Transcriptional inhibition of oxytocin receptor expression in human myometrial cells by melatonin involves protein kinase C signaling

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 10, 2007, Pages 4015-4019

  Sharkey, James ^a   Olcese, James ^a  

^a FLORIDA STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; MELATONIN; MELATONIN 2 RECEPTOR; MELATONIN DERIVATIVE; MESSENGER RNA; OXYTOCIN RECEPTOR; PHOSPHOLIPASE C; PROTEIN KINASE C; TELOMERASE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MYOMETRIUM; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION;

EID: 35348937107     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2007-1128     Document Type: Article

References (28)

1. Sanborn BM, Qian A, Ku CY, Wen Y, Anwer K, Monga M, Singh SP 1995 Mechanisms regulating oxytocin receptor coupling to phospholipase C in rat and human myometrium. Adv Exp Med Biol 395:469-479
2. Gimpl G, Fahrenholz F 2001 The oxytocin receptor system: structure, function and regulation. Physiol Rev 81:629-683
3. Åkerlund M 2006 Targeting the oxytocin receptor to relax the myometrium. Expert Opin Ther Targets 10:423-427
4. Martensson LG, Andersson RG, Berg G 1996 Melatonin together with noradrenaline augments contractions of human myometrium. Eur J Pharmacol 316:273-275
5. Masana MI, Dubocovich ML 2001 Melatonin receptor signaling: finding the path through the dark. Sci STKE 107:39-43
6. Schlabritz-Loutsevitch N, Hellner N, Middendorf R, Müller D, Olcese J 2003 The human myometrium as a target for melatonin. J Clin Endocrinol Metab 88:908-913
7. Condon J, Yin S, Mayhew B, Word RA, Wright WE, Shay JW, Rainey WE 2002 Telomerase immortalization of human myometrial cells. Biol Reprod 67:506-514
8. Devost D, Zingg HH 2007 Novel in vitro system for functional assessment of oxytocin action. Am J Physiol Endocrinol Metab 292:E1-E6
9. Takayama H, Nakamura Y, Tamura H, Yamagata Y, Harada A, Nakata M, Sugino N, Kato H 2003 Pineal gland (melatonin) affects the parturition time, but not luteal function and fetal growth, in pregnant rats. Endocr J 50:37-43
10. Hertz-Eshel M, Rahamimoff R 1965 Effect of melatonin on uterine contractility. Life Sci 4:1367-1372
11. Burns JK 1972 Effects of melatonin on some blood constituents and on uterine contractility in the rat. J Physiol 226:106P-107P
12. Cohen M, Roselle D, Chabner B, Schmidt TJ, Lippman M 1978 Evidence for a cytoplasmic melatonin receptor. Nature 274:894-895
13. Gimeno MF, Landa A, Sterin-Speziale N, Cardinali DP, Gimeno AL 1980 Melatonin blocks in vitro generation of prostaglandin by the uterus and hypothalamus. Eur J Pharmacol 62:309-317
14. Abd-Allah ARA, El-Sayed EM, Abdel-Wahab MH, Hamada FMA 2003 Effect of melatonin on estrogen and progesterone receptors in relation to uterine contraction in rats. Pharmacol Res 47:349-354
15. Ca channel activity. Mol Endocrinol 17:2103-2115
16. Khan RN, Matharoo-Ball B, Arulkumaran S, Ashford ML 2001 Potassium channels in the human myometrium. Exp Physiol 86:255-264
17. Matharoo-Ball B, Ashford ML, Arulkumaran S, Khan RN 2003 Down-regulation of the α- and β-subunits of the calcium-activated potassium channel in human myometrium with parturition. Biol Reprod 68:2135-2141
18. Glattre E, Bjerkedal T 1983 The 24-hour rhythmicity of birth. A population study. Acta Obstet Gynecol Scand 62:31-36
19. Cooperstock M, England JE, Wolfe RA 1987 Circadian incidence of labor onset hour in preterm birth and chorioamnionitis. Obstet Gynecol 70:852-855
20. Panduro-Baron G, Gonzales-Moreno J, Hernandez-Figuerolla E 1994 The biorhythm of birth. Int J Gynecol Obstet 45:283-284
21. Europe-Finner GN, Phaneuf S, Tolkovsky AM, Watson SP, Lopez Bernal A 1994 Down-regulation of Gαs in human myometrium in term and preterm labour: a mechanism for parturition. J Clin Endocrinol Metab 79:1835-1839
22. Brodt-Eppley J, Myatt L 1999 Prostaglandin receptors in lower segment myometrium during gestation and labor. Obstet Gynecol 93:89-93
23. Fuchs AF, Husslein P, Fuchs F 1981 Oxytocin and the initiation of human parturition. II. Stimulation of prostaglandin production in human decidua by oxytocin. Am J Obstet Gynecol 141:694-697
24. Phaneuf S, Rodriguez Linares B, TambyRaja RL, MacKenzie IZ, Lopez Bernal A 2000 Loss of myometrial oxytocin receptors during oxytocin-induced and oxytocin-augmented labour. J Reprod Fertil 120:91-97
25. Kimura T, Saji F, Nishimori K, Ogita K, Nakamura H, Koyama M, Murata Y 2003 Molecular regulation of the oxytocin receptor in peripheral organs. J Mol Endocrinol 30:109-115
26. Wierrani F, Grin W, Hlawka B, Kroiss A, Grünberger W 1997 Elevated serum melatonin levels during human late pregnancy and labour. J Obstet Gynaecol 17:449-451
27. Matsumoto T, Hess DL, Kaushal KM, Valenzuela GJ, Yellon SM, Ducsay CA 1991 Circadian myometrial and endocrine rhythms in the pregnant rhesus macaque: effects of constant light and timed melatonin infusion. Am J Obstet Gynecol 165:1777-1784
28. Ramirez-Rodriquez G, Ortiz-Lopez L, Benetiz-King G 2007 Melatonin increases stress fibers and focal adhesions in MDCK cells: participation of Rho-associated kinase and protein kinase C. J Pineal Res 42:180-190