Effect of combined humanPTH(1-34) and calcitonin treatment in ovariectomized rats

Bone

Volumn 41, Issue 5, 2007, Pages 786-793

  Washimi, Yuki ^a   Ito, Masato ^a   Morishima, Yosuke ^a   Taguma, Kanako ^a   Ojima, Yoshihide ^b   Uzawa, Toyonobu ^b   Hori, Masayuki ^b  

^a Ichinomiya Nishi Hospital   (Japan)

^b ASAHI KASEI PHARMA CORPORATION   (Japan)

Author keywords

CT; Calcitonin; Combination therapy; Dual energy X ray absorptiometry; Ovariectomized rats; Parathyroid hormone

Indexed keywords

ELCATONIN; PARATHYROID HORMONE; PARATHYROID HORMONE 10; PARATHYROID HORMONE 20; PARATHYROID HORMONE 5; PARATHYROID HORMONE[1-34]; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE DENSITY; BONE MASS; BONE STRENGTH; COMPRESSIVE STRENGTH; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG EFFECT; FEMALE; LEG LENGTHENING; METAPHYSIS; MORPHOMETRICS; NONHUMAN; OSTEOLYSIS; OVARIECTOMY; RAT; TRABECULAR BONE;

ANIMALS; BODY WEIGHT; BONE DENSITY; BONE RESORPTION; CALCITONIN; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; OVARIECTOMY; PARATHYROID HORMONE; RATS; RATS, WISTAR;

EID: 35348841541     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2007.06.019     Document Type: Article

References (32)

