Structural and functional injury in minipig salivary glands following fractionated exposure to 70 Gy of ionizing radiation: An animal model for human radiation-induced salivary gland injury

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

Volumn 96, Issue 3, 2003, Pages 267-274

  Radfar, Lida ^a   Sirois, David A ^b  

^a UNIVERSITY AT BUFFALO   (United States)

^b NEW YORK UNIVERSITY COLLEGE OF DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CLINICAL PRACTICE; CONTROLLED STUDY; ENDOCRINE GLAND; FEASIBILITY STUDY; FRACTIONATION; GAMMA IRRADIATION; GAMMA RADIATION; HUMAN; MALE; NONHUMAN; PARENCHYMA; PAROTID GLAND; RADIATION DOSE; SALIVARY GLAND; SALIVARY GLAND DISEASE; SALIVATION; SWINE;

EID: 0042335962     PISSN: 10792104     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1079-2104(03)00369-X     Document Type: Article

References (36)

1. Cheng V.S., Downs J., Herbert D., Aramany M. The function of the parotid gland following radiation therapy for head and neck cancer. Int J Radiat Oncol Biol Phys. 7:1981;253-258.
2. Frank R.M., Herdly J., Phillipe E. Acquired dental defects and salivary gland lesions after irradiation for carcinoma. J Am Dent Assoc. 70:1965;868-883.
3. Dreizen S., Brown L., Handler S., Levy B.M. Radiation-induced xerostomia in cancer patients. Effect on salivary and serum electrolytes. Cancer. 38:1976;273-278.
4. Valdez I.H., Atkinson J.C., Ship J.A., Fox P.C. Major salivary gland function in patients with radiation-induced xerostomia flow rates and sialochemistry . Int J Radiat Oncol Biol Phys. 25:1993;41-47.
5. Wolff A., Atkinson J.C., Macynski A.A., Fox P.C. Oral complications of cancer therapies. Pretherapy interventions to modify salivary dysfunction. NCI Monogr. 9:1990;87-90.
6. Wolff A., Fox P.C., Ship J.A., Atkinson J.C., Macynski A.A., Baum B.J. Oral mucosal status and major salivary gland function. Oral Surg Oral Med Oral Pathol. 70:1990;49-54.
7. Ship J.A., Eisbruch A., D'Hondt E., Jones R.E. Parotid sparing study in head and neck cancer patients receiving bilateral radiation therapy one-year results . J Dent Res. 76:1997;807-813.
8. Eisbruch A., Dawson L.A., Kim H.M., Bradford C.R., Terrell J.E., Chepeha D.B., et al. Conformal and intensity modulated irradiation of head and neck cancer the potential for improved target irradiation, salivary gland function, and quality of life . Acta Otorhinolaryngol Belg. 3:1999;271-275.
9. Eisbruch A., Ten Haken R.K., Kim H.M., Marsh L.H., Ship J.A. Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer. Int J Radiat Oncol Biol Phys. 45:1999;577-587.
10. Jha N., Seikaly H., Harris J., Williams D., Liu R., McGaw T., et al. Prevention of radiation-induced xerostomia by surgical transfer of submandibular salivary gland into the submental space. Radiother Oncol. 66:2003;283-289.
11. Haddad P., Karimi M. A randomized, double-blind, placebo-controlled trial of concomitant pilocarpine with head and neck irradiation for prevention of radiation-induced xerostomia. Radiother Oncol. 64:2002;29-32.
12. Anne P.R., Curran W.J. A phase II trial of subcutaneous amifostine and radiation therapy in patients with head and neck cancer. Semin Radiat Oncol. 12:(1 Suppl 1):2002;18-19. Jan.
13. Mossman K., Shatzman A., Chencharick J. Long-term effects of radiotherapy on taste and salivary function in man. Int J Radiat Oncol Biol Phys. 8:1982;991-997.
14. Abok K., Brunk U., Jung B. Morphologic and histochemical studies on the differing radiosensitivity of ductular and acinar cells of the rat submandibular gland. Virchows Arch B Cell Pathol Incl Mol Pathol. 45:1984;443-460.
