The miniature pig: A useful large animal model for dental and orofacial research

Oral Diseases

Volumn 13, Issue 6, 2007, Pages 530-537

  Wang, S ^a   Liu, Y ^a   Fang, D ^a   Shi, S ^b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Laboratory animal model; Miniature pig; Oral diseases; Oral maxillofacial region

Indexed keywords

BONE NECROSIS; BONE REGENERATION; CLINICAL RESEARCH; CRANIOFACIAL DEVELOPMENT; DENTAL RESEARCH; GENE TRANSFER; MINIPIG; MOUTH DISEASE; NONHUMAN; PERIODONTAL DISEASE; PRIORITY JOURNAL; RADIATION INJURY; REVIEW; SALIVARY GLAND; SALIVATION;

ANIMALS; DENTAL RESEARCH; GENE TRANSFER TECHNIQUES; HUMANS; MODELS, ANIMAL; PAROTID GLAND; PERIODONTAL DISEASES; RADIATION INJURIES, EXPERIMENTAL; SALIVATION; SWINE; SWINE, MINIATURE; TOOTH;

EID: 35348953134     PISSN: 1354523X     EISSN: 16010825     Source Type: Journal    
DOI: 10.1111/j.1601-0825.2006.01337.x     Document Type: Review

References (49)

1. Baum BJ, Zheng C, Cotrim AP et al (2006). Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction. Biochim Biophys Acta 1758 : 1071 1077.
2. Bermejo A, Gonzalez O, Gonzalez JM (1993). The pig as an animal model for experimentation on the temporomandibular articular complex. Oral Surg Oral Med Oral Pathol 75 : 18 23.
3. Buchter A, Kleinheinz J, Wiesmann HP et al (2005). Biological and biomechanical evaluation of bone remodelling and implant stability after using an osteotome technique. Clin Oral Implants Res 16 : 1 8.
4. Chen L, Shi Q, Scharf SM (2000). Hemodynamic effects of periodic obstructive apneas in sedated pigs with congestive heart failure. J Appl Physiol 88 : 1051 1060.
5. Craig RG, Kallur SP, Inoue M, Rosenberg PA, LeGeros RZ (2004). Effect of enamel matrix proteins on the periodontal connective tissue-material interface after wound healing. J Biomed Mater Res A 69 : 180 187.
6. Delporte C, O'Connell BC, He X et al (1997). Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands. Proc Natl Acad Sci U S A 94 : 3268 3273.
7. England DC, Winters LM, Carpenter LE (1954). The development of a breed of miniature swine; a preliminary report. Growth 18 : 207 214.
8. Gosselin TK, Pavilonis H (2002). Head and neck cancer: managing xerostomia and other treatment induced side effects. ORL Head Neck Nurs 20 : 15 22.
9. Gronthos S, Brahim J, Li W et al (2002). Stem cell properties of human dental pulp stem cells. J Dent Res 81 : 531 535.
10. Hickey JS, O'Neal RB, Scheidt MJ, Strong SL, Turgeon D, Van Dyke TE (1991). Microbiologic characterization of ligature-induced peri-implantitis in the microswine model. J Periodontol 62 : 548 553.
11. Hollister SJ, Levy RA, Chu TM, Halloran JW, Feinberg SE (2000). An image-based approach for designing and manufacturing craniofacial scafflolds. Int J Oral Maxillofac Surg 29 : 66 67.
12. Kalkwarf KL, Krejci RF (1983). Effect of inflammation on periodontal attachment levels in miniature swine with mucogingival defects. J Periodontol 54 : 361 364.
13. Lang H, Schuler N, Nolden R (1998). Attachment formation following replantation of cultured cells into periodontal defects - a study in minipigs. J Dent Res 77 : 393 405.
14. Larsen MO, Rolin B (2004). Use of the Gottingen minipig as a model of diabetes, with special focus on type 1 diabetes research. ILAR J 45 : 303 313.
15. Li YJ (1993). The characters of the dental system in Chinese minipig. Zhonghua Kou Qiang Yi Xue Za Zhi 28 : 234 236 (in Chinese).
16. Li J, Zheng C, Zhang X et al (2004). Developing a convenient large animal model for gene transfer to salivary glands in vivo. J Gene Med 6 : 55 63.
17. Li B, Zhao LM, Xiu QY et al (2005a). An experimental study on the minipig model of obstructive sleep apnea syndrome. J Biomed Eng 22 : 565 569 (in Chinese).
18. Li J, Shan Z, Ou G et al (2005b). Structural and functional characteristics of irradiation damage to parotid glands in the miniature pig. Int J Radiat Oncol Biol Phys 62 : 1510 1516.
19. Li YT, Liu Y, Zhang CM, Liu XY, Wang SL (2006). Comparative analysis of mixed saliva flow rate, pH, buffer capacity and biochemistry among miniature pigs, rats and humans. Beijing J Stomatol (in press) (in Chinese).
20. Lotz S, Caselitz J, Tschakert H, Rehpenning W, Seifert G (1990). Radioprotection of minipig salivary glands by orciprenaline-carbachol. An ultrastructural and semiquantitative light microscopic study. Virchows Arch A Pathol Anat Histopathol 417 : 119 128.
21. Ma DQ (2002). Diseases of the salivary glands, 2nd edn. People's Health Publishing House : Beijing (in Chinese).
22. Meng H, Xie H, Chen Z (1996). Evaluation of ligature-induced periodontitis in minipig. Zhonghua Kou Qiang Yi Xue Za Zhi 31 : 333 336 (in Chinese).
