Lung cancer risk of Mayak workers: Modelling of carcinogenesis and bystander effect

Radiation and Environmental Biophysics

Volumn 46, Issue 4, 2007, Pages 383-394

  Jacob, P ^a   Meckbach, R ^a   Sokolnikov, M ^b   Khokhryakov, V V ^b   Vasilenko, E ^c  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b Southern Ural Biophysics Institute   (Russian Federation)

^c MAYAK PRODUCTION ASSOCIATION   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL EFFECTIVENESS; BYSTANDER EFFECT; TWO-STAGE CLONAL EXPANSION (TSCE); UNCERTAINTY BANDS;

CARCINOGENS; MATHEMATICAL MODELS; PLUTONIUM; PULMONARY DISEASES; RISK ASSESSMENT;

MOLECULAR BIOLOGY;

PLUTONIUM;

ADULT; ARTICLE; ATOMIC BOMB; BYSTANDER EFFECT; CANCER MORTALITY; CANCER RISK; CANCER SURVIVOR; CARCINOGENESIS; CIGARETTE SMOKING; CONTROLLED STUDY; GENE MUTATION; HUMAN; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; PATIENT INFORMATION; RADIATION DOSE DISTRIBUTION; WORKER;

ADULT; BYSTANDER EFFECT; COMORBIDITY; COMPUTER SIMULATION; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MODELS, BIOLOGICAL; NEOPLASMS, RADIATION-INDUCED; OCCUPATIONAL EXPOSURE; PREVALENCE; RISK ASSESSMENT; RISK FACTORS; RUSSIA; SMOKING;

EID: 35348945457     PISSN: 0301634X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00411-007-0117-0     Document Type: Article

References (30)

