Effects of neoadjuvant therapy on perioperative morbidity in elderly patients undergoing esophagectomy for esophageal cancer

Annals of Surgical Oncology

Volumn 14, Issue 11, 2007, Pages 3243-3250

  Ruol, Alberto ^a   Portale, Giuseppe ^a   Castoro, Carlo ^a   Merigliano, Stefano ^a   Cagol, Matteo ^a   Cavallin, Francesco ^a   Chiarion Sileni, Vanna ^a   Corti, Luigi ^b   Rampado, Sabrina ^a   Costantini, Mario ^a   Ancona, Ermanno ^a  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Elderly patients; Esophageal cancer; Esophagectomy; Morbidity; Mortality; Neoadjuvant therapy; Survival

Indexed keywords

FLUOROURACIL; PLATINUM DERIVATIVE; TAXANE DERIVATIVE;

ADJUVANT CHEMOTHERAPY; ADULT; ADVANCED CANCER; AGE DISTRIBUTION; AGED; ARTICLE; CANCER MORTALITY; CANCER RADIOTHERAPY; COMORBIDITY; CONTINUOUS INFUSION; CONTROLLED STUDY; CYTOREDUCTIVE SURGERY; ESOPHAGUS CANCER; ESOPHAGUS RESECTION; FEMALE; HEART DISEASE; HUMAN; LUNG DISEASE; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MULTIPLE CYCLE TREATMENT; PERIOPERATIVE PERIOD; PROGNOSIS; TREATMENT OUTCOME; VASCULAR DISEASE;

ADENOCARCINOMA; AGE DISTRIBUTION; AGED; CARCINOMA, SQUAMOUS CELL; ESOPHAGEAL NEOPLASMS; ESOPHAGECTOMY; FEMALE; GAMMA RAYS; HOSPITAL MORTALITY; HUMANS; MALE; MIDDLE AGED; MORBIDITY; NEOADJUVANT THERAPY; ORGANOPLATINUM COMPOUNDS; RISK FACTORS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 35348864874     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-007-9455-z     Document Type: Article

References (20)

1. Walsh TN, Noonan N, Hollywood D, Kelly A, Keeling N, Hennessy TP. A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med 1996;335:462-7
2. Bosset JF, Gignoux M, Triboulet JP, et al. Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus. N Engl J Med 1997;161-7
3. Kelsen DP, Ginsberg R, Pajak TF, et al. Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer. N Engl J Med 1998;339:1979-84
4. Medical Research Council Oesophageal Cancer Working Group. Surgical resection with or without preoperative chemotherapy in oesophageal cancer: a randomized controlled trial. Lancet 2002;359:1727-33
5. Burmeister B, Smithers B, Gebski V, et al. Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the esophagus: a randomized controlled phase III trial. Lancet Oncol 2005;6:659-68
6. Urba SG, Orringer MB, Turrisi A, et al. Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma. J Clin Oncol 2001;19:305-13
7. Urschel JD, Vasan H. A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer. Am J Surg 2003;185:538-43
8. Kaklamanos IG, Walker GR, Ferri K, et al. Neoadjuvant treatment for resectable cancer of the esophagus and the gastroesophageal junction: a meta-analysis of randomized clinical trials. Ann Surg Oncol 2003;10:754-61
9. Malthaner RA, Collin S, Fenlon D. Preoperative chemotherapy for resectable thoracic esophageal cancer. Cochrane Database Syst Rev. 2006;19:3:CD001556
10. Ancona E, Ruol A, Santi S, et al. Only pathologic complete response to neoadjuvant chemotherapy improves significantly the long term survival of patients with resectable esophageal squamous cell carcinoma: final report of a randomized, controlled trial of preoperative chemotherapy versus surgery alone. Cancer 2001;91:2165-74
11. Devesa SS, Blot WJ, Fraumeni JF. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer 1998;83:2049-53
12. Hutchins LF, Unger J, Crowley J, et al. Underreppresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med 1999;341:2061-67
13. Lin FC, Durkin AE, Ferguson MK. Induction therapy does not increase surgical morbidity after esophagectomy for cancer. Ann Thoracic Surg 2004;78:1783-89
14. Kelly ST, Coppola D, Karl RC. Neoadjuvant chemotherapy is not associated with a higher complication rate vs. surgery alone in patients undergoing esophagectomy. J Gastrointest Surg 2004;8:227-32
15. Rice DC, Correa AM, Vaporciyan AA, et al. Preoperative chemoradiotherapy prior to esophagectomy in elderly patients is not associated with increased morbidity. Ann Thoracic Surg 2005;79:391-7
16. Ruol A, Portale G, Zaninotto G, et al. Age does not affect outcome and survival after esophagectomy for esophageal cancer. J Thorac Cardiovasc Surg 2007;133:1186-1192
17. Ferguson MK, Martin TR, Reeder LB, et al. Mortality after esophagectomy: risk factor analysis. World J Surg 1997;21:599-604
18. Rahamin JS, Murphy GJ, Awan Y, et al. The effect of age on the outcome of surgical treatment for carcinoma of the oesophagus and gastric cardia. Eur J Cardiothorac Surg 2003;23:805-10
19. Merigliano S, Ruol A, Baldan N, et al. Management and prognosis of esophageal cancer in elderly patients. J Chemotherapy 1996;8:72-4
20. Naunheim KS, Hanosh J, Zwischenberger J, et al. Esophagectomy in the septuagenarian. Ann Thorac Surg 1993;56:880-4