1. Reeve J., Meunier P.J., Parsons J.A., Bernat M., Bijvoet O.L., Courpron P., et al. Anabolic effect of human PTH on trabecular bone in involutional osteoporosis: a multicenter trial. Br. Med. J. 280 (1980) 1340-1344
2. Slovik D.M., and Rosenthal D.I. Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone(1-34) and 1,25-dihydroxyvitamin D. J. Bone Miner. Res. 1 (1986) 377-381
3. Lindsay R., Nieves J., Formica C., Henneman E., Woelfert L., Shen V., et al. Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis. Lancet 350 (1997) 550-555
4. Neer R.M., Arnaud C.D., Zanchetta J.R., Prince R., Gaich G.A., and Reginster J.Y. Effect of parathyroid hormone(1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N. Engl. J. Med. 344 (2001) 1434-1441
5. Komatsubara S., Mori S., Mashiba T., Nonaka K., Seki A., Akiyama T., et al. Human parathyroid hormone (1-34) accelerates the fracture healing process of woven to lamellar bone replacement and new cortical shell formation in rat femora. Bone 36 (2005) 678-687
6. Black D.M., Greenspan S.L., Ensrud K.E., Palermo L., McGowan J.A., Lang T.F., et al. The effect of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N. Engl. J. Med. 349 (2003) 1207-1215
7. Finkelsten J.S., Hayes A., Hunzelman J.L., Wyland J.J., Lee H., and Neer R.M. The effects of parathyroid hormone, alendronate, or both in men with osteoporosis. N. Engl. J. Med. 349 (2003) 1216-1226
8. Gruber H.E., Grigsby J., and Chesnut C.H. Osteoblast numbers after calcitonin therapy: a retrospective study of paired biopsies obtained during long-term calcitonin therapy in postmenopausal osteoporosis. Calcif. Tissue Int. 66 1 (2000) 29-34
9. Laib A., Kumer J.L., Majumdar S., and Lane N.E. The temporal changes of trabecular architecture in ovariectomized rats assessed by microCT. Osteoporos. Int. 12 (2001) 936-941
10. Hahn M., Vogel M., Pompesius-Kempa M., and Delling G. Trabecular bone pattern factor - a new parameter for simple quantification of bone microarchitecture. Bone 13 (1992) 327-330
11. Compston J.E., Mellish R.W.E., and Garrahan N.J.X. Age-related change in iliac crest trabecular microanatomic bone structure in man. Bone 8 (1987) 289-292
12. Mosekilde L., Thomsen J., Mackey M., and Phipps R. Treatment with risedronate or alendronate prevents hind-limb immobilization-induced loss of bone density and strength in adult female rats. Bone 27 (2000) 639-645
13. Miyakoshi N., Sato K., Tamura Y., Tsuchida T., Kudo T., and Kasukawa Y. Evaluation of long-term sequential changes in bone mass and strength following withdrawal of incadronate disodium (YM175) in ovariectomized rats. J. Orthop. Sci. 6 (2001) 167-176
14. Hock J.M. Anabolic actions of PTH in the skeletons of animals. J. Musculoskelet. Neuronal Interact. 2 1 (Sep 2001) 33-47
15. Cosman F., and Lindsay R. Therapeutic potential of parathyroid hormone. Curr. Osteoporos. Rep. 2 1 (2004) 5-11
16. Podbesek R., and Edourard C. Effect of two treatment regimes with synthetic human parathyroid hormone fragment on bone formation and the tissue balance of trabecular bone in greyhounds. Endocrinology 112 (1983) 1000-1006
17. Sato M., Westmore M., Ma Y.L., Schmidt A., Zeng Q.Q., Glass E.V., et al. Teriparatide [PTH(1-34)] strengthens the proximal femur of ovariectomized nonhuman primates despite increasing porosity. J. Bone Miner. Res. 19 4 (2004) 623-629
18. Dempster D.W., Cosman F., and Kurland E.S. Effect of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis: a paired biopsy study. JBMR 16 10 (2001) 1846-1853
19. Chavassieux P.M., Arlot M.E., Reda C., Wei L., Yates A.J., and Meunier PJ. Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis. J. Clin. Invest. 100 6 (1997) 1475-1480
20. Odvina C.V., Zerwekh J.E., Rao D.S., Maalouf N., Gottschalk F.A., and Pak C.Y.C. Severely suppressed bone turnover: a potential complication of ALN therapy. J. Clin. Endocrinol. Metab. 90 (2005) 1294-1301
21. Hunziker J., Wronski T.J., and Miller S.C. Mandibular bone formation rates in aged ovariectomized rats treated with anti-resorptive agents alone and combination with intermittent parathyroid hormone. J Dent Res 79 6 (2000) 1431-1438
22. Hodsman A.B., Kisiel M., Adachi J.D., Fraher L.J., and Watson PH. Histomorphometric evidence for increased bone turnover without change in cortical thickness or porosity after 2 years of cyclical hPTH(1-34) therapy in women with severe osteoporosis. Bone 27 2 (2000) 311-318
23. Mosekilde L., Danielsen C.C., and Gasser J. The effect of vertebral bone mass and strength of long term treatment with antiresorptive agents(estrogen and calcitonin), human parathyroid hormone-(1-38), and combination therapy, assessed in aged ovariectomaized rats. Endocrinology 134 (1994) 2126-2134
24. Srivastava A.K., Libanati C., Hohmann O., Kriegmann A., and Baylink D.J. Acute effects of calcitonin nasal spray on serum C-telopeptide of type 1 collagen (CTx) levels in elderly osteopenic women with increased bone turnover. Calcif. Tissue Int. 75 (2004) 477-481
25. Hori M., Uzawa T., Morita K., Noda T., Takahashi H., and Inoue J. Effect of human parathyroid hormone (PTH(1-34)) on experimental osteopenia of rats induced by ovariectomy. Bone Miner. 3 3 (1988) 193-199
26. Ogawa K., Hori M., Takao R., and Sakurada T. Effects of combined elcatonin and alendronate treatment on the architecture and strength of bone in ovariectomized rats. J. Bone Miner. Metab. 23 5 (2005) 351-358
27. Qi H., Li M., and Wronski T.J. A comparison of the anabolic effects of parathyroid hormone at skeletal sites with moderate and severe osteopenia in aged ovariectomized rats. J. Bone Miner. Res. 10 6 (1995) 948-955
28. Silverman S.L., and Azria M. The analgesic role of calcitonin following osteoporotic fracture. Osteoporos. Int. 13 11 (2002) 858-867
29. Knopp J.A., Diner B.M., Blitz M., Lyritis G.P., and Rowe B.H. Calcitonin for treating acute pain of osteoporotic vertebral compression fractures: a systematic review of randomized, controlled trials. Osteoporos. Int. 16 10 (2005) 1281-1290
30. Nevitt M.C., Thompson D.E., Black D.M., Rubin S.R., Ensrud K., Yates A.J., et al. Effect of alendronate on limited-activity days and bed-disability days caused by back pain in postmenopausal women with existing vertebral fractures. Fracture Intervention Trial Research Group. Arch. Intern. Med. 160 1 (2000) 77-85
31. Gaggi R., Beltrandi E., Dall'Olio R., and Ferri S. Relationships between hypocalcaemic and anorectic effect of calcitonin in the rat. Pharmacol. Res. Commun. 17 (1985) 209-215
32. 19 sCT) retains full potency without inducing anorexia in rats. Endocrinology 126 (1990) 2845-2849