1. Brenner DJ, Doll R, Goodhead DT, Hall EJ, Land CE, Little JB, Lubin JH, Preston DL, Preston RJ, Puskin JS, Ron E, Sachs RK, Samet JM, Setlow RB, Zaider M (2003) Cancer risk attributable to low doses of ionizing radiation: assessing what we really know. Proc Natl Acad Sci 100:13761-13766
2. Sachs RK, Chan M, Hlatky L, Hahnfeldt P (2005) Modeling intercellular interactions during carcinogenesis. Radiat Res 164:324-331
3. Moolgavkar SH, Venzon DJ (1979) Two-events models for carcinogenesis: incidence curves for childhood and adult tumors. Math Biosci 47:55-77
4. Moolgavkar S, Knudson A (1981) Mutation and cancer: a model for human carcinogenesis. J Natl Cancer Inst 66:1037-1052
5. Jacob V, Jacob P (2004) Modelling of carcinogenesis and low-dose hypersensitivity: an application to lung cancer incidence among atomic bomb survivors. Radiat Environ Biophys 42:265-273
6. Coates PJ, Lorimore SA, Wright EG (2004) Damaging and protective cell signalling in the untargeted effects of ionizing radiation. Mutat Res 568:5-20
7. Nagasawa H, Little B (1999) Unexpected sensitivity to the induction of mutations by very low doses of alpha particle radiation: evidence for a bystander effect. Radiat Res 54:552-557
8. Zhou HG, Randers-Pehrson G, Waldren CA, Vannais D, Hall EJ, Hei TK (2000) Induction of a bystander mutagenic effect of alpha particles in mamalian cells. Proc Natl Acad Sci 97:2099-2104
9. Koshurnikova NA, Bolotnikova MG, Ilyin LA, Keirim-Markus IB, Menshikh ZS, Okatenko PV, Romanov SA, Tcvetkov VI, Shilnikova NS (1998) Lung cancer risk due to exposure to incorporated plutonium. Radiat Res 149:366-371
10. Kreisheimer M, Sokolnikov ME, Koshurnikova NA, Khokhryakov VF, Romanow SA, Shilnikova NS, Okatenko PV, Nekolla EA, Kellerer AM (2003) Lung cancer mortality among nuclear workers of the Mayak facilities in the former Soviet Union. Radiat Environ Biophys 42:129-135
11. Gilbert ES, Koshurnikova NA, Sokolnikov ME, Shilnikova NS, Preston DL, Ron E, Okatenko PV, Khokhryakov VF, Vasilenko EK, Miller S, Eckerman K, Romanov SA (2004) Lung cancer in Mayak workers. Radiat Res 162:505-515
12. Jacob V, Jacob P, Meckbach R, Romanov SA, Vasilenko EK (2005) Lung cancer in Mayak workers: interaction of smoking and plutonium exposure. Radiat Environ Biophys 44:119-129
13. Jacob V, Jacob P, Meckbach R, Romanov SA, Vasilenko EK (2006) Lung cancer in Mayak workers: interaction of smoking and plutonium exposure. Radiat Environ Biophys 44:307 (Erratum)
14. Walsh L (2007) A short review of model selection techniques for radiation epidemiology. Radiat Environ Biophys. doi: 10.1007/s00411-007-0109-0
15. ICRP Publication 66 (1994) Human respiratory tract model for radiological protection. Ann ICRP 24(1-3):1-482
16. Khokhryakov VF, Suslova KG, Vostrotin VV, Romanov SA, Eckerman KF, Krahenbuhl MP, Miller SC (2005) Adaptation of the ICRP publication 66 respiratory tract model to data on plutonium biokinetics for Mayak workers. Health Phys 2:125-132
17. ICRP Publication 67 (1994) Age-dependent doses to members of the public from intake of radionuclides: Part 2. Ingestion dose coefficients. Ann ICRP 23(3-4):1-167
18. Leggett RW, Eckerman KF, Khokhryakov VF, Suslova KG, Krahenbuhl MP, Miller SC (2005) Mayak worker study: an improved biokinetic model for reconstructing doses from internally deposited plutonium. Radiat Res 164:111-122
19. Heidenreich WF, Jacob P, Paretzke HG (1997) Exact solutions of the clonal expansion model and their application to the incidence of solid tumors of atomic bomb survivors. Radiat Environ Biophys 36:45-58
20. Akaike H (1973) Information theory and an extension of the maximum likelihood principle. In: Petrov and BN, Caski F (eds) Proceedings of the 2nd international symposium on information theory. Budapest, Hungary, Akademiai Kiado, pp 267-281
21. Schwarz G (1978) Estimating the dimension of a model. Ann Stat 6:461-464
22. Luebeck AG, Heidenreich WF, Hazelton WD, Paretzke HG, Moolgavkar SH (1999) Biologically based analysis of the data for the Colorado uranium miners cohort: age, dose and dose-rate effects. Radiat Res 152:339-351
23. Jacob P, Walsh L, Eidemüller M (2007) Modelling of carcinogenesis and cell killing in the atomic bomb survivors with applications to the mortality from all solid, stomach and liver cancers. (submitted)
24. ICRP Publication 60 (1992) 1990 Recommendations of the international commission on radiological protection. Ann ICRP 21(1-3):1-201
25. Jacob P, Jacob V (2003) Biological parameters for lung cancer in mathematical models of carcinogenesis. Radiat Prot Dosim 104:357-366
26. Wistuba II, Behrens C, Virmani AK, Mele G, Milchgrub S, Girard L, Fondon JW, Garner HR, McKay B, Latif F, Lerman MI, Lam S, Gazdar AF, Minna JD (2000) High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints. Cancer Res 60:1949-1960
27. Kopp-Schneider A, Haertel T, Burkolder I, Bannasch P, Wesch H, Groos J, Heeger S (2006) Investigating the formation and growth of α-particle radiation-induced foci of altered hepatocytes: a model-based approach. Radiat Res 166:422-430
28. Sokolnikov ME, Khokhryakov VF, Vasilenko EK, Koshournikova NA (2003) Risk of lung cancer development in the personnel exposed to internal radiation as a result of incorporated Pu. Sibirian Med J 5:31-35 (in Russian)
29. Darby S, Hill D, Auvinen A, Barros-Dios JM, Baysson H, Bochicchio F, Deo H, Falk R, Forastiere F, Hakama M, Heid I, Kreienbrock L, Kreuzer M, Lagarde FC, Mäkeläinen I, Muirhead C, Oberaigner W, Pershagen G, Ruano-Ravina A, Ruosteenoja E, Schaffrath RA, Tirmarche MA, Tomášek L, Whitley E, Wichmann HE (2005) Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies. BMJ 330:223-226
30. Preston DL, Shimizu Y, Pierce DA, Suyama A, Mabuchi K (2003) Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and non-cancer disease mortality: 1950-1997. Radiat Res 160:381-407