Effect of berbering on HIF-1α expression induced by focal cerebral ischemia in rats

Acta Anatomica Sinica

Volumn 38, Issue 4, 2007, Pages 394-399

  Chen, Chun Hua ^a   Hu, Qin ^a   Yang, Lei ^a   Wang, Ke ^a   Zhou, Chang Man ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Apoptosis; Berberine; Cerebral ischemia; HIF 1 ; Immunohistochemical staining; Rat

Indexed keywords

BERBERINE; CASPASE 3; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN BNIP3; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL NECROSIS; NEUROPROTECTION; NICK END LABELING; NISSL STAINING; NONHUMAN; PROTEIN LOCALIZATION; RAT; SPRAGUE DAWLEY RAT;

RATTUS;

EID: 35348895606     PISSN: 05291356     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Sharp FR, Lu A, Tang Y, et al. Multiple molecular penumbras after focal cerebral ischemia[J]. J Cereb Blood Flow Metab, 2000, 20(7): 1011-1032.
2. Jiang Y, Wu J, Keep RF, et al. Hypoxia-inducible factor-1 alpha accumulation in the brain after experimental intracerebral hemorrhage [J].J Cereb Blood Flow Metab, 2002,22(6):689-696.
3. Sun W, Kim KH, Noh M, et al. Induction of CITED2 expression in the rat hippocampus following transient global ischemia [J]. Brain Res, 2006,1072(1):15-18.
4. Prass K, Scharff A, Ruscher K, et al. Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin[J]. Stroke, 2003, 34(8):1981-1986.
5. Bruick RK. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia[J]. Proc Natl Acad Sci USA, 2000, 97 (16):9082-9087.
6. Wei YZh, Yao ZhB, Yuan QF, et al. The protective effect of berberine on hippocampus after global ischemia [J]. Chinese Journal of Neuroanatomy, 1995,11(4):315-321.
7. Wu JF, Liu ShL, Pan XX, et al. The protective effect of berberine on the cultured neuronal cell of rat after ischemic injury [J]. Chinese Pharmacological Bulletin, 1999,15(3):243-246.
8. Badr AE, Yin W, Mychaskiw G, et al. Effect of hyperbaric oxygen on striatal metabolites: a microdialysis study in awake freely moving rats after MCA occlusion[J]. Brain Res, 2001,916(1-2):85-90.
9. Badr AE, Yin W, Mychaskiw G, et al. Dual effect of HBO on cerebral infarction in MCAO rats[J]. Am J Physiol Regul Integr Comp Physiol, 2001,280(3):766-770.
10. Yin W, Badr AE, Mychaskiw G, et al. Downregulation of COX-2 is involved in hyperbaric oxygen treatment in a rat transient focal cerebral ischemia model[J]. Brain Res,2002,926(1-2):165-171.
11. Pan LX, Yao ZhB, Chen YC. The selective injury on CA1 region of hippocampus after brain ischemia[J]. Journal of Apoplexy and Nervous Diseases, 1997,14(2):80-81.
12. Wu JF, Shi YJ, Liu TP. The protective effect of berberine on brain ischemia of rats and mice [J]. Chinese Journal of Pharmacology And Toxicology, 1995, 9(2):100-103.
13. Xi GM, He GH, Huang ChF. The therapeutic effect of berberine on brain infarction[J]. Journal of Apoplexy and Nervous Diseases, 2003, 20(5):459-460.
14. Shankung L, Shiow CT, Chun CL, et al. Berberine inhibits HIF-1α expression via enhanced proteolysis[J]. Mol Pharmacol, 2004, 66(3): 612-619.
15. Helton R, Cui J, Scheel JR, et al. Brain-specific knock-out of hypoxia-inducible factor-1 alpha reduces rather than increases hypoxic-ischemic damage[J].J Neurosci ,2005,25(16):4099-4107.