Low density of CD3+, CD4+ and CD8+ cells is associated with increased risk of relapse in squamous cell cervical cancer

British Journal of Cancer

Volumn 97, Issue 8, 2007, Pages 1135-1138

  Nedergaard, B S ^a   Ladekarl, M ^b   Thomsen, H F ^b   Nyengaard, J R ^c   Nielsen, K ^a  

^a AALBORG UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

Cervix carcinoma; Immunohistochemistry; Stereology; Tumour infiltrating lymphocytes

Indexed keywords

PARAFFIN;

ADULT; AGED; ANALYTIC METHOD; ARTICLE; CANCER DIAGNOSIS; CANCER RELAPSE; CANCER RISK; CANCER STAGING; CELL DENSITY; CELL TYPE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; HAZARD RATIO; HELPER CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; REGULATORY T LYMPHOCYTE; SQUAMOUS CELL CARCINOMA; STEREOLOGY; T LYMPHOCYTE; UTERINE CERVIX; UTERINE CERVIX CANCER;

ADULT; AGED; ANTIGENS, CD3; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIERS ESTIMATE; LYMPHOCYTES, TUMOR-INFILTRATING; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NEOPLASMS, SQUAMOUS CELL; T-LYMPHOCYTE SUBSETS; UTERINE CERVICAL NEOPLASMS;

EID: 35348901971     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604001     Document Type: Article

References (20)

1. Benedet JL, Bender H, Jones III H, Ngan HY, Pecorelli S (2000) FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology. Int J Gynaecol Obstet 70(2): 209-262
2. Bethwaite PB, Holloway LJ, Thornton A, Delahunt B (1996) Infiltration by immunocompetent cells in early stage invasive carcinoma of the uterine cervix: a prognostic study. Pathology 28: 321-327
3. Bosch FX, Munoz N (2002) The viral etiology of cervical cancer. Virus Res 89: 183-190
4. Chao HT, Wang PH, Tseng JY, Lai CR, Chiang SC, Yuan CC (1999) Lymphocyte-infiltrated FIGO Stage IIB squamous cell carcinoma of the cervix is a prominent factor for disease-free survival. Eur J Gynaecol Oncol 20: 136-140
5. Dupont G, Lauszus FF, Guttorm E, Vetner MO (2005) [Survival rate after radical hysterectomy for cervical cancer performed in a central hospital]. Ugeskr Laeger 167: 4367-4371
6. Eerola AK, Soini Y, Paakko P (2000) A high number of tumor-infiltrating lymphocytes are associated with a small tumor size, low tumor stage, and a favorable prognosis in operated small cell lung carcinoma. Clin Cancer Res 6: 1875-1881
7. Eiben GL, Velders MP, Kast WM (2002) The cell-mediated immune response to human papillomavirus-induced cervical cancer: implications for immunotherapy. Adv Cancer Res 86: 113-148
8. Guidoboni M, Gafa R, Viel A, Doglioni C, Russo A, Santini A, Del Tin L, Macri E, Lanza G, Boiocchi M, Dolcetti R (2001) Microsatellite instability and high content of activated cytotoxic lymphocytes identify colon cancer patients with a favorable prognosis. Am J Pathol 159: 297-304
9. Gundersen HJG (1977) Notes on the estimation of the numerical density of arbitrary profiles: the edge effect. J Microsc 111: 219-223
10. Hakim FT, Flomerfelt FA, Boyiadzis M, Gress RE (2004) Aging, immunity and cancer. Curr Opin Immunol 16: 151-156
11. Johnson SK, Kerr KM, Chapman AD, Kennedy MM, King G, Cockburn JS, Jeffrey RR (2000) Immune cell infiltrates and prognosis in primary carcinoma of the lung. Lung Cancer 27: 27-35
12. Kondratiev S, Sabo E, Yakirevich E, Lavie O, Resnick MB (2004) Intratumoral CD8+ T lymphocytes as a prognostic factor of survival in endometrial carcinoma. Clin Cancer Res 10: 4450-4456
13. Koutsky LA, Harper DM (2006) Chapter 13: current findings from prophylactic HPV vaccine trials. Vaccine 24(Suppl 3): S114-S121
14. Kristensen GB, Abeler VM, Risberg B, Trop C, Bryne M (1999) Tumor size, depth of invasion, and grading of the invasive tumor front are the main prognostic factors in early squamous cell cervical carcinoma. Gynecol Oncol 74: 245-251
15. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108
16. Piersma SJ, Jordanova ES, van Poelgeest MI, Kwappenberg KM, van der Hulst JM, Drijfhout JW, Melief CJ, Kenter GG, Fleuren GJ, Offringa R, van der Burg SH (2007) High number of intraepithelial CD8+ tumor-infiltrating lymphocytes is associated with the absence of lymph node metastases in patients with large early-stage cervical cancer. Cancer Res 67: 354-361
17. Sato E, Olson SH, Ahn J, Bundy B, Nishikawa H, Qian F, Jungbluth AA, Frosina D, Gnjatic S, Ambrosone C, Kepner J, Odunsi T, Ritter G, Lele S, Chen YT, Ohtani H, Old LJ, Odunsi K (2005) Intraepithelial CD8(+) tumor-infiltrating lymphocytes and a high CD8(+)/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci USA 102: 18538-18543
18. Sheu BC, Hsu SM, Ho HN, Lin RH, Torng PL, Huang SC (1999) Reversed CD4/CD8 ratios of tumor-infiltrating lymphocytes are correlated with the progression of human cervical carcinoma. Cancer 86: 1537-1543
19. Singh N, Arif S (2004) Histopathologic parameters of prognosis in cervical cancer - a review. Int J Gynecol Cancer 14: 741-750
20. Zhang L, Conejo-Garcia JR, Katsaros D, Gimotty PA, Massobrio M, Regnani G, Makrigiannakis A, Gray H, Schlienger K, Liebman MN, Rubin SC, Coukos G (2003) Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med 348: 203-213