Constipation: Evaluation and Treatment of Colonic and Anorectal Motility Disorders

Gastroenterology Clinics of North America

Volumn 36, Issue 3, 2007, Pages 687-711

  Rao, Satish S C ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALVIMOPAN; BISACODYL; DOCUSATE SODIUM; ISPAGULA; LACTULOSE; LUBIPROSTONE; MACROGOL; METHYLCELLULOSE; POLYCARBOPHIL CALCIUM; RENZAPRIDE; SENNA EXTRACT; TEGASEROD;

ABDOMINAL PAIN; ANORECTAL PRESSURE; CONSTIPATION; DEFECATION DISORDER; DEFECOGRAPHY; DIAGNOSTIC PROCEDURE; DIARRHEA; DIET; ENTEROPATHY; EXERCISE; FECES IMPACTION; FIBER; FLUID INTAKE; HEADACHE; HUMAN; INTESTINE MOTILITY; INTESTINE MOTILITY DISORDER; NAUSEA; PATHOPHYSIOLOGY; PHYSICAL EXAMINATION; RADIOGRAPHY; REVIEW;

CONSTIPATION; DIAGNOSTIC TECHNIQUES, DIGESTIVE SYSTEM; DIETARY FIBER; EVIDENCE-BASED MEDICINE; EXERCISE THERAPY; GASTROINTESTINAL TRANSIT; HUMANS; LAXATIVES;

EID: 35348813332     PISSN: 08898553     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gtc.2007.07.013     Document Type: Review

References (118)

1. Pare P., Ferrazzi S., Thompson W.G., et al. An epidemiological survey of constipation in canada: definitions, rates, demographics, and predictors of health care seeking. Am J Gastroenterol 96 (2001) 3130-3137
2. Stewart W.F., Liberman J.N., Sandler R.S., et al. Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features. Am J Gastroenterol 94 (1999) 3530-3540
3. Pare P., Ferrazzi S., and Thompson W.G. A Longitudinal Survey of Self-reported Bowel Habits in the United States. Dig Dis Sci 34 (1989) 1153-1162
4. Talley N.J., Fleming K.C., Evans J.M., et al. Constipation in an elderly community: a study of prevalence and potential risk factors. Am J Gastroenterol 91 (1996) 19-25
5. Sonnenberg A., and Koch T.R. Physician visits in the United States for constipation: 1958 to 1986. Dig Dis Sci 34 (1989) 606-611
6. Higgins P.D., and Johanson J.F. Epidemiology of constipation in North America: a systematic review. Am J Gastroenterol 99 (2004) 750-759
7. Martin B.C., Barghout V., and Cerulli A. Direct medical costs of constipation in the United States. Manag Care Interface 19 (2006) 43-49
8. Chang L., Toner B.B., Fukudo S., et al. Gender, age, society, culture, and the patient's perspective in the functional gastrointestinal disorders. Gastroenterology 130 (2006) 1435-1446
9. Rao S.S., Tuteja A.K., Vellema T., et al. Dyssynergic defecation: demographics, symptoms, stool patterns, and quality of life. J Clin Gastroenterol 38 (2004) 680-685
10. Pare P., Gray J., Lam S., et al. Health-related quality of life, work productivity, and health care resource utilization of subjects with irritable bowel syndrome: baseline results from LOGIC (Longitudinal Outcomes Study of Gastrointestinal Symptoms in Canada), a naturalistic study. Clin Ther 28 (2006) 1726-1735 discussion 1710-1
11. Singh G. Use of Health Care Resources and Cost of Care for Adults With Constipation. Clin Gastroenterol Hepatol (2007 Jul 9) [Epub ahead of print]
12. Rao S.S.C. Constipation-Method of Conn's Current Therapy. In: Rakel R.E. (Ed) (1999), W.B. Saunders Company, Philadelphia 20-23
13. Rao S.S.C. Dyssynergic Defecation. Gastroenterol Clin North Am. Volume 30 (2001) 97-114
14. Preston D.M., and Lennard-Jones J.E. Anismus in Chronic Constipation. Dig Dis Sci 30 (1985) 413-418
15. Whitehead W.E., Devroede G., Habib F.I., et al. Functional Disorders of the Anorectum. Gastroenterology International 5 (1992) 92-108
16. Kawimbe B.M., Papachrysostomou M., Binnie N.R., et al. Outlet Obstruction Constipation (Anismus) Managed by Biofeedback. Gut 32 (1991) 1175-1179
