in actin monomers. 90: 985-992.
25. NACHMIAS, V.T. et al. 1993. Thymosin beta 4 in activated platelets. Eur. J. Cell Biol. 61: 314-320.
26. SANGER, J.M. et al. 1995. Increasing intracellular concentrations of thymosin beta 4 in PtK2 cells: effects on stress fibers, cytokinesis, and cell spreading. Cell Motil. Cytoskel. 31: 307-322.
27. MUALLEM, S. et al. 1995. Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells. J. Cell Biol. 128: 589-598.
28. WYCZOLKOWSKA, J. et al. 2007. Thymosin beta 4 and thymosin beta 4-derived peptides induce mast cell exocytosis. Peptides 28: 752-759.
29. LAMAZE, C. et al. 1997. The actin cytoskeleton is required for receptor-mediated endocytosis in mammalian cells. J. Biol. Chem. 272: 20332-20335.
30. GOLLA, R. et al. 1997. Co-ordinate regulation of the cytoskeleton in 3T3 cells overexpressing thymosin-beta 4. Cell Motil. Cytoskel. 38: 187-200.
31. MOON, H.-S. et al. 2006. Zyxin is upregulated in the nucleus by thymosin beta 4 in SiHa cells. Exp. Cell Res. 312: 3425-3431.
32. HOFFMAN, L.M. et al. 2006. Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling. J. Cell Biol. 172: 771-782.
33. LIU, N. et al. 2007. Actin deficiency induces cofilin phosphorylation: proteome analysis of HeLa cells after beta-actin gene silencing. Cell Motil. Cytoskel. 64: 110-120.
34. ANDRIANANTOANDRO, E. & T.D. POLLARD. 2006. Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin. Mol. Cell. 24: 13-23.
35. ENDO, M., K. OHASHI & K. MIZUNO. 2007. LIM kinase and slingshot are critical for neurite extension. J. Biol. Chem. 282: 13692-13702.
36. MINAMIDE, L.S. et al. 1997. Differential regulation of actin depolymerizing factor and cofilin in response to alterations in the actin monomer pool. J. Biol. Chem. 272: 8303-8309.
37. SAUNDERS, R.M. et al. 2006. Role of vinculin in regulating focal adhesion turnover. Eur. J. Cell Biol. 85: 487-500.
38. DELON, I. & N.H. BROWN. 2007. Integrins and the actin cytoskeleton. Curr. Opin. Cell Biol. 19: 43-50.
39. HEHLGANS, S., M. HAASE & N. CORDES. 2007. Signalling via integrins: Implications for cell survival and anticancer strategies. Biochim. Biophys. Acta 1775: 163-180.
40. BOCK-MARQUETTE, I. et al. 2004. Thymosin beta 4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 432: 466-472.
41. BENDIG, G. et al. 2006. Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart. Genes Dev. 20: 2361-2372.
42. SRIVASTAVA, D. & S. YU. 2006. Stretching to meet needs: integrin-linked kinase and the cardiac pump. Genes Dev. 20: 2327-2331.
43. HUANG, H.C. et al. 2007. Thymosin beta4 triggers an epithelial-mesenchymal transition in colorectal carcinoma by upregulating integrin-linked kinase. Oncogene 26: 2781-2790
44. NIX, D.A. et al. 2001. Targeting of zyxin to sites of actin membrane interaction and to the nucleus. J. Biol. Chem. 276: 34759-34767.
45. KATO, T. et al. 2005. Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. J. Clin. Invest. 115: 2716-2730.
46. HUFF, T. et al. 2004. Nuclear localisation of the G-actin sequestering peptide thymosin beta4. J. Cell Sci. 117: 5333-5341.
47. VARGHESE, S. & H.M. KRONENBERG. 1991. Rat thymosin beta 4 gene. Intron-containing gene and multiple retroposons. J. Biol. Chem. 266: 14256-14261.
48. LI, X., et al. 1996. The mouse thymosin beta 4 gene: structure, promoter Identification, and chromosome localization. Genomics 32: 388-394.
49. SHU-PING, Y., L. HUI-JU & S. YEU. 2005. Molecular cloning and structural characterization of the functional human thymosin β4 gene. Mol. Cell. Biochem. 272: 97-105.
50. RUDIN, C.M., P. ENGLER & U. STORB. 1990. Differential splicing of thymosin beta 4 mRNA. J. Immunol. 144: 4857-4862.
51. SMART, N., P.J. SCAMBLER & P.R. RILEY. 2005. A rapid and sensitive assay for quantification of siRNA efficiency and specificity. Biol. Proced. Online 7: 1-7.
52. GIBBONS, D.L., C. SHASHIKANT & A.C. HAYDAY. 2004. A comparative analysis of RNA targeting strategies in the thymosin beta 4 gene. J. Mol. Biol. 342: 1069-1076.
53. SMART, N. et al. 2007. Thymosin beta 4 induces adult epicardial progenitor mobilization and neovascularization. Nature 445: 177-182.
54. PHILP, D. et al. 2004. Thymosin beta 4 increases hair growth by activation of hair follicle stem cells. FASEB J. 18(2): 385-387.
55. BONNET, D. et al. 1996. Thymosin beta 4, inhibitor for normal hematopoietic progenitor cells. Exp. Hematol. 24: 776-782.