Metabolic engineering of a genetic selection system with tunable stringency

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 35, 2007, Pages 13907-13912

  Kleeb, Andreas C ^a   Edalat, Maryam Hansson ^a   Gamper, Marianne ^a   Haugstetter, Johannes ^a   Giger, Lars ^a   Neuenschwander, Martin ^a   Kast, Peter ^a   Hilvert, Donald ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Directed evolution; Enzyme design; Genetic complementation; Prephenate dehydratase; Tetracycline promoter

Indexed keywords

AMINO ACID DERIVATIVE; PHENYLALANINE; PHENYLPYRUVIC ACID; PREPHENATE DEHYDRATASE; PREPHENIC ACID; TETRACYCLINE; UNCLASSIFIED DRUG; AMINO ACID; RECOMBINANT PROTEIN; SHIKIMIC ACID;

ARTICLE; BACTERIUM MUTANT; CATALYSIS; CATALYST; CONCENTRATION RESPONSE; ENZYME ACTIVITY; ENZYME ISOLATION; ESCHERICHIA COLI; GENETIC COMPLEMENTATION; GENETIC SELECTION; METABOLIC ENGINEERING; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REACTION ANALYSIS; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DIRECTED MOLECULAR EVOLUTION; GENETIC ENGINEERING; GENETIC VARIABILITY; GENETICS; KINETICS; METABOLISM; METHODOLOGY; PLASMID; PROTEIN CONFORMATION;

BACTERIA (MICROORGANISMS);

AMINO ACIDS; DIRECTED MOLECULAR EVOLUTION; GENETIC ENGINEERING; KINETICS; MODELS, GENETIC; MODELS, MOLECULAR; PLASMIDS; PREPHENATE DEHYDRATASE; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SELECTION (GENETICS); SHIKIMIC ACID; VARIATION (GENETICS);

EID: 35348863113     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0705379104     Document Type: Article

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