17. Martelli H., Devroede G., Arhan P., et al. Mechanisms of Idiopathic Constipation: Outlet obstruction. Gastroenterology 75 (1978) 623-631
18. Mertz H., Naliboff B., and Mayer E. Physiology of Refractory Chronic Constipation. Am J Gastroenterol 94 (1999) 609-615
19. Bharucha A.E., and Phillips S.F. Slow Transit Constipation. Gastroenterol Clin North Am 30 (2001) 77-95
20. Locke III G.R., Pemberton J.H., and Phillips S.F. American Gastroenterological Association Medical Position Statement: guidelines on constipation. Gastroenterology 119 (2000) 1761-1766
21. Thompson W.G., Longstreth G.F., Drossman D.A., et al. Functional Bowel Disorders and Functional Abdominal Pain. Gut 45 (1999) 1143-1147
22. Whitehead W.E., Devrode G., Habib F., et al. Functional Disorders of the Anus and Rectum. In: Drossman D.A. (Ed). The Functional Gastrointestinal Disorders (1994), Little Brown & Company, Boston 217-263
23. Whitehead W.E., Wald A., Diamant N.E., et al. Functional disorders of the anus and rectum. Gut 45 Suppl. 2 (1999) II55-II59
24. Bharucha A.E., Wald A., Enck P., et al. Functional anorectal disorders. Gastroenterology 130 (2006) 1510-1518
25. Rao S.S.C., Welcher K.D., and Leistikow J.S. Obstructive Defecation: A Failure of Rectoanal Coordination. Am J Gastroenterol 93 (1998) 1042-1050
26. Longstreth G.F., Thompson W.G., Chey W.D., et al. Functional bowel disorders. Gastroenterology 130 (2006) 1480-1491
27. Klauser A.G., Voderholzer W.A., Heinrich C.A., et al. Behavioural Modification of Colonic Function: Can Constipation be Learned?. Dig Dis Sci 35 (1990) 1271-1275
28. Bassotti G., Betti C., Imbimbo B.P., et al. Colonic Motor Response to Eating: A Manometric Investigation in Proximal and Distal Portion of the Viscus in Man. Am J Gastroenterol (1989) 84-86
29. Rao S.S.C., Kavelock R., Beaty J., et al. Effects of Fat and Carbohydrate Meals on Colonic Motor Response. Gut 46 (2000) 205-211
30. Rao S.S.C., Sadeghi P., Beaty J., et al. Ambulatory 24-h Colonic Manometry in Healthy Humans. Am J Physiol Gastrointest Liver Physiol 280 (2001) G629-G639
31. Rao S.S.C., Beaty J., Chamberlain M., et al. Effects of Acute Graded Exercise on Human Colonic Motility. Am J Physiol 276 (1999) G1221-G1226
32. Chowdhury A.B., Dinoso V.P., and Lorber S.H. Characterization of a Hyperactive Segment at the Rectosigmoid Junction. Gastroenterology 71 (1976) 584-588
33. Narducci F. Twenty four hour manometric recordings of colonic motor activity in man. Gut 28 (1987) 17-25
34. Rao S.S., and Patel R.S. How useful are manometric tests of anorectal function in the management of defecation disorders?. Am J Gastroenterol 92 (1997) 469-475
35. Rao S.S.C., Hatfield R., Soffer E., et al. Manometric Tests of Anorectal Function in Healthy Adults. Am J Gastroenterol 94 (1999) 773-783
36. Rao S. Colonic motor patterns in healthy humans: A 24 hour ambulatory study. Gastroenterology (1998) A114-A829
37. Rao S.S., Sadeghi P., Beaty J., et al. Ambulatory 24-hour colonic manometry in slow-transit constipation. Am J Gastroenterol 99 (2004) 2405-2416
38. Rao S.S.C., Welcher K., and Hatfield R. Periodic Rectal Motor Activity (PRMA): The Intrinsic Colonic Gatekeeper. Gastroenterology (1995) 108
39. Rao S.S., Sadeghi P., Batterson K., et al. Altered periodic rectal motor activity: a mechanism for slow transit constipation. Neurogastroenterol Motil 13 (2001) 591-598
40. Rao S.S.C., Sadeghi P., Kavlock R., et al. Specialized Propagating Contractions (SPC) in Health and Constipation. Gastroenterology 116 (1999) G4635
41. Bassotti G. Manometric investigation of high amplitude propagated contractile activityof the human colon. Am J Physiology 255 (1988) G660-G664
