Modification of axial fiber contact residues impact sickle hemoglobin polymerization by perturbing a network of coupled interactions

Protein Journal

Volumn 26, Issue 7, 2007, Pages 445-455

  Banerjee, Srijita ^a   Mirsamadi, Neda ^b   Anantharaman, Lavanya ^a   Sivaram, Mylavarapu V S ^a   Gupta, Rasik B ^c   Choudhury, Devapriya ^b   Roy, Rajendra P ^a  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^b JAWAHARLAL NEHRU UNIVERSITY   (India)

^c Regional Medical Research Centre for Tribals   (India)

Author keywords

Fiber assembly; Interaction linkage; Molecular dynamics; Mutant hemoglobins; Sickle hemoglobin polymerization

Indexed keywords

ALPHA GLOBIN; BETA GLOBIN; HEMOGLOBIN S; MUTANT PROTEIN; POLYMER;

ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; MASS SPECTROMETRY; MOLECULAR DYNAMICS; POINT MUTATION; PROTEIN ASSEMBLY; PROTEIN POLYMERIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SIMULATION; SOLUBILITY; ULTRAVIOLET SPECTROSCOPY;

BINDING SITES; CIRCULAR DICHROISM; DIMERIZATION; HEMOGLOBIN, SICKLE; HUMANS; MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 35348890113     PISSN: 15723887     EISSN: 15734943     Source Type: Journal    
DOI: 10.1007/s10930-007-9084-1     Document Type: Article

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