23. Meng H, Cao C, Zhang SW, Chen ZB, Zhang KH, Wang HJ (1997). The study of gingivitis in deciduous teeth of minipigs. J Beijing Med Univ 29 : 53 55 (in Chinese).
24. Millikan LE, Boylon JL, Hook RR, Manning PJ (1974). Melanoma in Sinclair swine: a new animal model. J Invest Dermatol 62 : 20 30.
25. Nagler RM (2003). Effects of head and neck radiotherapy on major salivary glands - animal studies and human implications. In Vitro 17 : 369 375.
26. Niederhagen B, Braumann B, Schmolke C, Appel T, von Lindern JJ, Berge S (1999). Tooth-borne distraction of the mandible. An experimental study. Int J Oral Maxillofac Surg 28 : 475 479.
27. Nkenke E, Lehner B, Fenner M et al (2005). Immediate versus delayed loading of dental implants in the maxillae of minipigs: follow-up of implant stability and implant failures. Int J Oral Maxillofac Implants 20 : 39 47.
28. Polejaeva IA, Chen SH, Vaught TD et al (2000). Cloned pigs produced by nuclear transfer from adult somatic cells. Nature 407 : 86 90.
29. Radfar L, Sirois DA (2003). Structural and functional injury in minipig salivary glands following fractionated exposure to 70 Gy of ionizing radiation: an animal model for human radiation-induced salivary gland injury. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96 : 267 274.
30. Schultze-Mosgau S, Schliephake H, Radespiel-Troger M, Neukam FW (2000). Osseointegration of endodontic endosseous cones: zirconium oxide vs titanurm. Oral Surg Oral Med Ord Pathol Oral Radiol Endod 89 : 91 98.
31. Schwartz HC, Kagan AR (2002). Osteoradionecrosis of the mandible: scientific basis for clinical staging. Am J Clin Oncol 25 : 168 171.
32. Screaton NJ, Coxson HO, Kalloger SE et al (2003). Detection of lung perfusion abnormalities using computed tomography in a porcine model of pulmonary embolism. J Thorac Imaging 18 : 14 20.
33. Seo BM, Miura M, Gronthos S et al (2004). Multipotent postnatal stem cells from human periodontal ligament. Lancet 364 : 149 155.
34. Shan Z, Li J, Zheng C et al (2005). Increased fluid secretion after adenoviral-mediated transfer of the human aquaporin-1 cDNA to irradiated miniature pig parotid glands. Mol Ther 11 : 444 451.
35. Shi S, Gronthos S (2003). Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp. J Bone Miner Res 18 : 696 704.
36. Singh G, O'Neal RB, Brennan WA, Strong SL, Horner JA, Van Dyke TE (1993). Surgical treatment of induced peri-implantitis in the micro pig: clinical and histological analysis. J Periodontol 64 : 984 989.
37. Sun T, Zhu J, Yang X, Wang SL (2006). Growth of miniature pig parotid cells on biomaterials in vitro. Arch Oral Biol 51 : 351 358.
38. Van Dorp AG, Verhoeven MC, Koerten HK, Van Der Nat-Van Der Meij TH, Van Blitterswijk CA, Ponec M (1998). Dermal regeneration in full-thickness wounds in Yucatan miniature pigs using a biodegradable copolymer. Wound Repair Regen 6 : 556 568.
39. Wang SL, Li J, Zhu XZ, Sun K, Liu XY, Zhang YG (1998). Sialographic characterization of the normal parotid gland of the miniature pig. Dentomaxillofac Radiol 27 : 178 181.
40. Weaver ME, Jump EB, McKean CF (1966). The eruption pattern of deciduous teeth in miniature swine. Anat Rec 154 : 81 86.
41. Weaver ME, Jump EB, McKean CF (1969). The eruption pattern of permanent teeth in miniature swine. Arch Oral Biol 14 : 323 331.
42. Wurzler KK, Heisterkamp M, Bohm H, Kubler NR, Sebald W, Reuther JF (2004). Mandibular reconstruction with autologous bone and osseoinductive implant in the Gottingen minipig. Mund Kiefer Gesichtschir 8 : 75 82.
43. Xia DS, Deng DJ, Wang SL (2003a). Alterations of nitrate and nitrite content in saliva, serum, and urine in patients with salivary dysfunction. J Oral Pathol Med 32 : 95 99.
44. Xia DS, Deng DJ, Wang SL (2003b). Destruction of parotid glands affects nitrate and nitrite metabolism. J Dent Res 82 : 101 105.
45. Xu Q, Yu D, Qiu Y, Zhang H, Ding Y (2003). Function of a new internal bioartificial liver: an in vitro study. Ann Clin Lab Sci 33 : 306 312.
46. Yu SM, Wang CW, Zhao DM, Zhang QC, Pei DZ (2003). Raising and pathogen purification of Chinese experimental mini-pig. Lab Anim Sci Admin 20 : 44 46.
47. Zhang X, Li J, Liu XY, Sun YL, Zhang CM, Wang SL (2003). Comparative study of sialography and anatomy of salivary glands of five species experimental animals. Beijing J Stomatol 11 : 195 199 (in Chinese).
48. Zhang X, Li J, Liu XY, Sun YL, Zhang CM, Wang SL (2005). Morphological characteristics of submandibular gland of miniature pig. Chin Med J 118 : 1368 1373.
49. Ziegler A, Keilig L, Kawarizadeh A, Jager A, Bourauel C (2005). Numerical simulation of the biomechanical behaviour of multi-rooted teeth. Eur J Orthod 27 : 333 339.