42. Rao S.S.C., Sadeghi P., Kavlock R., et al. Specialized Propagating Pressure Waves (SSPW) in Health and Constipation. Am J Gastroenterol 94 (1999) A2684
43. Law N.M., Bharucha A.E., and Zinsmeister A.R. Rectal and colonic distension elicit viscerovisceral reflexes in humans. Am J Physiol Gastrointest Liver Physiol 283 (2002) G384-G389
44. O'Brien M.D. Camilleri M, von der Ohe MR, et al. Motility and tone of the left colon in constipation: a role in clinical practice?. Am J Gastroenterol 91 (1996) 2532-2538
45. Knowles C.H., Scott M., and Lunniss P.J. Outcome of colectomy for slow transit constipation. Ann Surg 230 (1999) 627-638
46. Surrenti E., Rath D.M., Pemberton J.H., et al. Audit of Constipation in a Tertiary Referral Gastroenterology Practice. Am J Gastroenterol 90 (1995) 1471-1475
47. He C.L., Burgart L., Wang L., et al. Decreased interstitial cell of cajal volume in patients with slow-transit constipation. Gastroenterology 118 (2000) 14-21
48. Mollen R.M., Hopman W.P., Kuijpers H.H., et al. Abnormalities of upper gut motility in patients with slow-transit constipation. Eur J Gastroenterol Hepatol 11 (1999) 701-708
49. Spiller R.C. Upper gut dysmotility in slow-transit constipation: is it evidence for a pan-enteric neurological deficit in severe slow transit constipation?. Eur J Gastroenterol Hepatol 11 (1999) 693-696
50. Devroede G., and Soffie M. Colonic Absorption in Idiopathic Constipation. Gastroenterology 64 (1973) 552-561
51. Preston D.M., and Lennard-Jones J. Severe Chronic Constipation of Young Women: Idiopathic Slow Transit Constipation?. Gut 27 (1986) 41-48
52. Kamm M.A., Farthing M.J., and Lennard-Jones J.E. Bowel function and transit rate during the menstrual cycle. Gut 30 (1989) 605-608
53. Wald A., Van Thiel D.H., Hoechstetter L., et al. Gastrointestinal transit: the effect of the menstrual cycle. Gastroenterology 80 (1981) 1497-1500
54. Turnbull G.K., Thompson D.G., Day S., et al. Relationships between symptoms, menstrual cycle and orocaecal transit in normal and constipated women. Gut 30 (1989) 30-34
55. Kamm M.A. Pathophysiology of Constipation. In: Phillips S.F., and Shorter R.G. (Eds). The Large Intestine. Physiology, Pathophysiology and Disease (1991), Raven Press, New York 709-726
56. Koch T.R., Carney J.A., Go L., et al. Idiopathic chronic constipation is associated with decreased colonic vasoactive intestinal peptide. Gastroenterology 94 (1988) 300-310
57. Lincoln J., Crowe R., Kamm M.A., et al. Serotonin and 5-hydroxyindoleacetic acid are increased in the sigmoid colon in severe idiopathic constipation. Gastroenterology 98 (1990) 1219-1225
58. Xiao Z.L., Pricolo V., Biancani P., et al. Role of progesterone signaling in the regulation of G-protein levels in female chronic constipation. Gastroenterology 128 (2005) 667-675
59. Xiao Z.L., Cao W., Biancani P., et al. Nongenomic effects of progesterone on the contraction of muscle cells from the guinea pig colon. Am J Physiol Gastrointest Liver Physiol 290 (2006) G1008-G1015
60. Pimentel M., Chatterjee S., Chow E.J., et al. Neomycin improves constipation-predominant irritable bowel syndrome in a fashion that is dependent on the presence of methane gas: subanalysis of a double-blind randomized controlled study. Dig Dis Sci 51 (2006) 1297-1301
61. Pimentel M., Mayer A.G., Park S., et al. Methane production during lactulose breath test is associated with gastrointestinal disease presentation. Dig Dis Sci 48 (2003) 86-92
62. Attaluri A, Rao SSC. Is methanogenic flora associated with chronic constipation and altered colonic transit & stool characteristics? Gastroenterology Vol. 132:4(Supp 2:T1945).