15. Ahlner B.H., Hagelqvist E., Lind M. Influence on rabbit submandibular gland injury by stimulation or inhibition of gland function during irradiation. Histology and morphometry after 15 gray. Ann Otol Rhinol Laryngol. 103:1994;125-134.
16. Ahlner B.H., Hagelqvist E., Lind M., Ruden B.I. Irradiation of rabbit submandibular glands. Histology and morphometry after 15 Gy. Acta Otolaryngol. 113:1993;210-219.
17. Stephens L.C., King G.K., Peters L.J., Ang K.K., Schultheiss T.E., Jardine J.H. Acute and late radiation injury in Rhesus monkey parotid glands. Evidence of interphase cell death. IS J Patrol. 124:1986;469-478.
18. Stephens L.C., King G.K., Peters L.J., Ang K.K., Schultheiss T.E., Jardine J.H. Unique radiosensitivity of serous cells in rhesus monkey submandibular glands. Am J Pathol. 124:1986;479-487.
19. Stephens L.C., Ang K.K., Schultheiss T.E., King G.K., Brock W.A., Peters L.J. Target cell and mode of radiation injury in rhesus salivary glands. Radiother Oncol. 7:1986;165-174.
20. Nagler R.M., Baum B.J., Miller G., Fox P.C. Long-term salivary effects of single-dose head and neck irradiation in the rat. Arch Oral Biol. 43:1998;297-303.
21. Veninga T., Visser A.G., van den Berg A.P., van Hooije C.M., van Geel C.A., Levendag P.C. Equivalence of hyperfractionated and continuous brachytherapy in a rat tumor model and remarkable effectiveness when preceded by external irradiation. J Radiat Oncol Biol Phys. 49:2001;1351-1360.
22. Bohuslavizki K.H., Klutmann S., Jenicke L., Kroger S., Buchert R., Mester J., et al. Salivary gland protection by S-2-(3-aminopropylamino)-ethylphosphorothioic acid (amifostine in high-dose radioiodine treatment results obtained in a rabbit animal model and in a double-blind multi-arm trial . Cancer Biother Radiopharm. 4:1999;337-347.
23. Boshell J., Wilborn W. Histology and ultrastructure of the pig parotid gland. Am J Anat. 152:1978;447-465.
24. Lotz S., Caselitz J., Tschakert H., Rehpenning W., Seifert G. Radioprotection of minipig salivary glands by orciprenaline-carbachol. An ultrastructural and semiquantitative light microscopic study. Virchows Arch A Pathol Anat Histopathol. 417:1990;119-128.
25. Casarett G.W. Radiation injury. Surg Annu. 4:1972;103-122.
26. Rubin P., Casarett G.W. Clinical radiation pathology. 1968;WB Saunders Co, Philadelphia.
27. Law M.P. Radiation-induced vascular injury and its relation to late effect in normal tissues. Adv Radiat Biol. 9:1981;38-70.
28. Fajardo L.F., Berthrong M. Radiation injury in surgical pathology. Part III. Salivary glands, pancreas and skin. Am J Surg Pathol. 5:1981;279-296.
29. Berthrong M. Pathologic changes secondary to radiation. World J Surg. 10:1986;155-170.
30. Busuttil A. Irradiation-induced changes in human salivary glands. Clin Otolaryngol. 2:1977;199-206.
31. Mossman K.L. Quantitative radiation dose-response relationships for normal tissues in man. II. Response of the salivary glands during radiotherapy. Radiat Res. 95:1983;392-398.
32. O'Connel A.C., Redman R.S., Evans R.L., Ambudkar I.S. Radiation induced progressive decrease in fluid secretion in rat submandibular glands is related to decreased acinar volume and not impaired calcium signaling. Radiat Res. 151:1999;150-158.
33. Casarett G.W. Radiation histopathology. Vol 1. 1980;CRC Press, Boca Raton (Fla).
34. Squier C.A. Mucosal alterations. NCI Monogr. 9:1990;169-172.
35. Nagler R., Marmary Y., Fox P.C., Baum B.J., Har-El R., Chevion M. Irradiation-induced damage to the salivary glands the role of redox-active iron and copper . Radiat Res. 147:1997;468-477.
36. Nagler R.M., Laufer D. Protection against irradiation-induced damage to salivary glands by adrenergic agonist administration. Int J Radiat Oncol Biol Phys. 40:1998;477-481.