63. Pimentel M., Lin H.C., Enayati P., et al. Methane, a gas produced by enteric bacteria, slows intestinal transit and augments small intestinal contractile activity. Am J Physiol Gastrointest Liver Physiol 290 (2006) G1089-G1095
64. Bleijenberg G., and Kuijpers H.C. Treatment of Spastic Pelvic Floor Syndrome with Biofeedback. Dis Colon Rectum 30 (1987) 101-111
65. Duthie G.S., and Bartolo D.C.C. Anismus: The Cause of Constipation? Results of Investigation and Treatment. World J Surg 16 (1992) 831-835
66. Rao S.S., Kavlock R., and Rao S. Influence of body position and stool characteristics on defecation in humans. Am J Gastroenterol 101 (2006) 2790-2796
67. Pinho M., Yoshioka K., and Keighley M.R.B. Long Term Results of Anorectal Myectomy for Chronic Constipation. Br J Surg 76 (1989) 1163-1164
68. Hallan R.I., Williams N.S., Melling J., et al. Treatment of Animus in Intractable Constipation with Botulinum A Toxin. Lancet ii (1988) 714-717
69. Joo J.S., Agachan F., Wolff B., et al. Initial North American Experience with Botulinum Toxin Type A for Treatment of Anismus. Dis Colon Rectum 39 (1996) 1107-1111
70. Heaton K.W., Radvan J., Cripps H., et al. Defecation frequency and timing, and stool form in the general population: a prospective study. Gut 33 (1992) 818-824
71. O'Donnell L.J., Virjee J., and Heaton K.W. Detection of pseudodiarrhoea by simple clinical assessment of intestinal transit rate. Bmj 300 (1990) 439-440
72. Koch A., Voderholzer W.A., Klauser A.G., et al. Symptoms in Chronic Constipation. Dis Colon Rectum 40 (1997) 902-906
73. Glia A., Lindberg F., L.H, Mihocsa L., et al. Clinical Value of Symptom Assessment in Patients with Constipation. Dis Colon Rectum 42 (1999) 1401-1408
74. Karasick S., and Ehrlich S.M. Is constipation a disorder of defecation or impaired motility?: distinction based on defecography and colonic transit studies. AJR Am J Roentgenol 166 (1996) 63-66
75. Ashraf W., Park F., Quigley E.M.M., et al. An Examination of the Reliability of Reported Stool Frequency in the Diagnosis of Idiopathic Constipation. Am J Gastroenterol 91 (1996) 26-32
76. Metcalf A.M., Phillips S.F., and Zinsmeister A.R. Simplified Assessment of Segmental Colonic Transit. Gastroenterology 92 (1987) 40-47
77. Ehrenpreis E.D., Jorge J.M.N., Schiano T.D., et al. Why Colonic Marker Studies Don't Measure Transit Time. Gastroenterology 110A (1997) 728
78. Rao S. A comparative study of SmartPill® and radioopaque markers for the assessment of colonic transit time in humans. Gastroenterology Vol. 132:4(Supp 2).
79. Rao S.S.C., Mudipalli R.S., Stessman M., et al. Characterization of Manometric Changes in Dyssynergic Defecation (Anismus). Am J Gastroenterol 96 (2001) A99
80. Pelsang R.E., Rao S.S.C., and Welcher K. FECOM: A New Artificial Stool for Evaluating Defecation. Am J Gastroenterol 94 (1999) 183-186
81. Chaudhary N.A., and Truelone S.C. Human Colonic Motility: A Comparative Study of Normal Subjects, Patients with Ulcerative Colitis and Patients with Irritable Bowel Syndrome. A Resting Pattern of Motility. Gastroenterology 40 (1961) 11-17
82. Gertken J.T., Cocjin J., Pehlivanov N., et al. Comorbidities associated with constipation in children referred for colon manometry may mask functional diagnoses. J Pediatr Gastroenterol Nutr 41 (2005) 328-331
83. Remes-Troche J.M., and Rao S.S. Diagnostic testing in patients with chronic constipation. Curr Gastroenterol Rep 8 (2006) 416-424
84. Sackett D.L. Rules of evidence and clinical recommendations on the use of antithrombotic agents. Chest 89 (1986) 2S-3S
85. Brandt L.J., Schoenfeld P., Prather C.M., et al. Evidence-based position statement on the management of chronic constipation in North America. Am J Gastroenterol 100 (2005) S1-S22
86. Ramkumar D., and Rao S.S. Efficacy and safety of traditional medical therapies for chronic constipation: systematic review. Am J Gastroenterol 100 (2005) 936-971
87. Chung B.D., Parekh U., and Sellin J.H. Effect of increased fluid intake on stool output in normal healthy volunteers. J Clin Gastroenterol 28 (1999) 29-32
88. Whitehead W.E., Drinkwater D., Cheskin L.J., et al. Constipation in the Elderly Living at Home: Definition, Prevalence, and Relationship to Life Style and Health Status. J Am Geriatr Soc 37 (1989) 423-429
89. Heaton K.W., Wood N., Cripps H.A., et al. The Call to Stool and its Relationship to Constipation: A Community Study. Eur J Gast Hepaol 6 (1994) 145-149
90. Burkitt D.P., Walker A.R.P., and Painter N.S. Effect of Dietary Fiber on Stool and Transit Times and its Role in the Causation of Disease. Lancet ii (1972) 1408-1411
91. Tucker D.M., Sandstead H.H., and Logan G.M. Dietary Fiber and Personality Factors as Determinants of Stool Output. Gastroenterology 81 (1981) 879-883
92. Voderholzer W.A., Schatke W., Muhldorfer B.E., et al. Clinical Response to Dietary Fiber Treatment of Chronic Constipation. Am J Gastroenterol 92 (1997) 95-98
93. Tramonte S.M., Brand M.B., Mulrow C.D., et al. The Treatment of Chronic Constipation in Adults: A Systematic Review. J Gen Intern Med 12 (1997) 15-24
94. Kline & Company, Non Prescription Drugs USA 2000; Table 3-3: 44.
95. Lederle F.A., Busch D.L., Mattox K.M., et al. Cost-effective treatment of constipation in the elderly: a randomized double-blind comparison of sorbitol and lactulose. Am J Med 89 (1990) 597-601
96. Passmore A.P., Davies K.W., Flanagan P.G., et al. A comparison of Agiolax and lactulose in elderly patients with chronic constipation. Pharmacology 47 Suppl 1 (1993) 249-252
97. DiPalma J.A., DeRidder P.H., Orlando R.C., et al. A randomized, placebo-controlled, multicenter study of the safety and efficacy of a new polyethylene glycol laxative. Am J Gastroenterol 95 (2000) 446-450
98. Corazziari E., Badiali D., Habib F.I., et al. Small volume isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in treatment of chronic nonorganic constipation. Dig Dis Sci 41 (1996) 1636-1642
99. Corazziari E., Badiali D., Bazzocchi G., et al. Long term efficacy, safety, and tolerabilitity of low daily doses of isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in the treatment of functional chronic constipation. Gut 46 (2000) 522-526
100. Verne G.N., Eaker E.Y., Davis R.H., et al. Colchicine is an effective treatment for patients with chronic constipation: an open-label trial. Dig Dis Sci 42 (1997) 1959-1963
101. Cuppoletti J., Malinowska D.H., Tewari K.P., et al. SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents. Am J Physiol Cell Physiol 287 (2004) C1173-C1183
102. Camilleri M., Bharucha A.E., Ueno R., et al. Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers. Am J Physiol Gastrointest Liver Physiol 290 (2006) G942-G947
103. Johanson J.F., Wald A., Tougas G., et al. Effect of tegaserod in chronic constipation: a randomized, double-blind, controlled trial. Clin Gastroenterol Hepatol 2 (2004) 796-805
104. Prather C.M., Camilleri M., Zinsmeister A.R., et al. Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome. Gastroenterology 118 (2000) 463-468
105. Kamm M.A., Muller-Lissner S., Talley N.J., et al. Tegaserod for the treatment of chronic constipation: a randomized, double-blind, placebo-controlled multinational study. Am J Gastroenterol 100 (2005) 362-372
106. Camilleri M., McKinzie S., Fox J., et al. Effect of renzapride on transit in constipation-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol 2 (2004) 895-904
107. Gonenne J., Camilleri M., Ferber I., Burton D., Baxter K., Keyashian K., Foss J., Wallin B., Du W., and Zinsmeister A.R. Effect of alvimopan and codeine on gastrointestinal transit: a randomized controlled study. Clin Gastroenterol Hepatol 3 (2005) 784-791
108. Paulson D.M., Kennedy D.T., Donovick R.A., et al. Alvimopan: an oral, peripherally acting, mu-opioid receptor antagonist for the treatment of opioid-induced bowel dysfunction-a 21-day treatment-randomized clinical trial. J Pain 6 (2005) 184-192
109. Camilleri M. Alvimopan, a selective peripherally acting mu-opioid antagonist. Neurogastroenterol Motil 17 (2005) 157-165
110. Currie M. Effects of a single dose administration of MD-1100 on safety,tolerability,exposure, and stool consistency in heathy subjects. Am J Gastroenterol 100 (2005) S328
111. Kurtz C. Effects of multi-dose administration of MD-1100 on safety,tolerability,exposure, and pharmacodynamics in healthy subjects. Gastroenterology 130 (2006) A26
112. Chiarioni G., Whitehead W.E., Pezza V., et al. Biofeedback is superior to laxatives for normal transit constipation due to pelvic floor dyssynergia. Gastroenterology 130 (2006) 657-664
113. Chiarioni G., Salandini L., and Whitehead W.E. Biofeedback benefits only patients with outlet dysfunction, not patients with isolated slow transit constipation. Gastroenterology 129 (2005) 86-97
114. Rao S.S., Seaton K., Miller M., et al. Randomized controlled trial of biofeedback, sham feedback, and standard therapy for dyssynergic defecation. Clin Gastroenterol Hepatol 5 (2007) 331-338
115. Lorenzo D.I.C., Flores A.F., Reddy S.N., et al. Use of Colonic Manometry to Differentiate Causes of Contractable Constipation in Children. J Pediatr 120 (1992) 690-695
116. Pemberton J.H., Rath D.M., and Ilstrup D.M. Evaluation and surgical treatment of severe chronic constipation. Ann Surg 214 (1991) 403-411 discussion 411-3
117. Ho Y.H., Tan M., Eu K.W., et al. Laparoscopic-assisted compared with open total colectomy in treating slow transit constipation. Aust N Z J Surg 67 (1997) 562-565
118. Nyam D.C., Pemberton J.H., Ilstrup D.M., et al. Long-term results of surgery for chronic constipation. Dis Colon Rectum 40 (1997) 273-279